Muscle cramps

References

Key articles

Katzberg HD. Case studies in management of muscle cramps. Neurol Clin. 2020 Aug;38(3):679-96. Abstract

Leung AK, Wong BE, Chan PY, et al. Nocturnal leg cramps in children: incidence and clinical characteristics. J Natl Med Assoc. 1999;91:329-32.Full text  Abstract

Maughan RJ, Shirreffs SM. Muscle cramping during exercise: causes, solutions, and questions remaining. Sports Med. 2019 Dec;49(suppl 2):115-24. Abstract

Zhou K, West HM, Zhang J, et al. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015;(8):CD010655.Full text  Abstract

Maquirriain J, Merello M. The athlete with muscular cramps: clinical approach. J Am Acad Orthop Surg. 2007;15:425-431. Abstract

Garrison SR, Korownyk CS, Kolber MR, et al. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2020 Sep 21;(9):CD009402.Full text  Abstract

El-Tawil S, Al Musa T, Valli H, et al. Quinine for muscle cramps. Cochrane Database Syst Rev. 2015;(4):CD005044.Full text  Abstract

Reference articles

1. Bradley WG, Daroff RB, Fenichel GM, et al. Neurology in clinical practice. 5th ed. Volumes 1 and 2. Philadelphia, PA: Butterworth-Heinemann-Elsevier; 2008.

2. Katzberg HD. Case studies in management of muscle cramps. Neurol Clin. 2020 Aug;38(3):679-96. Abstract

3. American Academy of Sleep Medicine. International classification of sleep disorders - third edition, text revision (ICSD-3-TR). Jun 2023 [internet publication].

4. McGee SR. Muscle cramps. Arch Intern Med. 1990;150:511-518. Abstract

5. Parisi L, Pierelli F, Amabile G, et al. Muscular cramps: proposals for a new classification. Acta Neurol Scand. 2003;107:176-186. Abstract

6. Layzer RB, Rowland LP. Cramps. N Engl J Med. 1971;285:31-40. Abstract

7. Rowland LP. Cramps, spasms and muscle stiffness. Rev Neurol (Paris). 1985;141:261-273. Abstract

8. Oboler SK, Prochazka AV, Meyer TJ. Leg symptoms in outpatient veterans. West J Med. 1991;155:256-259.Full text  Abstract

9. Naylor JR, Young JB. A general population survey of rest cramps. Age Ageing. 1994;23:418-420. Abstract

10. Abdulla AJ, Jones PW, Pearce VR. Leg cramps in the elderly: prevalence, drug and disease associations. Int J Clin Pract. 1999;53:494-496. Abstract

11. Grandner MA, Winkelman JW. Nocturnal leg cramps: Prevalence and associations with demographics, sleep disturbance symptoms, medical conditions, and cardiometabolic risk factors. PLoS One. 2017;12(6):e0178465.Full text  Abstract

12. Maisonneuve H, Chambe J, Delacour C, et al. Prevalence of cramps in patients over the age of 60 in primary care : a cross sectional study. BMC Fam Pract. 2016 Aug 12;17(1):111.Full text  Abstract

13. Hallegraeff J, de Greef M, Krijnen W, et al. Criteria in diagnosing nocturnal leg cramps: a systematic review. BMC Fam Pract. 2017 Feb 28;18(1):29.Full text  Abstract

14. Jansen PH, Joosten EM, van Dijck J, et al. The incidence of muscle cramp. J Neurol Neurosurg Psychiatry. 1991;54:1124-1125.Full text  Abstract

15. Leung AK, Wong BE, Chan PY, et al. Nocturnal leg cramps in children: incidence and clinical characteristics. J Natl Med Assoc. 1999;91:329-32.Full text  Abstract

16. Miller TM, Layzer RB. Muscle cramps. Muscle Nerve. 2005;32:431-42. Abstract

17. Hertz G, Fast A, Feinsilver SH, et al. Sleep in normal late pregnancy. Sleep. 1992;15:246-251. Abstract

18. Neal CR, Resnikoff E, Unger AM. Treatment of dialysis-related muscle cramps with hypertonic dextrose. Arch Intern Med. 1981;141:171-173. Abstract

19. Donauer J, Kolblin D, Bek M, et al. Ultrafiltration profiling and measurement of relative blood volume as strategies to reduce hemodialysis-related side effects. Am J Kid Dis. 2000;36:115-123. Abstract

