Erectile dysfunction

References

Key articles

Dewitte M, Bettocchi C, Carvalho J, et al. A psychosocial approach to erectile dysfunction: position statements from the European Society of Sexual Medicine (ESSM). Sex Med. 2021 Dec;9(6):100434.Full text  Abstract

Burnett AL, Nehra A, Breau RH, et al. Erectile dysfunction: AUA guideline. J Urol. 2018 Sep;200(3):633-41.Full text  Abstract

Nehra A, Jackson G, Miner M, et al. The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc. 2012 Aug;87(8):766-78.Full text  Abstract

Rosen RC, Cappelleri JC, Smith MD, et al. Development and evaluation of an abridged, 5-item version of the international index of erectile function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999 Dec;11(6):319-26. Abstract

Reference articles

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29. De Berardis G, Pellegrini F, Franciosi M, et al; Quality of Care and Outcomes in Type 2 Diabetes Study Group. Identifying patients with type 2 diabetes with a higher likelihood of erectile dysfunction: the role of the interaction between clinical and psychological factors. J Urol. 2003 Apr;169(4):1422-8. Abstract

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31. Pizzol D, Smith L, Fontana L, et al. Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and META-analysis. Rev Endocr Metab Disord. 2020 Dec;21(4):657-66.Full text  Abstract

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34. Kovac JR, Labbate C, Ramasamy R, et al. Effects of cigarette smoking on erectile dysfunction. Andrologia. 2015 Dec;47(10):1087-92.Full text  Abstract

35. Burnett AL. Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: association and management. Curr Urol Rep. 2005 Nov;6(6):470-5. Abstract

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40. Padma-Nathan H, McCullough A, Forest C. Erectile dysfunction secondary to nerve-sparing radical retropubic prostatectomy: comparative phosphodiesterase-5 inhibitor efficacy for therapy and novel prevention strategies. Curr Urol Rep. 2004 Dec;5(6):467-71. Abstract

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43. Rosen RC, Lane RM, Menza M. Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol. 1999 Feb;19(1):67-85. Abstract

44. Shindel AW, Althof SE, Carrier S, et al. Disorders of ejaculation: an AUA/SMSNA guideline. J Urol. 2022 Mar;207(3):504-12.Full text  Abstract

45. Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018 May 1;103(5):1715-44.Full text  Abstract

46. Ricchiuti VS, Haas CA, Seftel AD, et al. Pudendal nerve injury associated with avid bicycling. J Urol. 1999 Dec;162(6):2099-100. Abstract

47. Egerdie RB, Auerbach S, Roehrborn CG, et al. Tadalafil 2.5 or 5 mg administered once daily for 12 weeks in men with both erectile dysfunction and signs and symptoms of benign prostatic hyperplasia: results of a randomized, placebo-controlled, double-blind study. J Sex Med. 2012 Jan;9(1):271-81. Abstract

48. Burnett AL, Nehra A, Breau RH, et al. Erectile dysfunction: AUA guideline. J Urol. 2018 Sep;200(3):633-41.Full text  Abstract

49. Nehra A, Jackson G, Miner M, et al. The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc. 2012 Aug;87(8):766-78.Full text  Abstract

50. Rosen RC, Riley A, Wagner G, et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997 Jun;49(6):822-30. Abstract

51. Rosen RC, Cappelleri JC, Smith MD, et al. Development and evaluation of an abridged, 5-item version of the international index of erectile function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999 Dec;11(6):319-26. Abstract

52. Moreland RB, Nehra A. Pathophysiology of Peyronie's disease. Int J Impot Res. 2002 Oct;14(5):406-10. Abstract

53. Ciocanel O, Power K, Eriksen A. Interventions to treat erectile dysfunction and premature ejaculation: an overview of systematic reviews. Sex Med. 2019 Sep;7(3):251-69.Full text  Abstract

54. Gholami SS, Gonzalez-Cadavid NF, Lin CS, et al. Peyronie's disease: a review. J Urol. 2003 Apr;169(4):1234-41. Abstract

