Evaluation of coma

Greer DM, Kirschen MP, Lewis A, et al. Pediatric and adult brain death/death by neurologic criteria consensus guideline. Neurology. 2023 Dec 12;101(24):1112-32.Full text  Abstract

National Institute for Health and Care Excellence. Head injury: assessment and early management. Sep 2023​ [internet publication].Full text

Carney N, Totten AM, O'Reilly C, et al. Guidelines for the management of severe traumatic brain injury 4th edition. September 2016 [internet publication].Full text

1. Posner JB, Saper CB, Schiff ND, et al. Psychogenic unresponsiveness. Plum and Posner's diagnosis of stupor and coma. New York, NY: Oxford University Press; 2007.

2. Wijdicks EFM. The comatose patient. New York, NY: Oxford University Press; 2007.

3. Young GB, Wijdicks EFM, eds. Disorders of consciousness. Volume 90. The Handbook of Clinical Neurology, 3rd series. New York, NY: Elsevier; 2008.

4. Sporns O. Structure and function of complex brain networks. Dialogues Clin Neurosci. 2013 Sep;15(3):247-62.Full text  Abstract

5. Bodien YG, Carlowicz CA, Chatelle C, et al. Sensitivity and specificity of the coma recovery scale--revised total score in detection of conscious awareness. Arch Phys Med Rehabil. 2016 Mar;97(3):490-492.e1. Abstract

6. Greer DM, Kirschen MP, Lewis A, et al. Pediatric and adult brain death/death by neurologic criteria consensus guideline. Neurology. 2023 Dec 12;101(24):1112-32.Full text  Abstract

7. Laureys S, Celesia GG, Cohadon F, et al. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med. 2010 Nov 1;8:68.Full text  Abstract

8. Vincent SR. The ascending reticular activating system - from aminergic neurons to nitric oxide. J Chem Neuroanat. 2000 Feb;18(1-2):23-30. Abstract

9. Department of Health. Hospital Episode Statistics (England). 2002-2003 [internet publication].Full text

10. Matthes G, Bernhard M, Kanz KG, et al. Emergency anesthesia, airway management and ventilation in major trauma. Background and key messages of the interdisciplinary S3 guidelines for major trauma patients [in German]. Unfallchirurg. 2012 Mar;115(3):251-64. Abstract

11. Bruno MA, Ledoux D, Lambermont B, et al. Comparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an intensive care unit population. Neurocrit Care. 2011 Dec;15(3):447-53. Abstract

12. Meschia JF, Bushnell C, Boden-Albala B, et al; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; Council on Hypertension. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014 Dec;45(12):3754-832.Full text  Abstract

13. Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021 Jul;52(7):e364-467.Full text  Abstract

14. Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2022 Jul;53(7):e282-361.Full text  Abstract

15. Hoh BL, Ko NU, Amin-Hanjani S, et al. 2023 guideline for the management of patients with aneurysmal subarachnoid hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2023 Jul;54(7):e314-70.Full text  Abstract

16. Centers for Disease Control and Prevention. Traumatic brain injury & concussion​: prevention. May 2021 [internet publication].Full text

17. National Institute for Health and Care Excellence. Head injury: assessment and early management. Sep 2023​ [internet publication].Full text

18. Carney N, Totten AM, O'Reilly C, et al. Guidelines for the management of severe traumatic brain injury 4th edition. September 2016 [internet publication].Full text

19. Pandor A, Harnan S, Goodacre S, et al. Diagnostic accuracy of clinical characteristics for identifying CT abnormality after minor brain injury: a systematic review and meta-analysis. J Neurotrauma. 2012 Mar 20;29(5):707-18. Abstract

20. Coffeng SM, Foks KA, van den Brand CL, et al. Evaluation of clinical characteristics and CT decision rules in elderly patients with minor head injury: a prospective multicenter cohort study. J Clin Med. 2023 Jan 27;12(3).Full text  Abstract

21. Kim YJ. A systematic review of factors contributing to outcomes in patients with traumatic brain injury. J Clin Nurs. 2011 Jun;20(11-12):1518-32. Abstract

22. Oliveira L, Fregni F. Pharmacological and electrical stimulation in chronic disorders of consciousness: new insights and future directions. Brain Inj. 2011;25(4):315-27. Abstract

23. Cowperthwaite MC, Burnett MG. The association between weather and spontaneous subarachnoid hemorrhage: an analysis of 155 US hospitals. Neurosurgery. 2011 Jan;68(1):132-8. Abstract

24. Wilson JX, Young GB. Sepsis-associated encephalopathy: evolving concepts. Can J Neurol Sci. 2003 May;30(2):98-105. Abstract

