Ileus

References

Key articles

Wattchow D, Heitmann P, Smolilo D, et al. Postoperative ileus- an ongoing conundrum. Neurogastroenterol Motil. 2021 May;33(5):e14046. Abstract

Gustafsson UO, Scott MJ, Hubner M, et al. Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations: 2018. World J Surg. 2019 Mar;43(3):659-95.Full text  Abstract

American College of Radiology. ACR appropriateness criteria: suspected small-bowel obstruction. 2019 [internet publication].Full text

Reference articles

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3. Wattchow D, Heitmann P, Smolilo D, et al. Postoperative ileus- an ongoing conundrum. Neurogastroenterol Motil. 2021 May;33(5):e14046. Abstract

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7. Senagore AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Am J Health Syst Pharm. 2007 Oct 15;64(20 suppl 13):S3-7.Full text  Abstract

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11. Parvizi J, Han SB, Tarity TD, et al. Postoperative ileus after total joint arthroplasty. J Arthroplasty. 2008 Apr;23(3):360-5. Abstract

12. Fineberg SJ, Nandyala SV, Kurd MF, et al. Incidence and risk factors for postoperative ileus following anterior, posterior, and circumferential lumbar fusion. Spine J. 2013 Oct 31;14(8):1680-5.Full text  Abstract

13. Lee MJ, Vaughan-Shaw P, Vimalachandran D, et al. A systematic review and meta-analysis of baseline risk factors for the development of postoperative ileus in patients undergoing gastrointestinal surgery. Ann R Coll Surg Engl. 2020 Mar;102(3):194-203.Full text  Abstract

14. Brady JT, Dosokey EM, Crawshaw BP, et al. The use of alvimopan for postoperative ileus in small and large bowel resections. Expert Rev Gastroenterol Hepatol. 2015 Oct 21;9(11):1351-8. Abstract

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18. Bederman SS, Betsy M, Winiarsky R, et al. Postoperative ileus in the lower extremity arthroplasty patient. J Arthroplasty. 2001 Dec;16(8):1066-70.Full text  Abstract

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21. Khawaja ZH, Gendia A, Adnan N, et al. Prevention and management of postoperative ileus: a review of current practice. Cureus. 2022 Feb 27;14(2):e22652.Full text  Abstract

22. Person B, Wexner SD. The management of postoperative ileus. Curr Probl Surg. 2006 Jan;43(1):6-65. Abstract

23. Le Blanc-Louvry I, Denis P, Ducrotte P. The role of remote gut inflammation in duodenojejunal dysmotility. Neurogastroenterol Motil. 2002 Apr;14(2):143-50. Abstract

24. Wang X, Gong Z, Wu K, et al. GI dysmotility in patients with acute pancreatitis. J Gastroenterol Hepatol. 2003 Jan;18(1):57-62. Abstract

25. Wang X, Liu D. Hemodynamic influences on mesenteric blood flow in shock conditions. Am J Med Sci. 2021 Sep;362(3):243-51. Abstract

26. Sundaram V, Fang JC. Gastrointestinal and liver issues in heart failure. Circulation. 2016 Apr 26;133(17):1696-703.Full text  Abstract

27. Luckey A, Livingston E, Taché Y. Mechanisms and treatment of postoperative ileus. Arch Surg. 2003 Feb;138(2):206-14.Full text  Abstract

28. Gustafsson UO, Scott MJ, Hubner M, et al. Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations: 2018. World J Surg. 2019 Mar;43(3):659-95.Full text  Abstract

29. Story SK, Chamberlain RS. A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus. Dig Surg. 2009;26(4):265-75.Full text  Abstract

30. Joh YG, Lindsetmo RO, Stulberg J, et al. Standardized postoperative pathway: accelerating recovery after ileostomy closure. Dis Colon Rectum. 2008 Dec;51(12):1786-9. Abstract

31. Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg. 2017 Mar 1;152(3):292-8. Abstract

32. Hedrick TL, McEvoy MD, Mythen MMG, et al. American Society for Enhanced Recovery and Perioperative Quality Initiative joint consensus statement on postoperative gastrointestinal dysfunction within an enhanced recovery pathway for elective colorectal surgery. Anesth Analg. 2018 Jun;126(6):1896-907.Full text  Abstract

33. Chan KC, Cheng YJ, Huang GT, et al. The effect of IVPCA morphine on post-hysterectomy bowel function. Acta Anaesthesiol Sin. 2002 Jun;40(2):61-4. Abstract

34. Senagore AJ, Delaney CP, Mekhail N, et al. Randomized clinical trial comparing epidural anaesthesia and patient-controlled analgesia after laparoscopic segmental colectomy. Br J Surg. 2003 Oct;90(10):1195-9. Abstract

35. Marret E, Remy C, Bonnet F. Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery. Br J Surg. 2007 Jun;94(6):665-73.Full text  Abstract

36. Gendall KA, Kennedy RR, Watson AJ, et al. The effect of epidural analgesia on postoperative outcome after colorectal surgery. Colorectal Dis. 2007 Sep;9(7):584-98;discussion 598-600. Abstract