55. Lue TF, Giuliano F, Montorsi F, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med. 2004 Jul;1(1):6-23. Abstract

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58. Bivalacqua TJ, Allen BK, Brock G, et al. Acute ischemic priapism: an AUA/SMSNA guideline. J Urol. 2021 Nov;206(5):1114-21.Full text  Abstract

59. Bivalacqua TJ, Allen BK, Brock GB, et al. The diagnosis and management of recurrent ischemic priapism, priapism in sickle sell patients, and non-ischemic priapism: an AUA/SMSNA guideline. J Urol. 2022 Jul;208(1):43-52.Full text  Abstract

60. Rosen RC, Cappelleri JC, Gendrano N 3rd. The International Index of Erectile Function (IIEF): a state-of-the-science review. Int J Impot Res. 2002 Aug;14(4):226-44.Full text  Abstract

61. Cappelleri JC, Rosen RC, Smith MD, et al. Diagnostic evaluation of the erectile function domain of the international index of erectile function. Urology. 1999 Aug;54(2):346-51. Abstract

62. Bella AJ, Lee JC, Grober ED, et al. 2018 Canadian Urological Association guideline for Peyronie's disease and congenital penile curvature. Can Urol Assoc J. 2018 Feb 22;12(5):E197-209.Full text  Abstract

63. Domes T, Najafabadi BT, Roberts M, et al. Canadian Urological Association guideline: erectile dysfunction. Can Urol Assoc J. 2021 Oct;15(10):310-22.Full text  Abstract

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65. Wing RR, Rosen RC, Fava JL, et al. Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. J Sex Med. 2010 Jan;7(1 Pt 1):156-65. Abstract

66. Gupta BP, Murad MH, Clifton MM, et al. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2011 Nov 14;171(20):1797-803.Full text  Abstract

67. Salonia A, Adaikan G, Buvat J, et al. Sexual rehabilitation after treatment for prostate cancer-part 2: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med. 2017 Mar;14(3):297-315.Full text  Abstract

68. Hatzimouratidis K, Salonia A, Adaikan G, et al. Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med. 2016 Mar 25;13(4):465-88. Abstract

69. Pyrgidis N, Mykoniatis I, Haidich AB, et al. The effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews. Front Pharmacol. 2021;12:735708.Full text  Abstract

70. Yafi FA, Sharlip ID, Becher EF. Update on the safety of phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction. Sex Med Rev. 2018 Apr;6(2):242-52. Abstract

71. Azzouni F, Abu Samra K. Are phosphodiesterase type 5 inhibitors associated with vision-threatening adverse events? A critical analysis and review of the literature. J Sex Med. 2011 Oct;8(10):2894-903. Abstract

72. Zhou Z, Chen H, Wu J, et al. Meta-analysis of the long-term efficacy and tolerance of tadalafil daily compared with tadalafil on-demand in treating men with erectile dysfunction. Sex Med. 2019 Sep;7(3):282-91.Full text  Abstract

73. Kim E, Seftel A, Goldfischer E, et al. Comparative efficacy of tadalafil once daily in men with erectile dysfunction who demonstrated previous partial responses to as-needed sildenafil, tadalafil, or vardenafil. Curr Med Res Opin. 2014 Dec 2;31(2):379-89. Abstract

74. Loeb S, Folkvaljon Y, Lambe M, et al. Use of phosphodiesterase type 5 inhibitors for erectile dysfunction and risk of malignant melanoma. JAMA. 2015 Jun 23-30;313(24):2449-55.Full text  Abstract

75. Jenkins LC, Hall M, Deveci S, et al. An evaluation of a clinical care pathway for the management of men with nonorganic erectile dysfunction. J Sex Med. 2019 Oct;16(10):1541-6.Full text  Abstract