20. Noordzij M, Boeschoten EW, Bos WJ, et al. Disturbed mineral metabolism is associated with muscle and skin complaints in a prospective cohort of dialysis patients. Nephrol Dial Transplant. 2007;22:2944-2949.Full text  Abstract

21. Brass EP, Adler S, Sietsema KE, et al. Peripheral arterial disease is not associated with an increased prevalence of intradialytic cramps in patients on maintenance hemodialysis. Am J Nephrol. 2002;22:491-496. Abstract

22. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int. 1990;38:912-918.Full text  Abstract

23. Marotta PJ, Graziadei IW, Ghent CN. Muscle cramps: a 'complication' of cirrhosis. Can J Gastroenterol. 2000;14(suppl D):21D-25D. Abstract

24. Konikoff F, Theodor E. Painful muscle cramps. A symptom of liver cirrhosis? J Clin Gastroenterol. 1986;8:669-672. Abstract

25. Kobayashi Y, Kawasaki T, Yoshimi T, et al. Muscle cramps in chronic liver diseases and treatment with antispastic agent (eperisone hydrochloride). Dig Dis Sci. 1992;37:1145-1146. Abstract

26. Angeli P, Albino G, Carraro P, et al. Cirrhosis and muscle cramps: evidence of a causal relationship. Hepatology. 1996;23:264-273.Full text  Abstract

27. Abrams GA, Concato J, Fallon MB. Muscle cramps in patients with cirrhosis. Am J Gastroenterol. 1996;91:1363-1366. Abstract

28. Schwellnus MP, Drew N, Collins M. Muscle cramping in athletes - risk factors, clinical assessment, and management. Clin Sports Med. 2008;27:183-194. Abstract

29. Fallon KE. Musculoskeletal injuries in the ultramarathon: the 1990 Westfield Sydney to Melbourne run. Br J Sports Med. 1996;30:319-323.Full text  Abstract

30. Maughan RJ, Shirreffs SM. Muscle cramping during exercise: causes, solutions, and questions remaining. Sports Med. 2019 Dec;49(suppl 2):115-24. Abstract

31. Tamura N, Kuwabara S, Misawa S, et al. Increased nodal persistent Na+ currents in human neuropathy and motor neuron disease estimated by latent addition. Clin Neurophysiol. 2006;117:2451-2458. Abstract

32. Layzer RB. The origin of muscle fasciculations and cramps. Muscle Nerve. 1994;17:1243-1249. Abstract

33. Roeleveld K, van Engelen BG, Stegeman DF. Possible mechanisms of muscle cramp from temporal and spatial surface EMG characteristics. J Appl Physiol. 2000;88:1698-1706.Full text  Abstract

34. Serrao M, Arendt-Nielsen L, Ge HY, et al. Experimental muscle pain decreases the frequency threshold of electrically elicited muscle cramps. Exp Brain Res. 2007;182:301-308. Abstract

35. Zhou K, West HM, Zhang J, et al. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015;(8):CD010655.Full text  Abstract

36. Hantoushzadeh S, Jafarabadi M, Khazardoust S. Serum magnesium levels, muscle cramps, and preterm labor. Int J Gynaecol Obstet. 2007;98:153-154. Abstract

37. Abrams J, Aponte GE. The leg cramp syndrome during pregnancy; the relationship to calcium and phosphorus metabolism. Am J Obstet Gynecol. 1958;76:432-437. Abstract

38. Hammar M, Berg G, Solheim F, et al. Calcium and magnesium status in pregnant women. A comparison between treatment with calcium and vitamin C in pregnant women with leg cramps. Int J Vitam Nutr Res. 1987;57:179-183. Abstract

39. Schwellnus MP, Nicol J, Laubscher R, et al. Serum electrolyte concentrations and hydration status are not associated with exercise associated muscle cramping (EAMC) in distance runners. Br J Sports Med. 2004;38:488-492.Full text  Abstract

40. Schwellnus MP. Muscle cramping in the marathon: aetiology and risk factors. Sports Med. 2007;37:364-367. Abstract

41. Schwellnus MP, Drew N, Collins M. Increased running speed and previous cramps rather than dehydration or serum sodium changes predict exercise-associated muscle cramping: a prospective cohort study in 210 Ironman triathletes. Br J Sports Med. 2011 Jun;45(8):650-6. Abstract

42. Maquirriain J, Merello M. The athlete with muscular cramps: clinical approach. J Am Acad Orthop Surg. 2007;15:425-431. Abstract