25. Huang Y, Chen R, Jiang L, et al. Basic research and clinical progress of sepsis-associated encephalopathy. J Intensive Med. 2021 Oct;1(2):90-5.Full text  Abstract

26. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008 Dec;7(12):1091-8. Abstract

27. Graus F, Saiz A, Lai M, et al. Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations. Neurology. 2008 Sep 16;71(12):930-6. Abstract

28. Lai M, Hughes EG, Peng X, et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009 Apr;65(4):424-34. Abstract

29. Hjalmarsson A, Blomqvist P, Sköldenberg B. Herpes simplex encephalitis in Sweden, 1990-2001: incidence, morbidity, and mortality. Clin Infect Dis. 2007 Oct 1;45(7):875-80. Abstract

30. Ropper AH, Gorson KC. Clinical practice: concussion. N Eng J Med. 2007 Jan 11;356(2):166-72.Full text  Abstract

31. Shaw NA. The neurophysiology of concussion. Prog Neurobiol. 2002 Jul;67(4):281-344. Abstract

32. Holbourn AH. The mechanics of brain injuries. Br Med Bull. 1945;3:147-9.

33. Povlishock JT, Christman CW. The pathobiology of traumatically induced axonal injury in animals and humans. J Neurotrauma. 1995 Aug;12(4):555-64. Abstract

34. Moulton R. Head Injury. In: Young GB, Ropper AH, Bolton CF, eds. Coma and impaired consciousness: a clinical perspective. New York, NY: McGraw-Hill; 1998:149-181.

35. Young GB, Doig GS. Continuous EEG monitoring in comatose intensive care unit patients: epileptiform activity in etiologically distinct groups. Neurocrit Care. 2005;2(1):5-10. Abstract

36. Calland JF, Ingraham AM, Martin N, et al. Evaluation and management of geriatric trauma: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg. 2012 Nov;73(5 Suppl 4):S345-50. Abstract

37. Grubb BP. Clinical practice: neurocardiac syncope. N Engl J Med. 2005 Mar 10;352(10):1004-10. Abstract

38. Canaris GJ, Manowitz NR, Mayor G, et al. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000 Feb 28;160(4):526-34. Abstract

39. Gajdos PH, Korach JM, Conso F, et al. Epidemiological investigation of acute carbon monoxide poisoning (A-CMP) in the Hauts-de-Seine department. Intensive Care Med. 1988;14:434-40.

40. Friedman Y, Lee L, Wherrett JR, et al. Simulation of brain death from fulminant de-efferentation. Can J Neurol Sci. 2003 Nov;30(4):397-404. Abstract

41. Benbadis SR, Agrawal V, Tatum WO. How many patients with psychogenic nonepileptic seizures also have epilepsy? Neurology. 2001 Sep 11;57(5):915-7. Abstract

42. Lindboe CF, Loberg EM. Wernicke's encephalopathy in nonalcoholics: an autopsy study. J Neurol Sci. 1989 Apr;90(2):125-9. Abstract

43. Koguchi K, Nakatsui Y, Abe K, et al. Wernicke's encephalopathy after glucose infusion. Neurology. 2004 Feb 10;62(3):512. Abstract

44. Dunn LT, Fitzpatrick MO, Beard D, et al. Patients with a head injury who "talk and die" in the 1990s. J Trauma. 2003 Mar;54(3):497-502. Abstract

45. Schmahmann JD. Vascular syndromes of the thalamus. Stroke. 2003 Sep;34(9):2264-78.Full text  Abstract

46. Fujioka M, Okuchi K, Hiramatsu KI, et al. Specific changes in the human brain after hypoglycemic injury. Stroke. 1997 Mar;28(3):584-7.Full text  Abstract

47. Abraham MB, Karges B, Dovc K, et al. ISPAD clinical practice consensus guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.Full text

48. Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.Full text  Abstract

49. National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].Full text

50. ElSayed NA, Aleppo G, Aroda VR, et al. 6. Glycemic targets: standards of care in diabetes-2023. Diabetes Care. 2023 Jan 1;46(suppl 1):S97-110.Full text  Abstract

51. Desimone ME, Weinstock RS. Hypoglycemia. South Dartmouth (MA): MDText.com, Inc; 2000.

52. Masuhr F, Mehraien S, Einhaupl K. Cerebral venous and sinus thrombosis. J Neurol. 2004 Jan;251(1):11-23. Abstract

53. Ulivi L, Squitieri M, Cohen H, et al. Cerebral venous thrombosis: a practical guide. Pract Neurol. 2020 Oct;20(5):356-67. Abstract

