Common childhood-onset disorder characterized by inattention, hyperactivity, and/or impulsivity demonstrated across 2 or more settings (such as home and school).
Some impairment must be present by 12 years of age, and 60% to 70% of patients have persistent functional impairment into adulthood.
Diagnosed by clinical history, which should include information from multiple sources, including parents, caregivers, and teachers.
Mainstay of treatment is stimulant medication, which can be effective in 85% of patients; nonstimulants are less often effective, but may have other advantages in terms of duration of action or in particular populations.
Stimulant medications have been associated with cardiovascular side effects. These should be monitored in children with heart conditions.
ADHD is a problem of inattention, hyperactivity, and impulsivity according to the American Psychiatric Association. This disorder is recognized globally and is referred to as hyperkinetic disorder in Europe and other countries that use the WHO classification system. ADHD is a chronic condition with symptoms that begin in early childhood but often persist into adult life. A key element of the definition is functional impairment across 2 or more domains, most often in school and at home. As a result, ADHD can limit academic, interpersonal, and occupational success and can also lead to greater risk-taking and accidents. In addition, patients with ADHD are more likely to have coexisting psychiatric disorders such as oppositional defiant disorder (ODD), conduct disorder, substance abuse, and possibly mood disorders, such as depression and mania.
History and exam
- failure to give close attention to details or making careless mistakes in schoolwork, work, or other activities
- difficulty sustaining attention in tasks or play activities
- does not seem to listen when spoken to directly
- does not follow through on instructions and fails to finish schoolwork, chores, or duties in the workplace
- often has difficulty organizing tasks and activities
- avoids, dislikes, or is reluctant to engage in tasks that require sustained mental effort (such as schoolwork or homework)
- often loses things necessary for tasks or activities (e.g., toys, school assignments, pencils, books, or tools)
- easily distracted by extraneous stimuli
- forgetful in daily activities
- fidgets with hands or feet or squirms in seat
- leaves seat in classroom or in other situations in which remaining seated is expected
- runs about or climbs excessively during inappropriate situations
- difficulty playing or engaging in leisure activities quietly
- often "on the go" or often acts as if "driven by a motor"
- often talks excessively
- often blurts out answers before questions have been completed
- often has difficulty awaiting turn
- often interrupts or intrudes on others (e.g., butts into conversations or games)
Associate Professor of Neurology and Pediatrics
Director, Pediatric Neuropsychiatry Program
Children's Hospital of Philadelphia
LWB has been reimbursed by Sunovion for participation in a Medical Advisory Board.
Dr Lawrence W. Brown would like to gratefully acknowledge Dr Kristin S. Russell, Dr Howard Y. Liu, and Dr Michael S. Jellinek, previous contributors to this topic. KSR, HYL, and MSJ declare that they have no competing interests.
College of Health Professions
BPD declares that he has no competing interests.
Academic Specialist Registrar
Academic Department of Paediatrics and Obstetrics and Gynaecology
MMH declares that he has no competing interests.
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