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Diverticular disease

Last reviewed: 1 Feb 2025
Last updated: 27 Feb 2025

Summary

Definition

History and exam

Key diagnostic factors

  • left lower quadrant abdominal pain
  • fever
Full details

Other diagnostic factors

  • guarding in left lower quadrant
  • tenderness in left lower quadrant
  • rebound tenderness
  • diffuse abdominal tenderness
  • change in bowel habit
  • palpable abdominal mass
Full details

Risk factors

  • age >50 years
  • low dietary fiber
  • diet rich in salt, meat, and sugar
  • obesity (BMI >30)
  • use of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or opioids
  • tobacco smoking
  • alcohol consumption
Full details

Diagnostic tests

1st tests to order

  • CBC with differential
  • CRP
  • basic metabolic panel
  • contrast CT scan of abdomen
Full details

Tests to consider

  • blood culture
  • ABG and serum lactate
  • noncontrast CT scan of abdomen
  • abdominal ultrasound (graded-compression)
  • abdominal MRI scan
  • colonoscopy or sigmoidoscopy
  • diagnostic laparoscopy/exploratory laparotomy
Full details

Treatment algorithm

ACUTE

asymptomatic diverticulosis

acute uncomplicated diverticulitis

acute complicated diverticulitis

ONGOING

recurrent diverticulitis

Contributors

Authors

Marilyse Boutros, MD, FACS, FRCSC

Vice-Chair and Regional Director of Research for the Digestive Disease Institute, Cleveland Clinic Weston Hospital

Colorectal Surgeon, Cleveland Clinic Florida

Weston

FL

Clinical Affiliate Professor of Surgery, Florida Atlantic University

Boca Raton

FL

Professor of Surgery, McGill University

Montreal

Canada

Disclosures

MB has received teaching honorarium from Ethicon and Johnson and Johnson.

Sameh Hany Emile, MBBCh, MSc, MD, FACS

Project Scientist

Department of Colorectal Surgery

Cleveland Clinic Florida

Weston

FL

Clinical Affiliate Associate Professor of Surgery

Florida Atlantic University

Boca Raton

FL

Associate Professor of Surgery

Mansoura University Faculty of Medicine

Mansoura City

Egypt

Disclosures

SHE receives consultancy fees from Becton, Dickinson and Company.

Acknowledgements

Dr Marilyse Boutros and Dr Sameh Hany Emile would like to gratefully acknowledge Dr Mohamed A. Thaha, Dr Jayan D. Jayasinghe, Dr Emma Carrington, Ms Kathryn Lynes, Professor Norman S. Williams, and Dr Abbasi Akhtar, the previous contributors to this topic.

Disclosures

MAT declares he has no competing interests. JDJ declares that he has no competing interests. EC has received honoraria for teaching, and acts as a consultant for Laborie Medical Management Systems. KL has received funding for a research fellowship from the David Johnston Fellowship through the Royal College of Surgeons of England. NSW is an author of a reference cited in this topic. AA declares that he has no competing interests.

Peer reviewers

Ned Snyder, MD, FACP

Professor of Medicine

Chief of Clinical Gastroenterology and Hepatology

University of Texas Medical Branch

Galveston

TX

Disclosures

NS declares that he has no competing interests.

Nicolas Regenet, MD

Clinic of digestive and endocrine surgery

University Hospital

Nantes

France

Disclosures

NR declares that he has no competing interests.

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