Acute appendicitis

References

Key articles

Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.Full text  Abstract

American College of Radiology. ACR appropriateness criteria: right lower quadrant pain - suspected appendicitis. 2022 [internet publication].Full text

Sartelli M, Chichom-Mefire A, Labricciosa FM, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg. 2017 Jul 10;12:29.Full text  Abstract

Reference articles

1. Fitz RH. Perforating inflammation of the vermiform appendix with special reference to its early diagnosis and treatment. Am J Med Sci. 1886;92:321-46.

2. Moris D, Paulson EK, Pappas TN. Diagnosis and management of acute appendicitis in adults: A Review. JAMA. 2021 Dec 14;326(22):2299-311. Abstract

3. Lapsa S, Ozolins A, Strumfa I, et al. Acute appendicitis in the elderly: a literature review on an increasingly frequent surgical problem. Geriatrics (Basel). 2021 Sep 18;6(3):93.Full text  Abstract

4. Antoniou SA, Mavridis D, Kontouli KM, et al. EAES rapid guideline: appendicitis in the elderly. Surg Endosc. 2021 Jul;35(7):3233-43. Abstract

5. Fugazzola P, Ceresoli M, Agnoletti V, et al. The SIFIPAC/WSES/SICG/SIMEU guidelines for diagnosis and treatment of acute appendicitis in the elderly (2019 edition). World J Emerg Surg. 2020 Mar 10;15(1):19.Full text  Abstract

6. Andersen B, Nielsen TF. Appendicitis in pregnancy: diagnosis, management and complications. Acta Obstet Gynecol Scand. 1999 Oct;78(9):758-62. Abstract

7. Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.Full text  Abstract

8. Davenport M. Acute abdominal pain in children. BMJ. 1996 Feb 24;312(7029):498-501.Full text  Abstract

9. Benabbas R, Hanna M, Shah J, et al. Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis. Acad Emerg Med. 2017 May;24(5):523-51.Full text  Abstract

10. Ferris M, Quan S, Kaplan BS, et al. The global incidence of appendicitis: a systematic review of population-based studies. Ann Surg. 2017 Aug;266(2):237-41. Abstract

11. NHS Digital. Hospital admitted patient care activity, 2021-22. Sep 2022 [internet publication].Full text

12. Snyder MJ, Guthrie M, Cagle S. Acute appendicitis: efficient diagnosis and management. Am Fam Physician. 2018 Jul 1;98(1):25-33.Full text  Abstract

13. Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis. EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-90.Full text  Abstract

14. Singh JP, Mariadason JG. Role of the faecolith in modern-day appendicitis. Ann R Coll Surg Engl. 2013 Jan;95(1):48-51.Full text  Abstract

15. Ramdass MJ, Young Sing Q, Milne D, et al. Association between the appendix and the fecalith in adults. Can J Surg. 2015 Feb;58(1):10-4.Full text  Abstract

16. Eslahi AV, Olfatifar M, Houshmand E, et al. Parasites in surgically removed appendices as a neglected public health concern: a systematic review and meta-analysis. Pathog Glob Health. 2022 Sep;116(6):341-55.Full text  Abstract

17. Zacarias M, Pizzol D, de Miranda H, et al. Schistosomal appendicitis: Case series and systematic literature review. PLoS Negl Trop Dis. 2021 Jun;15(6):e0009478.Full text  Abstract

18. Di Sebastiano P, Fink T, di Mola FF, et al. Neuroimmune appendicitis. Lancet. 1999 Aug 7;354(9177):461-6. Abstract

19. Peisl S, Burckhardt O, Egger B. Neurogenic appendicopathy: an underestimated disease-systematic review of the literature. Int J Colorectal Dis. 2021 Sep;36(9):1995-2005. Abstract

20. Soffer D, Zait S, Klausner J, et al. Peritoneal cultures and antibiotic treatment in patients with perforated appendicitis. Eur J Surg. 2001 Mar;167(3):214-6. Abstract

21. Brunicardi FC, Andersen DK, Billiar TR, et al, eds. The appendix. In: Schwartz's principles of surgery. 8th ed. New York, NY: McGraw-Hill; 2005:1119-37.

22. Huis in 't Veld JH. Gastrointestinal flora and health in man and animal [in Dutch]. Tijdschr Diergeneeskd. 1991 Mar 1;116(5):232-9. Abstract

23. Walker AR, Segal I. What causes appendicitis? J Clin Gastroenterol. 1990 Apr;12(2):127-9. Abstract

24. Montgomery SM, Pounder RE, Wakefield AJ. Smoking in adults and passive smoking in children are associated with acute appendicitis. Lancet. 1999 Jan 30;353(9150):379. Abstract

25. Oldmeadow C, Wood I, Mengersen K, et al. Investigation of the relationship between smoking and appendicitis in Australian twins. Ann Epidemiol. 2008 Aug;18(8):631-6. Abstract

26. Bendeck SE, Nino-Murcia M, Berry GJ, et al. Imaging for suspected appendicitis: negative appendectomy and perforation rates. Radiology. 2002 Oct;225(1):131-6. Abstract

27. Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986 May;15(5):557-64. Abstract

28. Kularatna M, Lauti M, Haran C, et al. Clinical prediction rules for appendicitis in adults: which is best? World J Surg. 2017 Jul;41(7):1769-81. Abstract

29. Frountzas M, Stergios K, Kopsini D, et al. Alvarado or RIPASA score for diagnosis of acute appendicitis? A meta-analysis of randomized trials. Int J Surg. 2018 Aug;56:307-14. Abstract

30. American College of Radiology. ACR appropriateness criteria: right lower quadrant pain - suspected appendicitis. 2022 [internet publication].Full text

31. Basaran A, Basaran M. Diagnosis of acute appendicitis during pregnancy: a systematic review. Obstet Gynecol Surv. 2009 Jul;64(7):481-8; quiz 499. Abstract

32. Baird DLH, Simillis C, Kontovounisios C, et al. Acute appendicitis. BMJ. 2017 Apr 19;357:j1703.Full text  Abstract

33. Lee SL, Walsh AJ, Ho HS. Computed tomography and ultrasonography do not improve and may delay the diagnosis and treatment of acute appendicitis. Arch Surg. 2001 May;136(5):556-62.Full text  Abstract

34. Lewis SR, Mahony PJ, Simpson J. Appendicitis. BMJ. 2011 Oct 6;343:d5976. Abstract

35. Petroianu A. Diagnosis of acute appendicitis. Int J Surg. 2012;10(3):115-9.Full text  Abstract

36. Brown JJ, Wilson C, Coleman S, Joypaul BV. Appendicitis in pregnancy: an ongoing diagnostic dilemma. Colorectal Dis. 2009 Feb;11(2):116-22. Abstract

37. Temple CL, Shirley AH, Temple WJ. The natural history of appendicitis in adults. A prospective study. Ann Surg. 1995 Mar;221(3):278-81.Full text  Abstract

38. Franz MG, Norman J, Fabri PJ. Increased morbidity of appendicitis with advancing age. Am Surg. 1995 Jan;61(1):40-4. Abstract

