References
Key articles
International Headache Society. 2018 International Headache Society international classification of headache disorders (ICHD), 3rd edition. 2018 [internet publication].Full text
Ashina S, Terwindt GM, Steiner TJ, et al. Medication overuse headache. Nat Rev Dis Primers. 2023 Feb 2;9(1):5. Abstract
Diener HC, Antonaci F, Braschinsky M, et al. European Academy of Neurology guideline on the management of medication-overuse headache. Eur J Neurol. 2020 Jul;27(7):1102-16.Full text Abstract
Reference articles
1. International Headache Society. 2018 International Headache Society international classification of headache disorders (ICHD), 3rd edition. 2018 [internet publication].Full text
2. Schwedt TJ, Alam A, Reed ML, et al. Factors associated with acute medication overuse in people with migraine: results from the 2017 migraine in America symptoms and treatment (MAST) study. J Headache Pain. 2018 May 24;19(1):38.Full text Abstract
3. Bigal ME, Serrano D, Buse D, et al. Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. Headache. 2008 Sep;48(8):1157-68.Full text Abstract
4. Hagen K, Linde M, Steiner TJ, et al. Risk factors for medication-overuse headache: an 11-year follow-up study. The Nord-Trøndelag Health Studies. Pain. 2012 Jan;153(1):56-61. Abstract
5. Wakerley BR. Medication-overuse headache. Pract Neurol. 2019 Oct;19(5):399-403. Abstract
6. Diener HC, Kropp P, Dresler T, et al. Management of medication overuse (MO) and medication overuse headache (MOH) S1 guideline. Neurol Res Pract. 2022 Aug 29;4(1):37.Full text Abstract
7. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1545-602.Full text Abstract
8. Westergaard ML, Hansen EH, Glümer C, et al. Definitions of medication-overuse headache in population-based studies and their implications on prevalence estimates: a systematic review. Cephalalgia. 2014 May;34(6):409-25.Full text Abstract
9. Diener HC, Dodick D, Evers S, et al. Pathophysiology, prevention, and treatment of medication overuse headache. Lancet Neurol. 2019 Sep;18(9):891-902. Abstract
10. Ashina S, Terwindt GM, Steiner TJ, et al. Medication overuse headache. Nat Rev Dis Primers. 2023 Feb 2;9(1):5. Abstract
11. Cheung V, Amoozegar F, Dilli E. Medication overuse headache. Curr Neurol Neurosci Rep. 2015 Jan;15(1):509. Abstract
12. Munksgaard SB, Jensen RH. Medication overuse headache. Headache. 2014 Jul-Aug;54(7):1251-7. Abstract
13. Irimia P, Palma JA, Fernandez-Torron R, et al. Refractory migraine in a headache clinic population. BMC Neurol. 2011 Aug 1;11:94.Full text Abstract
14. Bigal ME, Rapoport AM, Sheftell FD, et al. Transformed migraine and medication overuse in a tertiary headache centre - clinical characteristics and treatment outcomes. Cephalalgia. 2004 Jun;24(6):483-90.Full text Abstract
15. Westergaard ML, Glümer C, Hansen EH, et al. Prevalence of chronic headache with and without medication overuse: associations with socioeconomic position and physical and mental health status. Pain. 2014 Oct;155(10):2005-13. Abstract
16. Jonsson P, Hedenrud T, Linde M. Epidemiology of medication overuse headache in the general Swedish population. Cephalalgia. 2011 Jul;31(9):1015-22.Full text Abstract
17. Diener HC, Holle D, Solbach K, et al. Medication-overuse headache: risk factors, pathophysiology and management. Nat Rev Neurol. 2016 Oct;12(10):575-83. Abstract
18. Schwedt TJ, Buse DC, Argoff CE, et al. Medication overuse and headache burden: results from the CaMEO Study. Neurol Clin Pract. 2021 Jun;11(3):216-26.Full text Abstract
19. Bottiroli S, Allena M, Sances G, et al; COMOESTAS Consortium. Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: a six-month follow-up of the COMOESTAS Project. Cephalalgia. 2019 Jan;39(1):135-47.Full text Abstract
