Zinc deficiency

References

Key articles

Goh J, O'Morain CA. Review article: nutrition and adult inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Feb;17(3):307-20.Full text  Abstract

Goh J, O'Morain CA. Review article: nutrition and adult inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Feb;17(3):307-20.Full text  Abstract

Prasad AS. Zinc deficiency. BMJ. 2003 Feb 22;326(7386):409-10.Full text  Abstract

Meunier N, O'Connor JM, Maiani G, et al. Importance of zinc in the elderly: the ZENITH study. Eur J Clin Nutr. 2005 Nov;59 Suppl 2:S1-4.Full text  Abstract

Ackland ML, Michalczyk A. Zinc deficiency and its inherited disorders - a review. Genes Nutr. 2006 Mar;1(1):41-9. Abstract

Lassi ZS, Kurji J, Oliveira CS, et al. Zinc supplementation for the promotion of growth and prevention of infections in infants less than six months of age. Cochrane Database Syst Rev. 2020 Apr 8;4:CD010205.Full text  Abstract

Haase H, Overbeck S, Rink L. Zinc supplementation for the treatment or prevention of disease: current status and future perspectives. Exp Gerontol. 2008 May;43(5):394-408. Abstract

Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections: a review of the evidence. Food Nutr Bull. 2009 Mar;30(1 suppl):S41-59.Full text  Abstract

Reference articles

1. Singhal N, Alam S, Sherwani R, et al. Serum zinc levels in celiac disease. Indian Pediatr. 2008 Apr;45(4):319-21. Abstract

2. Goh J, O'Morain CA. Review article: nutrition and adult inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Feb;17(3):307-20.Full text  Abstract

3. Ojuawo A, Keith L. The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease. Cent Afr J Med. 2002 Sep-Oct;48(9-10):116-9. Abstract

4. Narkewicz MR, Krebs N, Karrer F, et al. Correction of hypozincemia following liver transplantation in children is associated with reduced urinary zinc loss. Hepatology. 1999 Mar;29(3):830-3.Full text  Abstract

5. Stamoulis I, Kouraklis G, Theocharis S. Zinc and the liver: an active interaction. Dig Dis Sci. 2007 Jul;52(7):1595-612. Abstract

6. Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr. 1998 Apr;17(2):109-15. Abstract

7. Zheng Y, Li XK, Wang Y, et al. The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators. Hemoglobin. 2008;32(1-2):135-45. Abstract

8. Nagalla S, Ballas SK. Drugs for preventing red blood cell dehydration in people with sickle cell disease. Cochrane Database Syst Rev. 2018 Oct 19;10:CD003426.Full text  Abstract

9. Kalantar-Zadeh K, Kopple JD. Trace elements and vitamins in maintenance dialysis patients. Adv Ren Replace Ther. 2003 Jul;10(3):170-82. Abstract

10. Mahajan SK. Zinc in kidney disease. J Am Coll Nutr. 1989 Aug;8(4):296-304. Abstract

11. Prasad AS. Zinc deficiency in patients with sickle cell disease. Am J Clin Nutr. 2002 Feb;75(2):181-2.Full text  Abstract

12. Koch J, Neal EA, Schlott MJ, et al. Zinc levels and infections in hospitalized patients with AIDS. Nutrition. 1996 Jul-Aug;12(7-8):515-8. Abstract

13. Kupka R, Fawzi W. Zinc nutrition and HIV infection. Nutr Rev. 2002 Mar;60(3):69-79. Abstract

14. Singhal N, Alam S, Sherwani R, et al. Serum zinc levels in celiac disease. Indian Pediatr. 2008 Apr;45(4):319-21. Abstract

15. Goh J, O'Morain CA. Review article: nutrition and adult inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Feb;17(3):307-20.Full text  Abstract

16. Ojuawo A, Keith L. The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease. Cent Afr J Med. 2002 Sep-Oct;48(9-10):116-9. Abstract

17. Narkewicz MR, Krebs N, Karrer F, et al. Correction of hypozincemia following liver transplantation in children is associated with reduced urinary zinc loss. Hepatology. 1999 Mar;29(3):830-3.Full text  Abstract

18. Stamoulis I, Kouraklis G, Theocharis S. Zinc and the liver: an active interaction. Dig Dis Sci. 2007 Jul;52(7):1595-612. Abstract

19. Mahajan SK. Zinc in kidney disease. J Am Coll Nutr. 1989 Aug;8(4):296-304. Abstract

20. Perrone L, Gialanella G, Giordano V, et al. Impaired zinc metabolic status in children affected by idiopathic nephrotic syndrome. Eur J Pediatr. 1990 Mar;149(6):438-40. Abstract

21. Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr. 1998 Apr;17(2):109-15. Abstract

