Differentials

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Infection with Epstein-Barr virus (EBV) may resemble features of HIV acute seroconversion illness with fever, lymphadenopathy, pharyngitis, and maculopapular rash.

INVESTIGATIONS

EBV: IgM serology and Paul Bunnell positive.

HIV test negative.

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

May resemble HIV acute seroconversion illness with fever, lymphadenopathy, rash, and splenomegaly.

INVESTIGATIONS

CMV serology positive.

HIV test negative.

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

No specific differentiating signs; viral infections such as influenza may resemble acute seroconversion illness with fever, pharyngitis, and lymphadenopathy.

INVESTIGATIONS

Influenza viral culture or nucleic acid test (nasopharyngeal or respiratory sample) positive

HIV test negative.

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

No specific differentiating signs; viral infections such as the common cold may resemble acute seroconversion illness with fever, pharyngitis, and lymphadenopathy.

INVESTIGATIONS

HIV test negative.

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Right upper quadrant abdominal pain, jaundice.

INVESTIGATIONS

Elevated liver function tests.

Hepatitis B or C serology positive.

HIV test negative.

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Fever, malaise, pharyngitis, lymphadenopathy, maculopapular rash. Condylomata lata on genital areas and oral ulcers. May have been preceded by painless genital chancre and inguinal lymphadenopathy (primary syphilis). Can coexist with HIV.

INVESTIGATIONS

Venereal disease research laboratory test positive.

Treponema pallidum hemagglutination test positive.

HIV test negative.

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Residence in/travel to a country/area or territory with local transmission, or close contact with a confirmed or probable case of COVID-19, in the 14 days prior to symptom onset.

The situation is evolving rapidly; see our COVID-19 topic for further information. 

INVESTIGATIONS

Real-time reverse transcription polymerase chain reaction (RT-PCR): positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA.

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