References
Key articles
Stoltey JE, Cohen SE. Syphilis transmission: a review of the current evidence. Sex Health. 2015 Apr;12(2):103-9.Full text Abstract
British Association for Sexual Health and HIV (BASHH). UK national guidelines on the management of syphilis. December 2015 [internet publication].Full text
World Health Organization. Guidelines for the treatment of Treponema pallidum (syphilis). 2016 [internet publication].Full text
Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text Abstract
World Health Organization. WHO guideline on syphilis screening and treatment for pregnant women. 2017 [internet publication].Full text
Reference articles
1. Stoltey JE, Cohen SE. Syphilis transmission: a review of the current evidence. Sex Health. 2015 Apr;12(2):103-9.Full text Abstract
2. Baughn RE, Musher DM. Secondary syphilitic lesions. Clin Microbiol Rev. 2005 Jan;18(1):205-16.Full text Abstract
3. Newman L, Kamb M, Hawkes S, et al. Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data. PLoS Med. 2013;10(2):e1001396.Full text Abstract
4. British Association for Sexual Health and HIV (BASHH). UK national guidelines on the management of syphilis. December 2015 [internet publication].Full text
6. O'Byrne P, MacPherson P. Syphilis. BMJ. 2019 Jun 28;365:l4159. [Erratum in: Syphilis. BMJ. 2019 Jul 19;366:l4746.]Full text Abstract
7. World Health Organization. Guidelines for the treatment of Treponema pallidum (syphilis). 2016 [internet publication].Full text
8. Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text Abstract
9. Ghanem KG, Ram S, Rice PA. The modern epidemic of syphilis. N Engl J Med. 2020 Feb 27;382(9):845-54. Abstract
10. World Health Organization. Data on syphilis. 2024 [internet publiation].Full text
11. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance, 2023. Nov 2023 [internet publication].Full text Abstract
12. Edmondson DG, Hu B, Norris SJ. Long-term in vitro culture of the syphilis spirochete Treponema pallidum subsp. pallidum. mBio. 2018 Jun 26;9(3).Full text Abstract
14. Centers for Disease Control and Prevention. Transmission of primary and secondary syphilis by oral sex - Chicago, Illinois, 1998-2002. MMWR Morb Mortal Wkly Rep. 2004 Oct 22;53(41):966-8.Full text Abstract
15. French P. Syphilis. BMJ. 2007 Jan 20;334(7585):143-7. Abstract
16. Ropper AH. Neurosyphilis. N Engl J Med. 2019 Oct 3;381(14):1358-63. Abstract
17. Clark EG, Danbolt N. The Oslo study of the natural course of untreated syphilis. Med Clin North Am. 1964;48:613-21.
18. Chaudhary PM, Roninson IB. Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol Res. 1992;4(7):281-90. Abstract
19. Peterman TA, Heffelfinger JD, Swint EB, et al. The changing epidemiology of syphilis. Sex Transm Dis. 2005 Oct;32(10 suppl):S4-10. Abstract
20. Centers for Disease Control and Prevention. Outbreak of syphilis among men who have sex with men - Southern California, 2000. MMWR Morb Mortal Wkly Rep. 2001 Feb 23;50(7):117-20. Abstract
21. Janier M, Unemo M, Dupin N, et al. 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2021 Mar;35(3):574-88. Abstract
22. Keuning MW, Kamp GA, Schonenberg-Meinema D, et al. Congenital syphilis, the great imitator-case report and review. Lancet Infect Dis. 2020 Jul;20(7):e173-9. Abstract
23. Saloojee H, Velaphi S, Goga Y, et al. The prevention and management of congenital syphilis: an overview and recommendations. Bull World Health Organ. 2004 Jun;82(6):424-30.Full text Abstract
24. National Institute for Health and Care Excellence. Recommendations on reducing sexually transmitted infections. Jun 2022 [internet publication].Full text
25. Holmes KK, Levine R, Weaver M. Effectiveness of condoms in preventing sexually transmitted infections. Bull World Health Organ. 2004 Jun;82(6):454-61. Abstract
26. Tobian AA, Serwadda D, Quinn TC, et al. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med. 2009 Mar 26;360(13):1298-309.Full text Abstract
27. US Preventive Services Task Force. Syphilis infection in pregnant women: screening. Sept 2018 [internet publication].Full text
28. Molina JM, Charreau I, Chidiac C, et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis. 2018 Mar;18(3):308-17.Full text Abstract
29. Luetkemeyer AF, Donnell D, Dombrowski JC, et al. Postexposure doxycycline to prevent bacterial sexually transmitted infections. N Engl J Med. 2023 Apr 6;388(14):1296-306.Full text Abstract
30. Molina JM, Bercot B, Assoumou L, et al. Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design. Lancet Infect Dis. 2024 Oct;24(10):1093-104.Full text Abstract