22. Zheng Y, Li XK, Wang Y, et al. The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators. Hemoglobin. 2008;32(1-2):135-45. Abstract

23. Prasad AS. Zinc deficiency in patients with sickle cell disease. Am J Clin Nutr. 2002 Feb;75(2):181-2.Full text  Abstract

24. Koch J, Neal EA, Schlott MJ, et al. Zinc levels and infections in hospitalized patients with AIDS. Nutrition. 1996 Jul-Aug;12(7-8):515-8. Abstract

25. Kupka R, Fawzi W. Zinc nutrition and HIV infection. Nutr Rev. 2002 Mar;60(3):69-79. Abstract

26. Kang YJ, Zhou Z. Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med. 2005 Aug-Oct;26(4-5):391-404. Abstract

27. Rico H. Alcohol and bone disease. Alcohol Alcohol. 1990;25(4):345-52. Abstract

28. Hambidge KM, Krebs NF. Zinc deficiency: a special challenge. J Nutr. 2007 Apr;137(4):1101-5.Full text  Abstract

29. Atik OS, Uslu MM, Eksioglu F, et al. Etiology of senile osteoporosis: a hypothesis. Clin Orthop Relat Res. 2006 Feb;443:25-7. Abstract

30. Haase H, Mocchegiani E, Rink L. Correlation between zinc status and immune function in the elderly. BBiogerontology. 2006 Oct-Dec;7(5-6):421-8. Abstract

31. Prasad AS. Zinc deficiency. BMJ. 2003 Feb 22;326(7386):409-10.Full text  Abstract

32. Meunier N, O'Connor JM, Maiani G, et al. Importance of zinc in the elderly: the ZENITH study. Eur J Clin Nutr. 2005 Nov;59 Suppl 2:S1-4.Full text  Abstract

33. Prasad AS, Beck FW, Bao B, et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr. 2007 Mar;85(3):837-44.Full text  Abstract

34. Ackland ML, Michalczyk A. Zinc deficiency and its inherited disorders - a review. Genes Nutr. 2006 Mar;1(1):41-9. Abstract

35. Bhatnagar S, Natchu UC. Zinc in child health and disease. Indian J Pediatr. 2004 Nov;71(11):991-5. Abstract

36. Prasad AS, Miale A Jr, Farid Z, et al. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism. J Lab Clin Med. 1963 Apr;61:537-49. Abstract

37. Müller O, Krawinkel M. Malnutrition and health in developing countries. CMAJ. 2005 Aug 2;173(3):279-86.Full text  Abstract

38. Jameson S. Coeliac disease, insulin-like growth factor, bone mineral density, and zinc. Scand J Gastroenterol. 2000 Aug;35(8):894-6. Abstract

39. Altuntas B, Filik B, Ensari A, et al. Can zinc deficiency be used as a marker for the diagnosis of celiac disease in Turkish children with short stature? Pediatr Int. 2000 Dec;42(6):682-4. Abstract

40. El-Tawil AM. Zinc deficiency in men with Crohn's disease may contribute to poor sperm function and male infertility. Andrologia. 2003 Dec;35(6):337-41. Abstract

41. Shen YC, Chang YH, Fang CJ, et al. Zinc supplementation in patients with cirrhosis and hepatic encephalopathy: a systematic review and meta-analysis. Nutr J. 2019 Jul 6;18(1):34.Full text  Abstract

42. Tumer N, Baskan S, Arcasoy A, et al. Hypozincemia in nephrotic syndrome. Clin Nephrol. 1991 Mar;35(3):135-7. Abstract

43. Stec J, Podracka L, Pavkovcekova O, et al. Zinc and copper metabolism in nephrotic syndrome. Nephron. 1990;56(2):186-7. Abstract

44. Mafra D, Cuppari L, Favaro DI, et al. Zinc levels after iron supplementation in patients with chronic kidney disease. J Ren Nutr. 2004 Jul;14(3):164-9. Abstract

45. Yuzbasiyan-Gurkan VA, Brewer GJ, Vander AJ, et al. Net renal tubular reabsorption of zinc in healthy man and impaired handling in sickle cell anemia. Am J Hematol. 1989 Jun;31(2):87-90. Abstract

46. Salgueiro MJ, Krebs N, Zubillaga MB, et al. Zinc and diabetes mellitus: is there a need of zinc supplementation in diabetes mellitus patients? Biol Trace Elem Res. 2001 Sep;81(3):215-28. Abstract

47. El Dib R, Gameiro OL, Ogata MS, et al. Zinc supplementation for the prevention of type 2 diabetes mellitus in adults with insulin resistance. Cochrane Database Syst Rev. 2015;(5):CD005525.Full text  Abstract

48. Visser ME, Durao S, Sinclair D, et al. Micronutrient supplementation in adults with HIV infection. Cochrane Database Syst Rev. 2017;(5):CD003650.Full text  Abstract

