Osteoarthritis

References

Key articles

Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-62.Full text  Abstract

National Institute for Health and Care Excellence. Osteoarthritis in over 16s: diagnosis and management. Oct 2022 [internet publication].Full text

Bruyère O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec;49(3):337-50.Full text  Abstract

Reference articles

1. Sharma L, Kapoor D, Issa S. Epidemiology of osteoarthritis: an update. Curr Opin Rheumatol. 2006;18:147-156. Abstract

2. Hunter DJ, Felson DT. Osteoarthritis. BMJ. 2006;332:639-642. Abstract

3. Altman R, Asch E, Bloch D, et al; Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum. 1986;29:1039-49. Abstract

4. Altman RD. Criteria for classification of clinical osteoarthritis. J Rheumatol Suppl. 1991 Feb;27:10-2. Abstract

5. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957 Dec;16(4):494-502.Full text  Abstract

6. Schiphof D, Boers M, Bierma-Zeinstra SM. Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis. Ann Rheum Dis. 2008 Jul;67(7):1034-6. Abstract

7. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-62.Full text  Abstract

8. Cisternas MG, Murphy L, Sacks JJ, et al. Alternative methods for defining osteoarthritis and the impact on estimating prevalence in a US population-based survey. Arthritis Care Res (Hoboken). 2016 May;68(5):574-80.Full text  Abstract

9. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010 Aug;26(3):355-69.Full text  Abstract

10. Prieto-Alhambra D, Judge A, Javaid MK, et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014 Sep;73(9):1659-64.Full text  Abstract

11. van der Oest MJW, Duraku LS, Andrinopoulou ER, et al. The prevalence of radiographic thumb base osteoarthritis: a meta-analysis. Osteoarthr Cartil. 2021 Jun;29(6):785-92.Full text  Abstract

12. Wilson MG, Michel CJ Jr, Ilstrup DM, et al. Idiopathic symptomatic osteoarthritis of the hip and knee: a population-based incidence study. Mayo Clin Proc. 1990; 65:1214-1221. Abstract

13. Oliveria SA, Felson DT, Reed JI, et al. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum. 1995;38:1134-1141. Abstract

14. Moss AS, Murphy LB, Helmick CG, et al. Annual incidence rates of hip symptoms and three hip OA outcomes from a U.S. population-based cohort study: the Johnston County Osteoarthritis Project. Osteoarthr Cartil. 2016 Sep;24(9):1518-27.Full text  Abstract

15. Felson DT, Naimark A, Anderson J, et al. The prevalence of knee osteoarthritis in the elderly: the Framingham Osteoarthritis Study. Arthritis Rheum. 1987;30:914-918. Abstract

16. Felson DT, Zhang Y, Hannan MT, et al. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1995;38:1500-1505. Abstract

17. Kim C, Linsenmeyer KD, Vlad SC, et al. Prevalence of radiographic and symptomatic hip osteoarthritis in an urban United States community: the Framingham osteoarthritis study. Arthritis Rheumatol. 2014 Nov;66(11):3013-7.Full text  Abstract

18. Nevitt MC, Xu L, Zhang Y, et al. Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum. 2002;46:1773-1779. Abstract

19. Zhang Y, Xu L, Nevitt MC, et al. Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: the Beijing Osteoarthritis Study. Arthritis Rheum. 2001;44:2065-2071. Abstract

20. Fan Z, Yan L, Liu H, et al. The prevalence of hip osteoarthritis: a systematic review and meta-analysis. Arthritis Res Ther. 2023 Mar 29;25(1):51.Full text  Abstract

21. Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet. 2015 Jul 25;386(9991):376-87. Abstract

22. Reyes C, Leyland KM, Peat G, et al. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study. Arthritis Rheumatol. 2016 Aug;68(8):1869-75.Full text  Abstract

23. Silverwood V, Blagojevic-Bucknall M, Jinks C, et al. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015 Apr;23(4):507-15.Full text  Abstract

24. Spector TD, Cicuttini F, Baker J, et al. Genetic influences on osteoarthritis in women: a twin study. BMJ. 1996;312:940-3. Abstract

25. Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol. 2011 Jan;7(1):23-32. Abstract

26. Tanamas S, Hanna FS, Cicuttini FM, et al. Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Rheum. 2009 Apr 15;61(4):459-67.Full text  Abstract

27. Brouwer GM, van Tol AW, Bergink AP, et al. Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum. 2007 Apr;56(4):1204-11.Full text  Abstract

28. van Buuren MMA, Arden NK, Bierma-Zeinstra SMA, et al. Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review. Osteoarthr Cartil. 2021 May;29(5):607-18.Full text  Abstract

29. Cinque ME, Dornan GJ, Chahla J, et al. High rates of osteoarthritis develop after anterior cruciate ligament surgery: an analysis of 4108 patients. Am J Sports Med. 2018 Jul;46(8):2011-19. Abstract

30. Chen T, Wang S, Li Y, et al. Radiographic osteoarthritis prevalence over ten years after anterior cruciate ligament reconstruction. Int J Sports Med. 2019 Oct;40(11):683-95.Full text  Abstract

31. Cerejo R, Dunlop DD, Cahue S, et al. The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease. Arthritis Rheum. 2002 Oct;46(10):2632-6.Full text  Abstract

32. Chang A, Hayes K, Dunlop D, et al. Thrust during ambulation and progression of knee osteoarthritis. Arthritis Rheum. 2004;50:3897-903. Abstract

33. Felson DT. Clinical practice. Osteoarthritis of the knee. N Engl J Med. 2006;354:841-8. Abstract

34. Heinemeier KM, Schjerling P, Heinemeier J, et al. Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage. Sci Transl Med. 2016 Jul 6;8(346):346ra90. Abstract

35. Sohn DH, Sokolove J, Sharpe O, et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther. 2012 Jan 8;14(1):R7.Full text  Abstract

36. Li T, Chubinskaya S, Esposito A, et al. TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. Sci Transl Med. 2019 May 8;11(491):eaan2585.Full text  Abstract

37. Budhiparama NC, Lumban-Gaol I, Sudoyo H, et al. Interleukin-1 genetic polymorphisms in knee osteoarthritis: What do we know? A meta-analysis and systematic review. J Orthop Surg (Hong Kong). 2022 Jan-Apr;30(1):23094990221076652.Full text  Abstract

38. Lee YH, Song GG. Association between IL-17 gene polymorphisms and circulating IL-17 levels in osteoarthritis: a meta-analysis. Z Rheumatol. 2020 Jun;79(5):482-90. Abstract

39. Gao S, Mao C, Cheng J, et al. Association of IL-17A-197G/A and IL-17F-7488T/C polymorphisms and osteoarthritis susceptibility: a meta-analysis. Int J Rheum Dis. 2020 Jan;23(1):37-46. Abstract

40. Tu M, Yao Y, Qiao FH, et al. The pathogenic role of connective tissue growth factor in osteoarthritis. Biosci Rep. 2019 Jul 31;39(7):BSR20191374.Full text  Abstract

41. Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta. 2012 Jan;1824(1):133-45.Full text  Abstract

42. Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016 Jul;12(7):412-20.Full text  Abstract

43. Coryell PR, Diekman BO, Loeser RF. Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Nat Rev Rheumatol. 2021 Jan;17(1):47-57. Abstract

44. Van Pevenage PM, Birchmier JT, June RK. Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: a systematic review. Semin Arthritis Rheum. 2023 Apr;59:152163.Full text  Abstract

