Hypertensive emergencies


Key articles

Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018 May 15;71(19):e127-248.Full text  Abstract

Vaughan CJ, Delanty N. Hypertensive emergencies. Lancet. 2000 Jul 29;356(9227):411-7. Abstract

Reference articles

1. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018 May 15;71(19):e127-248.Full text  Abstract

2. Mills KT, Bundy JD, Kelly TN, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation. 2016 Aug 9;134(6):441-50.Full text  Abstract

3. Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet. 2005 Jan 15-21;365(9455):217-23. Abstract

4. Bloch MJ. Worldwide prevalence of hypertension exceeds 1.3 billion. J Am Soc Hypertens. 2016 Oct;10(10):753-4.Full text  Abstract

5. Martin JF, Higashiama E, Garcia E, et al. Hypertensive crisis profile. Prevalence and clinical presentation. Arq Bras Cardiol. 2004 Aug;83(2):131-6.Full text  Abstract

6. Deshmukh A, Kumar G, Kumar N, et al. Effect of Joint National Committee VII report on hospitalizations for hypertensive emergencies in the United States. Am J Cardiol. 2011 Sep 3;108(9):1277-82.Full text  Abstract

7. Alshami A, Romero C, Avila A, et al. Management of hypertensive crises in the elderly. J Geriatr Cardiol. 2018 Jul;15(7):504-12.Full text  Abstract

8. Waldron FA, Benenson I, Jones-Dillon SA, et al. Prevalence and risk factors for hypertensive crisis in a predominantly African American inner-city community. Blood Press. 2019 Jan 22;28(2):114-23. Abstract

9. Hyman DJ, Pavlik VN. Characteristics of patients with uncontrolled hypertension in the United States [published correction appears in N Engl J Med. 2002 Feb 14;346(7):544]. N Engl J Med. 2001 Aug 16;345(7):479-86.Full text  Abstract

10. Tisdale JE, Huang MB, Borzak S, et al. Risk factors for hypertensive crisis: importance of out-patient blood pressure control. Fam Pract. 2004 Aug;21(4):420-4.Full text  Abstract

11. Shea S, Misra D, Ehrlich MH, et al. Predisposing factors for severe, uncontrolled hypertension in an inner-city minority population. N Engl J Med. 1992 Sep 10;327(11):776-81. Abstract

12. Bennett NM, Shea S. Hypertensive emergency: case criteria, sociodemographic profile, and previous care of 100 cases. Am J Public Health. 1988 Jun;78(6):636-40.Full text  Abstract

13. Lip GY, Beevers M, Beevers G. The failure of malignant hypertension to decline: a survey of 24 years' experience in a multiracial population in England. J Hypertens. 1994 Nov;12(11):1297-305. Abstract

14. Guerin C, Gonthier R, Berthoux FC. Long-term prognosis in malignant or accelerated hypertension. Nephrol Dial Transplant. 1988;3(1):33-7. Abstract

15. Davis TK, Halabi CM, Siefken P, et al. Aggressive blood pressure control for chronic kidney disease unmasks moyamoya! Clin Kidney J. 2013 Oct;6(5):495-9.Full text  Abstract

16. Judd E, Calhoun DA. Management of hypertension in CKD: beyond the guidelines. Adv Chronic Kidney Dis. 2015 Mar;22(2):116-22.Full text  Abstract

17. Macedo TA, Drager LF, Pedrosa RP, et al. Intermittent claudication and severe renal artery stenosis are independently associated in hypertensive patients referred for renal arteriography. Clinics (Sao Paulo). 2017 Jul;72(7):411-4.Full text  Abstract

18. Kasiske BL, Anjum S, Shah R, et al. Hypertension after kidney transplantation. Am J Kidney Dis. 2004 Jun;43(6):1071-81. Abstract

19. Chen W, Kayler LK, Zand MS, et al. Transplant renal artery stenosis: clinical manifestations, diagnosis and therapy. Clin Kidney J. 2015 Feb;8(1):71-8.Full text  Abstract

20. Suneja M, Sanders ML. Hypertensive emergency. Med Clin North Am. 2017 May;101(3):465-78. Abstract

21. Phillips CL, O'Driscoll DM. Hypertension and obstructive sleep apnea. Nat Sci Sleep. 2013 May 10;5:43-52.Full text  Abstract

22. Silaruks S, Sawanyawisuth K. A case of obstructive sleep apnoea presented with hypertensive emergency. Heart Lung Circ. 2015;24(suppl 3):S121.