39. Humes DJ, Simpson J. Acute appendicitis. BMJ. 2006 Sep 9;333(7567):530-4.Full text  Abstract

40. Andersson RE. Meta-analysis of the clinical and laboratory diagnosis of acute appendicitis. Br J Surg. 2004 Jan;91(1):28-37. Abstract

41. Green R, Bulloch B, Kabani A, et al. Early analgesia for children with acute abdominal pain. Pediatrics. 2005 Oct;116(4):978-83. Abstract

42. Manterola C, Vial M, Moraga J, et al. Analgesia in patients with acute abdominal pain. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD005660.Full text  Abstract

43. Carstens AK, Fensby L, Penninga L. Nonoperative treatment of appendicitis during pregnancy in a remote area. AJP Rep. 2018 Jan;8(1):e37-8.Full text  Abstract

44. Bachur RG, Callahan MJ, Monuteaux MC, et al. Integration of ultrasound findings and a clinical score in the diagnostic evaluation of pediatric appendicitis. J Pediatr. 2015 May;166(5):1134-9. Abstract

45. Terasawa T, Blackmore CC, Bent S, et al. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents. Ann Intern Med. 2004 Oct 5;141(7):537-46. Abstract

46. Dahabreh IJ, Adam GP, Halladay CW, et al. Diagnosis of right lower quadrant pain and suspected acute appendicitis. In: Agency for Healthcare Research and Quality (US). AHRQ Comparative effectiveness reviews report no. 15(16)-EHC025-EF. 2015. Rockville, MD: Agency for Healthcare Research and Quality (US).Full text  Abstract

47. Fu J, Zhou X, Chen L, et al. Abdominal ultrasound and its diagnostic accuracy in diagnosing acute appendicitis: a meta-analysis. Front Surg. 2021 Jun 28:8:707160.Full text  Abstract

48. American College of Emergency Physicians Clinical Policies Subcommittee (Writing Committee) on Appendicitis, Diercks DB, Adkins EJ, et al. Clinical policy: critical issues in the evaluation and management of emergency department patients with suspected appendicitis: approved by ACEP Board of Directors February 1, 2023. Ann Emerg Med. 2023 Jun;81(6):e115-52.Full text  Abstract

49. American College of Radiology. ACR appropriateness criteria: acute nonlocalized abdominal pain. 2018 [internet publication].Full text

50. Musunuru S, Chen H, Rikkers LF, et al. Computed tomography in the diagnosis of acute appendicitis: definitive or detrimental? J Gastrointest Surg. 2007 Nov;11(11):1417-21; discussion 1421-2. Abstract

51. Chiu YH, Chen JD, Wang SH, et al. Whether intravenous contrast is necessary for CT diagnosis of acute appendicitis in adult ED patients? Acad Radiol. 2013 Jan;20(1):73-8.Full text  Abstract

52. Hlibczuk V, Dattaro JA, Jin Z, et al. Diagnostic accuracy of noncontrast computed tomography for appendicitis in adults: a systematic review. Ann Emerg Med. 2010 Jan;55(1):51-9.e1. Abstract

53. Arruzza E, Milanese S, Li LSK, et al. Diagnostic accuracy of computed tomography and ultrasound for the diagnosis of acute appendicitis: A systematic review and meta-analysis. Radiography (Lond). 2022 Nov;28(4):1127-41. Abstract

54. D'Souza N, Hicks G, Beable R, et al. Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis. Cochrane Database Syst Rev. 2021 Dec 14;(12):CD012028.Full text  Abstract

55. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med. 2018;56(12):2015-38. Abstract

56. Eun S, Ho IG, Bae GE, et al. Neutrophil-to-lymphocyte ratio for the diagnosis of pediatric acute appendicitis: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):7097-107.Full text  Abstract

57. Giannis D, Matenoglou E, Moris D. Hyponatremia as a marker of complicated appendicitis: A systematic review. Surgeon. 2020 Oct;18(5):295-304. Abstract

58. Zhan W, Deng W, Liu Y, et al. Hyponatremia as a predictor of complicated appendicitis in children: A systematic review and meta-analysis. Asian J Surg. 2022 Oct;45(10):2009-11.Full text  Abstract

59. Anand S, Pakkasjärvi N, Bajpai M, et al. Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis. Pediatr Surg Int. 2022 Aug;38(8):1105-12.Full text  Abstract

60. Shi W, Wu Y, Zhong L, et al. Diagnostic accuracy of serum amyloid A in acute appendicitis: a systematic review and meta-analysis. Surg Infect (Larchmt). 2022 May;23(4):380-7. Abstract

61. Tullavardhana T, Sanguanlosit S, Chartkitchareon A. Role of platelet indices as a biomarker for the diagnosis of acute appendicitis and as a predictor of complicated appendicitis: a meta-analysis. Ann Med Surg (Lond). 2021 Jun;66:102448.Full text  Abstract

62. Shen G, Li S, Shao Z, et al. Platelet indices in patients with acute appendicitis: a systematic review with meta-analysis. Updates Surg. 2021 Aug;73(4):1327-41. Abstract

63. Makama JG, Kache SA, Ajah LJ, et al. Intestinal obstruction caused by appendicitis: a systematic review. J West Afr Coll Surg. 2017 Jul-Sep;7(3):94-115.Full text  Abstract

64. Choi D, Park H, Lee YR, et al. The most useful finding for the diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiol. 2003 Nov;44(6):574-82. Abstract

65. Eng KA, Abadeh A, Ligocki C, et al. Acute appendicitis: a meta-analysis of the diagnostic accuracy of US, CT, and MRI as second-line imaging tests after an initial US. Radiology. 2018 Sep;288(3):717-27.Full text  Abstract

66. Zhang H, Liao M, Chen J, et al. Ultrasound, computed tomography or magnetic resonance imaging - which is preferred for acute appendicitis in children? A Meta-analysis. Pediatr Radiol. 2017 Feb;47(2):186-96. Abstract

67. Hajibandeh S, Hajibandeh S, Hobbs N, et al. Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: a systematic review and meta-analysis. Am J Surg. 2020 Jan;219(1):154-63. Abstract

68. Sabiston D. The biliary system. In: Sabiston D, Lyerly HK, eds. Textbook of surgery: the biological basis of modern surgical practice. 15th ed. Philadelphia, PA: W.B. Saunders Company; 1997:1127.