45. Zheng L, Zhang Z, Sheng P, et al. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Ageing Res Rev. 2021 Mar;66:101249.Full text  Abstract

46. Lee YH, Song GG. Circulating leptin level in osteoarthritis and associations between leptin receptor polymorphisms and disease susceptibility: a meta-analysis. Int J Rheum Dis. 2023 Jul;26(7):1305-13. Abstract

47. Chen B, Ning K, Sun ML, et al. Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review. Cell Commun Signal. 2023 Apr 3;21(1):67.Full text  Abstract

48. Sharma L, Song J, Felson DT, et al. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA. 2001;286:188-195. Abstract

49. Hart DJ, Doyle DV, Spector TD. Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum. 1999;42:17-24. Abstract

50. Kallman DA, Wigley FM, Scott WW Jr, et al. The longitudinal course of hand osteoarthritis in a male population. Arthritis Rheum. 1990;33:1323-1331. Abstract

51. Felson DT, Zhang Y, Hannan MT, et al. Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum. 1997 Apr;40(4):728-33.Full text  Abstract

52. Felson DT, Anderson JJ, Naimark A, et al. Obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med. 1988;109:18-24. Abstract

53. Francomano CA, Liberfarb RM, Hirose T, et al. The Stickler syndrome: evidence for close linkage to the structural gene for type II collagen. Genomics. 1987;1:293-6. Abstract

54. Kannu P, Bateman JF, Randle S, et al. Premature arthritis is a distinct type II collagen phenotype. Arthritis Rheum. 2010 May;62(5):1421-30.Full text  Abstract

55. Kannu P, Bateman J, Savarirayan R. Clinical phenotypes associated with type II collagen mutations. J Paediatr Child Health. 2012 Feb;48(2):E38-43. Abstract

56. Zhang W, Doherty M, Leeb BF, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009 Jan;68(1):8-17.Full text  Abstract

57. Casartelli NC, Maffiuletti NA, Valenzuela PL, et al. Is hip morphology a risk factor for developing hip osteoarthritis? A systematic review with meta-analysis. Osteoarthr Cartil. 2021 Sep;29(9):1252-64.Full text  Abstract

58. Cooper C. Occupational activity and the risk of osteoarthritis. J Rheumatol Suppl. 1995;22(Suppl 43):10-12. Abstract

59. Maetzel A, Makela M, Hawker G, et al. Osteoarthritis of the hip and knee and mechanical occupational exposure - a systematic overview of the evidence. J Rheumatol. 1997;24:1599-1607. Abstract

60. Sapolsky HM. Prospective payment in perspective. J Health Polit Policy Law. 1986;11(4):633-45. Abstract

61. Croft P, Cooper C, Wickham C, et al. Osteoarthritis of the hip and occupational activity. Scand J Work Env Health. 1992;18:59-63. Abstract

62. Driban JB, Hootman JM, Sitler MR, et al. Is participation in certain sports associated with knee osteoarthritis? A systematic review. J Athl Train. 2017 Jun 2;52(6):497-506.Full text  Abstract

63. Whittaker JL, Losciale JM, Juhl CB, et al. Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus. Br J Sports Med. 2022 Dec;56(24):1406-21.Full text  Abstract

64. Webster KE, Hewett TE. Anterior cruciate ligament injury and knee osteoarthritis: an umbrella systematic review and meta-analysis. Clin J Sport Med. 2022 Mar 1;32(2):145-52. Abstract

65. Hannan MT, Anderson JJ, Zhang Y, et al. Bone mineral density and knee osteoarthritis in elderly men and women. The Framingham Study. Arthritis Rheum. 1993;36:1671-1680. Abstract

66. Bergink AP, Rivadeneira F, Bierma-Zeinstra SM, et al. Are bone mineral density and fractures related to the incidence and progression of radiographic osteoarthritis of the knee, hip, and hand in elderly men and women? The Rotterdam study. Arthritis Rheumatol. 2019 Mar;71(3):361-9. Abstract

67. Hartley A, Hardcastle SA, Frysz M, et al. Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study. Arthritis Res Ther. 2021 Jan 6;23(1):4.Full text  Abstract

68. Whittaker JL, Culvenor AG, Juhl CB, et al. OPTIKNEE 2022: consensus recommendations to optimise knee health after traumatic knee injury to prevent osteoarthritis. Br J Sports Med. 2022 Dec;56(24):1393-405.Full text  Abstract

69. Brandt KD, Mazzuca SA, Katz BP, et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 2005;52:2015-2025. Abstract

70. da Costa BR, Nüesch E, Reichenbach S, et al. Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2012 Nov 14;(11):CD007323. Abstract

71. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int. 2010 Jan;30(3):357-63. Abstract

72. Kouki I, Tuffet S, Crema MD, et al. Metacarpophalangeal joint impairment in hand osteoarthritis and its association with mechanical factors: results from the digital cohort osteoarthritis design hand osteoarthritis cohort. Arthritis Care Res (Hoboken). 2022 Oct;74(10):1696-703. Abstract

73. National Institute for Health and Care Excellence. Osteoarthritis in over 16s: diagnosis and management. Oct 2022 [internet publication].Full text

74. van Tunen JAC, Dell'Isola A, Juhl C, et al. Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis. BMC Musculoskelet Disord. 2018 Jul 28;19(1):273.Full text  Abstract

75. Altman R, Alarcon G, Appelrouth D. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990;33:1601-1610. Abstract

76. Peat G, Duncan RC, Wood LR, et al. Clinical features of symptomatic patellofemoral joint osteoarthritis. Arthritis Res Ther. 2012 Mar 14;14(2):R63.Full text  Abstract

77. Sakellariou G, Conaghan PG, Zhang W, et al. EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis. Ann Rheum Dis. 2017 Sep;76(9):1484-94.Full text  Abstract

78. Altman R, Alarcon G, Appelrouth D. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991;34:505-514. Abstract

79. Fox MG, Chang EY, Amini B, et al; Expert Panel on Musculoskeletal Imaging. ACR appropriateness criteria®: chronic knee pain. J Am Coll Radiol. 2018 Nov;15(11s):S302-12.Full text  Abstract

80. Hayashi D, Roemer FW, Guermazi A. Imaging for osteoarthritis. Ann Phys Rehabil Med. 2016 Jun;59(3):161-9.Full text  Abstract

81. Wesseling J, Bierma-Zeinstra SM, Kloppenburg M, et al. Worsening of pain and function over 5 years in individuals with 'early' OA is related to structural damage: data from the Osteoarthritis Initiative and CHECK (Cohort Hip & Cohort Knee) study. Ann Rheum Dis. 2015;74:347-353. Abstract

82. Yusuf E, Kortekaas MC, Watt I, et al. Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review. Ann Rheum Dis. 2011 Jan;70(1):60-7. Abstract

83. Foong YC, Khan HI, Blizzard L, et al. The clinical significance, natural history and predictors of bone marrow lesion change over eight years. Arthritis Res Ther. 2014 Jul 14;16(4):R149.Full text  Abstract

84. Felson DT, McLaughlin S, Goggins J, et al. Bone marrow edema and its relation to progression to knee osteoarthritis. Ann Intern Med. 2003;139:330-336. Abstract

85. Imhof H, Breitenseher M, Trattnig S, et al. Imaging of avascular necrosis of bone. Eur Radiol. 1997;7:180-186. Abstract

