Test-of-cure requires repeating diagnostic methods to confirm that infection has cleared.

If the patient was treated with first-line treatment, no further specific follow-up is needed for test-of-cure.

Test-of-cure is indicated if a nonrecommended treatment is used. Patients should be told to have rescreening in 3 months or at the first presentation in the following 3 months, because they are at risk of reinfection. Rescreening men and women with recent gonorrhea infections every 3 to 6 months is an important method to detect new gonorrhea infections. This is because those who have had a gonorrhea infection are at higher risk of acquiring it again due to reinfection from the original source or from their sexual network.[77][78]

Retesting pregnant women is recommended because of the possible morbidity related to unresolved infection. Retesting in the third trimester is recommended in pregnant women with prenatal gonococcal infection unless recently treated.[72]

When using a nucleic acid amplification test to assess for gonorrhea infection, it is uncertain how long a positive test may persist following treatment, but 2 to 3 weeks should be adequate.

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