23. Whitworth JA, Mangos GJ, Kelley JJ. Hypertension in Cushing’s syndrome. In: Mansoor GA, ed. Secondary hypertension, clinical presentation, diagnosis, and treatment. Totowa, NJ: Humana Press; 2004.

24. Pappachan JM, Buch HN. Endocrine hypertension: a practical approach. Adv Exp Med Biol. 2017;956:215-37. Abstract

25. Lenders JW, Duh QY, Eisenhofer G, et al. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014 Jun;99(6):1915-42. Abstract

26. Garg MK, Kharb S, Brar KS, et al. Medical management of pheochromocytoma: role of the endocrinologist. Indian J Endocrinol Metab. 2011 Oct;15(suppl 4):S329-36.Full text  Abstract

27. Kaplan NM. Kaplan's clinical hypertension, 9th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006.

28. Zampaglione B, Pascale C, Marchisio M, et al. Hypertensive urgencies and emergencies: prevalence and clinical presentation. Hypertension. 1996 Jan;27(1):144-7.Full text  Abstract

29. Vaughan CJ, Delanty N. Hypertensive emergencies. Lancet. 2000 Jul 29;356(9227):411-7. Abstract

30. Marik PE, Varon J. Hypertensive crises: challenges and management [published correction appears in Chest. 2007 Nov;132(5):1721]. Chest. 2007 Jun;131(6):1949-62.Full text  Abstract

31. Ault MJ, Ellrodt AG. Pathophysiological events leading to the end-organ effects of acute hypertension. Am J Emerg Med. 1985 Dec;3(6 suppl):10-5. Abstract

32. Luft FC, Mervaala E, Müller DN, et al. Hypertension-induced end-organ damage: a new transgenic approach to an old problem. Hypertension. 1999 Jan;33(1 Pt 2):212-8.Full text  Abstract

33. Taylor DA. Hypertensive crisis: a review of pathophysiology and treatment. Crit Care Nurs Clin North Am. 2015 Dec;27(4):439-47. Abstract

34. Blumenfeld JD, Laragh JH. Management of hypertensive crises: the scientific basis for treatment decisions. Am J Hypertens. 2001 Nov;14(11 Pt 1):1154-67. Abstract

35. Kettritz R, Luft FC. Severe hypertension with large-vessel arteritis. Hypertension. 2012 Feb;59(2):179-83.Full text  Abstract

36. Denton CP, Lapadula G, Mouthon L, et al. Renal complications and scleroderma renal crisis. Rheumatology (Oxford). 2009 Jun;48 (suppl 3):iii32-5. Abstract

37. Ong KL, Cheung BM, Man YB, et al. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension. 2007 Jan;49(1):69-75.Full text  Abstract

38. Fryar CD, Ostchega Y, Hales CM, et al. Hypertension prevalence and control among adults: United States, 2015-2016. NCHS Data Brief. 2017 Oct;(289):1-8.Full text  Abstract

39. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018 Sep 1;39(33):3021-104.Full text  Abstract

40. Bossone E, Rampoldi V, Nienaber CA, et al. Usefulness of pulse deficit to predict in-hospital complications and mortality in patients with acute type A aortic dissection. Am J Cardiol. 2002 Apr 1;89(7):851-5. Abstract