20. Cargnin S, Viana M, Sances G, et al. A systematic review and critical appraisal of gene polymorphism association studies in medication-overuse headache. Cephalalgia. 2018 Jun;38(7):1361-73.Full text Abstract
21. Verhagen IE, Spaink HA, van der Arend BW, et al. Validation of diagnostic ICHD-3 criteria for menstrual migraine. Cephalalgia. 2022 Oct;42(11-12):1184-93.Full text Abstract
22. van Casteren DS, Kurth T, Danser AHJ, et al. Sex differences in response to triptans: a systematic review and meta-analysis. Neurology. 2021 Jan 26;96(4):162-70. Abstract
23. Chong CD. Brain structural and functional imaging findings in medication-overuse headache. Front Neurol. 2020 Jan 28;10:1336.Full text Abstract
24. Schwedt TJ, Chong CD. Medication overuse headache: pathophysiological insights from structural and functional brain MRI research. Headache. 2017 Jul;57(7):1173-8. Abstract
25. Fumal A, Laureys S, Di Clemente L, et al. Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain. 2006 Feb;129(pt 2):543-50.Full text Abstract
26. Coppola G, Schoenen J. Cortical excitability in chronic migraine. Curr Pain Headache Rep. 2012 Feb;16(1):93-100. Abstract
27. Diener HC, Antonaci F, Braschinsky M, et al. European Academy of Neurology guideline on the management of medication-overuse headache. Eur J Neurol. 2020 Jul;27(7):1102-16.Full text Abstract
28. Find NL, Terlizzi R, Munksgaard SB, et al; COMOESTAS Consortium. Medication overuse headache in Europe and Latin America: general demographic and clinical characteristics, referral pathways and national distribution of painkillers in a descriptive, multinational, multicenter study. J Headache Pain. 2016 Mar 8;17:20.Full text Abstract
29. Scher AI, Lipton RB, Stewart WF, et al. Patterns of medication use by chronic and episodic headache sufferers in the general population: results from the frequent headache epidemiology study. Cephalalgia. 2010 Mar;30(3):321-8.Full text Abstract
30. British Association for the Study of Headache. National headache management system for adults 2019. 2019 [internet publication].Full text
31. Ailani J, Burch RC, Robbins MS, et al. The American Headache Society consensus statement: update on integrating new migraine treatments into clinical practice. Headache. 2021 Jul;61(7):1021-39.Full text Abstract
32. Limmroth V, Katsarava Z, Fritsche G, et al. Features of medication overuse headache following overuse of different acute headache drugs. Neurology. 2002 Oct 8;59(7):1011-4. Abstract
33. Charles AC, Digre KB, Goadsby PJ, et al; American Headache Society. Calcitonin gene-related peptide-targeting therapies are a first-line option for the prevention of migraine: an American Headache Society position statement update. Headache. 2024 Apr;64(4):333-41.Full text Abstract
34. Pakalnis A, Butz C, Splaingard D, et al. Emotional problems and prevalence of medication overuse in pediatric chronic daily headache. J Child Neurol. 2007 Dec;22(12):1356-9. Abstract
35. Moavero R, Stornelli M, Papetti L, et al. Medication overuse withdrawal in children and adolescents does not always improve headache: a cross-sectional study. Front Neurol. 2020 Aug 19;11:823.Full text Abstract
36. Lau CI, Liu MN, Chen WH, et al. Chapter 14. Clinical and biobehavioral perspectives: is medication overuse headache a behavior of dependence? In: Wang SJ, Lau CI, eds. Update on emerging treatments for migraine. Prog Brain Res. 2020;255:371-402. Abstract
37. Takahashi TT, Ornello R, Quatrosi G, et al; European Headache Federation School of Advanced Studies (EHF-SAS). Medication overuse and drug addiction: a narrative review from addiction perspective. J Headache Pain. 2021 Apr 28;22(1):32.Full text Abstract
38. Wilcox SL, Ludwick AM, Lebel A, et al. Age- and sex-related differences in the presentation of paediatric migraine: a retrospective cohort study. Cephalalgia. 2018 May;38(6):1107-18.Full text Abstract