69. Vincelette J, Schirm J, Bogard M, et al. Multicenter evaluation of the fully automated COBAS AMPLICATOR PCR test for detection of Chlamydia trachomatis in urogenital specimens. J Clin Microbiol. 1999 Jan;37(1):74-80.Full text  Abstract

70. Uhe I, Meyer J, Viviano M, et al. Caecal diverticulitis can be misdiagnosed as acute appendicitis: a systematic review of the literature. Colorectal Dis. 2021 Oct;23(10):2515-26.Full text  Abstract

71. Favara G, Maugeri A, Barchitta M, et al. Comparison of RIPASA and ALVARADO scores for risk assessment of acute appendicitis: a systematic review and meta-analysis. PLoS One. 2022;17(9):e0275427.Full text  Abstract

72. Sammalkorpi HE, Mentula P, Savolainen H, et al. The introduction of adult appendicitis score reduced negative appendectomy rate. Scand J Surg. 2017 Sep;106(3):196-201.Full text  Abstract

73. Sammalkorpi HE, Mentula P, Leppäniemi A. A new adult appendicitis score improves diagnostic accuracy of acute appendicitis--a prospective study. BMC Gastroenterol. 2014 Jun 26;14:114.Full text  Abstract

74. Andersson M, Andersson RE. The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the Alvarado score. World J Surg. 2008 Aug;32(8):1843-9. Abstract

75. Chong CF, Adi MI, Thien A, et al. Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis. Singapore Med J. 2010 Mar;51(3):220-5.Full text  Abstract

76. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29. Abstract

77. Shapiro NI, Wolfe RE, Moore RB, et al. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003 Mar;31(3):670-5. Abstract

78. Knaus WA, Wagner DP, Draper EA, et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest. 1991 Dec;100(6):1619-36. Abstract

79. Rivers EP, Nguyen HB, Amponsah D. Sepsis: a landscape from the emergency department to the intensive care unit. Crit Care Med. 2003 Mar;31(3):968-9. Abstract

80. American College of Radiology. ACR appropriateness criteria: fever without source or unknown origin - child. 2015 [internet publication].Full text

81. Mayumi T, Yoshida M, Tazuma S, et al. The practice guidelines for primary care of acute abdomen 2015. Jpn J Radiol. 2016 Jan;34(1):80-115.Full text  Abstract

82. de Almeida Leite RM, Seo DJ, Gomez-Eslava B, et al. Nonoperative vs operative management of uncomplicated acute appendicitis: a systematic review and meta-analysis. JAMA Surg. 2022 Sep 1;157(9):828-34.Full text  Abstract

83. Salminen P, Tuominen R, Paajanen H, et al. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018 Sep 25;320(12):1259-65.Full text  Abstract

84. Sakran JV, Mylonas KS, Gryparis A, et al. Operation versus antibiotics: the "appendicitis conundrum" continues - a meta-analysis. J Trauma Acute Care Surg. 2017 Jun;82(6):1129-37. Abstract

85. Sartelli M, Chichom-Mefire A, Labricciosa FM, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg. 2017 Jul 10;12:29.Full text  Abstract

86. Emile SH, Sakr A, Shalaby M, et al. Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-analyses. World J Surg. 2022 May;46(5):1022-38.Full text  Abstract

87. Herrod PJJ, Kwok AT, Lobo DN. Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open. 2022 Jul 7;6(4):zrac100.Full text  Abstract

88. Talan DA, Di Saverio S. Treatment of acute uncomplicated appendicitis. N Engl J Med. 2021 Sep 16;385(12):1116-23. Abstract

89. Meier J, Stevens A, Bhat A, et al. Outcomes of nonoperative vs operative management of acute appendicitis in older adults in the US. JAMA Surg. 2023 Jun 1;158(6):625-32.Full text  Abstract

90. Georgiou R, Eaton S, Stanton MP, et al. Efficacy and safety of nonoperative treatment for acute appendicitis: a meta-analysis. Pediatrics. 2017 Mar;139(3):e20163003.Full text  Abstract

91. Gorter RR, The SML, Gorter-Stam MAW, et al. Systematic review of nonoperative versus operative treatment of uncomplicated appendicitis. J Pediatr Surg. 2017 Aug;52(8):1219-27. Abstract

92. Podda M, Cillara N, Di Saverio S, et al. Antibiotics-first strategy for uncomplicated acute appendicitis in adults is associated with increased rates of peritonitis at surgery. A systematic review with meta-analysis of randomized controlled trials comparing appendectomy and non-operative management with antibiotics. Surgeon. 2017 Oct;15(5):303-14. Abstract

93. Kessler U, Mosbahi S, Walker B, et al. Conservative treatment versus surgery for uncomplicated appendicitis in children: a systematic review and meta-analysis. Arch Dis Child. 2017 Dec;102(12):1118-24. Abstract

94. Harnoss JC, Zelienka I, Probst P, et al. Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015: CRD42015016882). Ann Surg. 2017 May;265(5):889-900. Abstract

95. Rollins KE, Varadhan KK, Neal KR, et al. Antibiotics versus appendicectomy for the treatment of uncomplicated acute appendicitis: an updated meta-analysis of randomised controlled trials. World J Surg. 2016 Oct;40(10):2305-18. Abstract

96. Weston P, Moroz P. Appendicitis in pregnancy: how to manage and whether to deliver. Obstet Gynaecol. 2015 Apr;17(2):105-10.Full text

97. Miller TE, Myles PS. Perioperative fluid therapy for major surgery. Anesthesiology. 2019 May;130(5):825-32.Full text  Abstract

98. Mazuski JE, Tessier JM, May AK, et al. The Surgical Infection Society revised guidelines on the management of intra-abdominal infection. Surg Infect (Larchmt). 2017 Jan;18(1):1-76.Full text  Abstract

99. CODA Collaborative., Flum DR, Davidson GH, et al. A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med. 2020 Nov 12;383(20):1907-19.Full text  Abstract

100. Rusu A, Munteanu AC, Arbănași EM, et al. Overview of side-effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics. 2023 Mar 1;15(3):804.Full text  Abstract

101. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. May 2017 [internet publication].Full text

102. Mason RJ. Surgery for appendicitis: is it necessary? Surg Infect (Larchmt). 2008 Aug;9(4):481-8. Abstract

103. Deakin DE, Ahmed I. Interval appendicectomy after resolution of adult inflammatory appendix mass - is it necessary? Surgeon. 2007 Feb;5(1):45-50. Abstract

104. Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: a systematic review and meta-analysis. Ann Surg. 2007 Nov;246(5):741-8. Abstract

105. Rushing A, Bugaev N, Jones C, et al. Management of acute appendicitis in adults: a practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2019 Jul;87(1):214-24.Full text  Abstract

106. Hayes D, Reiter S, Hagen E, et al. Is interval appendectomy really needed? A closer look at neoplasm rates in adult patients undergoing interval appendectomy after complicated appendicitis. Surg Endosc. 2021 Jul;35(7):3855-60. Abstract

107. Mällinen J, Rautio T, Grönroos J, et al. Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging: 1-Year outcomes of the prei-appendicitis acuta randomized clinical trial. JAMA Surg. 2019 Mar 1;154(3):200-7.Full text  Abstract

108. Darwazeh G, Cunningham SC, Kowdley GC. A systematic review of perforated appendicitis and phlegmon: interval appendectomy or wait-and-see? Am Surg. 2016 Jan;82(1):11-5. Abstract

109. Peltrini R, Cantoni V, Green R, et al. Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: a systematic review and meta-analysis. Surgeon. 2021 Dec;19(6):e549-58. Abstract

110. Skendelas JP, Alemany VS, Au V, et al. Appendiceal adenocarcinoma found by surgery for acute appendicitis is associated with older age. BMC Surg. 2021 May 2;21(1):228.Full text  Abstract

111. Ahmed A, Feroz SH, Dominic JL, et al. Is emergency appendicectomy better than elective appendicectomy for the treatment of appendiceal phlegmon?: a review. Cureus. 2020 Dec 12;12(12):e12045.Full text  Abstract