31. Centers for Disease Control and Prevention. CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention, United States, 2024. Jun 2024 [internet publication].Full text
32. Papp JR, Park IU, Fakile Y, et al. CDC laboratory recommendations for syphilis testing, United States, 2024. MMWR Recomm Rep. 2024 Feb 8;73(1):1-32.Full text Abstract
33. Brown DL, Frank JE. Diagnosis and management of syphilis. Am Fam Physician. 2003 Jul 15;68(2):283-90. Abstract
34. Rompalo AM, Lawlor J, Seaman P, et al. Modification of syphilitic genital ulcer manifestations by coexistent HIV infection. Sex Transm Dis. 2001 Aug;28(8):448-54.Full text Abstract
35. Lafond RE, Lukehart SA. Biological basis for syphilis. Clin Microbiol Rev. 2006 Jan;19(1):29-49.Full text Abstract
36. Tucker JD, Li JZ, Robbins GK, et al. Ocular syphilis among HIV-infected patients: a systematic analysis of the literature. Sex Trans Infect. 2011 Feb;87(1):4-8. Abstract
37. Rottingen JA, Cameron DW, Garnett GP. A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV: how much is really known? Sex Transm Dis. 2001 Oct;28(10):579-97. Abstract
38. Centers for Disease Control and Prevention. Sexually transmitted disease (STDs): syphilis & MSM fact sheet. 22 July 2021 [internet publication].Full text
39. Fojaco RM, Hensley GT, Moskowitz L. Congenital syphilis and necrotizing funisitis. JAMA. 1989 Mar 24-31;261(12):1788-90. Abstract
40. Hammerschlag MR, Guillén CD. Medical and legal implications of testing for sexually transmitted infections in children. Clin Microbiol Rev. 2010 Jul;23(3):493-506.Full text Abstract
41. Wheeler HL, Agarwal S, Goh BT. Dark ground microscopy and treponemal serological tests in the diagnosis of early syphilis. Sex Transm Infect. 2004 Oct;80(5):411-4. Abstract
42. Centers for Disease Control and Prevention. Sexually transmitted diseases: syphilis. CDC fact sheet (detailed). 10 August 2021 [internet publication].Full text
43. Centers for Disease Control and Prevention (CDC). Discordant results from reverse sequence syphilis screening - five laboratories, United States, 2006-2010. MMWR Morb Mortal Wkly Rep. 2011 Feb 11;60(5):133-7.Full text Abstract
44. Park IU, Fakile YF, Chow JM, et al. Performance of treponemal tests for the diagnosis of syphilis. Clin Infect Dis. 2019 Mar 5;68(6):913-18.Full text Abstract
45. Pope V. Use of treponemal tests to screen for syphilis. Infect Med. 2004;21:399-402.
46. Seña AC, Wolff M, Behets F, et al. Rate of decline in nontreponemal antibody titers and seroreversion after treatment of early syphilis. Sex Transm Dis. 2017 Jan;44(1):6-10.Full text Abstract
47. Smith G, Holman RP. The prozone phenomenon with syphilis and HIV-1 co-infection. South Med J. 2004 Apr;97(4):379-82. Abstract
48. Kingston AA, Vujevich J, Shapiro M, et al. Seronegative secondary syphilis in 2 patients coinfected with human immunodeficiency virus. Arch Dermatol. 2005 Apr;141(4):431-3. Abstract
49. British Association for Sexual Health and HIV (BASHH). BASHH national guideline on the management of sexually transmitted infections and related conditions in children and young people 2021. 2021 [internet publication].Full text
50. Lam TK, Lau HY, Lee YP, et al. Comparative evaluation of the INNO-LIA syphilis score and the MarDx Treponema pallidum immunoglobulin G Marblot test assays for the serological diagnosis of syphilis. Int J STD AIDS. 2010 Feb;21(2):110-3. Abstract
51. Hagedorn HJ, Kraminer-Hagedorn A, de Bosschere K, et al. Evaluation of INNO-LIA syphilis assay as a confirmatory test for syphilis. J Clin Microbiol. 2002 Mar;40(3):973-8.Full text Abstract
52. Gayet-Ageron A, Lautenschlager S, Ninet B, et al. Sensitivity, specificity and likelihood ratios of PCR in the diagnosis of syphilis: a systematic review and meta-analysis. Sex Transm Infect. 2013 May;89(3):251-6. Abstract
53. Gayet-Ageron A, Sednaoui P, Lautenschlager S, et al. Use of Treponema pallidum PCR in testing of ulcers for diagnosis of primary syphilis. Emerg Infect Dis. 2015 Jan;21(1):127-9.Full text Abstract
54. Shahrook S, Mori R, Ochirbat T, et al. Strategies of testing for syphilis during pregnancy. Cochrane Database Syst Rev. 2014 Oct 29;(10):CD010385.Full text Abstract
55. Pan American Health Organization (PAHO). Guidance on syphilis testing in Latin America and the Caribbean: improving uptake, interpretation, and quality of testing in different clinical settings. 2015. 2015 [internet publication].Full text