39. Borsook D, Erpelding N, Lebel A, et al. Sex and the migraine brain. Neurobiol Dis. 2014 Aug;68:200-14.Full text Abstract
40. Do TP, Remmers A, Schytz HW, et al. Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list. Neurology. 2019 Jan 15;92(3):134-44.Full text Abstract
41. Dodick DW. Clinical clues and clinical rules: primary vs secondary headache. Adv Stud Med. 2003 Jun;3:550-5.Full text
42. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia. 2004;24 Suppl 1:9-160.Full text Abstract
43. Jellestad PL, Carlsen LN, Westergaard ML, et al; COMOESTAS Consortium. Economic benefits of treating medication-overuse headache - results from the multicenter COMOESTAS project. Cephalalgia. 2019 Feb;39(2):274-85.Full text Abstract
44. Shah AM, Bendtsen L, Zeeberg P, et al. Reduction of medication costs after detoxification for medication-overuse headache. Headache. 2013 Apr;53(4):665-72. Abstract
45. American College of Radiology. ACR appropriateness criteria: headache. 2022 [internet publication].Full text
46. Hoffmann J, Mollan SP, Paemeleire K, et al. European Headache Federation guideline on idiopathic intracranial hypertension. J Headache Pain. 2018 Oct 8;19(1):93.Full text Abstract
47. Whiteley W, Al-Shahi R, Warlow CP, Zeidler M, Lueck CJ. CSF opening pressure: reference interval and the effect of body mass index. Neurology. 2006 Nov 14;67(9):1690-1. Abstract
48. Bond KM, Benson JC, Cutsforth-Gregory JK, et al. Spontaneous intracranial hypotension: atypical radiologic appearances, imaging mimickers, and clinical look-alikes. AJNR Am J Neuroradiol. 2020 Aug;41(8):1339-47.Full text Abstract
49. Pareek AV, Edmondson E, Kung D. Cervicogenic headaches: a literature review and proposed multifaceted approach to diagnosis and management. Neurol Clin. 2024 May;42(2):543-57. Abstract
50. Newman DS, Levine SR, Curtis VL, et al. Migraine-like visual phenomena associated with cerebral venous thrombosis. Headache. 1989 Feb;29(2):82-5. Abstract
51. Linn FH, Wijdicks EF. Causes and management of thunderclap headache: a comprehensive review. Neurologist. 2002 Sep;8(5):279-89. Abstract
52. Oliveira IM, Duarte JÁ, Dalaqua M, et al. Cerebral venous thrombosis: imaging patterns. Radiol Bras. 2022 Jan-Feb;55(1):54-61.Full text Abstract
53. Baldwin KJ, Zunt JR. Evaluation and treatment of chronic meningitis. Neurohospitalist. 2014 Oct;4(4):185-95.Full text Abstract
54. Schwedt TJ, Hentz JG, Sahai-Srivastava S, et al; MOTS Investigators. Patient-centered treatment of chronic migraine with medication overuse: a prospective, randomized, pragmatic clinical trial. Neurology. 2022 Apr 5;98(14):e1409-21. Abstract
55. Bendtsen L, Munksgaard S, Tassorelli C, et al; COMOESTAS Consortium. Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project). Cephalalgia. 2014 May;34(6):426-33.Full text Abstract
56. Carlsen LN, Munksgaard SB, Nielsen M, et al. Comparison of 3 treatment strategies for medication overuse headache: a randomized clinical trial. JAMA Neurol. 2020 Sep 1;77(9):1069-78.Full text Abstract
57. Rossi P, Di Lorenzo C, Faroni J, et al. Advice alone vs. structured detoxification programmes for medication overuse headache: a prospective, randomized, open-label trial in transformed migraine patients with low medical needs. Cephalalgia. 2006 Sep;26(9):1097-105.Full text Abstract
58. Kristoffersen ES, Straand J, Vetvik KG, et al. Brief intervention for medication-overuse headache in primary care. The BIMOH study: a double-blind pragmatic cluster randomised parallel controlled trial. J Neurol Neurosurg Psychiatry. 2015 May;86(5):505-12.Full text Abstract
59. Kristoffersen ES, Straand J, Russell MB, et al. Lasting improvement of medication-overuse headache after brief intervention - a long-term follow-up in primary care. Eur J Neurol. 2017 Jul;24(7):883-91. Abstract