112. Kiblawi R, Zoeller C, Zanini A, et al. Laparoscopic versus open pediatric surgery: three decades of comparative studies. Eur J Pediatr Surg. 2022 Feb;32(1):9-25. Abstract

113. Neogi S, Banerjee A, Panda SS, et al. Laparoscopic versus open appendicectomy for complicated appendicitis in children: A systematic review and meta-analysis. J Pediatr Surg. 2022 Mar;57(3):394-405. Abstract

114. Fugazzola P, Coccolini F, Tomasoni M, et al. Early appendectomy vs. conservative management in complicated acute appendicitis in children: a meta-analysis. J Pediatr Surg. 2019 Nov;54(11):2234-41. Abstract

115. Vaos G, Dimopoulou A, Gkioka E, et al. Immediate surgery or conservative treatment for complicated acute appendicitis in children? A meta-analysis. J Pediatr Surg. 2019 Jul;54(7):1365-71. Abstract

116. Jaschinski T, Mosch CG, Eikermann M, et al. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2018 Nov 28;(11):CD001546.Full text  Abstract

117. Zhang G, Wu B. Meta-analysis of the clinical efficacy of laparoscopic appendectomy in the treatment of acute appendicitis. World J Emerg Surg. 2022 May 26;17(1):26.Full text  Abstract

118. Wei HB, Huang JL, Zheng ZH, et al. Laparoscopic versus open appendectomy: a prospective randomized comparison. Surg Endosc. 2010 Feb;24(2):266-9. Abstract

119. Yau KK, Siu WT, Tang CN, et al. Laparoscopic versus open appendectomy for complicated appendicitis. J Am Coll Surg. 2007 Jul;205(1):60-5. Abstract

120. Woodham BL, Cox MR, Eslick GD. Evidence to support the use of laparoscopic over open appendicectomy for obese individuals: a meta-analysis. Surg Endosc. 2012 Sep;26(9):2566-70. Abstract

121. Katkhouda N, Mason RJ, Towfigh S, et al. Laparoscopic versus open appendectomy: a prospective randomized double-blind study. Ann Surg. 2005 Sep;242(3):439-48; discussion 448-50.Full text  Abstract

122. Billingham MJ, Basterfield SJ. Pediatric surgical technique: laparoscopic or open approach? A systematic review and meta-analysis. Eur J Pediatr Surg. 2010 Mar;20(2):73-7. Abstract

123. Zhang S, Du T, Jiang X, et al. Laparoscopic appendectomy in children with perforated appendicitis: a meta-analysis. Surg Laparosc Endosc Percutan Tech. 2017 Aug;27(4):262-66. Abstract

124. Yu MC, Feng YJ, Wang W, et al. Is laparoscopic appendectomy feasible for complicated appendicitis ?A systematic review and meta-analysis. Int J Surg. 2017 Apr;40:187-97.Full text  Abstract

125. Liew AN, Lim KY, Quach D, et al. Laparoscopic versus open appendicectomy in pregnancy: experience from a single institution and meta-analysis. ANZ J Surg. 2022 May;92(5):1071-8. Abstract

126. Zeng Q, Aierken A, Gu SS, et al. Laparoscopic versus open appendectomy for appendicitis in pregnancy: systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech. 2021 May 3;31(5):637-44. Abstract

127. Lee SH, Lee JY, Choi YY, et al. Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis. BMC Surg. 2019 Apr 25;19(1):41.Full text  Abstract

128. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;(1):CD007798.Full text  Abstract

129. de Wijkerslooth EML, Bakas JM, van Rosmalen J, et al. Same-day discharge after appendectomy for acute appendicitis: a systematic review and meta-analysis. Int J Colorectal Dis. 2021 Jun;36(6):1297-309.Full text  Abstract

130. Trejo-Ávila ME, Romero-Loera S, Cárdenas-Lailson E, et al. Enhanced recovery after surgery protocol allows ambulatory laparoscopic appendectomy in uncomplicated acute appendicitis: a prospective, randomized trial. Surg Endosc. 2019 Feb;33(2):429-36. Abstract

131. Lintula H, Kokki H, Vanamo K, et al. Laparoscopy in children with complicated appendicitis. J Pediatr Surg. 2002 Sep;37(9):1317-20. Abstract

132. Zhang J, Wang M, Xin Z, et al. Updated evaluation of laparoscopic vs. open appendicectomy during pregnancy: a systematic review and meta-analysis. Front Surg. 2021 Sep 23:8:720351.Full text  Abstract

133. Solomkin J, Evans D, Slepavicius A, et al. Assessing the efficacy and safety of eravacycline vs ertapenem in complicated intra-abdominal infections in the investigating gram-negative infections treated with eravacycline (IGNITE 1) trial: a randomized clinical trial. JAMA Surg. 2017 Mar 1;152(3):224-32.Full text  Abstract

134. Zhanel GG, Lawrence CK, Adam H, et al. Imipenem-relebactam and meropenem-vaborbactam: two novel carbapenem-β-lactamase inhibitor combinations. Drugs. 2018 Jan;78(1):65-98. Abstract

135. Starship Child Health. Acute abdominal pain. Mar 2024 [internet publication].Full text

136. Collard MK, Christou N, Lakkis Z, et al. Adult appendicitis: clinical practice guidelines from the French Society of Digestive Surgery and the Society of Abdominal and Digestive Imaging. J Visc Surg. 2021 Jun;158(3):242-52. Abstract

137. Royal College of Surgeons of England. Emergency general surgery: commissioning guide. Apr 2014 [internet publication].Full text

138. Livingston EH, Woodward WA, Sarosi GA, et al. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007 Jun;245(6):886-92.Full text  Abstract

139. Busch M, Gutzwiller FS, Aellig S, et al. In-hospital delay increases the risk of perforation in adults with appendicitis. World J Surg. 2011 Jul;35(7):1626-33. Abstract

140. Garba ES, Ahmed A. Management of appendiceal mass. Ann Afr Med. 2008 Dec;7(4):200-4. Abstract

141. Mentula P, Sammalkorpi H, Leppäniemi A. Laparoscopic surgery or conservative treatment for appendiceal abscess in adults? A Randomized Controlled Trial. Ann Surg. 2015 Aug;262(2):237-42. Abstract

142. Dimitriou I, Reckmann B, Nephuth O, et al. Single institution's experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis. Langenbecks Arch Surg. 2013 Jan;398(1):147-52. Abstract

143. Liberman MA, Greason KL, Frame S, et al. Single-dose cefotetan or cefoxitin versus multiple-dose cefoxitin as prophylaxis in patients undergoing appendectomy for acute nonperforated appendicitis. J Am Coll Surg. 1995 Jan;180(1):77-80. Abstract

144. Salazar MC, Canavan ME, Chilakamarry S, et al. Appendiceal cancer in the National Cancer Database: increasing frequency, decreasing age, and shifting histology. J Am Coll Surg. 2022 Jun 1;234(6):1082-9. Abstract

145. Casas MA, Dreifuss NH, Schlottmann F. High-volume center analysis and systematic review of stump appendicitis: solving the pending issue. Eur J Trauma Emerg Surg. 2022 Jun;48(3):1663-72. Abstract