54. Roos KL. Infectious etiologies of altered consciousness. Hand Clin Neurol. 2008;90:201-16. Abstract

55. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801-10.Full text  Abstract

56. National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. Mar 2024 [internet publication].Full text

57. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-143.Full text

58. Royal College of Physicians. National Early Warning Score (NEWS) 2. Dec 2017 [internet publication].Full text

59. American College of Emergency Physicians (ACEP) Expert Panel on Sepsis. DART: an evidence-driven tool to guide the early recognition and treatment of sepsis and septic shock. [internet publication].Full text

60. Academy of Medical Royal Colleges. Statement on the initial antimicrobial treatment of sepsis. Oct 2022 [internet publication].Full text

61. Schlapbach LJ, Watson RS, Sorce LR, et al. International consensus criteria for pediatric sepsis and septic shock. JAMA. 2024 Feb 27;331(8):665-74.Full text  Abstract

62. Society of Critical Care Medicine. Surviving Sepsis Campaign Hour-1 bundle. 2019 [internet publication].Full text

63. Vannatta JB, Whang R, Papper S. Efficacy of intravenous phosphorus therapy in the severely hypophosphatemic patient. Arch Intern Med. 1981 Jun;141(7):885-7. Abstract

64. Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Eng J Med. 1996 Feb 22;334(8):494-500.Full text  Abstract

65. Edlow JA, Caplan LR. Avoiding pitfalls in the diagnosis of subarachnoid hemorrhage. N Engl J Med. 2000 Jan 6;342(1):29-36. Abstract

66. Elder PT. Accidental hypothermia. In: Shoemaker W, ed. Textbook of critical care. Philadelphia, PA: WB Saunders; 1989:101-109.

67. Arrich J, Schütz N, Oppenauer J, et al. Hypothermia for neuroprotection in adults after cardiac arrest. Cochrane Database Syst Rev. 2023 May 22;5(5):CD004128.Full text  Abstract

68. Geocadin RG, Wijdicks E, Armstrong MJ, et al. Practice guideline summary: reducing brain injury following cardiopulmonary resuscitation: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017 May 30;88(22):2141-49.Full text  Abstract

69. Amacher SA, Blatter R, Briel M, et al. Predicting neurological outcome in adult patients with cardiac arrest: systematic review and meta-analysis of prediction model performance. Crit Care. 2022 Dec 11;26(1):382.Full text  Abstract

70. Zwingmann J, Mehlhorn AT, Hammer T, et al. Survival and neurologic outcome after traumatic out-of-hospital cardiopulmonary arrest in a pediatric and adult population: a systematic review. Crit Care. 2012 Jul 6;16(4):R117.Full text  Abstract

71. Friberg H, Rundgren M, Westhall E, et al. Continuous evaluation of neurological prognosis after cardiac arrest. Acta Anaesthesiol Scand. 2013 Jan;57(1):6-15. Abstract

72. Liao KH, Chang CK, Chang HC, et al. Clinical practice guidelines in severe traumatic brain injury in Taiwan. Surg Neurol. 2009 Dec;72 Suppl 2:S66-73. Abstract

73. Brain Trauma Foundation. Guidelines for the field management of combat-related head trauma. Assessment: Glasgow Coma Scale scoring and assessment of pupils [internet publication].

74. Knuth T, Letarte PB, Ling G, et al; Brain Trauma Foundation. Guidelines for the field management of combat-related head trauma. 2005 [internet publication].

75. Lang CJ, Heidenreich SP, Fahlbusch R, et al. Primary loss of consciousness and amnesia in subarachnoid hemorrhage: a quantitative study [in German]. Zentralbl Neurochir. 2004;65(1):18-24. Abstract

76. Ahmadi S, Sarveazad A, Babahajian A, et al. Comparison of Glasgow Coma Scale and Full Outline of UnResponsiveness score for prediction of in-hospital mortality in traumatic brain injury patients: a systematic review and meta-analysis. Eur J Trauma Emerg Surg. 2022 Sep 24. Abstract

77. Almojuela A, Hasen M, Zeiler FA. The Full Outline of UnResponsiveness (FOUR) Score and its use in outcome prediction: a scoping systematic review of the adult literature. Neurocrit Care. 2019 Aug;31(1):162-75.Full text  Abstract

78. Anestis DM, Tsitsopoulos PP, Tsonidis CA, et al. The current significance of the FOUR score: a systematic review and critical analysis of the literature. J Neurol Sci. 2020 Feb 15;409:116600. Abstract

79. Vanhaudenhuyse A, Schnakers C, Boly M, et al. Behavioural assessment and functional neuro-imaging in vegetative state patients. Rev Med Liege. 2007;62 Spec No:15-20. Abstract

