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Long bone fracture

Evidence last reviewed: 14 Feb 2026
Topic last updated: 24 Feb 2026

Summary

Definition

History and exam

Key diagnostic factors

  • pain
  • soft tissue swelling
  • ecchymosis
  • expanding hematoma
  • impaired limb function
  • inability to bear weight
  • point tenderness
  • deformity
  • guarding
  • wound overlying or near site of injury
  • signs of vascular injury
  • signs of acute compartment syndrome
  • hypotension/hypovolemic shock
Full details

Other diagnostic factors

  • altered nerve sensation
  • impaired motor function
  • bony crepitus
  • callus
  • reproduction of symptoms in stress fractures of the neck or shaft of the femur
Full details

Risk factors

  • direct trauma
  • indirect trauma
  • osteoporosis (insufficiency fractures)
  • chronic renal failure
  • bone tumor (pathologic fractures)
  • age >70 years
  • age <30 years
  • diabetes mellitus
  • male sex (acute fractures)
  • female sex (fatigue and insufficiency fractures)
  • prolonged corticosteroid use (insufficiency fractures)
  • low BMI (insufficiency fractures)
  • history of recent fall (insufficiency fractures)
  • prior fracture (insufficiency fractures)
  • seizures (proximal humerus fracture)
  • long-term bisphosphonate use
  • smoking
  • alcohol
Full details

Diagnostic tests

1st tests to order

  • x-ray limb
  • CBC, blood typing, and cross-matching (major trauma)
  • lactate
  • base excess
Full details

Tests to consider

  • MRI of area of interest without IV contrast
  • noncontrast CT of fracture
  • whole body bone scan with SPECT or SPECT/CT area of interest
  • compartment pressure testing
  • Doppler pressure (ankle/brachial systolic pressure index)
  • ultrasound duplex scanning
  • CT angiogram
  • angiography
  • dual-energy x-ray absorptiometry bone density scan
  • whole-body CT
Full details

Treatment algorithm

INITIAL

involved in high-energy trauma

ACUTE

distal humeral shaft: nonstress

midshaft humeral: nonstress

proximal humeral shaft: nonstress

radial or ulnar shaft: nonstress

upper limb stress fractures

femoral shaft: nonstress

tibia or fibula shaft: nonstress

femoral stress fractures

fibular or tibial stress fractures

Contributors

Authors

Nathan Olszewski, MD

Assistant Professor of Orthopedic Surgery

Orthopedic Surgeon

Boston University Chobanian & Avedisian School of Medicine

Boston Medical Center

Department of Orthopaedic Surgery

Boston

MA

Disclosures

NO has been reimbursed for travel from Stryker Corporation for participation in educational case conferences and equipment training sessions.

Paul Tornetta, III, MD, PhD

Chief and Chair, Professor and Residency Program Director, Director of Orthopedic Trauma

Boston University Chobanian & Avedisian School of Medicine

Boston Medical Center

Department of Orthopaedic Surgery

Boston

MA

Disclosures

PT holds intellectual property with Smith & Nephew and has received publishing royalties from Wolters Kluwer.

Acknowledgements

Dr Nathan Olszewski and Dr Paul Tornetta III would like to gratefully acknowledge Dr Philip H. Cohen, the previous contributor to this topic.

Disclosures

PHC has given lectures for MCE Conferences, a medical education company, and received a stipend/free hotel room during the conference. MCE Conferences accepts no funding from pharmaceutical companies or other outside agencies, and PHC declares that the lectures have no impact on the topic.

Peer reviewers

Robert D. Golden, MD

Chief, Orthopaedic Surgery

MedStar Washington Hospital Center

Regional Chief

Orthopaedic Trauma Surgery

MedStar Orthopaedic Institute

Washington

DC

Disclosures

RDG declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

American College of Radiology. ACR appropriateness criteria: stress (fatigue-insufficiency) fracture including sacrum excluding other vertebrae. 2024 [internet publication].Full text

National Institute for Health and Care Excellence. Fractures (complex): assessment and management. Nov 2022 [internet publication].Full text

American Academy of Orthopaedic Surgeons. Prevention of surgical site infections after major extremity trauma. Evidence-based clinical practice guideline. Mar 2022 [internet publication].Full text

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Long bone fracture images
  • Differentials

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  • Guidelines

    • ACR appropriateness criteria: stress (fatigue-insufficiency) fracture including sacrum excluding other vertebrae
    • Fractures (complex): assessment and management
    More Guidelines
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