86. American College of Radiology; Subhas N, Wu F, et al. ACR Appropriateness Criteria® chronic extremity joint pain-suspected inflammatory arthritis, crystalline arthritis, or erosive osteoarthritis: 2022 Update. J Am Coll Radiol. 2023 May;20(5s):S20-S32.Full text  Abstract

87. American College of Radiology. ACR appropriateness criteria: chronic hip pain. 2022 [internet publication].Full text

88. Zhang W, Robertson J, Jones AC, et al. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008;67:1716-23. Abstract

89. Previtali D, Merli G, Di Laura Frattura G, et al. The long-lasting effects of "placebo injections" in knee osteoarthritis: a meta-analysis. Cartilage. 2021 Dec;13(suppl 1):185S-96S.Full text  Abstract

90. Bannuru RR, McAlindon TE, Sullivan MC, et al. Effectiveness and implications of alternative placebo treatments: a systematic review and network meta-analysis of osteoarthritis trials. Ann Intern Med. 2015;163:365-372. Abstract

91. Bricca A, Juhl CB, Steultjens M, et al. Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials. Br J Sports Med. 2019 Aug;53(15):940-7.Full text  Abstract

92. Gohir SA, Eek F, Kelly A, et al. Effectiveness of internet-based exercises aimed at treating knee osteoarthritis: the iBEAT-OA randomized clinical trial. JAMA Netw Open. 2021 Feb 1;4(2):e210012.Full text  Abstract

93. Dong R, Wu Y, Xu S, et al. Is aquatic exercise more effective than land-based exercise for knee osteoarthritis? Medicine (Baltimore). 2018 Dec;97(52):e13823.Full text  Abstract

94. Goff AJ, De Oliveira Silva D, Merolli M, et al. Patient education improves pain and function in people with knee osteoarthritis with better effects when combined with exercise therapy: a systematic review. J Physiother. 2021 Jul;67(3):177-89.Full text  Abstract

95. Sasaki R, Honda Y, Oga S, et al. Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: a systematic review with meta-analysis. PLoS One. 2022;17(11):e0275591.Full text  Abstract

96. Hu L, Wang Y, Liu X, et al. Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis. Clin Rehabil. 2021 Jan;35(1):64-79.Full text  Abstract

97. Pitsillides A, Stasinopoulos D, Giannakou K. The effects of cognitive behavioural therapy delivered by physical therapists in knee osteoarthritis pain: a systematic review and meta-analysis of randomized controlled trials. J Bodyw Mov Ther. 2021 Jan;25:157-64. Abstract

98. Brosseau L, Wells GA, Pugh AG, et al. Ottawa Panel evidence-based clinical practice guidelines for therapeutic exercise in the management of hip osteoarthritis. Clin Rehabil. 2016 Oct;30(10):935-46. Abstract

99. Jansen MJ, Viechtbauer W, Lenssen AF, et al. Strength training alone, exercise therapy alone, and exercise therapy with passive manual mobilisation each reduce pain and disability in people with knee osteoarthritis: a systematic review. J Physiother. 2011;57:11-20. Abstract

100. Dziedzic K, Nicholls E, Hill S, et al. Self-management approaches for osteoarthritis in the hand: a 2x2 factorial randomised trial. Ann Rheum Dis. 2015;74:108-118.Full text  Abstract

101. Anwer S, Alghadir A, Zafar H, et al. Effects of orthopaedic manual therapy in knee osteoarthritis: a systematic review and meta-analysis. Physiotherapy. 2018 Sep;104(3):264-76. Abstract

102. Fransen M, McConnell S, Harmer AR, et al. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;(1):CD004376.Full text  Abstract

103. Fransen M, McConnell S, Hernandez-Molina G, et al. Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev. 2014;(4):CD007912.Full text  Abstract

104. Bennell KL, Egerton T, Martin J, et al. Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomized clinical trial. JAMA. 2014;311:1987-1997.Full text  Abstract

105. Fransen M, McConnell S, Hernandez-Molina G, et al. Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2010;18:613-620. Abstract

106. Teirlinck CH, Verhagen AP, Reijneveld EAE, et al. Responders to exercise therapy in patients with osteoarthritis of the hip: a systematic review and meta-analysis. Int J Environ Res Public Health. 2020 Oct 10;17(20):7380.Full text  Abstract

107. Thomas DT, R S, Prabhakar AJ, et al. Hip abductor strengthening in patients diagnosed with knee osteoarthritis - a systematic review and meta-analysis. BMC Musculoskelet Disord. 2022 Jun 29;23(1):622.Full text  Abstract

108. Messier SP, Mihalko SL, Legault C, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310:1263-1273.Full text  Abstract

109. Christensen R, Henriksen M, Leeds AR, et al. Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: a twelve-month randomized controlled trial. Arthritis Care Res (Hoboken). 2015;67:640-650.Full text  Abstract

110. Hislop AC, Collins NJ, Tucker K, et al. Does adding hip exercises to quadriceps exercises result in superior outcomes in pain, function and quality of life for people with knee osteoarthritis? A systematic review and meta-analysis. Br J Sports Med. 2020 Mar;54(5):263-71.Full text  Abstract

111. Raghava Neelapala YV, Bhagat M, Shah P. Hip muscle strengthening for knee osteoarthritis: a systematic review of literature. J Geriatr Phys Ther. 2020 Apr/Jun;43(2):89-98.Full text  Abstract

112. Jurado-Castro JM, Muñoz-López M, Ledesma AS, et al. Effectiveness of exercise in patients with overweight or obesity suffering from knee osteoarthritis: a systematic review and meta-analysis. Int J Environ Res Public Health. 2022 Aug 24;19(17):10510.Full text  Abstract

113. Hall M, Castelein B, Wittoek R, et al. Diet-induced weight loss alone or combined with exercise in overweight or obese people with knee osteoarthritis: A systematic review and meta-analysis. Semin Arthritis Rheum. 2019 Apr;48(5):765-77. Abstract

114. Chu SF, Liou TH, Chen HC, et al. Relative efficacy of weight management, exercise, and combined treatment for muscle mass and physical sarcopenia indices in adults with overweight or obesity and osteoarthritis: a network meta-analysis of randomized controlled trials. Nutrients. 2021 Jun 10;13(6):1992.Full text  Abstract

115. Huang XM, Yuan FZ, Chen YR, et al. Physical therapy and orthopaedic equipment-induced reduction in the biomechanical risk factors related to knee osteoarthritis: a systematic review and Bayesian network meta-analysis of randomised controlled trials. BMJ Open. 2022 Feb 9;12(2):e051608.Full text  Abstract

116. Parkes MJ, Maricar N, Lunt M, et al. Lateral wedge insoles as a conservative treatment for pain in patients with medial knee osteoarthritis: a meta-analysis. JAMA. 2013;310:722-730.Full text  Abstract

117. Yu L, Wang Y, Yang J, et al. Effects of orthopedic insoles on patients with knee osteoarthritis: a meta-analysis and systematic review. J Rehabil Med. 2021 May 18;53(5):jrm00191.Full text  Abstract

118. Jindasakchai P, Angthong C, Panyarachun P, et al. Therapeutic significance of insoles in patients with knee osteoarthritis. Eur Rev Med Pharmacol Sci. 2023 Jun;27(11):5023-30.Full text  Abstract

119. Alfatafta H, Onchonga D, Alfatafta M, et al. Effect of using knee valgus brace on pain and activity level over different time intervals among patients with medial knee OA: systematic review. BMC Musculoskelet Disord. 2021 Aug 12;22(1):687.Full text  Abstract

