Giant cell arteritis (GCA) is a common form of vasculitis in people aged 50 years or older. The extracranial branches of the carotid artery are usually affected.
Irreversible blindness is the most common serious consequence. Aortic aneurysms and large vessel stenoses may occur as a long-term complication.
Temporal artery biopsy is the definitive test to establish diagnosis.
Symptoms include new onset of temporal headache, visual disturbances, and jaw or tongue claudication.
Prednisone is highly effective therapy. Treatment should not be delayed while awaiting biopsy.
Tocilizumab is a biologic with therapeutic and corticosteroid-sparing benefit in the treatment of GCA.
Giant cell arteritis (GCA) is a granulomatous vasculitis of large and medium-sized arteries. It primarily affects branches of the external carotid artery, and it is the most common form of systemic vasculitis in adults. GCA typically occurs in people 50 years of age or older and is more common in women. Symptoms of polymyalgia rheumatica are frequently present. The most common serious consequence of GCA is irreversible loss of vision due to optic nerve ischemia. GCA is sometimes also referred to as temporal arteritis, cranial arteritis, or granulomatous arteritis.
History and exam
Key diagnostic factors
- polymyalgia rheumatica symptoms
- extremity claudication
- other cranial artery abnormalities
- loss of vision
- jaw claudication
- superficial temporal artery tenderness, thickening, or nodularity
- absent temporal artery pulse
- abnormal fundoscopy
Other diagnostic factors
- systemic symptoms
- neurologic symptoms
- cough, sore throat, hoarseness
- bruit on auscultation
- asymmetric blood pressure
- shoulder tenderness
- limited active range of movement of shoulders and hips
- wrist and knee swelling
- age ≥50 years
- female sex
- genetic factors
- environmental factors
1st investigations to order
- temporal artery biopsy
- temporal artery ultrasound
Investigations to consider
- noninvasive vascular imaging
- FDG-PET scan of head to mid-thigh
- ultrasound scan of the upper extremity arteries
- Polymyalgia rheumatica (PMR)
- Solid organ cancers and hematologic malignancies
- Takayasu arteritis (TA)
- American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for giant cell arteritis
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