41. Ranasinghe AM, Strong D, Boland B, et al. Acute aortic dissection. BMJ. 2011 Jul 29;343:d4487. Abstract

42. National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. March 2022 [internet publication].Full text

43. Fuchs FD. Study of the usefulness of optic fundi examination on patients with hypertension in a clinical setting. J Hum Hypertens. 1995 Jul;9(7):547-51. Abstract

44. Van den Born BJH, Honnebier UPF, Koopmans RP, et al. Microangiopathic hemolysis and renal failure in malignant hypertension. Hypertension. 2005 Feb;45(2):246-51.Full text  Abstract

45. Hagan PG, Nienaber CA, Isselbacher EM, et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA. 2000 Feb 16;283(7):897-903.Full text  Abstract

46. Nienaber CA, von Kodolitsch Y, Nicolas V, et al. The diagnosis of thoracic aortic dissection by noninvasive imaging procedures. N Engl J Med. 1993 Jan 7;328(1):1-9.Full text  Abstract

47. Shiga T, Wajima Z, Apfel CC, et al. Diagnostic accuracy of transesophageal echocardiography, helical computed tomography, and magnetic resonance imaging for suspected thoracic aortic dissection: systematic review and meta-analysis. Arch Intern Med. 2006 Jul 10;166(13):1350-6.Full text  Abstract

48. Moore AG, Eagle KA, Bruckman D, et al. Choice of computed tomography, transesophageal echocardiography, magnetic resonance imaging, and aortography in acute aortic dissection: International Registry of Acute Aortic Dissection (IRAD). Am J Cardiol. 2002 May 15;89(10):1235-8. Abstract

49. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019 Dec;50(12):e344-418.Full text  Abstract

50. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003 Dec;42(6):1206-52.Full text  Abstract

51. Elliott WJ. Clinical features and management of selected hypertensive emergencies. J Clin Hypertens (Greenwich). 2004 Oct;6(10):587-92.Full text  Abstract

52. Hemphill JC 3rd, Greenberg SM, Anderson CS, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015 May 28;46(7):2032-60.Full text  Abstract

53. Anderson CS, Heeley E, Huang Y, et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med. 2013 May 29;368(25):2355-65.Full text  Abstract

54. Qureshi AI, Palesch YY, Barsan WG, et al. Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. N Engl J Med. 2016 Jun 8;375(11):1033-43.Full text  Abstract

55. van den Born BH, Lip GYH, Brguljan-Hitij J, et al. ESC council on hypertension position document on the management of hypertensive emergencies. Eur Heart J Cardiovasc Pharmacother. 2019 Jan 1;5(1):37-46. Abstract

56. Peacock WF, Varon J, Baumann BM, et al. CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. Crit Care. 2011;15(3):R157.Full text  Abstract

57. Kondo T, Brock M, Bach H. Effect of intra-arterial sodium nitroprusside on intracranial pressure and cerebral autoregulation. Jpn Heart J. 1984 Mar;25(2):231-7. Abstract

58. Griswold WR, Reznik V, Mendoza SA. Nitroprusside-induced intracranial hypertension. JAMA. 1981 Dec 11;246(23):2679-80. Abstract

59. Anile C, Zanghi F, Bracali A, et al. Sodium nitroprusside and intracranial pressure. Acta Neurochir (Wien). 1981;58(3-4):203-11. Abstract

60. Tumlin JA, Dunbar LM, Oparil S, et al. Fenoldopam, a dopamine agonist, for hypertensive emergency: a multicenter randomized trial. Acad Emerg Med. 2000 Jun;7(6):653-62. Abstract

61. Devlin JW, Seta ML, Kanji S, Somerville AL. Fenoldopam versus nitroprusside for the treatment of hypertensive emergency. Ann Pharmacother. 2004 May;38(5):755-9. Abstract

62. Bath PM, Krishnan K. Interventions for deliberately altering blood pressure in acute stroke. Cochrane Database Syst Rev. 2014 Oct 28;(10):CD000039.Full text  Abstract