Comorbidities Manager reference articles

146. Elhassan MG, Chao PW, Curiel A. The conundrum of volume status assessment: revisiting current and future tools available for physicians at the bedside. Cureus. 2021 May 26;13(5):e15253.Full text  Abstract

147. Rezayat T, Barjaktarevic I, Mecham I, et al. Early protocolized bedside ultrasound in shock: renal function improvements and other lessons learned. Int J Crit Care Emerg Med. 2018 Oct 6;4(2):046.Full text

148. Seif D, Perera P, Mailhot T, et al. Bedside ultrasound in resuscitation and the rapid ultrasound in shock protocol. Crit Care Res Pract. 2012;2012:503254.Full text  Abstract

149. American Institute of Ultrasound in Medicine. The AIUM practice parameter for the performance of the Extended Focused Assessment With Sonography for Trauma (EFAST). J Ultrasound Med. 2023 Apr;42(4):E1-7.Full text  Abstract

150. American College of Emergency Physicians. Emergency ultrasound imaging criteria compendium. American College of Emergency Physicians. Ann Emerg Med. 2006 Oct;48(4):487-510.Full text  Abstract

151. Hogervorst VM, Buurman BM, De Jonghe A, et al. Emergency department management of older people living with frailty: a guide for emergency practitioners. Emerg Med J. 2021 Sep;38(9):724-9. Abstract

152. British Geriatrics Society. Guideline for the care of people living with frailty undergoing elective and emergency surgery that encompasses the whole perioperative pathway. September 2021 [internet publication].Full text

153. Cesari M, Calvani R, Marzetti E. Frailty in older persons. Clin Geriatr Med. 2017 Aug;33(3):293-303. Abstract

154. Rockwood K, British Geriatrics Society. Silver book II: frailty. February 2021 [internet publication].Full text

155. Tsui C, Kim K, Spencer M. The diagnosis "failure to thrive" and its impact on the care of hospitalized older adults: a matched case-control study. BMC Geriatr. 2020 Feb 14;20(1):62.Full text  Abstract

156. Anderson K, Baraldi C, Supiano M. Identifying failure to thrive in the long term care setting. J Am Med Dir Assoc. 2012 Sep;13(7):665.e15-9. Abstract

157. Rockwood K, Theou O. Using the clinical frailty scale in allocating scarce health care resources. Can Geriatr J. 2020 Sep;23(3):210-5.Full text  Abstract

158. Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005 Aug 30;173(5):489-95.Full text  Abstract

159. Church S, Rogers E, Rockwood K, et al. A scoping review of the Clinical Frailty Scale. BMC Geriatr. 2020 Oct 7;20(1):393.Full text  Abstract

160. Falk Erhag H, Guðnadóttir G, Alfredsson J, et al. The association between the clinical frailty scale and adverse health outcomes in older adults in acute clinical settings - a systematic review of the literature. Clin Interv Aging. 2023 Feb 18:18:249-61.Full text  Abstract

161. Quinn TJ, Mooijaart SP, Gallacher K, et al. Acute care assessment of older adults living with frailty. BMJ. 2019 Jan 31;364:l13. Abstract

162. Molnar F, Frank CC. Optimizing geriatric care with the GERIATRIC 5Ms. Can Fam Physician. 2019 Jan;65(1):39.Full text  Abstract

163. Tinetti M, Huang A, Molnar F. The Geriatrics 5M's: a new way of communicating what we do. J Am Geriatr Soc. 2017 Sep;65(9):2115.Full text  Abstract

164. Miller RK, Young M, Chippendale R, et al. Using the Geriatric 5Ms to teach structural and social determinants of health. J Am Geriatr Soc. 2023 Dec;71(12):3967-72. Abstract

165. Jamshed N, Gangavati A. Prioritizing the 5Ms in geriatric care: a holistic approach to care of the older adult. Am Fam Physician. 2024 Jun;109(6):498-500.Full text  Abstract

166. Conroy SP, Bardsley M, Smith P, et al. Comprehensive geriatric assessment for frail older people in acute hospitals: the HoW-CGA mixed-methods study. Southampton (UK): NIHR Journals Library; 2019 Apr.Full text  Abstract

167. American College of Surgeons. Best practice guidelines: geriatric trauma management. 2023 [internet publication].Full text

168. Nickel C, Arendts G, Lucke J, et al. Silver book II: Geriatric syndromes. February 2021 [internet publication].Full text

169. American College of Surgeons Trauma Quality Programs. Best practice guidelines for acute pain management in trauma patients. November 2020.Full text

170. Shenvi C, Kennedy M, Austin CA, et al. Managing delirium and agitation in the older emergency department patient: the ADEPT tool. Ann Emerg Med. 2020 Feb;75(2):136-45.Full text  Abstract

171. American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults. American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults. J Am Geriatr Soc. 2015 Jan;63(1):142-50. Abstract

172. Williams A, Bigham C, Marchbank A. Anaesthetic and surgical management of rib fractures. BJA Educ. 2020 Oct;20(10):332-40.Full text  Abstract

173. Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP. Validity of four pain intensity rating scales. Pain. 2011 Oct;152(10):2399-404. Abstract

174. Warden V, Hurley AC, Volicer L. Development and psychometric evaluation of the Pain Assessment in Advanced Dementia (PAINAD) scale. J Am Med Dir Assoc. 2003 Jan-Feb;4(1):9-15. Abstract

175. Fuchs-Lacelle S, Hadjistavropoulos T. Development and preliminary validation of the pain assessment checklist for seniors with limited ability to communicate (PACSLAC). Pain Manag Nurs. 2004 Mar;5(1):37-49. Abstract

176. Husebo BS, Strand LI, Moe-Nilssen R, et al. Pain in older persons with severe dementia: psychometric properties of the Mobilization-Observation-Behaviour-Intensity-Dementia (MOBID-2) pain scale in a clinical setting. Scand J Caring Sci. 2010 Jun;24(2):380-91. Abstract

177. The 2023 American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023 Jul;71(7):2052-81.Full text  Abstract

178. Dowell D, Ragan KR, Jones CM, et al. CDC cinical practice guideline for prescribing opioids for pain - United States, 2022. MMWR Recomm Rep. 2022 Nov 4;71(3):1-95.Full text  Abstract

179. Owsiany MT, Hawley CE, Triantafylidis LK, et al. Opioid management in older adults with chronic kidney disease: a review. Am J Med. 2019 Dec;132(12):1386-93.Full text  Abstract

180. Odoma VA, Pitliya A, AlEdani E, et al. Opioid prescription in patients with chronic kidney disease: a systematic review of comparing safety and efficacy of opioid use in chronic kidney disease patients. Cureus. 2023 Sep;15(9):e45485.Full text  Abstract

181. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024 Apr;105(4s):S117-314.Full text  Abstract

182. Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022 May 3;145(18):e895-1032.Full text  Abstract

183. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-726.Full text  Abstract

184. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2024 [internet publication].Full text

185. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012 Mar;2(1):1-138.Full text

186. Writing Committee Members, Thompson A, Fleischmann KE, et al. 2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM guideline for perioperative cardiovascular management for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2024 Nov 5;84(19):1869-969.Full text  Abstract