37. Carli F, Trudel JL, Belliveau P. The effect of intraoperative thoracic epidural anesthesia and postoperative analgesia on bowel function after colorectal surgery: a prospective, randomized trial. Dis Colon Rectum. 2001 Aug;44(8):1083-9. Abstract

38. Schlachta CM, Burpee SE, Fernandez C, et al. Optimizing recovery after laparoscopic colon surgery (ORAL-CS): effect of intravenous ketorolac on length of hospital stay. Surg Endosc. 2007 Dec;21(12):2212-9. Abstract

39. Chen JY, Wu GJ, Mok MS, et al. Effect of adding ketorolac to intravenous morphine patient-controlled analgesia on bowel function in colorectal surgery patients: a prospective, randomized, double-blind study. Acta Anaesthesiol Scand. 2005 Apr;49(4):546-51. Abstract

40. McNicol ED, Ferguson MC, Schumann R. Single-dose intravenous ketorolac for acute postoperative pain in adults. Cochrane Database Syst Rev. 2021 May 17;5(5):CD013263.Full text  Abstract

41. Bell S, Rennie T, Marwick CA, et al. Effects of peri-operative nonsteroidal anti-inflammatory drugs on post-operative kidney function for adults with normal kidney function. Cochrane Database Syst Rev. 2018 Nov 29;11(11):CD011274.Full text  Abstract

42. Chen JY, Ko TL, Wen YR, et al. Opioid-sparing effects of ketorolac and its correlation with the recovery of postoperative bowel function in colorectal surgery patients: a prospective randomized double-blinded study. Clin J Pain. 2009 Jul-Aug;25(6):485-9. Abstract

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45. Tilney HS, Lovegrove RE, Purkayastha S, et al. Laparoscopic vs open subtotal colectomy for benign and malignant disease. Colorectal Dis. 2006 Jun;8(5):441-50. Abstract

46. Alhashemi M, Fiore JF Jr, Safa N, et al. Incidence and predictors of prolonged postoperative ileus after colorectal surgery in the context of an enhanced recovery pathway. Surg Endosc. 2019 Jul;33(7):2313-22.Full text  Abstract

47. Orji EO, Olabode TO, Kuti O, et al. A randomised controlled trial of early initiation of oral feeding after cesarean section. J Matern Fetal Neonatal Med. 2009 Jan;22(1):65-71. Abstract

48. Boelens PG, Heesakkers FF, Luyer MD, et al. Reduction of postoperative ileus by early enteral nutrition in patients undergoing major rectal surgery: prospective, randomized, controlled trial. Ann Surg. 2014 Apr;259(4):649-55. Abstract

49. Chapman SJ, Pericleous A, Downey C, et al. Postoperative ileus following major colorectal surgery. Br J Surg. 2018 Jun;105(7):797-810.Full text  Abstract

50. Gannon RH. Current strategies for preventing or ameliorating postoperative ileus: a multimodal approach. Am J Health Syst Pharm. 2007 Oct 15;64(20 suppl 13):S8-12.Full text  Abstract

51. Holte K, Kehlet H. Postoperative ileus: a preventable event. Br J Surg. 2000 Nov;87(11):1480-93. Abstract

52. Zingg U, Miskovic D, Hamel CT, et al. Influence of thoracic epidural analgesia on postoperative pain relief and ileus after laparoscopic colorectal resection: benefit with epidural analgesia. Surg Endosc. 2009 Feb;23(2):276-82.Full text  Abstract

53. Guay J, Nishimori M, Kopp SL. Epidural local anesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting, and pain after abdominal surgery: a Cochrane review. Anesth Analg. 2016 Dec;123(6):1591-602.Full text  Abstract

54. Weibel S, Jelting Y, Pace NL, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev. 2018 Jun 4;6(6):CD009642.Full text  Abstract

55. Marret E, Rolin M, Beaussier M, et al. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surg. 2008 Nov;95(11):1331-8. Abstract

56. Hamel JF, Sabbagh C, Alves A, et al. Comparison of treatment to improve gastrointestinal functions after colorectal surgery within enhanced recovery programmes: a systematic review and meta-analysis. Sci Rep. 2021 Apr 1;11(1):7423.Full text  Abstract

57. Drake TM, Ward AE. Pharmacological management to prevent ileus in major abdominal surgery: a systematic review and meta-analysis. J Gastrointest Surg. 2016 Jun;20(6):1253-64. Abstract

58. Kraft MD. Emerging pharmacologic options for treating postoperative ileus. Am J Health Syst Pharm. 2007 Oct 15;64(20 suppl 13):S13-20.Full text  Abstract

59. U.S. Food and Drug Administration. FDA label: Entereg (Alvimopan) capsules. May 2008 [internet publication].Full text

60. Yeh YC, Klinger EV, Reddy P. Pharmacologic options to prevent postoperative ileus. Ann Pharmacother. 2009 Sep;43(9):1474-85. Abstract

61. Delaney CP, Weese JL, Hyman NH, et al. Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis Colon Rectum. 2005 Jun;48(6):1114-25;discussion 1125-6;author reply 1127-9. Abstract