80. Morrow SA, Young GB. Selective abolition of the vestibular-ocular reflex by sedative drugs. Neurocrit Care. 2007;6(1):45-8. Abstract

81. Kraft MD, Btaiche IF, Sacks GS. Review of the refeeding syndrome. Nutr Clin Pract. 2005 Dec;20(6):625-33. Abstract

82. Freund B, Kaplan PW. Post-hypoxic myoclonus: differentiating benign and malignant etiologies in diagnosis and prognosis. Clin Neurophysiol Pract. 2017;2:98-102.Full text  Abstract

83. Young GB, Jordan KG, Doig GS. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology. 1996 Jul;47(1):83-9. Abstract

84. American College of Radiology. ACR appropriateness criteria: altered mental status, coma, delirium, and psychosis. 2024 [internet publication].Full text

85. Expert Panel on Neurological Imaging, Shih RY, Burns J, et al. ACR appropriateness criteria® head trauma: 2021 Update. J Am Coll Radiol. 2021 May;18(5s):S13-36.Full text  Abstract

86. American College of Emergency Physicians Clinical Policies Subcommittee (Writing Committee) on Mild Traumatic Brain Injury, Valente JH, Anderson JD, et al. Clinical policy: critical issues in the management of adult patients presenting to the emergency department with mild traumatic brain injury: approved by ACEP board of directors, February 1, 2023 clinical policy endorsed by the Emergency Nurses Association (April 5, 2023). Ann Emerg Med. 2023 May;81(5):e63-105.Full text  Abstract

87. Vos PE, Alekseenko Y, Battistin L, et al. Mild traumatic brain injury. Eur J Neurol. 2012 Feb;19(2):191-8.Full text  Abstract

88. Delorenzo RJ, Waterhouse EJ, Towne AR, et al. Persistent non-convulsive status epilepticus following the control of convulsive status epilepticus. Epilepsia. 1998 Aug;39(8):833-40. Abstract

89. Towne AR, Waterhouse EJ, Boggs JG, et al. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology. 2000 Jan 25;54(2):340-5. Abstract

90. Turi Z, Lenz M, Paulus W, et al. Selecting stimulation intensity in repetitive transcranial magnetic stimulation studies: a systematic review between 1991 and 2020. Eur J Neurosci. 2021 May;53(10):3404-15.Full text  Abstract

91. Lescot T, Galanaud D, Puybasset L. Exploring altered consciousness states by magnetic resonance imaging in brain injury. Ann N Y Acad Sci. 2009 Mar;1157:71-80. Abstract

92. Wu HM, Huang SC, Hattori N, et al. Selective metabolic reduction in gray matter acutely following human traumatic brain injury. Neurotrauma. 2004 Feb;21(2):149-61. Abstract

93. Hayashi S, Inaji M, Nariai T, et al. Increased binding potential of brain adenosine A(1) receptor in chronic stages of patients with diffuse axonal injury measured with [1-methyl-(11)C] 8-dicyclopropylmethyl-1-methyl-3-propylxanthine positron emission tomography Imaging. J Neurotrauma. 2018 Jan 1;35(1):25-31. Abstract

94. Lee YC, Phan TG, Jolley DJ, et al. Accuracy of clinical signs, SEP, and EEG in predicting outcome of hypoxic coma: a meta-analysis. Neurology. 2010 Feb 16;74(7):572-8. Abstract

95. Wijdicks EF, Hijdra A, Young GB, et al. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation. Neurology. 2006 Jul 25;67(2):203-10. Abstract

96. Carrai R, Grippo A, Lori S, et al. Prognostic value of somatosensory evoked potentials in comatose children: a systematic literature review. Intensive Care Med. 2010 Jul;36(7):1112-26. Abstract

97. Rajajee V, Muehlschlegel S, Wartenberg KE, et al. Guidelines for neuroprognostication in comatose adult survivors of cardiac arrest. Neurocrit Care. 2023 Jun;38(3):533-63.Full text  Abstract

98. Xu J, Rasmussen IA, Lagopoulos J, et al. Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging. J Neurotrauma. 2007 May;24(5):753-65. Abstract

99. Ashwal S, Babikian T, Gardner-Nicols J, et al. Susceptibility-weighted imaging and proton magnetic resonance spectroscopy in assessment of outcome after pediatric traumatic brain injury. Arch Phys Med Rehabil. 2006 Dec;87(12 Suppl 2):S50-8. Abstract

100. Burch HB, Wartofsky L. Life-threatening thyrotoxicosis: thyroid storm. Endocrinol Metab Clin North Am. 1993 Jun;22(2):263-77. Abstract