63. Neutel JM, Smith DHG, Wallin D, et al. A comparison of intravenous nicardipine and sodium nitroprusside in the immediate treatment of severe hypertension. Am J Hypertens. 1994 Jul;7(7 Pt 1):623-8. Abstract

64. Allison TA, Bowman S, Gulbis BJ, et al. Comparison of clevidipine and nicardipine for acute blood pressure reduction in patients with stroke. Intensive Care Med. 2019 Nov-Dec;34(11-12):990-5. Abstract

65. Lau J, Antman EM, Jimenez-Silva J, Kupelnick B. Cumulative meta-analysis of therapeutic trials for MI. N Engl J Med. 1992 Jul 23;327(4):248-54. Abstract

66. Bussmann WD, Kenedi P, von Mengden HJ, et al. Comparison of nitroglycerin with nifedipine in patients with hypertensive crisis or severe hypertension. Clin Investig. 1992 Dec;70(12):1085-8. Abstract

67. Erbel R, Alfonso F, Boileau C, et al. Diagnosis and management of aortic dissection. Eur Heart J. 2001 Sep;22(18):1642-81. Abstract

68. Magee LA, Cham C, Waterman EJ, et al. Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis. BMJ. 2003 Oct 25;327(7421):955-60.Full text  Abstract

69. Mabie WC, Gonzalez AR, Sibai BM, et al. A comparative trial of labetalol and hydralazine in the acute management of severe hypertension complicating pregnancy. Obstet Gynecol. 1987 Sep;70(3 Pt 1):328-33. Abstract

70. Elatrous S, Nouira S, Ouanes Besbes L, et al. Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol. Intensive Care Med. 2002 Sep;28(9):1281-6. Abstract

71. National Institute for Health and Care Excellence. Hypertension in pregnancy: diagnosis and management. June 2019 [internet publication].Full text

72. American College of Obstetricians and Gynecologists. ACOG committee opinion no. 767: emergent therapy for acute-onset, severe hypertension during pregnancy and the postpartum period. Obstet Gynecol. 2019 Feb;133(2):e174-80.Full text  Abstract

73. Magee LA, von Dadelszen P, Rey E, et al. Less-tight versus tight control of hypertension in pregnancy. N Engl J Med. 2015 Jan 29;372(5):407-17.Full text  Abstract

74. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 202: gestational hypertension and preeclampsia. Obstet Gynecol. 2019 Jan;133(1):e1-25.Full text  Abstract

75. US Food and Drug Administration. Drug safety communication: FDA recommends against prolonged use of magnesium sulfate to stop pre-term labor due to bone changes in exposed babies. May 2013 [internet publication].Full text

76. Medicines and Healthcare products Regulatory Agency. Magnesium sulfate: risk of skeletal adverse effects in the neonate following prolonged or repeated use in pregnancy. May 2019 [internet publication].Full text

77. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;(1):CD007798.Full text  Abstract

78. Bernardes TP, Zwertbroek EF, Broekhuijsen K, et al. Delivery or expectant management for prevention of adverse maternal and neonatal outcomes in hypertensive disorders of pregnancy: an individual participant data meta-analysis. Ultrasound Obstet Gynecol. 2019 Apr;53(4):443-53.Full text  Abstract

79. Lip GY, Beevers M, Beevers DG. Complications and survival of 315 patients with malignant-phase hypertension. J Hypertens. 1995 Aug;13(8):915-24. Abstract

80. Webster J, Petrie JC, Jeffers TA, et al. Accelerated hypertension patterns or mortality and clinical factors affecting outcome in treated patients. Q J Med. 1993 Aug;86(8):485-93. Abstract

81. Midgley JP, Matthew AG, Greenwood CM, et al. Effect of reduced dietary sodium on blood pressure: a meta-analysis of randomized controlled trials. JAMA. 1996 May 22-29;275(20):1590-7. Abstract

82. Lichtenstein AH, Appel LJ, Brands M, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation. 2006 Jul 4;114(1):82-96.Full text  Abstract

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