187. Halvorsen S, Mehilli J, Cassese S, et al. 2022 ESC guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery. Eur Heart J. 2022 Oct 14;43(39):3826-924.Full text  Abstract

188. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016 Jun;47(6):e98-169.Full text  Abstract

189. Benesch C, Glance LG, Derdeyn CP, et al. Perioperative neurological evaluation and management to lower the risk of acute stroke in patients undergoing noncardiac, nonneurological surgery: a scientific statement from the American Heart Association/American Stroke Association. Circulation. 2021 May 11;143(19):e923-46.Full text  Abstract

190. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9. Abstract

191. Price CC. The new frontier of perioperative cognitive medicine for Alzheimer’s disease and related dementias. Neurotherapeutics. 2022 Jan;19(1):132-42.Full text  Abstract

192. Mohanty S, Rosenthal RA, Russell MM, et al. Optimal perioperative management of the geriatric patient: a best practices guideline from the American College of Surgeons NSQIP and the American Geriatrics Society. J Am Coll Surg. 2016 May;222(5):930-47. Abstract

193. Appelbaum PS. Clinical practice. Assessment of patients' competence to consent to treatment. N Engl J Med. 2007 Nov 1;357(18):1834-40. Abstract

194. Sulmasy LS, Bledsoe TA; ACP Ethics, Professionalism and Human Rights Committee. American College of Physicians ethics manual: seventh edition. Ann Intern Med. 2019 Jan 15;170(2 Suppl):S1-32.Full text  Abstract

195. Barstow C, Shahan B, Roberts M. Evaluating medical decision-making capacity in practice. Am Fam Physician. 2018 Jul 1;98(1):40-6.Full text  Abstract

196. Devlin JW, Skrobik Y, Gélinas C, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018 Sep;46(9):e825-73.Full text  Abstract

197. Inouye SK, Schlesinger MJ, Lydon TJ. Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care. Am J Med. 1999 May;106(5):565-73.Full text  Abstract

198. Han JH, Wilson A, Vasilevskis EE, et al. Diagnosing delirium in older emergency department patients: validity and reliability of the delirium triage screen and the brief confusion assessment method. Ann Emerg Med. 2013 Nov;62(5):457-65. Abstract

199. American College of Emergency Physicians, American Geriatrics Society, Emergency Nurses Association, et al. Geriatric emergency department guidelines. Ann Emerg Med. 2014 May;63(5):e7-25.Full text  Abstract

200. Inouye SK, van Dyck CH, Alessi CA, et al. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990 Dec 15;113(12):941-8. Abstract

201. Wei LA, Fearing MA, Sternberg EJ, et al. The Confusion Assessment Method: a systematic review of current usage. J Am Geriatr Soc. 2008 May;56(5):823-30. Abstract

202. Ely EW, Margolin R, Francis J, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001 Jul;29(7):1370-9. Abstract

203. Bergeron N, Dubois MJ, Dumont M, et al. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med. 2001 May;27(5):859-64. Abstract

204. National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. January 2023 [internet publication].Full text

205. American Diabetes Association Professional Practice Committee. 16. Diabetes care in the hospital: standards of care in diabetes - 2024. Diabetes Care. 2024 Jan 1;47(suppl 1):S295-306.Full text  Abstract

206. Blonde L, Umpierrez GE, Reddy SS, et al. American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan - 2022 update. Endocr Pract. 2022 Oct;28(10):923-1049.Full text  Abstract

207. US Food and Drug Administration. FDA revises labels of SGLT2 inhibitors for diabetes to include warnings about too much acid in the blood and serious urinary tract infections. March 2022 [internet publication].Full text

208. Umpierrez GE, Davis GM, ElSayed NA, et al. Hyperglycaemic crises in adults with diabetes: a consensus report. Diabetologia. 2024 Aug;67(8):1455-79.Full text  Abstract

209. Duggan EW, Carlson K, Umpierrez GE. Perioperative hyperglycemia management: an update. Anesthesiology. 2017 Mar;126(3):547-60.Full text  Abstract

210. Joint British Diabetes Societies for Inpatient Care. The use of variable rate intravenous insulin infusion (VRIII) in medical inpatients. October 2014 [internet publication].Full text

211. Avari P, Lumb A, Flanagan D, et al. Insulin pumps and hybrid close loop systems within hospital: a scoping review and practical guidance from the Joint British Diabetes Societies for Inpatient Care. J Diabetes Sci Technol. 2023 May;17(3):625-34.Full text  Abstract

212. Peters AL, Buschur EO, Buse JB, et al. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015 Sep;38(9):1687-93.Full text  Abstract

213. Joshi GP, Abdelmalak BB, Weigel WA et al. American Society of Anaesthesiologists consensus-based guidance on preoperative management of patients (adults and children) on glucagon-like peptide-1 (glp-1) receptor agonists. June 2023 [internet reference].Full text

214. Anderson WG, Berlinger N, Ragland J et al. Hospital-based prognosis and goals of care discussions with seriously ill patients: a pathway to integrate a key primary palliative care process into the workflow of hospitalist physicians and their teams. Society of Hospital Medicine and The Hastings Center, 2017 [internet publication].Full text

215. Secunda K, Wirpsa MJ, Neely KJ, et al. Use and meaning of "goals of care" in the healthcare literature: a systematic review and qualitative discourse analysis. J Gen Intern Med. 2020 May;35(5):1559-66.Full text  Abstract

216. Boyd C, Smith CD, Masoudi FA, et al. Decision making for older adults with multiple chronic conditions: executive summary for the American Geriatrics Society guiding principles on the care of older adults with multimorbidity. J Am Geriatr Soc. 2019 Apr;67(4):665-73. Abstract

217. Farrell TW, Widera E, Rosenberg L, et al. AGS position statement: making medical treatment decisions for unbefriended older adults. J Am Geriatr Soc. 2017 Jan;65(1):14-5.Full text  Abstract

218. Pope TM, Bennett J, Carson SS, et al. Making medical treatment decisions for unrepresented patients in the ICU. An official American Thoracic Society/American Geriatrics Society policy statement. Am J Respir Crit Care Med. 2020 May 15;201(10):1182-92.Full text  Abstract

219. Lim Y, Ohn JH, Jeong J, et al. Effect of the concomitant use of subcutaneous basal insulin and intravenous insulin infusion in the treatment of severe hyperglycemic patients. Endocrinol Metab (Seoul). 2022 Jun;37(3):444-54.Full text  Abstract

220. Thammakosol K, Sriphrapradang C. Effectiveness and safety of early insulin glargine administration in combination with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: a randomized controlled trial. Diabetes Obes Metab. 2023 Mar;25(3):815-22. Abstract

221. Honarmand K, Sirimaturos M, Hirshberg EL, et al. Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024. Crit Care Med. 2024 Apr 1;52(4):e161-e181.Full text  Abstract

222. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67.Full text  Abstract

223. NICE-SUGAR Study Investigators; Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97.Full text  Abstract

224. Yamada T, Shojima N, Noma H, et al. Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials. Intensive Care Med. 2017 Jan;43(1):1-15. Abstract