43. Hung CY, Chen YL, Chen CS, et al. Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study. Blood Purif. 2009;27:159-164. Abstract

44. Baskol M, Ozbakir O, Coskun R, et al. The role of serum zinc and other factors on the prevalence of muscle cramps in non-alcoholic cirrhotic patients. J Clin Gastroenterol. 2004;38:524-529. Abstract

45. Marchesini G, Bianchi G, Amodio P, et al. Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology. 2001;120:170-178. Abstract

46. Kim SH, Oh EG, Lee WH. Symptom experience, psychological distress, and quality of life in Korean patients with liver cirrhosis: a cross-sectional survey. Int J Nurs Stud. 2006;43:1047-1056. Abstract

47. Guilhot F, Druker B, Larson RA, et al. High rates of durable response are achieved with imatinib after treatment with interferon alpha plus cytarabine: results from the International Randomized Study of Interferon and STI571 (IRIS) trial. Haematologica. 2009 Dec;94:1669-75.Full text  Abstract

48. Deininger MW, O'Brien SG, Ford JM, et al. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol. Apr 15;21(8):1637-47. Abstract

49. Janssen L, Frambach SJCM, Allard NAE, et al. Skeletal muscle toxicity associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia. Leukemia. 2019 Aug;33(8):2116-20.Full text

50. Zimlichman R, Krauss S, Paran E. Muscle cramps induced by beta-blockers with intrinsic sympathomimetic activity properties: a hint of a possible mechanism. Arch Intern Med. 1991;151:1021. Abstract

51. Imai Y, Watanabe N, Hashimoto J, et al. Muscle cramps and elevated serum creatine phosphokinase levels induced by beta-adrenoceptor blockers. Eur J Clin Pharmacol. 1995;48:29-34. Abstract

52. Young JB, Javid M, George J. Rest cramps in the elderly. J R Coll Physicians Lond. 1989;23:103-106. Abstract

53. Delacour C, Chambe J, Lefebvre F, et al. Association between physical activity and Nocturnal Leg Cramps in patients over 60 years old: a case-control study. Sci Rep. 2020 Feb 14;10(1):2638.Full text  Abstract

54. Gillett RC Jr, Norrell A. Considerations for safe use of statins: liver enzyme abnormalities and muscle toxicity. Am Fam Physician. 2011;83:711-716. Abstract

55. Physicians' desk reference. 65th ed. Montvale, NJ: Medical Economics; 2011.

56. Hedenmalm K, Alvan G, Ohagen P, et al. Muscle toxicity with statins. Pharmacoepidemiol Drug Saf. 2010;19:223-231. Abstract

57. Mosenkis A, Townsend RR. Muscle cramps and diuretic therapy. J Clin Hypertens (Greenwich). 2005;7:134-135. Abstract

58. Fitzgerald MX, Brennan NJ. Muscle cramps, collapse, and seizures in two patients taking metolazone. Br Med J. 1976;1:1381-1382.Full text  Abstract

59. Macdonald JB. Muscle cramps during treatment with nifedipine. Br Med J (Clin Res Ed). 1982;285:1744.Full text  Abstract

60. Keidar S, Binenboim C, Palant A. Muscle cramps during treatment with nifedipine. Br Med J (Clin Res Ed). 1982;285:1241-1242.Full text  Abstract

61. Riley JD, Antony SJ. Leg cramps: differential diagnosis and management. Am Fam Physician. 1995;52:1794-1798. Abstract

62. Palmer KN. Muscle cramp and oral salbutamol. Br Med J. 1978;2:833.Full text  Abstract

63. Lear J, Daniels RG. Muscle cramps related to corticosteroids. BMJ. 1993;306:1169.Full text  Abstract

64. Meyer AH, Kirkman MS. Shock and prolonged muscle cramps after intravenous insulin therapy. N C Med J. 1992;53:484-486. Abstract

65. Kakaria PJ, Nashel DJ, Nylen ES. Debilitating muscle cramps after teriparatide therapy. Ann Intern Med. 2005;142:310. Abstract

66. Kanaan N, Sawaya R. Nocturnal leg cramps. Clinically mysterious and painful - but manageable. Geriatrics. 2001;56:34,39-42. Abstract

67. O'Malley B. Carbimazole-induced cramps. Lancet. 1989;1:1456-1457. Abstract

68. Siegal T, Haim N. Cisplatin-induced peripheral neuropathy. Frequent off-therapy deterioration, demyelinating syndromes, and muscle cramps. Cancer. 1990;66:1117-1123.Full text  Abstract

