小结
定义
病史和体格检查
关键诊断因素
- attempted self-harm
- repeated over-the-counter analgesic use for pain relief
- asymptomatic presentation
- nausea, vomiting, or abdominal pain
- right upper quadrant pain and tenderness
- jaundice
- confusion, decreased consciousness level, and/or asterixis
危险因素
- history of self-harm
- history of frequent or repeated use of medications for pain relief
- glutathione deficiency
- increased cytochrome P450 activity
- malnutrition or fasting
- chronic ethanol consumption
诊断性检查
首要检查
- serum acetaminophen level
- serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT)
需考虑的检查
- arterial pH and lactate level
- metabolic panel or serum electrolytes with BUN and creatinine
- serum prothrombin time and INR
- serum salicylate level
- ethanol level
- blood glucose level
- lipase level
- serum phosphate
治疗流程
acute single ingestion
repeated supratherapeutic acetaminophen ingestion
撰稿人
作者
Hannah Hays, MD, FACEP, FAACT, FACMT
Medical Director
Central Ohio Poison Center
Chief of Toxicology
Nationwide Children’s Hospital
Assistant Professor of Emergency Medicine and Pediatrics
The Ohio State University College of Medicine
利益声明
HH declares that she has no competing interests.
鸣谢
Dr. Hannah Hays would like to gratefully acknowledge Dr. Daniel K. Colby, Dr. Alastair Newton, and Professor Allan R. Mottram, previous contributors to this topic. DKC, AN, and ARM declare that they have no competing interests.
同行评议者
Scott Phillips, MD
Clinical Faculty
Department of Toxicology
Rocky Mountain Poison & Drug Center
Denver
CO
利益声明
SP declares that he has no competing interests.
Gerald F. O'Malley, DO
Director
Division of Research
Department of Emergency Medicine
Albert Einstein Medical Center
Philadelphia
PA
利益声明
GFOM declares that he has no competing interests.
Sophie Gosselin, MD, FRCPC
Associate Professor
Department of Medicine
McGill University
Emergency Physician and Medical Toxicologist
McGill University Health Centre
Medical Toxicologist
Centre Antipoison du Québec
Montreal
Quebec
Canada
利益声明
SG declares that she is an unpaid co-investigator in the Canadian Acetaminophen Overdose Study and unpaid co-chair of the Extracorporeal Treatment In Poisoning workgroup.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
Dart RC, Mullins ME, Matoushek T, et al. Management of acetaminophen poisoning in the US and Canada: a consensus statement. JAMA Netw Open. 2023 Aug 1;6(8):e2327739.全文 摘要
Fontana RJ, Liou I, Reuben A, et al. AASLD practice guidance on drug, herbal, and dietary supplement-induced liver injury. Hepatology. 2023 Mar 1;77(3):1036-65.全文
Chiew AL, Gluud C, Brok J, et al. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev. 2018 Feb 23;(2):CD003328.全文 摘要
American College of Medical Toxicology. ACMT Position statement: duration of intravenous acetylcysteine therapy following acetaminophen overdose. J Med Toxicol. 2017 Mar;13(1):126-7.全文 摘要
参考文献
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
鉴别诊断
- Shock liver
- Acute hepatitis A
- Acute hepatitis B
更多 鉴别诊断指南
- Management of acetaminophen poisoning in the US and Canada: a consensus statement
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