60. National Institute for Health and Care Excellence. Headaches in over 12s: diagnosis and management. Dec 2021 [internet publication].Full text
61. Carlsen LN, Munksgaard SB, Jensen RH, et al. Complete detoxification is the most effective treatment of medication-overuse headache: a randomized controlled open-label trial. Cephalalgia. 2018 Feb;38(2):225-36.Full text Abstract
62. Engelstoft IMS, Carlsen LN, Munksgaard SB, et al. Complete withdrawal is the most feasible treatment for medication-overuse headache: a randomized controlled open-label trial. Eur J Pain. 2019 Jul;23(6):1162-70. Abstract
63. Loder E, Biondi D. Oral phenobarbital loading: a safe and effective method of withdrawing patients with headache from butalbital compounds. Headache. 2003 Sep;43(8):904-9. Abstract
64. International Headache Society. Medication-overuse headache awareness campaign. 2024 [internet publication].Full text
65. Diener HC, Dodick DW, Goadsby PJ, et al. Utility of topiramate for the treatment of patients with chronic migraine in the presence or absence of acute medication overuse. Cephalalgia. 2009 Oct;29(10):1021-7.Full text Abstract
66. Silberstein SD, Blumenfeld AM, Cady RK, et al. OnabotulinumtoxinA for treatment of chronic migraine: PREEMPT 24-week pooled subgroup analysis of patients who had acute headache medication overuse at baseline. J Neurol Sci. 2013 Aug 15;331(1-2):48-56. Abstract
67. Pijpers JA, Kies DA, Louter MA, et al. Acute withdrawal and botulinum toxin A in chronic migraine with medication overuse: a double-blind randomized controlled trial. Brain. 2019 May 1;142(5):1203-14.Full text Abstract
68. Goadsby PJ, Friedman DI, Holle-Lee D, et al. Efficacy of oral atogepant in people with chronic migraine with and without acute medication overuse: results from the PROGRESS trial. Paper presented at: 18th Migraine Trust International Symposium. Sep 2022. London. Cephalalgia. 2022 Sep;42(Suppl. 1):34-5.Full text
69. Goadsby PJ, Friedman DI, Holle-Lee D, et al. Efficacy of atogepant in chronic migraine with and without acute medication overuse in the randomized, double-blind, phase 3 PROGRESS trial. Neurology. 2024 Jul 23;103(2):e209584.Full text Abstract
70. Dodick DW, Doty EG, Aurora SK, et al. Medication overuse in a subgroup analysis of phase 3 placebo-controlled studies of galcanezumab in the prevention of episodic and chronic migraine. Cephalalgia. 2021 Mar;41(3):340-52.Full text Abstract
71. Silberstein SD, Cohen JM, Seminerio MJ, et al. The impact of fremanezumab on medication overuse in patients with chronic migraine: subgroup analysis of the HALO CM study. J Headache Pain. 2020 Sep 21;21(1):114.Full text Abstract
72. Tepper SJ, Diener HC, Ashina M, et al. Erenumab in chronic migraine with medication overuse: subgroup analysis of a randomized trial. Neurology. 2019 May 14;92(20):e2309-20.Full text Abstract
73. Diener HC, Marmura MJ, Tepper SJ, et al. Efficacy, tolerability, and safety of eptinezumab in patients with a dual diagnosis of chronic migraine and medication-overuse headache: subgroup analysis of PROMISE-2. Headache. 2021 Jan;61(1):125-36.Full text Abstract
74. Koumprentziotis IA, Mitsikostas DD. Therapies targeting CGRP signaling for medication overuse headache. Curr Opin Neurol. 2022 Jun 1;35(3):353-9. Abstract
75. Mascarella D, Matteo E, Favoni V, et al. The ultimate guide to the anti-CGRP monoclonal antibodies galaxy. Neurol Sci. 2022 Sep;43(9):5673-85. Abstract
76. Giri S, Tronvik E, Linde M, et al. Randomized controlled studies evaluating topiramate, botulinum toxin type A, and mABs targeting CGRP in patients with chronic migraine and medication overuse headache: a systematic review and meta-analysis. Cephalalgia. 2023 Apr;43(4):3331024231156922.Full text Abstract