69. Una E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280-282. Abstract

70. Gupta S, Gupta V, Kapoor B, et al. Pyrazinamide induced hyperuricaemia presenting as severe bilateral leg cramps. J Indian Med Assoc. 2007;105:341-342. Abstract

71. Alonso-Navarro H, Jimenez-Jimenez FJ. Myalgia and cramps associated with zolmitriptan. Clin Neuropharmacol. 2005;28:241-242. Abstract

72. Delacour C, Chambe J, Lefebvre F, et al. Association between alcohol consumption and nocturnal leg cramps in patients over 60 years old: a case-control study. Ann Fam Med. 2018 Jul;16(4):296-301.Full text  Abstract

73. Piccoli GB, Vigotti FN, Consiglio V, et al. Quiz page: severe hypocalcemia caused by intravascular calcium phosphate precipitation after sodium phosphate-containing bowel preparation. Am J Kidney Dis. 2010;55:A35-A37. Abstract

74. Roberts HJ. Spontaneous leg cramps and "restless legs" due to diabetogenic hyperinsulinism: observations on 131 patients. J Am Geriatr Soc. 1965;13:602-638. Abstract

75. Roberts HJ. Spontaneous leg cramps and "restless legs" due to diabetogenic (functional) hyperinsulinism. A basis for rational therapy. JFMA. 1973;60:29-31. Abstract

76. Haskell SG, Fiebach NH. Clinical epidemiology of nocturnal leg cramps in male veterans. Am J Med Sci. 1997;313:210-214. Abstract

77. Elphick DA, Baker M, Baxter JP, et al. Muscle cramps are the commonest side effects of home parenteral nutrition. Clin Nutr. 2009;28:351-354. Abstract

78. Garzoni D, Keusch G, Kleinoeder T, et al. Reduced complications during hemodialysis by automatic blood volume controlled ultrafiltration. Int J Artif Organs. 2007;30:16-24. Abstract

79. Mujais SK. Muscle cramps during hemodialysis. Int J Artif Organs. 1994;17:570-572. Abstract

80. Murray B, Mitsumoto H. Disorders of upper and lower motor neurons. In: Bradley WG, Daroff RB, Fenichel GM, et al, eds. Neurology in clinical practice. 5th ed. Philadelphia, PA: Butterworth Heinemann Elsevier; 2008:2183-2220.

81. Leung AK, Wong BE, Cho HY, et al. Leg cramps in children. Clin Pediatr (Phila). 1997;36:69-73. Abstract

82. Bye AM, Kan AE. Cramps following exercise. Aust Paediatr J. 1988;24:258-259. Abstract

83. Gilchrist JM. Time course of serum CK immediately before and after a single muscle cramp. Muscle Nerve. 2003;27:766. Abstract

84. Krivosic-Horber R, Depret T, Wagner JM, et al. Malignant hyperthermia susceptibility revealed by increased serum creatine kinase concentrations during statin treatment. Eur J Anaesthesiol. 2004;21:572-574. Abstract

85. Hernando P, Caramelo C, Lopez Garcia D, et al. Muscle cramps: a cause of elevated creatine kinase levels in hemodialysis patients. Nephron. 1990;55:231-232. Abstract

86. Fernandez C, de Paula AM, Figarella-Branger D, et al. Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia. Neurology. 2006;66:1585-1587. Abstract

87. Amato AA, Brooke MH. Disorders of skeletal muscle. In: Bradley WG, Daroff RB, Fenichel GM, et al, eds. Neurology in clinical practice. 5th ed. Philadelphia, PA: Butterworth Heinemann Elsevier; 2008:2403-2407.

88. Jankovic J, Shannon KM. Movement disorders. In: Bradley WG, Daroff RB, Fenichel GM, et al, eds. Neurology in clinical practice. 5th ed. Philadelphia, PA: Butterworth Heinemann Elsevier; 2008:2081-2122.

89. Satija P, Ondo WG. Restless legs syndrome: pathophysiology, diagnosis and treatment. CNS Drugs. 2008;22:497-518. Abstract

90. Lowe RM, Hashkes PJ. Growing pain: a noninflammatory pain syndrome of early childhood. Nat Clin Pract Rheumatol. 2008;4:542-549. Abstract

91. Kerchner GA, Lenz RA, Ptacek LJ. Channelopathies: episodic and electrical disorders of the nervous system. In: Bradley WG, Daroff RB, Fenichel GM, et al, eds. Neurology in clinical practice. 5th ed. Philadelphia, PA: Butterworth Heinemann Elsevier; 2008:1799-1820.