120. Duivenvoorden T, Brouwer RW, van Raaij TM, et al. Braces and orthoses for treating osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;(3):CD004020.Full text  Abstract

121. Moyer RF, Birmingham TB, Bryant DM, et al. Valgus bracing for knee osteoarthritis: a meta-analysis of randomized trials. Arthritis Care Res (Hoboken). 2015;67:493-501. Abstract

122. Gohal C, Shanmugaraj A, Tate P, et al. Effectiveness of valgus offloading knee braces in the treatment of medial compartment knee osteoarthritis: a systematic review. Sports Health. 2018 Nov/Dec;10(6):500-14. Abstract

123. Fan Y, Li Z, Zhang H, et al. Valgus knee bracing may have no long-term effect on pain improvement and functional activity in patients with knee osteoarthritis: a meta-analysis of randomized trials. J Orthop Surg Res. 2020 Sep 1;15(1):373.Full text  Abstract

124. Khosravi M, Babaee T, Daryabor A, et al. Effect of knee braces and insoles on clinical outcomes of individuals with medial knee osteoarthritis: a systematic review and meta-analysis. Assist Technol. 2022 Sep 3;34(5):501-17. Abstract

125. Hinman RS, Wrigley TV, Metcalf BR, et al. Unloading shoes for self-management of knee osteoarthritis: a randomized trial. Ann Intern Med. 2016;165:381-89. Abstract

126. Callaghan MJ, Parkes MJ, Hutchinson CE, et al. A randomised trial of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions. Ann Rheum Dis. 2015;74:1164-70.Full text  Abstract

127. Callaghan MJ, Palmer E, O'Neill T. Management of patellofemoral joint osteoarthritis using biomechanical device therapy: a systematic review with meta-analysis. Syst Rev. 2021 Jun 9;10(1):173.Full text  Abstract

128. Buhler M, Chapple CM, Stebbings S, et al. Effectiveness of splinting for pain and function in people with thumb carpometacarpal osteoarthritis: a systematic review with meta-analysis. Osteoarthritis Cartilage. 2019 Apr;27(4):547-59.Full text  Abstract

129. Honvo G, Reginster JY, Rabenda V, et al. Safety of symptomatic slow-acting drugs for osteoarthritis: outcomes of a systematic review and meta-analysis. Drugs Aging. 2019 Apr;36(suppl 1):65-99.Full text  Abstract

130. Gregori D, Giacovelli G, Minto C, et al. Association of pharmacological treatments with long-term pain control in patients with knee osteoarthritis: a systematic review and meta-analysis. JAMA. 2018 Dec 25;320(24):2564-79.Full text  Abstract

131. Simental-Mendía M, Sánchez-García A, Vilchez-Cavazos F, et al. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatol Int. 2018 Aug;38(8):1413-28. Abstract

132. Singh JA, Noorbaloochi S, MacDonald R, et al. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015;(1):CD005614.Full text  Abstract

133. Ogata T, Ideno Y, Akai M, et al. Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis. Clin Rheumatol. 2018 Sep;37(9):2479-87.Full text  Abstract

134. Knapik JJ, Pope R, Hoedebecke SS, et al. Effects of oral chondroitin sulfate on osteoarthritis-related pain and joint structural changes: systematic review and meta-analysis. J Spec Oper Med. Spring 2019;19(1):113-24. Abstract

135. Meng Z, Liu J, Zhou N. Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis. Arch Orthop Trauma Surg. 2023 Jan;143(1):409-21. Abstract

136. Bruyère O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec;49(3):337-50.Full text  Abstract

137. Suarez-Almazor ME, Looney C, Liu Y, et al. A randomized controlled trial of acupuncture for osteoarthritis of the knee: effects of patient-provider communication. Arthritis Care Res (Hoboken). 2010;62:1229-1236. Abstract

138. Kwon YD, Pittler MH, Ernst E. Acupuncture for peripheral joint osteoarthritis: a systematic review and meta-analysis. Rheumatology (Oxford). 2006;45:1331-1337.Full text  Abstract

139. Cao L, Zhang XL, Gao YS, et al. Needle acupuncture for osteoarthritis of the knee. A systematic review and updated meta-analysis. Saudi Med J. 2012;33:526-532. Abstract

140. Araya-Quintanilla F, Cuyúl-Vásquez I, Gutiérrez-Espinoza H. Does acupuncture provide pain relief in patients with osteoarthritis knee? An overview of systematic reviews. J Bodyw Mov Ther. 2022 Jan;29:117-26. Abstract

141. Manheimer E, Cheng K, Wieland LS, et al. Acupuncture for hip osteoarthritis. Cochrane Database Syst Rev. 2018 May 5;(5):CD013010.Full text  Abstract

142. Tian H, Huang L, Sun M, et al. Acupuncture for knee osteoarthritis: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses. Biomed Res Int. 2022;2022:6561633.Full text  Abstract

143. Kwak SG, Kwon JB, Seo YW, et al. The effectiveness of acupuncture as an adjunctive therapy to oral pharmacological medication in patient with knee osteoarthritis: a systematic review and meta-analysis. Medicine (Baltimore). 2023 Mar 17;102(11):e33262.Full text  Abstract

144. Rutjes AW, Nüesch E, Sterchi R, et al. Transcutaneous electrostimulation for osteoarthritis of the knee. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD002823.Full text  Abstract

145. Wu Y, Zhu F, Chen W, et al. Effects of transcutaneous electrical nerve stimulation (TENS) in people with knee osteoarthritis: a systematic review and meta-analysis. Clin Rehabil. 2022 Apr;36(4):472-85. Abstract

146. Stewart M, Cibere J, Sayre EC, et al. Efficacy of commonly prescribed analgesics in the management of osteoarthritis: a systematic review and meta-analysis. Rheumatol Int. 2018 Nov;38(11):1985-97. Abstract

147. da Costa BR, Pereira TV, Saadat P, et al. Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis. BMJ. 2021 Oct 12;375:n2321.Full text  Abstract

148. Zeng C, Wei J, Persson MS, et al. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. Br J Sports Med. 2018 May;52(10):642-50.Full text  Abstract

149. Sardana V, Burzynski J, Zalzal P. Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: a systematic review. Musculoskeletal Care. 2017 Jun;15(2):114-21. Abstract

150. Honvo G, Leclercq V, Geerinck A, et al. Safety of topical non-steroidal anti-inflammatory drugs in osteoarthritis: outcomes of a systematic review and meta-analysis. Drugs Aging. 2019 Apr;36(suppl 1):45-64.Full text  Abstract

151. Ling T, Li JJ, Xu RJ, et al. Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials. Biomed Res Int. 2020;2020:1758071.Full text  Abstract

152. Cameron M, Chrubasik S. Topical herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev. 2013;(5):CD010538.Full text  Abstract

153. Persson MSM, Stocks J, Walsh DA, et al. The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: a network meta-analysis of randomised controlled trials. Osteoarthritis Cartilage. 2018 Dec;26(12):1575-82.Full text  Abstract

154. Machado GC, Maher CG, Ferreira PH, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ. 2015;350:h1225.Full text  Abstract

155. Abdel Shaheed C, Ferreira GE, Dmitritchenko A, et al. The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews. Med J Aust. 2021 Apr;214(7):324-31.Full text  Abstract

156. da Costa BR, Reichenbach S, Keller N, et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2017 Jul 8;390(10090):e21-33. Abstract