56. Luger AF, Schmidt BL, Kaulich M. Significance of laboratory findings for the diagnosis of neurosyphilis. Int J STD AIDS. 2000 Apr;11(4):224-34. Abstract
57. Lavi R, Yarnitsky D, Rowe JM, et al. Standard vs atraumatic Whitacre needle for diagnostic lumbar puncture: a randomized trial. Neurology. 2006 Oct 24;67(8):1492-4. Abstract
58. Arendt K, Demaerschalk BM, Wingerchuk DM, et al. Atraumatic lumbar puncture needles: after all these years, are we still missing the point? Neurologist. 2009 Jan;15(1):17-20. Abstract
59. Nath S, Koziarz A, Badhiwala JH, et al. Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis. Lancet. 2018 Mar 24;391(10126):1197-204. Abstract
60. Rochwerg B, Almenawer SA, Siemieniuk RAC, et al. Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline. BMJ. 2018 May 22;361:k1920.Full text Abstract
61. Ahmed SV, Jayawarna C, Jude E. Post lumbar puncture headache: diagnosis and management. Postgrad Med J. 2006 Nov;82(973):713-6.Full text Abstract
62. Arevalo-Rodriguez I, Ciapponi A, Roqué i Figuls M, et al. Posture and fluids for preventing post-dural puncture headache. Cochrane Database Syst Rev. 2016 Mar 7;(3):CD009199.Full text Abstract
63. World Health Organization. WHO guideline on syphilis screening and treatment for pregnant women. 2017 [internet publication].Full text
64. American College of Obstetricians and Gynecologists. Screening for syphilis in pregnancy. Apr 2024 [internet publication].Full text
65. American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 752: prenatal and perinatal human immunodeficiency virus testing. Sep 2018 [internet publication].Full text Abstract
66. National Institute for Health and Care Excellence (UK). Antenatal care. 19 August 2021 [internet publication].Full text
67. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med. 2018;56(12):2015-38. Abstract
68. Hollier LM, Harstad TW, Sanchez PJ, et al. Fetal syphilis: clinical and laboratory characteristics. Obstet Gynecol. 2001 Jun;97(6):947-53. Abstract
69. Arnesen L, Serruya S, Duran P. Gestational syphilis and stillbirth in the Americas: a systematic review and meta-analysis. Rev Panam Salud Publica. 2015 Jun;37(6):422-9.Full text Abstract
70. Cole M, Perry K. MHRA 04109: ten syphilis EIAs. UK: HSMO; 2004.
71. Creegan L, Bauer HM, Samuel MC, et al. An evaluation of the relative sensitivities of the venereal disease research laboratory test and the Treponema Pallidum particle agglutination test among patients diagnosed with primary syphilis. Sex Transm Dis. 2007 Dec;34(12):1016-18. Abstract
72. Manavi K, Young H, McMillan A. The sensitivity of syphilis assays in detecting different stages of early syphilis. Int J STD AIDS. 2006 Nov;17(11):768-71. Abstract
73. Cantor A, Nelson HD, Daeges M, et al. Screening for syphilis in nonpregnant adolescents and adults: systematic review to update the 2004 US Preventive Services Task Force recommendation [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Jun. Report No: 14-05213-EF-1.Full text Abstract
74. US Food and Drug Administration. Possible false RPR reactivity with BioPlex 2200 Syphilis Total & RPR test kit following a COVID-19 vaccine - letter to clinical laboratory staff and health care providers. Dec 2021 [internet publication].Full text
75. Lewis DA. Chancroid: clinical manifestations, diagnosis, and management. Sex Transm Infect. 2003 Feb;79(1):68-71.Full text Abstract
76. Patterson K, Olsen B, Thomas C, et al. Development of a rapid immunodiagnostic test for Haemophilus ducreyi. J Clin Microbiol. 2002 Oct;40(10):3694-702.Full text Abstract
77. US Preventive Services Task Force. Syphilis infection in nonpregnant adults and adolescents: screening. Sep 2022 [internet publication]Full text
78. World Health Organization. Screening donated blood for transfusion-transmissible infections: recommendations. 2009 [internet publication].Full text Abstract
79. Tucker JD, Bu J, Brown LB, et al. Accelerating worldwide syphilis screening through rapid testing: a systematic review. Lancet Infect Dis. 2010 Jun;10(6):381-6. Abstract
80. World Health Organization. The use of rapid syphilis tests. 2006 [internet publication].Full text
81. Young H. Guidelines for serological testing for syphilis. Sex Transm Infect. 2000 Oct;76(5):403-5. Abstract
82. Centers for Disease Control and Prevention. Recommendations for partner services programs for HIV infection, syphilis, gonorrhea, and chlamydial infection. MMWR Recomm Rep. 2008 Nov 7;57(RR-9):1-83;quiz CE1-4.Full text Abstract