92. Ashalatha R, Kishore A, Sarada C, et al. Satoyoshi syndrome. Neurol India. 2004;52:94-95.Full text  Abstract

93. Eymard B, Laforet P. Metabolic myopathies into adulthood. Features and clues for diagnosis. Rev Med Interne. 2001;22(suppl 3):328S-337S. Abstract

94. De Ruiter CJ, Wevers RA, Van Engelen BG, et al. Muscle function in a patient with Brody's disease. Muscle Nerve. 1999;22:704-711. Abstract

95. Brody IA. Muscle contracture induced by exercise. A syndrome attributable to decreased relaxing factor. N Engl J Med. 1969;281:187-192. Abstract

96. Bissonnette B, Luginbuehl I, Marciniak B, et al. Syndromes. Rapid recognition and perioperative implications. New York, NY: McGraw-Hill; 2006:732.

97. Hall AJ. Cramp and salt balance in ordinary life. Lancet. 1947;2:231-233.

98. Katzberg HD, Khan AH, So YT. Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American Academy of Neurology. Neurology. 2010;74:691-696.Full text  Abstract

99. Man-Son-Hing M, Wells G. Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people. BMJ. 1995;310:13-17.Full text  Abstract

100. Man-Son-Hing M, Wells G, Lau A. Quinine for nocturnal leg cramps: a meta-analysis including unpublished data. J Gen Intern Med. 1998;13:600-606.Full text  Abstract

101. Guay DR. Are there alternatives to the use of quinine to treat nocturnal leg cramps? Consult Pharm. 2008;23:141-156. Abstract

102. Anonymous. Quinine sulfate. In: AHFS drug information 2008. Bethesda, MD: American Society of Health-System Pharmacists; 2008:875-881.

103. Baltodano N, Gallo BV, Weidler DJ. Verapamil vs quinine in recumbent nocturnal leg cramps in the elderly. Arch Intern Med. 1988;148:1969-1970. Abstract

104. Stern FH. Value of carisoprodol (Soma) in relieving leg cramps. J Am Geriatr Soc. 1963;11:1008-1013. Abstract

105. Chesrow EJ, Kaplitz SE, Breme JT, et al. Use of carisoprodol (Soma) for treatment of leg cramps associated with vascular, neurologic, or arthritic disease. J Am Geriatr Soc. 1963;11:1014-1016. Abstract

106. Serrao M, Rossi P, Cardinali P, et al. Gabapentin treatment for muscle cramps: an open-label trial. Clin Neuropharmacol. 2000;23:45-49. Abstract

107. Garrison SR, Korownyk CS, Kolber MR, et al. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2020 Sep 21;(9):CD009402.Full text  Abstract

108. El-Tawil S, Al Musa T, Valli H, et al. Quinine for muscle cramps. Cochrane Database Syst Rev. 2015;(4):CD005044.Full text  Abstract

109. Shuman CR. Nocturnal cramps in diabetes mellitus; clinical and physiological correlations. Am J Med Sci. 1953;225:54-60. Abstract

110. Patel A, MacMahon S, Chalmers J, et al; The ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2560-72.Full text  Abstract

111. Hypoglycemia in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group. Diabetes. 1997;46:271-286. Abstract

112. Nygaard IH, Valbo A, Pethick SV, et al. Does oral magnesium substitution relieve pregnancy-induced leg cramps? Eur J Obstet Gynecol Reprod Biol. 2008;141:23-26. Abstract

113. Avsar AF, Ozmen S, Soylemez F. Vitamin B1 and B6 substitution in pregnancy for leg cramps. Am J Obstet Gynecol. 1996;175:233-234. Abstract

114. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 8th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2008.