157. Leopoldino AO, Machado GC, Ferreira PH, et al. Paracetamol versus placebo for knee and hip osteoarthritis. Cochrane Database Syst Rev. 2019 Feb 25;(2):CD013273.Full text  Abstract

158. Bannuru RR, Schmid CH, Kent DM, et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162:46-54. Abstract

159. Machado GC, Abdel-Shaheed C, Underwood M, et al. Non-steroidal anti-inflammatory drugs (NSAIDs) for musculoskeletal pain. BMJ. 2021 Jan 29;372:n104. Abstract

160. Yeomans ND, Tulassay Z, Juhasz L, et al; Acid suppression trial: ranitidine versus omeprazole for NSAID-associated ulcer treatment (ASTRONAUT) study group. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1998;338:719-26.Full text  Abstract

161. Hawkey CJ, Karrasch JA, Szczepanski L, et al. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1998;338:727-734.Full text  Abstract

162. Elliott SL, Yeomans ND, Buchanan RR, et al. Efficacy of 12 months' misoprostol as prophylaxis against NSAID-induced gastric ulcers. A placebo-controlled trial. Scand J Rheumatol. 1994;23:171-176. Abstract

163. Graham DY, Agrawal NM, Roth SH. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet. 1988;2:1277-1280. Abstract

164. Graham DJ, Campen D, Hui R, et al. Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study. Lancet. 2005;365:475-481. Abstract

165. Maxwell SR, Payne RA, Murray GD, et al. Selectivity of NSAIDs for COX-2 and cardiovascular outcome. Br J Clin Pharmacol. 2006;62:243-245. Abstract

166. Wang X, Tian HJ, Yang HK, et al. Meta-analysis: cyclooxygenase-2 inhibitors are no better than nonselective nonsteroidal anti-inflammatory drugs with proton pump inhibitors in regard to gastrointestinal adverse events in osteoarthritis and rheumatoid arthritis. Eur J Gastroenterol Hepatol. 2011;23:876-880. Abstract

167. Curtis E, Fuggle N, Shaw S, et al. Safety of cyclooxygenase-2 inhibitors in osteoarthritis: outcomes of a systematic review and meta-analysis. Drugs Aging. 2019 Apr;36(suppl 1):25-44.Full text  Abstract

168. Cryer BL, Sostek MB, Fort JG, et al. A fixed-dose combination of naproxen and esomeprazole magnesium has comparable upper gastrointestinal tolerability to celecoxib in patients with osteoarthritis of the knee: results from two randomized, parallel-group, placebo-controlled trials. Ann Med. 2011;43:594-605. Abstract

169. Atiquzzaman M, Karim ME, Kopec J, et al. Role of nonsteroidal antiinflammatory drugs in the association between osteoarthritis and cardiovascular diseases: a longitudinal study. Arthritis Rheumatol. 2019 Nov;71(11):1835-43. Abstract

170. Osani MC, Vaysbrot EE, Zhou M, et al. Duration of symptom relief and early trajectory of adverse events for oral nonsteroidal antiinflammatory drugs in knee osteoarthritis: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2020 May;72(5):641-51.Full text  Abstract

171. Solomon DH, Glynn RJ, Rothman KJ, et al. Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups. Arthritis Rheum. 2008;59:1097-1104.Full text  Abstract

172. Antman EM, DeMets D, Loscalzo J. Cyclooxygenase inhibition and cardiovascular risk. Circulation. 2005;112:759-770.Full text  Abstract

173. Nissen SE. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 2017 Apr 6;376(14):1390. Abstract

174. Osani MC, Lohmander LS, Bannuru RR. Is There any role for opioids in the management of knee and hip osteoarthritis? A systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2021 Oct;73(10):1413-24.Full text  Abstract

175. da Costa BR, Nüesch E, Kasteler R, et al. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2014;(9):CD003115.Full text  Abstract

176. Welsch P, Petzke F, Klose P, et al. Opioids for chronic osteoarthritis pain: an updated systematic review and meta-analysis of efficacy, tolerability and safety in randomized placebo-controlled studies of at least 4 weeks double-blind duration. Eur J Pain. 2020 Apr;24(4):685-703.Full text  Abstract

177. Toupin April K, Bisaillon J, Welch V, et al. Tramadol for osteoarthritis. Cochrane Database Syst Rev. 2019 May 27;(5):CD005522.Full text  Abstract

178. Zhang X, Li X, Xiong Y, et al. Efficacy and safety of tramadol for knee or hip osteoarthritis: a systematic review and network meta-analysis of randomized controlled trials. Arthritis Care Res (Hoboken). 2023 Jan;75(1):158-65. Abstract

179. Citrome L, Weiss-Citrome A. A systematic review of duloxetine for osteoarthritic pain: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed? Postgrad Med. 2012;124:83-93. Abstract

180. Myers J, Wielage RC, Han B, et al. The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis. BMC Musculoskelet Disord. 2014 Mar 11;15:76.Full text  Abstract

181. Osani MC, Bannuru RR. Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis. Korean J Intern Med. 2019 Sep;34(5):966-73.Full text  Abstract

182. Chen L, Gong M, Liu G, et al. Efficacy and tolerability of duloxetine in patients with knee osteoarthritis: a meta-analysis of randomised controlled trials. Intern Med J. 2019 Dec;49(12):1514-23. Abstract

183. Weng C, Xu J, Wang Q, et al. Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2020 Jun;28(6):721-34.Full text  Abstract

184. Chen B, Duan J, Wen S, et al. An updated systematic review and meta-analysis of duloxetine for knee osteoarthritis Pain. Clin J Pain. 2021 Nov 1;37(11):852-62.Full text  Abstract

185. Saltzman BM, Leroux T, Meyer MA, et al. The therapeutic effect of intra-articular normal saline injections for knee osteoarthritis: a meta-analysis of evidence level 1 studies. Am J Sports Med. 2017 Sep;45(11):2647-53. Abstract

186. Gazendam A, Ekhtiari S, Bozzo A, et al. Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain: a systematic review and network meta-analysis of randomised controlled trials. Br J Sports Med. 2021 Mar;55(5):256-61.Full text  Abstract

187. Jüni P, Hari R, Rutjes AW, et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015 Oct 22;(10):CD005328.Full text  Abstract

188. McCabe PS, Maricar N, Parkes MJ, et al. The efficacy of intra-articular steroids in hip osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2016 Sep;24(9):1509-17.Full text  Abstract

189. Najm A, Alunno A, Gwinnutt JM, et al. Efficacy of intra-articular corticosteroid injections in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Joint Bone Spine. 2021 Jul;88(4):105198. Abstract

190. Wang X, Wang P, Faramand A, et al. Efficacy and safety of corticosteroid in the treatment of hand osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Clin Rheumatol. 2022 Jun;41(6):1825-32. Abstract

191. Xie Y, Zhao K, Ye G, et al. Effectiveness of intra-articular injections of sodium hyaluronate, corticosteroids, platelet-rich plasma on temporomandibular joint osteoarthritis: a systematic review and network meta-analysis of randomized controlled trials. J Evid Based Dent Pract. 2022 Sep;22(3):101720. Abstract

192. Choueiri M, Chevalier X, Eymard F. Intraarticular corticosteroids for hip osteoarthritis: a review. Cartilage. 2021 Dec;13(suppl 1):122S-31S.Full text  Abstract