83. World Health Organization. WHO guideline on self-care interventions for health and well-being, 2022 revision. Jun 2022 [internet publication].Full text
84. Lin JS, Eder ML, Bean SI. Screening for syphilis infection in pregnant women: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2018 Sep 4;320(9):918-25.Full text Abstract
85. Miller JM, Binnicker MJ, Campbell S, et al. Guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2024 update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis. 2024 Mar 5:ciae104.Full text Abstract
86. World Health Organization, Department of Reproductive Health and Research. The global elimination of congenital syphilis: rationale and strategy for action. 2007 [internet publication].Full text
87. Menezes EV, Yakoob MY, Soomro T, et al. Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy. BMC Pregnancy Childbirth. 2009 May 7;9(suppl 1):S4.Full text Abstract
88. Hawkes SJ, Gomez GB, Broutet N. Early antenatal care: does it make a difference to outcomes of pregnancy associated with syphilis? A systematic review and meta-analysis. PLoS One. 2013;8(2):e56713.Full text Abstract
89. Blencowe H, Cousens S, Kamb M, et al. Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality. BMC Public Health. 2011 Apr 13;11(suppl 3):S9.Full text Abstract
90. Chen XS, Peeling RW, Yin YP, Mabey D. Improving antenatal care to prevent adverse pregnancy outcomes caused by syphilis. Future Microbiol. 2011 Oct;6(10):1131-4. Abstract
91. Hawkes S, Matin N, Broutet N, et al. Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis. Lancet Infect Dis. 2011 Sep;11(9):684-91. Abstract
92. Munkhuu B, Liabsuetrakul T, Chongsuvivatwong V, et al. One-stop service for antenatal syphilis screening and prevention of congenital syphilis in Ulaanbaatar, Mongolia: a cluster randomized trial. Sex Transm Dis. 2009 Nov;36(11):714-20. Abstract
93. Stoner BP. Current controversies in the management of adult syphilis. Clin Infect Dis. 2007 Apr 1;44(suppl 3):S130-46.Full text Abstract
94. Parkes R, Renton A, Meheus A, et al. Review of current evidence and comparison for effective syphilis treatment in Europe. Int J STD AIDS. 2004 Feb;15(2):73-88. Abstract
95. Hook EW 3rd, Martin DH, Stephens J, et al. A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. Sex Transm Dis. 2002 Aug;29(8):486-90. Abstract
96. Riedner G, Rusizoka M, Todd J, et al. Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. N Engl J Med. 2005 Sep 22;353(12):1236-44.Full text Abstract
97. Lukehart SA, Godornes C, Molini BJ, et al. Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med. 2004 Jul 8;351(2):154-8.Full text Abstract
98. Ansotegui IJ, Melioli G, Canonica GW, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020 Feb;13(2):100080.Full text Abstract
99. Chastain DB, Hutzley VJ, Parekh J, et al. Antimicrobial desensitization: a review of published protocols. Pharmacy (Basel). 2019 Aug 9;7(3):112.Full text Abstract
100. Walker GJ, Walker D, Molano Franco D, et al. Antibiotic treatment for newborns with congenital syphilis. Cochrane Database Syst Rev. 2019 Feb 15;(2):CD012071.Full text Abstract
101. Liang Z, Chen YP, Yang CS, et al. Meta-analysis of ceftriaxone compared with penicillin for the treatment of syphilis. Int J Antimicrob Agents. 2016 Jan;47(1):6-11. Abstract
102. Liu HY, Han Y, Chen XS, et al. Comparison of efficacy of treatments for early syphilis: A systematic review and network meta-analysis of randomized controlled trials and observational studies. PLoS One. 2017 Jun 28;12(6):e0180001.Full text Abstract
103. Faculty of Sexual and Reproductive Healthcare. Barrier methods for contraception and STI prevention. August 2015 [internet publication].Full text
104. Ng BE, Butler LM, Horvath T, et al. Population-based biomedical sexually transmitted infection control interventions for reducing HIV infection. Cochrane Database Syst Rev. 2011 Mar 16;(3):CD001220.Full text Abstract
105. de Walque D, Dow WH, Nathan R, et al. Incentivising safe sex: a randomised trial of conditional cash transfers for HIV and sexually transmitted infection prevention in rural Tanzania. BMJ Open. 2012 Feb 8;2(1):e000747.Full text Abstract
106. British Association for Sexual Health and HIV (BASHH). BASHH National Guideline on the Management of Sexually Transmitted Infections and Related Conditions in Children and Young People 2021. 2021 [internet publication].Full text
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