225. Yatabe T, Inoue S, Sakaguchi M, et al. The optimal target for acute glycemic control in critically ill patients: a network meta-analysis. Intensive Care Med. 2017 Jan;43(1):16-28. Abstract

226. Pasquel FJ, Lansang MC, Dhatariya K, et al. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-88.Full text  Abstract

227. Rehman A, Setter SM, Vue MH. Drug-induced glucose alterations part 2: drug-Induced hyperglycemia. Diabetes Spect. 2011 Nov;24(4):234-8.Full text

228. Vue MH, Setter SM. Drug-Induced Glucose Alterations Part 1: Drug-Induced Hypoglycemia. Diabetes Spectr 1 August 2011; 24 (3): 171–7.Full text  Abstract

229. Wang C, Fang W, Li Z, et al. Clinical features, risk factors, diagnosis, and treatment of trimethoprim-sulfamethoxazole-induced hypoglycemia. Front Endocrinol (Lausanne). 2023;14:1059522.Full text  Abstract

230. American Diabetes Association Professional Practice Committee. 6. Glycemic goals and hypoglycemia: standards of care in diabetes - 2024. Diabetes Care. 2024 Jan 1;47(suppl 1):S111-25.Full text  Abstract

231. McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.Full text  Abstract

232. Galindo RJ, Umpierrez GE, Rushakoff RJ, et al. Continuous glucose monitors and automated insulin dosing systems in the hospital consensus guideline. J Diabetes Sci Technol. 2020 Nov;14(6):1035-64.Full text  Abstract

233. Rajan N, Duggan EW, Abdelmalak BB, et al. Society for Ambulatory Anesthesia updated consensus statement on perioperative blood glucose management in adult patients with diabetes mellitus undergoing ambulatory surgery. Anesth Analg. 2024 Sep 1;139(3):459-77.Full text  Abstract

234. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication].Full text

235. American Diabetes Association Professional Practice Committee. 12. Retinopathy, neuropathy, and foot care: standards of care in diabetes - 2024. Diabetes Care. 2024 Jan 1;47(suppl 1):S231-43.Full text  Abstract

236. White S, Griffiths R, Baxter M, et al. Guidelines for the peri-operative care of people with dementia: guidelines from the Association of Anaesthetists. Anaesthesia. 2019 Mar;74(3):357-72.Full text  Abstract

237. Inouye SK, Kosar CM, Tommet D, et al. The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med. 2014 Apr 15;160(8):526-33.Full text  Abstract

238. Peden CJ, Miller TR, Deiner SG, et al. Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team. Br J Anaesth. 2021 Feb;126(2):423-432.Full text  Abstract

239. Nikooie R, Neufeld KJ, Oh ES, et al. Antipsychotics for treating delirium in hospitalized adults: a systematic review. Ann Intern Med. 2019 Oct 1;171(7):485-95.Full text  Abstract

240. Mühlbauer V, Möhler R, Dichter MN, et al. Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev. 2021 Dec 17;(12):CD013304.Full text  Abstract

241. Yunusa I, Alsumali A, Garba AE, et al. Assessment of reported comparative effectiveness and safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia: a network meta-analysis. JAMA Netw Open. 2019 Mar 1;2(3):e190828.Full text  Abstract

242. Van Leeuwen E, Petrovic M, van Driel ML, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018 Apr 1;(3):CD007726.Full text  Abstract

243. Verbrugge FH, Grieten L, Mullens W. Management of the cardiorenal syndrome in decompensated heart failure. Cardiorenal Med. 2014 Dec;4(3-4):176-88.Full text  Abstract

244. Hollenberg SM, Warner Stevenson L, Ahmad T, et al. 2019 ACC expert consensus decision pathway on risk assessment, management, and clinical trajectory of patients hospitalized with heart failure: a report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2019 Oct 15;74(15):1966-2011.Full text  Abstract

245. Kanwar MK, Billia F, Randhawa V, et al. Heart failure related cardiogenic shock: an ISHLT consensus conference content summary. J Heart Lung Transplant. 2024 Feb;43(2):189-203.Full text  Abstract

246. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2024 [internet publication].Full text

247. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21. Abstract

248. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51. Abstract

249. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13.Full text  Abstract

250. Silverman JJ, Galanter M, Jackson-Triche M, et al. The American Psychiatric Association practice guidelines for the psychiatric evaluation of adults. Am J Psychiatry. 2015 Aug 1;172(8):798-802.Full text  Abstract

251. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 May;106(5):906-14. Abstract

252. Bauer M, Severus E, Köhler S, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders. part 2: maintenance treatment of major depressive disorder-update 2015. World J Biol Psychiatry. 2015 Feb;16(2):76-95. Abstract

253. Hoffelt C, Gross T. A review of significant pharmacokinetic drug interactions with antidepressants and their management. Ment Health Clin. 2016 Mar 8;6(1):35-41.Full text  Abstract

254. Van Leeuwen E, van Driel ML, Horowitz MA, et al. Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults. Cochrane Database Syst Rev. 2021 Apr 15;(4):CD013495.Full text  Abstract

255. Qaseem A, Owens DK, Etxeandia-Ikobaltzeta I, et al. Nonpharmacologic and pharmacologic treatments of adults in the acute phase of major depressive disorder: a living clinical guideline from the American College of Physicians. Ann Intern Med. 2023 Feb;176(2):239-52.Full text  Abstract

256. Liamis G, Milionis H, Elisaf M. A review of drug-induced hyponatremia. Am J Kidney Dis. 2008 Jul;52(1):144-53. Abstract

257. Liamis G, Filippatos TD, Elisaf MS. Thiazide-associated hyponatremia in the elderly: what the clinician needs to know. J Geriatr Cardiol. 2016 Feb;13(2):175-82.Full text  Abstract

258. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20. Abstract

259. Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014 Feb 19;348:g1626. Abstract

260. Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013 Winter;13(4):533-40.Full text  Abstract

261. Chander WP, Singh N, Mukhiya GK. Serotonin syndrome in maintenance haemodialysis patients following sertraline treatment for depression. J Indian Med Assoc. 2011 Jan;109(1):36-7. Abstract

262. Voican CS, Corruble E, Naveau S, et al. Antidepressant-induced liver injury: a review for clinicians. Am J Psychiatry. 2014 Apr;171(4):404-15.Full text  Abstract

263. Saraghi M, Golden LR, Hersh EV. Anesthetic considerations for patients on antidepressant therapy-part I. Anesth Prog. 2017 Winter;64(4):253-61.Full text  Abstract

264. Harbell MW, Dumitrascu C, Bettini L, et al. Anesthetic considerations for patients on psychotropic drug therapies. Neurol Int. 2021 Nov 29;13(4):640-58.Full text  Abstract

265. Tisdale JE, Chung MK, Campbell KB, et al. Drug-induced arrhythmias: a scientific statement from the American Heart Association. Circulation. 2020 Oct 13;142(15):e214-233.Full text  Abstract

266. Siu AL, US Preventive Services Task Force (USPSTF), Bibbins-Domingo K, et al. Screening for depression in adults: US Preventive Services Task Force recommendation statement. JAMA. 2016 Jan 26;315(4):380-7.Full text  Abstract

267. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci. 2007;9(1):47-59.Full text  Abstract

268. Nochaiwong S, Ruengorn C, Awiphan R, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med. 2022 Dec;54(1):80-97.Full text  Abstract

269. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2008 Jan 1;27(1):31-40.Full text  Abstract

270. Flowers L. Nicotine replacement therapy. Am J Psychiatry Resid J. 2016 Jun;11(6):4-7.Full text

271. Desai HD, Seabolt J, Jann MW. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs. 2001;15(6):469-94. Abstract

272. Oliveira P, Ribeiro J, Donato H, et al. Smoking and antidepressants pharmacokinetics: a systematic review. Ann Gen Psychiatry. 2017 Mar 6:16:17.Full text  Abstract

273. Saraghi M, Golden L, Hersh EV. Anesthetic considerations for patients on antidepressant therapy - part II. Anesth Prog. 2018 Spring;65(1):60-5.Full text  Abstract

274. Roose SP, Rutherford BR. Selective serotonin reuptake inhibitors and operative bleeding risk: a review of the literature. J Clin Psychopharmacol. 2016 Dec;36(6):704-9. Abstract

275. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7.Full text  Abstract

276. Lapa ME, Swabe GM, Rollman BL, et al. Assessment of depression and adherence to guideline-directed medical therapies following percutaneous coronary intervention. JAMA Netw Open. 2022 Dec 1;5(12):e2246317.Full text  Abstract

277. Poletti V, Pagnini F, Banfi P, et al. The role of depression on treatment adherence in patients with heart failure-a systematic review of the literature. Curr Cardiol Rep. 2022 Dec;24(12):1995-2008.Full text  Abstract

278. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2015 Jan;78(1):25-33.Full text  Abstract

279. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(s7):S54-60.Full text  Abstract

280. Archer G, Kuh D, Hotopf M, et al. Association between lifetime affective symptoms and premature mortality. JAMA Psychiatry. 2020 Aug 1;77(8):806-13.Full text  Abstract

281. Machado MO, Veronese N, Sanches M, et al. The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses. BMC Med. 2018 Jul 20;16(1):112.Full text  Abstract

282. US Preventive Services Task Force, Krist AH, Davidson KW, et al. Interventions for tobacco smoking cessation in adults, including pregnant persons: US Preventive Services Task Force recommendation statement. JAMA. 2021 Jan 19;325(3):265-79.Full text  Abstract

283. Fiore MC, Jaén CR, Baker TB, et al. Treating tobacco use and dependence: 2008 update. Clinical practice guideline. Rockville, MD: US Department of Health and Human Services Public Health Service; May 2008 [internet publication].Full text

284. United States Public Health Service Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. Smoking cessation: a report of the Surgeon General. Washington, DC: US Department of Health and Human Services; 2020 [internet publication].Full text  Abstract

285. Streck JM, Rigotti NA, Livingstone-Banks J, et al. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2024 May 21;(5):CD001837.Full text  Abstract

286. Theodoulou A, Chepkin SC, Ye W, et al. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 19;(6):CD013308.Full text  Abstract

287. Rigotti NA, Kruse GR, Livingstone-Banks J, et al. Treatment of tobacco smoking: a review. JAMA. 2022 Feb 8;327(6):566-77. Abstract

288. Agrawal S, Evison M, Ananth S, et al. Medical management of inpatients with tobacco dependency. Thorax. 2024 Mar 26;79(suppl 1):3-11. Abstract

289. Thomas KH, Dalili MN, López-López JA, et al. Comparative clinical effectiveness and safety of tobacco cessation pharmacotherapies and electronic cigarettes: a systematic review and network meta-analysis of randomized controlled trials. Addiction. 2022 Apr;117(4):861-76.Full text  Abstract

290. Livingstone-Banks J, Fanshawe TR, Thomas KH, et al. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 28;(6):CD006103.Full text

291. Perret J, Yip SWS, Idrose NS, et al. Undiagnosed and 'overdiagnosed' COPD using postbronchodilator spirometry in primary healthcare settings: a systematic review and meta-analysis. BMJ Open Respir Res. 2023 Apr;10(1):e001478.Full text  Abstract

292. Korytkowski MT, Muniyappa R, Antinori-Lent K, et al. Management of hyperglycemia in hospitalized adult patients in non-critical care settings: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2022 Jul 14;107(8):2101-28.Full text  Abstract

293. Grunberger G, Sherr J, Allende M, et al. American Association of Clinical Endocrinology clinical practice guideline: the use of advanced technology in the management of persons with diabetes mellitus. Endocr Pract. 2021 Jun;27(6):505-37.Full text  Abstract

294. Umapathysivam MM, Gunton J, Stranks SN, et al. Euglycemic ketoacidosis in two patients without diabetes after introduction of sodium-glucose cotransporter 2 inhibitor for heart failure with reduced ejection fraction. Diabetes Care. 2024 Jan 1;47(1):140-3.Full text  Abstract

295. Honarmand K, Sirimaturos M, Hirshberg EL, et al. Society of Critical Care Medicine guidelines on glycemic control for critically ill children and adults 2024. Crit Care Med. 2024 Apr 1;52(4):e161-81.Full text  Abstract

296. Canadian Geriatrics Society. Update: Public launch of the geriatric 5Ms. 2017 [internet publication].Full text

297. Inouye SK, Bogardus ST Jr, Baker DI, et al. The Hospital Elder Life Program: a model of care to prevent cognitive and functional decline in older hospitalized patients. Hospital Elder Life Program. J Am Geriatr Soc. 2000 Dec;48(12):1697-706. Abstract

298. Hshieh TT, Yang T, Gartaganis SL, et al. Hospital Elder Life Program: systematic review and meta-analysis of effectiveness. Am J Geriatr Psychiatry. 2018 Oct;26(10):1015-33. Abstract

299. Hshieh TT, Yue J, Oh E, et al. Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. JAMA Intern Med. 2015 Apr;175(4):512-20.Full text  Abstract

300. Burton JK, Craig L, Yong SQ, et al. Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2021 Nov 26;(11):CD013307.Full text  Abstract

301. Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010 Dec;6(12):681-94. Abstract

302. Elkind MSV, Boehme AK, Smith CJ, et al. Infection as a Stroke risk factor and determinant of outcome after stroke. Stroke. 2020 Oct;51(10):3156-68.Full text  Abstract

303. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000 Oct;31(10):2307-13.Full text  Abstract

304. Wang C, Fang W, Li Z, et al. Clinical features, risk factors, diagnosis, and treatment of trimethoprim-sulfamethoxazole-induced hypoglycemia. Front Endocrinol (Lausanne). 2023;14:1059522.Full text  Abstract

305. Shen WK, Sheldon RS, Benditt DG, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2017 Aug 1;70(5):e39-110.Full text  Abstract

306. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72. Abstract

307. Griffin M, Rao VS, Ivey-Miranda J, et al. Empagliflozin in heart failure: diuretic and cardiorenal effects. Circulation. 2020 Sep 15;142(11):1028-39.Full text  Abstract

Use of this content is subject to our disclaimer