193. Zhong HM, Zhao GF, Lin T, et al. Intra-articular steroid injection for patients with hip osteoarthritis: a systematic review and meta-analysis. Biomed Res Int. 2020;2020:6320154.Full text  Abstract

194. Okike K, King RK, Merchant JC, et al. Rapidly destructive hip disease following intra-articular corticosteroid injection of the hip. J Bone Joint Surg Am. 2021 Nov 17;103(22):2070-79. Abstract

195. van Middelkoop M, Arden NK, Atchia I, et al. The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids. Osteoarthritis Cartilage. 2016 Jul;24(7):1143-52.Full text  Abstract

196. McAlindon TE, LaValley MP, Harvey WF, et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial. JAMA. 2017 May 16;317(19):1967-75.Full text  Abstract

197. Raynauld JP, Buckland-Wright C, Ward R, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2003 Feb;48(2):370-7.Full text  Abstract

198. Donovan RL, Edwards TA, Judge A, et al. Effects of recurrent intra-articular corticosteroid injections for osteoarthritis at 3 months and beyond: a systematic review and meta-analysis in comparison to other injectables. Osteoarthritis Cartilage. 2022 Dec;30(12):1658-69.Full text  Abstract

199. Bannuru RR, Natov NS, Obadan IE, et al. Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis. Arthritis Rheum. 2009;61:1704-1711. Abstract

200. Leite VF, Daud Amadera JE, Buehler AM. Viscosupplementation for hip osteoarthritis: a systematic review and meta-analysis of the efficacy on pain and disability, and the occurrence of adverse events. Arch Phys Med Rehabil. 2018 Mar;99(3):574-83.e1. Abstract

201. Bellamy N, Campbell J, Welch V, et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD005321.Full text  Abstract

202. Maheu E, Bannuru RR, Herrero-Beaumont G, et al. Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: results of an extensive critical literature review. Semin Arthritis Rheum. 2019 Feb;48(4):563-72.Full text  Abstract

203. Richette P, Chevalier X, Ea HK, et al. Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias. RMD Open. 2015 May 14;1(1):e000071.Full text  Abstract

204. Pereira TV, Jüni P, Saadat P, et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. 2022 Jul 6;378:e069722.Full text  Abstract

205. Skou ST, Roos EM, Laursen MB, et al. A randomized, controlled trial of total knee replacement. N Engl J Med. 2015;373:1597-1606.Full text  Abstract

206. Kyriakidis T, Asopa V, Baums M, et al. Unicompartmental knee arthroplasty in patients under the age of 60 years provides excellent clinical outcomes and 10-year implant survival: a systematic review : a study performed by the Early Osteoarthritis group of ESSKA-European Knee Associates section. Knee Surg Sports Traumatol Arthrosc. 2023 Mar;31(3):922-32. Abstract

207. Katz JN, Brophy RH, Chaisson CE, et al. Surgery versus physical therapy for a meniscal tear and osteoarthritis. N Engl J Med. 2013;368:1675-1684.Full text  Abstract

208. Moseley JB, O'Malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2002 Jul 11;347(2):81-8.Full text  Abstract

209. O'Connor D, Johnston RV, Brignardello-Petersen R, et al. Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears). Cochrane Database Syst Rev. 2022 Mar 3;3(3):CD014328.Full text  Abstract

210. Singh Jagdev B, McGrath J, Cole A, et al. Total shoulder arthroplasty vs. hemiarthroplasty in patients with primary glenohumeral arthritis with intact rotator cuff: meta-analysis using the ratio of means. J Shoulder Elbow Surg. 2022 Dec;31(12):2657-70. Abstract

211. Gandolfi S, Carloni R, Mouton J, et al. Finger joint denervation in hand osteoarthritis: indications, surgical techniques and outcomes. A systematic review of published cases. Hand Surg Rehabil. 2020 Sep;39(4):239-50. Abstract

212. Zhu SL, Chin B, Sarraj M, et al. Denervation as a treatment for arthritis of the hands: a systematic review of the current literature. Hand (N Y). 2023 Mar;18(2):183-91.Full text  Abstract

213. Kloppenburg M, Kroon FP, Blanco FJ, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019 Jan;78(1):16-24.Full text  Abstract

214. Knightly N, Sullivan P. Surgery for trapeziometacarpal joint osteoarthritis: a meta-analysis on efficacy and safety. J Hand Surg Asian Pac Vol. 2021 Jun;26(2):245-64. Abstract

215. Pozzobon D, Ferreira PH, Blyth FM, et al. Can obesity and physical activity predict outcomes of elective knee or hip surgery due to osteoarthritis? A meta-analysis of cohort studies. BMJ Open. 2018 Feb 27;8(2):e017689.Full text  Abstract

216. Wallis JA, Taylor NF. Pre-operative interventions (non-surgical and non-pharmacological) for patients with hip or knee osteoarthritis awaiting joint replacement surgery - a systematic review and meta-analysis. Osteoarthritis Cartilage. 2011;19:1381-1395. Abstract

217. Schairer WW, Nwachukwu BU, Mayman DJ, et al. Preoperative hip injections increase the rate of periprosthetic infection after total hip arthroplasty. J Arthroplasty. 2016;31(suppl):S166-S169. Abstract

218. Werner BC, Cancienne JM, Browne JA. The timing of total hip arthroplasty after intraarticular hip injection affects postoperative infection risk. J Arthroplasty. 2016;31:820-823. Abstract

219. Li J, Li YX, Luo LJ, et al. The effectiveness and safety of acupuncture for knee osteoarthritis: an overview of systematic reviews. Medicine (Baltimore). 2019 Jul;98(28):e16301.Full text  Abstract

220. Ahmed I, Gertner E. Safety of arthrocentesis and joint injection in patients receiving anticoagulation at therapeutic levels. Am J Med. 2012 Mar;125(3):265-9.Full text  Abstract

221. Bashir MA, Ray R, Sarda P, et al. Determination of a safe INR for joint injections in patients taking warfarin. Ann R Coll Surg Engl. 2015 Nov;97(8):589-91.Full text  Abstract

222. The Primary Care Rheumatology and Musculoskeletal Medicine Society. Joint and Soft Tissue Injection Recommendations. 2021 [internet publication].Full text

223. Mushtaq S, Choudhary R, Scanzello CR. Non-surgical treatment of osteoarthritis-related pain in the elderly. Curr Rev Musculoskelet Med. 2011 Sep;4(3):113-22.Full text  Abstract

224. Bashir MA, Ray R, Sarda P, et al. Determination of a safe INR for joint injections in patients taking warfarin. Ann R Coll Surg Engl. 2015 Nov;97(8):589-91.Full text  Abstract

225. Mushtaq S, Choudhary R, Scanzello CR. Non-surgical treatment of osteoarthritis-related pain in the elderly. Curr Rev Musculoskelet Med. 2011 Sep;4(3):113-22.Full text  Abstract

226. Avendaño-Coy J, Comino-Suárez N, Grande-Muñoz J, et al. Extracorporeal shockwave therapy improves pain and function in subjects with knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials. Int J Surg. 2020 Oct;82:64-75.Full text  Abstract

227. Ma H, Zhang W, Shi J, et al. The efficacy and safety of extracorporeal shockwave therapy in knee osteoarthritis: a systematic review and meta-analysis. Int J Surg. 2020 Mar;75:24-34.Full text  Abstract