62. Buchler MWS, Seiler CM, Monson JR, et al. Clinical trial: Alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study. Aliment Pharmacol Ther. 2008 Aug 1;28(3):312-25. Abstract

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64. Traut U, Brügger L, Kunz R, et al. Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults. Cochrane Database Syst Rev. 2008 Jan 23:(1):CD004930.Full text  Abstract

65. Ludwig K, Viscusi ER, Wolff BG, et al. Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis. World J Surg. 2010 Sep;34(9):2185-90.Full text  Abstract

66. Vaughan-Shaw PG, Fecher IC, Harris S, et al. A meta-analysis of the effectiveness of the opioid receptor antagonist alvimopan in reducing hospital length of stay and time to GI recovery in patients enrolled in a standardized accelerated recovery program after abdominal surgery. Dis Colon Rectum. 2012 May;55(5):611-20.Full text  Abstract

67. Sultan S, Coles B, Dahm P. Alvimopan for recovery of bowel function after radical cystectomy. Cochrane Database Syst Rev. 2017 May 2;5(5):CD012111.Full text  Abstract

68. Vasquez W, Hernandez AV, Garcia-Sabrido JL, et al. Is gum chewing useful for ileus after elective colorectal surgery? A systematic review and meta-analysis of randomized clinical trials. J Gastrointest Surg. 2009 Apr;13(4):649-56. Abstract

69. Purkayastha S, Tilney HS, Darzi AW, et al. Meta-analysis of randomized studies evaluating chewing gum to enhance postoperative recovery following colectomy. Arch Surg. 2008 Aug;143(8):788-93.Full text  Abstract

70. Noble EJH, Harris R, Hosie KB, et al. Gum chewing reduces postoperative ileus? A systematic review and meta-analysis. Int J Surg. 2009 Apr;7(2):100-5.Full text  Abstract

71. Fitzgerald JE, Ahmed I. Systematic review and meta-analysis of chewing-gum therapy in the reduction of postoperative paralytic ileus following gastrointestinal surgery. World J Surg. 2009 Dec;33(12):2557-66. Abstract

72. Short V, Herbert G, Perry R, et al. Chewing gum for postoperative recovery of gastrointestinal function. Cochrane Database Syst Rev. 2015 Feb 20;(2):CD006506.Full text  Abstract

73. van den Heijkant TC, Costes LM, van der Lee DG, et al. Randomized clinical trial of the effect of gum chewing on postoperative ileus and inflammation in colorectal surgery. Br J Surg. 2015 Feb;102(3):202-11. Abstract

74. Zhu YP, Wang WJ, Zhang SL, et al. Effects of gum chewing on postoperative bowel motility after caesarean section: a meta-analysis of randomised controlled trials. BJOG. 2014 Jun;121(7):787-92.Full text  Abstract

75. Andersson T, Bjerså K, Falk K, et al. Effects of chewing gum against postoperative ileus after pancreaticoduodenectomy - a randomized controlled trial. BMC Res Notes. 2015 Feb 10;8:37.Full text  Abstract

76. Pereira Gomes Morais E, Riera R, Porfírio GJ, et al. Chewing gum for enhancing early recovery of bowel function after caesarean section. Cochrane Database Syst Rev. 2016 Oct 17;10(10):CD011562.Full text  Abstract

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78. Gero D, Gié O, Hübner M, et al. Postoperative ileus: in search of an international consensus on definition, diagnosis, and treatment. Langenbecks Arch Surg. 2017 Feb;402(1):149-58. Abstract

79. Frager DH, Baer JW, Rothpearl A, et al. Distinction between postoperative ileus and mechanical small-bowel obstruction: value of CT compared with clinical and other radiographic findings. AJR Am J Roentgenol. 1995 Apr;164(4):891-4.Full text  Abstract

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81. Golzarian J, Scott HW Jr, Richards WO. Hypermagnesemia-induced paralytic ileus. Dig Dis Sci. 1994 May;39(5):1138-42. Abstract

82. De Giorgio R, Knowles CH. Acute colonic pseudo-obstruction. Br J Surg. 2009 Mar;96(3):229-39. Abstract

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85. Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016 Feb;17(2):131-57.Full text  Abstract

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92. Vather R, Josephson R, Jaung R, et al. Gastrografin in prolonged postoperative ileus: a double-blinded randomized controlled trial. Ann Surg. 2015 Jul;262(1):23-30. Abstract

93. Cheape JD, Wexner SD, James K, et al. Does metoclopramide reduce the length of ileus after colorectal surgery? A prospective randomized trial. Dis Colon Rectum. 1991 Jun;34(6):437-41. Abstract

94. Seta ML, Kale-Pradhan PB. Efficacy of metoclopramide in postoperative ileus after exploratory laparotomy. Pharmacotherapy. 2001 Oct;21(10):1181-6. Abstract

95. Lightfoot AJ, Eno M, Kreder KJ, et al. Treatment of postoperative ileus after bowel surgery with low-dose intravenous erythromycin. Urology. 2007 Apr;69(4):611-5. Abstract

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