Salicylate poisoning

References

Key articles

Chyka PA, Erdman AR, Christianson G, et al. Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2007;45(2):95-131.Full text  Abstract

Dargan PI, Wallace CI, Jones AL. An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose. Emerg Med J. 2002 May;19(3):206-9.Full text  Abstract

Reference articles

1. Chyka PA, Erdman AR, Christianson G, et al. Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2007;45(2):95-131.Full text  Abstract

2. Gummin DD, Mowry JB, Spyker DA, et al. 2017 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 35th Annual Report. Clin Toxicol (Phila). 2018 Dec 21;56(12):1213-415.Full text  Abstract

3. Srisuma S, Cao D, Kleinschmidt K, et al. Missed opportunities?: an evaluation of potentially preventable poisoning deaths. Clin Toxicol (Phila). 2016 Mar 21;54(5):441-6. Abstract

4. Hawton K, Simkin S, Deeks J, et al. UK legislation on analgesic packs: before and after study of long term effect on poisonings. BMJ. 2004 Nov 6;329(7474):1076.Full text  Abstract

5. International Programme on Chemical Safety. Poisoning prevention and management. 2015 [internet publication].Full text

6. Vandenberg SA, Smolinske SC, Spoerke DG, et al. Non-aspirin salicylates: conversion factors for estimating aspirin equivalency. Vet Hum Toxicol. 1989 Feb;31(1):49-50. Abstract

7. McEvoy GK, ed. AHFS drug information 2004. Bethesda, MD: American Society of Health-System Pharmacists; 2004:1956.

8. Davison C. Salicylate metabolism in man. Ann NY Acad Sci. 1971 Jul 6;179:249-68. Abstract

9. Gabow PA, Anderson RJ, Potts DE, et al. Acid-base disturbances in the salicylate-intoxicated adult. Arch Intern Med. 1978 Oct;138(10):1481-4. Abstract

10. Reed JR, Palmisano PA. Central nervous system salicylate. Clin Toxicol. 1975;8(6):623-31. Abstract

11. Snodgrass W, Rumack BH, Peterson RG, et al. Salicylate toxicity following therapeutic doses in young children. Clin Toxicol. 1981 Mar;18(3):247-59. Abstract

12. Jacob J, Lavonas EJ. Falsely normal anion gap in severe salicylate poisoning caused by laboratory interference. Ann Emerg Med. 2011 Sep;58(3):280-1 Abstract

13. Rich RR, Johnson JS. Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis. Arthritis Rheum. 1973 Jan-Feb;16(1):1-9. Abstract

14. Wolfe JD, Metzger AL, Goldstein RC. Aspirin hepatitis. Ann Intern Med. 1974 Jan;80(1):74-6. Abstract

15. Dargan PI, Wallace CI, Jones AL. An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose. Emerg Med J. 2002 May;19(3):206-9.Full text  Abstract

16. Kent K, Ganetsky M, Cohen J, et al. Non-fatal ventricular dysrhythmias associated with severe salicylate toxicity. Clin Toxicol (Phila). 2008 Apr;46(4):297-9. Abstract

17. Fahlen M, Duarte AG. Gait disturbance, confusion, and coma in a 93-year-old blind woman. Chest. 2001 Jul;120(1):295-7.Full text  Abstract

18. Lynd LD, Richardson KJ, Purssell RA, et al. An evaluation of the osmole gap as a screening test for toxic alcohol poisoning. BMC Emerg Med. 2008 Apr 28;8:5.Full text  Abstract

19. Done AK. Aspirin overdose: incidence, diagnosis and management. Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):890-7.

20. Dugandzic RM, Tierney MG, Dickinson GE, et al. Evaluation of the validity of the Done nomogram in the management of acute salicylate intoxication. Ann Emerg Med. 1989 Nov;18(11):1186-90. Abstract

21. The Royal Children's Hospital Melbourne. Salicylates poisoning. June 2017 [internet publication].Full text

22. Barone, J, Raia J, Huang YC. Evaluation of the effects of multiple-dose activated charcoal on the absorption of orally administered salicylate in a simulated toxic ingestion model. Ann Emerg Med. 1988 Jan;17(1):34-7. Abstract

23. Neuvonen PJ, Elfving SM, Elonen E. Reduction of absorption of digoxin, phenytoin, and aspirin by activated charcoal in man. Eur J Clin Pharmacol. 1978 May 31;13(3):213-8. Abstract

24. Johnson D, Eppler J, Giesbrecht E, et al. Effect of multiple-dose activated charcoal on the clearance of high-dose intravenous aspirin in a porcine model. Ann Emerg Med. 1995 Nov;26(5):569-74. Abstract

25. Prescott LF, Balali-Mood M, Critchley JA, et al. Diuresis or urinary alkalinisation for salicylate poisoning? BMJ. 1982 Nov 13;285(6352):1383-6.Full text  Abstract

26. Oh MS, Halperin ML. Toxin-induced metabolic acidosis. In: Gennari FJ, Adrogue HJ, Galla JH, et al, eds. Acid-base disorders and their treatment. Boca Raton, FL: Taylor & Francis; 2005:383-416.

27. Vree TB, Van Ewijk-Beneken Kolmer EW, Verwey-Van Wissen CP, et al. Effect of urinary pH on the pharmacokinetics of salicylate acid, with its glycine and glucoronide conjugates in humans. Int J Clin Pharmacol Ther. 1994 Oct;32(10):550-8. Abstract

28. Dove DJ, Jones T. Delayed coma associated with salicylate intoxication. J Pediatr. 1982 Mar;100(3):493-6. Abstract

29. Higgins RM, Connolly JO, Hendry BM. Alkalinization and hemodialysis in severe salicylate poisoning: comparison of elimination techniques in the same patient. Clin Nephrol. 1998 Sep;50(3):178-83. Abstract

30. American Academy of Clinical Toxicology, European Association of Poisons Centres and Clinical Toxicologists. Position paper: single-dose activated charcoal. Clin Toxicol (Phila). 2005;43(2):61-87.Full text  Abstract

31. Proudfoot AT, Krenzelok EP, Vale JA. Position paper on urine alkalinization. J Toxicol Clin Toxicol. 2004;42(1):1-26.Full text  Abstract

32. Done AK. Salicylate intoxication: significance of measurements of salicylate in blood in cases of acute ingestion. Pediatrics. 1960 Nov;26:800-7. Abstract

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