228. Wang YC, Huang HT, Huang PJ, et al. Efficacy and safety of extracorporeal shockwave therapy for treatment of knee osteoarthritis: a systematic review and meta-analysis. Pain Med. 2020 Apr 1;21(4):822-35.Full text  Abstract

229. Leone R, de Rosa A, Iudicone P, et al. Pain control and functional improvement in patients treated by autologous conditioned serum after failure of platelet rich plasma treatments in knee osteoarthritis. Transfus Med. 2021 Oct;31(5):357-64. Abstract

230. Simon MJK, Aartsen VE, Coghlan JA, et al. Shoulder injections with autologous conditioned serum reduce pain and disability in glenohumeral osteoarthritis: longitudinal observational study. ANZ J Surg. 2021 Apr;91(4):673-9.Full text  Abstract

231. Zarringam D, Bekkers JE, Saris DB. Long-term effect of injection treatment for osteoarthritis in the knee by orthokin autologous conditioned serum. Cartilage. 2018 Apr;9(2):140-5.Full text  Abstract

232. Baltzer AW, Moser C, Jansen SA, et al. Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis Cartilage. 2009;17:152-160. Abstract

233. Khoshbin A, Leroux T, Wasserstein D, et al. The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. Arthroscopy. 2013;29:2037-2048. Abstract

234. Campbell KA, Saltzman BM, Mascarenhas R, et al. Does intra-articular platelet-rich plasma injection provide clinically superior outcomes compared with other therapies in the treatment of knee osteoarthritis? A systematic review of overlapping meta-analyses. Arthroscopy. 2015;31:2213-2221. Abstract

235. Ye Y, Zhou X, Mao S, et al. Platelet rich plasma versus hyaluronic acid in patients with hip osteoarthritis: a meta-analysis of randomized controlled trials. Int J Surg. 2018 May;53:279-87. Abstract

236. Chen P, Huang L, Ma Y, et al. Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses. J Orthop Surg Res. 2019 Nov 27;14(1):385.Full text  Abstract

237. Dong Y, Zhang B, Yang Q, et al. The effects of platelet-rich plasma injection in knee and hip osteoarthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2021 Jan;40(1):263-77. Abstract

238. Berney M, McCarroll P, Glynn L, et al. Platelet-rich plasma injections for hip osteoarthritis: a review of the evidence. Ir J Med Sci. 2021 Aug;190(3):1021-25. Abstract

239. Laohajaroensombat S, Prusmetikul S, Rattanasiri S, et al. Platelet-rich plasma injection for the treatment of ankle osteoarthritis: a systematic review and meta-analysis. J Orthop Surg Res. 2023 May 19;18(1):373.Full text  Abstract

240. National Institute for Health and Care Excellence. Platelet-rich plasma injections for knee osteoarthritis. Jan 2019 [internet publication].Full text

241. Belk JW, Lim JJ, Keeter C, et al. Patients with knee osteoarthritis who receive platelet-rich plasma or bone marrow aspirate concentrate injections have better outcomes than patients who receive hyaluronic acid: systematic review and meta-analysis. Arthroscopy. 2023 Jul;39(7):1714-34. Abstract

242. Belk JW, Kraeutler MJ, Houck DA, et al. Platelet-rich plasma versus hyaluronic acid for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Am J Sports Med. 2021 Jan;49(1):249-60.Full text  Abstract

243. Belk JW, Houck DA, Littlefield CP, et al. Platelet-rich plasma versus hyaluronic acid for hip osteoarthritis yields similarly beneficial short-term clinical outcomes: a systematic review and meta-analysis of Level I and II randomized controlled trials. Arthroscopy. 2022 Jun;38(6):2035-46.Full text  Abstract

244. Filardo G, Previtali D, Napoli F, et al. PRP injections for the treatment of knee osteoarthritis: a meta-analysis of rndomized controlled trials. Cartilage. 2021 Dec;13(suppl 1):364S-75S.Full text  Abstract

245. Paget LDA, Reurink G, de Vos RJ, et al. Platelet-rich plasma injections for the treatment of ankle osteoarthritis. Am J Sports Med. 2023 Aug;51(10):2625-34.Full text  Abstract

246. Chou SH, Shen PC, Lu CC, et al. Comparison of efficacy among three radiofrequency ablation techniques for treating knee osteoarthritis: a systematic review and meta-analysis. Int J Environ Res Public Health. 2021 Jul 12;18(14):7424.Full text  Abstract

247. Gupta A, Huettner DP, Dukewich M. Comparative effectiveness review of cooled versus pulsed radiofrequency ablation for the treatment of knee osteoarthritis: a systematic review. Pain Physician. 2017 Mar;20(3):155-71.Full text  Abstract

248. Ajrawat P, Radomski L, Bhatia A, et al. Radiofrequency procedures for the treatment of symptomatic knee osteoarthritis: a systematic review. Pain Med. 2020 Feb 1;21(2):333-48.Full text  Abstract

249. Fogarty AE, Burnham T, Kuo K, et al. The effectiveness of fluoroscopically guided genicular nerve radiofrequency ablation for the treatment of chronic knee pain due to osteoarthritis: a systematic review. Am J Phys Med Rehabil. 2022 May 1;101(5):482-92. Abstract

250. Li G, Zhang Y, Tian L, et al. Radiofrequency ablation reduces pain for knee osteoarthritis: a meta-analysis of randomized controlled trials. Int J Surg. 2021 Jul;91:105951.Full text  Abstract

251. Tan YL, Neo EJR, Wee TC. Ultrasound-guided genicular nerve blockade with pharmacological agents for chronic knee osteoarthritis: a systematic review. Pain Physician. 2022 Jul;25(4):E489-502.Full text  Abstract

252. Liu J, Wang T, Zhu ZH. Efficacy and safety of radiofrequency treatment for improving knee pain and function in knee osteoarthritis: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2022 Jan 15;17(1):21.Full text  Abstract

253. Chen AF, Mullen K, Casambre F, et al. Thermal nerve radiofrequency ablation for the nonsurgical treatment of knee osteoarthritis: a systematic literature review. J Am Acad Orthop Surg. 2021 May 1;29(9):387-96. Abstract

254. Guevara-Noriega KA, Chavez-Abiega R, Castro-Rios JG. Embolization of genicular arteries in patients with knee osteoarthritis as an alternative for refractory pain treatment: a systematic review. [in spa]. Med Clin (Barc). 2022 Dec 23;159(12):592-7. Abstract

255. Epelboym Y, Mandell JC, Collins JE, et al. Genicular artery embolization as a treatment for osteoarthritis related knee pain: a systematic review and meta-analysis. Cardiovasc Intervent Radiol. 2023 Jun;46(6):760-9. Abstract

256. Lange B, von Zabern D, Elling C, et al. Efficacy and safety of tapentadol prolonged release for moderate-to-severe chronic osteoarthritis knee pain: a pooled analysis of two double-blind, randomized, placebo- and oxycodone controlled release-controlled studies. Curr Med Res Opin. 2017 Aug;33(8):1413-22. Abstract

257. Jurgensmeier K, Jurgensmeier D, Kunz DE, et al. Intra-articular injections of the hip and knee with triamcinolone vs ketorolac: a randomized controlled trial. J Arthroplasty. 2021 Feb;36(2):416-22. Abstract

258. Bellamy JL, Goff BJ, Sayeed SA. Economic impact of ketorolac vs corticosteroid intra-articular knee injections for osteoarthritis: a randomized, double-blind, prospective study. J Arthroplasty. 2016 Sep;31(9 Suppl):293-7. Abstract