77. Karadaş Ö, Özön AÖ, Özçelik F, et al. Greater occipital nerve block in the treatment of triptan-overuse headache: a randomized comparative study. Acta Neurol Scand. 2017 Apr;135(4):426-33. Abstract
78. Bendtsen L, Evers S, Linde M, et al. EFNS guideline on the treatment of tension-type headache - report of an EFNS task force. Eur J Neurol. 2010 Nov;17(11):1318-25.Full text Abstract
79. Ashina S, Mitsikostas DD, Lee MJ, et al. Tension-type headache. Nat Rev Dis Primers. 2021 Mar 25;7(1):24. Abstract
80. Pijpers JA, Kies DA, van Zwet EW, et al. Behavioural intervention in medication overuse headache: a concealed double-blind randomized controlled trial. Eur J Neurol. 2022 May;29(5):1496-504.Full text Abstract
81. Rausa M, Palomba D, Cevoli S, et al. Biofeedback in the prophylactic treatment of medication overuse headache: a pilot randomized controlled trial. J Headache Pain. 2016 Dec;17(1):87.Full text Abstract
82. Grazzi L, Raggi A, Guastafierro E, et al. A preliminary analysis on the feasibility and short-term efficacy of a phase-III RCT on mindfulness added to treatment as usual for patients with chronic migraine and medication overuse headache. Int J Environ Res Public Health. 2022 Oct 29;19(21):14116.Full text Abstract
83. Vandenbussche N, Laterza D, Lisicki M, et al. Medication-overuse headache: a widely recognized entity amidst ongoing debate. J Headache Pain. 2018 Jul 13;19(1):50.Full text Abstract
84. Oskoui M, Pringsheim T, Billinghurst L, et al. Practice guideline update summary: pharmacologic treatment for pediatric migraine prevention. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):500-9.Full text Abstract
85. Gelfand AA, Goadsby PJ. Medication overuse in children and adolescents. Curr Pain Headache Rep. 2014 Jul;18(7):428.Full text Abstract
86. Hershey AD, Burdine D, Kabbouche MA, et al. Genomic expression patterns in medication overuse headaches. Cephalalgia. 2011 Jan;31(2):161-71.Full text Abstract
87. Hering-Hanit R, Gadoth N, Cohen A, et al. Successful withdrawal from analgesic abuse in a group of youngsters with chronic daily headache. J Child Neurol. 2001 Jun;16(6):448-9. Abstract
88. Kossoff EH, Mankad DN. Medication-overuse headache in children: is initial preventive therapy necessary? J Child Neurol. 2006 Jan;21(1):45-8. Abstract
89. Oskoui M, Pringsheim T, Holler-Managan Y, et al. Practice guideline update summary: acute treatment of migraine in children and adolescents. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):487-99.Full text Abstract
90. Gibler RC, Knestrick KE, Reidy BL, et al. Management of chronic migraine in children and adolescents: where are we in 2022? Pediatric Health Med Ther. 2022;13:309-23.Full text Abstract
91. Locher C, Kossowsky J, Koechlin H, et al. Efficacy, safety, and acceptability of pharmacologic treatments for pediatric migraine prophylaxis: a systematic review and network meta-analysis. JAMA Pediatr. 2020 Apr 1;174(4):341-9.Full text Abstract
92. Anttila P. Tension-type headache in childhood and adolescence. Lancet Neurol. 2006 Mar;5(3):268-74. Abstract
93. Hershey AD, Powers SW, Bentti AL, et al. Effectiveness of amitriptyline in the prophylactic management of childhood headaches. Headache. 2000 Jul-Aug;40(7):539-49. Abstract
94. Seshia SS, Abu-Arafeh I, Hershey AD. Tension-type headache in children: the Cinderella of headache disorders!. Can J Neurol Sci. 2009 Nov;36(6):687-95. Abstract
95. American College of Obstetricians and Gynecologists. Headaches in pregnancy and postpartum: ACOG Clinical Practice Guideline no. 3. Obstet Gynecol. 2022 May 1;139(5):944-72. [Erratum in: Obstet Gynecol. 2022 Aug 1;140(2):344.] Abstract
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