76. Khera M, Goldstein I. Erectile dysfunction. BMJ Clin Evid. 2011 Jun 29;2011. pii: 1803.Full text  Abstract

77. Costa P, Potempa AJ. Intraurethral alprostadil for erectile dysfunction: a review of the literature. Drugs. 2012 Dec 3;72(17):2243-54. Abstract

78. Anaissie J, Hellstrom WJ. Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review. Res Rep Urol. 2016;8:123-31.Full text  Abstract

79. Babaei AR, Safarinejad MR, Kolahi AA, et al. Penile revascularization for erectile dysfunction: a systematic review and meta-analysis of effectiveness and complications. Urol J. 2009 Winter;6(1):1-7.Full text  Abstract

80. Kim ED, Owen RC, White GS, et al. Endovascular treatment of vasculogenic erectile dysfunction. Asian J Androl. 2015 Jan-Feb;17(1):40-3.Full text  Abstract

81. Melnik T, Soares BG, Nasselo AG. Psychosocial interventions for erectile dysfunction. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004825.Full text  Abstract

82. Montorsi F, Adaikan G, Becher E, et al. Committee 26. Summary of the recommendations on sexual dysfunctions in men. In: Montorsi F, Basson R, Adaikan G, eds. Sexual medicine: sexual dysfunctions in men and women. Edition 2010. Paris: Editions 21; 2010:1265-82.Full text  Abstract

83. Pyrgidis N, Mykoniatis I, Haidich AB, et al. Effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews and meta-analyses. BMJ Open. 2021 Aug 24;11(8):e047396.Full text  Abstract

84. Hellstrom WJ, Gittelman M, Karlin G, et al. Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. J Androl. 2002 Nov-Dec;23(6):763-71.Full text  Abstract

85. Padma-Nathan H, Hellstrom WJ, Kaiser FE, et al; Medicated Urethral System for Erection (MUSE) Study Group. Treatment of men with erectile dysfunction with transurethral alprostadil. N Engl J Med. 1997 Jan 2;336(1):1-7. Abstract

86. Cookson MS, Nadig PW. Long-term results with vacuum constriction device. J Urol. 1993 Feb;149(2):290-4. Abstract

87. Mulcahy JJ. Current approach to the treatment of penile implant infections. Ther Adv Urol. 2010 Apr;2(2):69-75.Full text  Abstract

88. Bella AJ, Deyoung LX, Al-Numi M, et al. Daily administration of phosphodiesterase type 5 inhibitors for urological and nonurological indications. Eur Urol. 2007 Oct;52(4):990-1005. Abstract

89. Liu JL, Chu KY, Gabrielson AT, et al. Restorative therapies for erectile dysfunction: position statement from the Sexual Medicine Society of North America (SMSNA). Sex Med. 2021 Jun;9(3):100343.Full text  Abstract

90. Raheem OA, Natale C, Dick B, et al. Novel treatments of erectile dysfunction: review of the current literature. Sex Med Rev. 2021 Jan;9(1):123-32. Abstract

91. Yao H, Wang X, Liu H, et al. Systematic review and meta-analysis of 16 randomized controlled trials of clinical outcomes of low-intensity extracorporeal shock wave therapy in treating erectile dysfunction. Am J Mens Health. 2022 Mar-Apr;16(2):15579883221087532.Full text  Abstract

92. Montorsi F, Brock G, Stolzenburg JU, et al. Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT). Eur Urol. 2014 Mar;65(3):587-96. Abstract

93. Philippou YA, Jung JH, Steggall MJ, et al. Penile rehabilitation for postprostatectomy erectile dysfunction. Cochrane Database Syst Rev. 2018 Oct 23;(10):CD012414.Full text  Abstract

94. Pisansky TM, Pugh SL, Greenberg RE, et al. Tadalafil for prevention of erectile dysfunction after radiotherapy for prostate cancer: the Radiation Therapy Oncology Group [0831] randomized clinical trial. JAMA. 2014 Apr 2;311(13):1300-7. Abstract