49. Freiberg MS, Cheng DM, Gnatienko N, et al. Effect of Zinc Supplementation vs Placebo on Mortality Risk and HIV Disease Progression Among HIV-Positive Adults With Heavy Alcohol Use: A Randomized Clinical Trial. JAMA Netw Open. 2020 May 1;3(5):e204330.Full text  Abstract

50. Siegfried N, Irlam JH, Visser ME, et al. Micronutrient supplementation in pregnant women with HIV infection. Cochrane Database Syst Rev. 2012;(3):CD009755. Abstract

51. Zima T, Fialova L, Mestek O, et al. Oxidative stress, metabolism of ethanol and alcohol-related diseases. J Biomed Sci. 2001 Jan-Feb;8(1):59-70. Abstract

52. Chaudhry AA, Warthan MM, Pariser RJ, et al. Acquired acrodermatitis enteropathica secondary to alcoholism. Cutis. 2008 Jul;82(1):60-2. Abstract

53. West BL, Anderson PC. Alcohol and acquired acrodermatitis enteropathica. J Am Acad Dermatol. 1986 Dec;15(6):1305. Abstract

54. Hunt JR. Moving toward a plant-based diet: are iron and zinc at risk? Nutr Rev. 2002 May;60(5 Pt 1):127-34. Abstract

55. Donovan UM, Gibson RS. Iron and zinc status of young women aged 14 to 19 years consuming vegetarian and omnivorous diets. J Am Coll Nutr. 1995 Oct;14(5):463-72. Abstract

56. Gardner CD, Kim S, Bersamin A, et al. Micronutrient quality of weight-loss diets that focus on macronutrients: results from the A TO Z study. Am J Clin Nutr. 2010 Aug;92(2):304-12.Full text  Abstract

57. Lutter CK, Rivera JA. Nutritional status of infants and young children and characteristics of their diets. J Nutr. 2003 Sep;133(9):2941S-9S.Full text  Abstract

58. Lindberg L, Ostberg M, Isacson IM, et al. Feeding disorders related to nutrition. Acta Paediatr. 2006 Apr;95(4):425-9. Abstract

59. Castro J, Deulofeu R, Gila A, et al. Persistence of nutritional deficiencies after short-term weight recovery in adolescents with anorexia nervosa. Int J Eat Disord. 2004 Mar;35(2):169-78. Abstract

60. Das JK, Kumar R, Salam RA, et al. Systematic review of zinc fortification trials. Ann Nutr Metab. 2013;62(suppl 1):44-56.Full text  Abstract

61. Shah D, Sachdev HS, Gera T, et al. Fortification of staple foods with zinc for improving zinc status and other health outcomes in the general population. Cochrane Database Syst Rev. 2016;(6):CD010697.Full text  Abstract

62. Stewart CP, Christian P, LeClerq SC, et al. Antenatal supplementation with folic acid + iron + zinc improves linear growth and reduces peripheral adiposity in school-age children in rural Nepal. Am J Clin Nutr. 2009 Jul;90(1):132-40.Full text  Abstract

63. Mayo-Wilson E, Junior JA, Imdad A, et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database Syst Rev. 2014;(5):CD009384.Full text  Abstract

64. Garcia-Guerra A, Neufeld LM, Hernandez-Cordero S, et al. Prenatal multiple micronutrient supplementation impact on biochemical indicators during pregnancy and postpartum. Salud Publica Mex. 2009 Jul-Aug;51(4):327-35.Full text  Abstract

65. Carducci B, Keats EC, Bhutta ZA. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev. 2021 Mar 16;3:CD000230.Full text  Abstract

66. Lassi ZS, Kurji J, Oliveira CS, et al. Zinc supplementation for the promotion of growth and prevention of infections in infants less than six months of age. Cochrane Database Syst Rev. 2020 Apr 8;4:CD010205.Full text  Abstract

67. U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary guidelines for Americans, 2020-2025. Dec 2020 [internet publication].Full text  Abstract

68. Troesch B, van Stujivenberg ME, Smuts CM, et al. A micronutrient powder with low doses of highly absorbable iron and zinc reduces iron and zinc deficiency and improves weight-for-age Z-scores in South African children. J Nutr. 2011 Feb;141(2):237-42.Full text  Abstract

69. DiGirolamo AM, Ramirez-Zea M, Wang M, et al. Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala. Am J Clin Nutr. 2010 Nov;92(5):1241-50.Full text  Abstract

70. Lassi ZS, Moin A, Bhutta ZA. Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months. Cochrane Database Syst Rev. 2016;(12):CD005978.Full text  Abstract

71. Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis. Pediatrics. 2007 Jun;119(6):1120-30. Abstract

72. Haase H, Overbeck S, Rink L. Zinc supplementation for the treatment or prevention of disease: current status and future perspectives. Exp Gerontol. 2008 May;43(5):394-408. Abstract