115. Khajehdehi P, Mojerlou M, Behzadi S, et al. A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. Nephrol Dial Transplant. 2001;16:1448-1451.Full text  Abstract

116. El-Hennawy AS, Zaib S. A selected controlled trial of supplementary vitamin E for treatment of muscle cramps in hemodialysis patients. Am J Ther. 2010;17:455-459. Abstract

117. Roca AO, Jarjoura D, Blend D, et al. Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO J. 1992;38:M481-M485. Abstract

118. Hespel P, Derave W. Ergogenic effects of creatine in sports and rehabilitation. Subcell Biochem. 2007;46:245-259. Abstract

119. Chang CT, Wu CH, Yang CW, et al. Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis. Nephrol Dial Transplant. 2002;17:1978-1981.Full text  Abstract

120. Kaji DM, Ackad A, Nottage WG, et al. Prevention of muscle cramps in haemodialysis patients by quinine sulphate. Lancet. 1976;2:66-67. Abstract

121. Sidhom OA, Odeh YK, Krumlovsky FA, et al. Low-dose prazosin in patients with muscle cramps during hemodialysis. Clin Pharmacol Ther. 1994;56:445-451. Abstract

122. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr. 2000;19:13-15. Abstract

123. Konikoff F, Ben-Amitay G, Halpern Z, et al. Vitamin E and cirrhotic muscle cramps. Isr J Med Sci. 1991;27:221-223. Abstract

124. Lee FY, Lee SD, Tsai YT, et al. A randomized controlled trial of quinidine in the treatment of cirrhotic patients with muscle cramps. J Hepatol. 1991;12:236-240. Abstract

125. Motoo Y, Taga H, Yamaguchi Y, et al. Effect of niuche-shen-qi-wan on painful muscle cramps in patients with liver cirrhosis: a preliminary report. Am J Chin Med. 1997;25:97-102. Abstract

126. Mueller ME, Gruenthal M, Olson WL, et al. Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis. Arch Phys Med Rehabil. 1997;78:521-524. Abstract

127. Bedlack RS, Pastula DM, Hawes J, et al. Open-label pilot trial of levetiracetam for cramps and spasticity in patients with motor neuron disease. Amyotroph Lateral Scler. 2009;10:210-215. Abstract

128. Kanai K, Kuwabara S, Arai K, et al. Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. Brain. 2003;126:965-973.Full text  Abstract

129. Katzberg HD. Neurogenic muscle cramps. J Neurol. 2015 Aug;262(8):1814-21. Abstract

130. Miller RG, Jackson CE, Kasarskis EJ, et al. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2009 Oct 13;73(15):1227-33.Full text  Abstract

131. Baldinger R, Katzberg HD, Weber, M. Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev. 2012;(4):CD004157.Full text  Abstract

132. Forshew DA, Bromberg MB. A survey of clinicians' practice in the symptomatic treatment of ALS. Amyotroph Lateral Scler Other Motor Neuron Disord. 2003;4:258-263. Abstract

133. Bertolasi L, Priori A, Tomelleri G, et al. Botulinum toxin treatment of muscle cramps: a clinical and neurophysiological study. Ann Neurol. 1997;41:181-186. Abstract

134. Minaker KL, Flier JS, Landsberg L, et al. Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy. Arch Neurol. 1989;46:981-985. Abstract

135. Zisfein J, Sivak M, Aron AM, et al. Isaacs' syndrome with muscle hypertrophy reversed by phenytoin therapy. Arch Neurol. 1983;40:241-242. Abstract

136. Chang YJ, Wu CL, Chen RS, et al. Case of Isaacs syndrome successfully treated with phenytoin. J Formos Med Assoc. 1993;92:1010-1012. Abstract

137. Phoenix J, Hopkins P, Bartram C, et al. Effect of vitamin B6 supplementation in McArdle's disease: a strategic case study. Neuromuscul Disord. 1998;8:210-212. Abstract

138. Serrao M, Cardinali P, Rossi P, et al. A case of myokymia-cramp syndrome successfully treated with gabapentin. Acta Neurol Scand. 1998;98:458-460. Abstract

139. Medeiros BC, Lipton JH. Chlordiazepoxide for imatinib-induced muscular cramps. Eur J Haematol. 2006;77:538. Abstract

140. Shewman DA, Craig JM. Creatine supplementation prevents statin-induced muscle toxicity. Ann Intern Med. 2010;153:690-692. Abstract

141. Pasternak RC, Smith SC Jr, Bairey-Merz CN, et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. J Am Coll Cardiol. 2002;40:567-572.Full text  Abstract

142. Woloson SK, Littooy FN. Superficial femoral artery branch avulsion after severe muscle cramping. J Vasc Surg. 1999;30:954-956. Abstract

143. Saskin P, Welton C, Moldofsky H, et al. Sleep and nocturnal leg cramps. Sleep. 1988;11:307-308. Abstract

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