95. Mulhall JP, Brock G, Oelke M, et al. Effects of tadalafil once-daily or on-demand vs placebo on return to baseline erectile function after bilateral nerve-sparing radical prostatectomy--results from a randomized controlled trial (REACTT). J Sex Med. 2016 Apr;13(4):679-83.Full text  Abstract

96. King SH, Mayorov AV, Balse-Srinivasan P, et al. Melanocortin receptors, melanotropic peptides and penile erection. Curr Top Med Chem. 2007;7(11):1098-106. Abstract

97. Rosen RC, Diamond LE, Earle DC, et al. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to viagra. Int J Impot Res. 2004 Apr;16(2):135-42. Abstract

98. Safarinejad MR, Hosseini SY. Expression of concern: salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study. J Urol. 2023 Jan 10;:101097JU0000000000003117. Abstract

99. Kim S, Cho MC, Cho SY, et al. Novel emerging therapies for erectile dysfunction. World J Mens Health. 2021 Jan;39(1):48-64.Full text  Abstract

100. Diamond LE, Earle DC, Garcia WD, et al. Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology. 2005 Apr;65(4):755-9. Abstract

101. Yoshimura N, Kato R, Chancellor MB, et al. Gene therapy as future treatment of erectile dysfunction. Expert Opin Biol Ther. 2010 Sep;10(9):1305-14.Full text  Abstract

102. Lai BY, Cao HJ, Yang GY, et al. Acupuncture for treatment of erectile dysfunction: a systematic review and meta-analysis. World J Mens Health. 2019 Sep;37(3):322-38.Full text  Abstract

103. McMahon CN, Smith CJ, Shabsigh R. Treating erectile dysfunction when PDE5 inhibitors fail. BMJ. 2006 Mar 11;332(7541):589-92.Full text  Abstract

104. Madeira CR, Tonin FS, Fachi MM, et al. Efficacy and safety of oral phosphodiesterase 5 inhibitors for erectile dysfunction: a network meta-analysis and multicriteria decision analysis. World J Urol. 2021 Mar;39(3):953-62. Abstract

105. Zhu J, Zhang W, Ou N, et al. Do testosterone supplements enhance response to phosphodiesterase 5 inhibitors in men with erectile dysfunction and hypogonadism: a systematic review and meta-analysis. Transl Androl Urol. 2020 Apr;9(2):591-600.Full text  Abstract

106. Defeudis G, Mazzilli R, Tenuta M, et al. Erectile dysfunction and diabetes: a melting pot of circumstances and treatments. Diabetes Metab Res Rev. 2022 Feb;38(2):e3494.Full text  Abstract

107. Guay AT, Perez JB, Jacobson J, et al. Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors. J Androl. 2001 Sep-Oct;22(5):793-7. Abstract

108. Williams G, Abbou CC, Amar ET, et al. Efficacy and safety of transurethral alprostadil therapy in men with erectile dysfunction. MUSE Study Group. Br J Urol. 1998 Jun;81(6):889-94. Abstract

109. Hatzichristou DG, Pescatori ES. Current treatments and emerging therapeutic approaches in male erectile dysfunction. BJU Int. 2001;88(suppl 3):11-17. Abstract

110. Danesh-Meyer HV, Levin LA. Erectile dysfunction drugs and risk of anterior ischaemic optic neuropathy: casual or causal association? Br J Ophthalmol. 2007 Nov;91(11):1551-5. Abstract

111. Laties AM. Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date. Drug Saf. 2009;32(1):1-18. Abstract

112. Ostfeld RJ, Allen KE, Aspry K, et al. Vasculogenic erectile dysfunction: the impact of diet and lifestyle. Am J Med. 2021 Mar;134(3):310-6. Abstract

113. Begot I, Peixoto TC, Gonzaga LR, et al. A home-based walking program improves erectile dysfunction in men with an acute myocardial infarction. Am J Cardiol. 2015 Mar 1;115(5):571-5. Abstract

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