73. Gibson RS, Hess SY, Hotz C, et al. Indicators of zinc status at the population level: a review of the evidence. Br J Nutr. 2008 Jun;99(suppl 3):S14-23. Abstract

74. Kodama H, Tanaka M, Naito Y, et al. Japan's Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis. Int J Mol Sci. 2020 Apr 22;21(8):.Full text  Abstract

75. Kumbargere Nagraj S, George RP, Shetty N, et al. Interventions for managing taste disturbances. Cochrane Database Syst Rev. 2017 Dec 20;12:CD010470.Full text  Abstract

76. Hess SY, King JC. Effects of maternal zinc supplementation on pregnancy and lactation outcomes. Food Nutr Bull. 2009 Mar;30(1 suppl):S60-78.Full text  Abstract

77. Shah D, Sachdev HP. Zinc deficiency in pregnancy and fetal outcome. Nutr Rev. 2006 Jan;64(1):15-30. Abstract

78. Carducci B, Keats EC, Bhutta ZA. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev. 2021 Mar 16;3:CD000230.Full text  Abstract

79. Stewart CP, Christian P, LeClerq SC, et al. Antenatal supplementation with folic acid + iron + zinc improves linear growth and reduces peripheral adiposity in school-age children in rural Nepal. Am J Clin Nutr. 2009 Jul;90(1):132-40.Full text  Abstract

80. Heaney RP. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr. 2004 Dec;80(6 suppl):1706S-9S.Full text  Abstract

81. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;7(5):439-43. Abstract

82. Hambidge M. Human zinc deficiency. J Nutr. 2000;130(5S suppl):1344S-1349S.Full text  Abstract

83. Kodama H, Tanaka M, Naito Y, et al. Japan's Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis. Int J Mol Sci. 2020 Apr 22;21(8):.Full text  Abstract

84. Vakili R, Vahedian M, Khodaei GH, et al. Effects of zinc supplementation in occurrence and duration of common cold in school aged children during cold season: a double-blind placebo-controlled trial. Iran J Pediatr. 2009;19:376-80.Full text

85. Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016;(12):CD005436.Full text  Abstract

86. Mazariegos M, Hambidge KM, Westcott JE, et al. Neither a zinc supplement nor phytate-reduced maize nor their combination enhance growth of 6- to 12-month-old Guatemalan infants. J Nutr. 2010 May;140(5):1041-8.Full text  Abstract

87. Chang S, El AS, Bari S, et al. Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. Eur J Clin Nutr. 2010 Feb;64(2):153-60.Full text  Abstract

88. Institute of Medicine (U.S.). Panel on Micronutrients. DRI: Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Chapter 12: zinc. Washington, DC: National Academy Press; 2001:442-501.Full text

89. Sriram K, Lonchyna VA. Micronutrient supplementation in adult nutrition therapy: practical considerations. JPEN J Parenter Enteral Nutr. 2009 Sep-Oct;33(5):548-62. Abstract

90. Wang LJ, Wang MQ, Hu R, et al. Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. Biomed Res Int. 2017;2017:1024769.Full text  Abstract

91. Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections: a review of the evidence. Food Nutr Bull. 2009 Mar;30(1 suppl):S41-59.Full text  Abstract

92. Fischer Walker C, Black RE. Zinc and the risk for infectious disease. Annu Rev Nutr. 2004;24:255-75. Abstract

93. Valentiner-Branth P, Shrestha PS, Chandyo RK, et al. A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr. 2010 Jun;91(6):1667-74.Full text  Abstract

94. Yakoob MY, Theodoratou E, Jabeen A, et al. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health. 2011 Apr 13;11(suppl 3):S23.Full text  Abstract

95. Imdad A, Bhutta ZA. Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool. BMC Public Health. 2011 Apr 13;11(suppl 3):S22.Full text  Abstract

96. Cole CR, Lifshitz F. Zinc nutrition and growth retardation. Pediatr Endocrinol Rev. 2008 Jun;5(4):889-96.Full text  Abstract

97. Brown KH, Peerson JM, Baker SK, et al. Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food Nutr Bull. 2009 Mar;30(1 suppl):S12-40.Full text  Abstract

98. Black MM. The evidence linking zinc deficiency with children's cognitive and motor functioning. J Nutr. 2003 May;133(5 suppl 1):1473S-6S.Full text  Abstract

99. Sayeg Porto MA, Oliveira HP, Cunha AJ, et al. Linear growth and zinc supplementation in children with short stature. J Pediatr Endocrinol Metab. 2000 Sep-Oct;13(8):1121-8.Full text  Abstract

100. Palacios C. The role of nutrients in bone health, from A to Z. Crit Rev Food Sci Nutr. 2006;46(8):621-8. Abstract

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