259. Ha CW, Cho JJ, Elmallah RK, et al. A multicenter, single-blind, phase IIa clinical trial to evaluate the efficacy and safety of a cell-mediated gene therapy in degenerative knee arthritis patients. Hum Gene Ther Clin Dev. 2015 Jun;26(2):125-30. Abstract

260. Kim MK, Ha CW, In Y, et al. A multicenter, double-blind, phase III clinical trial to evaluate the efficacy and safety of a cell and gene therapy in knee osteoarthritis patients. Hum Gene Ther Clin Dev. 2018 Mar;29(1):48-59. Abstract

261. Borakati A, Mafi R, Mafi P, et al. A systematic review and meta-analysis of clinical trials of mesenchymal stem cell therapy for cartilage repair. Curr Stem Cell Res Ther. 2018 Feb 23;13(3):215-25. Abstract

262. Huang R, Li W, Zhao Y, et al. Clinical efficacy and safety of stem cell therapy for knee osteoarthritis: a meta-analysis. Medicine (Baltimore). 2020 Mar;99(11):e19434.Full text  Abstract

263. Ha CW, Park YB, Kim SH, et al. Intra-articular mesenchymal stem cells in osteoarthritis of the knee: a systematic review of clinical outcomes and evidence of cartilage repair. Arthroscopy. 2019 Jan;35(1):277-288.e2. Abstract

264. Kim SH, Ha CW, Park YB, et al. Intra-articular injection of mesenchymal stem cells for clinical outcomes and cartilage repair in osteoarthritis of the knee: a meta-analysis of randomized controlled trials. Arch Orthop Trauma Surg. 2019 Jul;139(7):971-80. Abstract

265. Di Matteo B, Anzillotti G, Gallese A, et al. Placenta-derived products demonstrate good safety profile and overall satisfactory outcomes for treating knee osteoarthritis: a systematic review of clinical evidence. Arthroscopy. 2023 Aug;39(8):1892-904. Abstract

266. Colombini A, Libonati F, Lopa S, et al. Autologous chondrocyte implantation provides good long-term clinical results in the treatment of knee osteoarthritis: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023 Jun;31(6):2338-48. Abstract

267. Wiggers TG, Winters M, Van den Boom NA, et al. Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials. Br J Sports Med. 2021 Oct;55(20):1161-9.Full text  Abstract

268. Smith C, Patel R, Vannabouathong C, et al. Combined intra-articular injection of corticosteroid and hyaluronic acid reduces pain compared to hyaluronic acid alone in the treatment of knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2019 Jun;27(6):1974-83. Abstract

269. Baria MR, Vasileff WK, Borchers J, et al. Treating knee osteoarthritis with platelet-rich plasma and hyaluronic acid combination therapy: a systematic review. Am J Sports Med. 2022 Jan;50(1):273-81.Full text  Abstract

270. Zhao J, Liang G, Han Y, et al. Combination of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) in the treatment of knee osteoarthritis: a meta-analysis of randomised controlled trials. BMJ Open. 2022 Nov 16;12(11):e061008.Full text  Abstract

271. Dakin P, DiMartino SJ, Gao H, et al. The efficacy, tolerability, and joint safety of fasinumab in osteoarthritis pain: a phase IIb/III double-blind, placebo-controlled, randomized clinical trial. Arthritis Rheumatol. 2019 Nov;71(11):1824-34.Full text  Abstract

272. ClinicalTrials.gov. Search for fasinumab trials [internet publication].Full text

273. American College of Rheumatology (ACR) and American Association of Hip and Knee Surgeons (AAHKS). Clinical practice guideline for the optimal timing of elective total hip or knee arthroplasty for patients with symptomatic moderate to severe osteoarthritis or osteonecrosis who have failed nonoperative therapy. Feb 2023 [internet publication].Full text

274. American Academy of Orthopedic Surgeons. ​Treatment for shoulder OA with intact rotator cuff and severe glenoid retroversion: appropriate use criteria. Mar 2023 [internet publication].Full text

275. American Academy of Orthopaedic Surgeons. Appropriate use criteria for the management of osteoarthritis of the knee (non-arthroplasty). Sep 2022 [internet publication].Full text

276. Goodman SM, Springer BD, Chen AF, et al. 2022 American College of Rheumatology/American Association of Hip and Knee Surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty. Arthritis Care Res (Hoboken). 2022 Sep;74(9):1399-408.Full text  Abstract

277. American Academy of Orthopaedic Surgeons. Surgical management of osteoarthritis of the knee: evidence-based clinical practice guideline. Dec 2022 [internet publication].Full text

278. American Academy of Orthopaedic Surgeons. Management of osteoarthritis of the knee (non-arthroplasty): evidence-based clinical practice guideline (3rd edition). Aug 2021 [internet publication].Full text

279. US Department of Veterans Affairs. VA/DoD clinical practice guideline for the non-surgical management of hip & knee osteoarthritis. 2020 [internet publication].Full text

280. Brosseau L, Thevenot O, MacKiddie O, et al. The Ottawa Panel guidelines on programmes involving therapeutic exercise for the management of hand osteoarthritis. Clin Rehabil. 2018 Nov;32(11):1449-71. Abstract

281. Qaseem A, Wilt TJ, McLean RM, et al. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017 Apr 4;166(7):514-30.Full text  Abstract

282. Manchikanti L, Kaye AM, Knezevic NN, et al. Responsible, safe, and effective prescription of opioids for chronic non-cancer pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2017 Feb;20(2s):S3-S92.Full text  Abstract

283. Quinn RH, Murray J, Pezold R, et al. Management of osteoarthritis of the hip. J Am Acad Orthop Surg. 2018 Oct 15;26(20):e434-6.Full text  Abstract

284. Manchikanti L, Abdi S, Atluri S, et al. An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician. 2013 Apr;16(2 suppl):S49-283.Full text  Abstract

285. Bannuru RR, Osani MC, Vaysbrot​ EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr Cartil. 2019 Nov;27(11):1578-89.

286. Haanen J, Obeid M, Spain L, et al. Management of toxicities from immunotherapy: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022 Dec;33(12):1217-38.Full text  Abstract

287. Gwinnutt JM, Wieczorek M, Balanescu A, et al. 2021 EULAR recommendations regarding lifestyle behaviours and work participation to prevent progression of rheumatic and musculoskeletal diseases. Ann Rheum Dis. 2023 Jan;82(1):48-56.Full text  Abstract

288. Uson J, Rodriguez-García SC, Castellanos-Moreira R, et al. EULAR recommendations for intra-articular therapies. Ann Rheum Dis. 2021 Oct;80(10):1299-305.Full text  Abstract

289. Fernandes L, Hagen KB, Bijlsma JW, et al; European League Against Rheumatism (EULAR). EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis. Ann Rheum Dis. 2013;72:1125-1135. Abstract

290. Felson DT, Zhang Y, Anthony JM, et al. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med. 1992 Apr 1;116(7):535-9. Abstract

291. Zhang R, Guo H, Yang X, et al. Potential candidate biomarkers associated with osteoarthritis: evidence from a comprehensive network and pathway analysis. J Cell Physiol. 2019 Aug;234(10):17433-43. Abstract

292. Ren G, Krawetz RJ. Biochemical markers for the early identification of osteoarthritis: systematic review and meta-analysis. Mol Diagn Ther. 2018 Dec;22(6):671-82. Abstract

Use of this content is subject to our disclaimer