Precocious puberty

References

Key articles

Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969 Jun;44(235):291-303.Full text  Abstract

Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child. 1970 Feb;45(239):13-23.Full text  Abstract

Bangalore Krishna K, Fuqua JS, Rogol AD, et al. Use of gonadotropin-releasing hormone analogs in children: update by an international consortium. Horm Res Paediatr. 2019;91(6):357-72.Full text  Abstract

Reference articles

1. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969 Jun;44(235):291-303.Full text  Abstract

2. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child. 1970 Feb;45(239):13-23.Full text  Abstract

3. Cesario SK, Hughes LA. Precocious puberty: a comprehensive review of literature. J Obstet Gynecol Neonatal Nurs. 2007 May-Jun;36(3):263-74. Abstract

4. Bridges NA, Christopher JA, Hindmarsh PC, et al. Sexual precocity: sex incidence and aetiology. Arch Dis Child. 1994 Feb;70(2):116-8.Full text  Abstract

5. Pescovitz OH, Comite F, Hench K, et al. The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy. J Pediatr. 1986 Jan;108(1):47-54. Abstract

6. Teilmann G, Pedersen CB, Jensen TK, et al. Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries. Pediatrics. 2005 Dec;116(6):1323-8. Abstract

7. Stanhope R, Brook CG, Pringle PJ, et al. Induction of puberty by pulsatile gonadotropin releasing hormone. Lancet. 1987 Sep 5;2(8558):552-5. Abstract

8. Biro FM, Galvez MP, Greenspan LC, et al. Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics. 2010 Sep;126(3):e583-90.Full text  Abstract

9. Carel JC, Léger J. Clinical practice. Precocious puberty. N Engl J Med. 2008 May 29;358(22):2366-77. Abstract

10. Tanner JM. Trend towards earlier menarche in London, Oslo, Copenhagen, the Netherlands and Hungary. Nature. 1973 May 11;243(5402):95-6. Abstract

11. Biro FM, Khoury P, Morrison JA. Influence of obesity on timing of puberty. Int J Androl. 2006 Feb;29(1):272-7. Abstract

12. Delemarre-van de Waal HA. Secular trend of timing of puberty. Endocr Dev. 2005;8:1-14. Abstract

13. Parent AS, Franssen D, Fudvoye J, et al. Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: revision of human observations and mechanistic insight from rodents. Front Neuroendocrinol. 2015 Jul;38:12-36.Full text  Abstract

14. Eckert-Lind C, Busch AS, Petersen JH, et al. Worldwide secular trends in age at pubertal onset assessed by breast development among girls: a systematic review and meta-analysis. JAMA Pediatr. 2020 Apr 1;174(4):e195881.Full text  Abstract

15. de la Puente ML, Canela J, Alvarez J, et al. Cross-sectional growth study of the child and adolescent population of Catalonia (Spain). Ann Hum Biol. 1997 Sep-Oct;24(5):435-52. Abstract

16. Mul D, Fredriks AM, van Buuren S, et al. Pubertal development in The Netherlands 1965-1997. Pediatr Res. 2001 Oct;50(4):479-86. Abstract

17. Wu T, Mendola P, Buck GM. Ethnic differences in the presence of secondary sex characteristics and menarche among US girls: the Third National Health and Nutrition Examination Survey, 1988-1994. Pediatrics. 2002 Oct;110(4):752-7. Abstract

18. Himes JH. Examining the evidence for recent secular changes in the timing of puberty in US children in light of increases in the prevalence of obesity. Mol Cell Endocrinol. 2006;254-55:13-21. Abstract

19. Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003-2006. JAMA. 2008 May 28;299(20):2401-5.Full text  Abstract

20. Osler DC, Crawford JD. Examination of the hypothesis of a critical weight at menarche in ambulatory and bedridden mentally retarded girls. Pediatrics. 1973 Apr;51(4):675-9. Abstract

21. Day FR, Bulik-Sullivan B, Hinds DA, et al. Shared genetic aetiology of puberty timing between sexes and with health-related outcomes. Nat Commun. 2015 Nov 9;6:8842.Full text  Abstract

22. Massart F, Parrino R, Seppia P, et al. How do environmental estrogen disruptors induce precocious puberty? Minerva Pediatr. 2006 Jun;58(3):247-54. Abstract

23. Cantas-Orsdemir S, Garb JL, Allen HF. Prevalence of cranial MRI findings in girls with central precocious puberty: a systematic review and meta-analysis. J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):701-10.Full text  Abstract

24. De Sanctis V, Corrias A, Rizzo V, et al. Etiology of central precocious puberty in males: the results of the Italian Study Group for Physiopathology of Puberty. J Pediatr Endocrinol Metab. 2000 Jul;13(suppl 1):687-93. Abstract

25. Yoon JS, So CH, Lee HS, et al. The prevalence of brain abnormalities in boys with central precocious puberty may be overestimated. PLoS One. 2018;13(4):e0195209.Full text  Abstract

26. Lee J, Kim J, Yang A, et al. Etiological trends in male central precocious puberty. Ann Pediatr Endocrinol Metab. 2018 Jun;23(2):75-80.Full text  Abstract

27. Habiby R, Silverman B, Listernick R, et al. Precocious puberty in children with neurofibromatosis type 1. J Pediatr. 1995 Mar;126(3):364-7. Abstract

28. Carmi D, Shohat M, Metzker A, et al. Growth, puberty, and endocrine functions in patients with sporadic or familial neurofibromatosis type 1: a longitudinal study. Pediatrics. 1999 Jun;103(6 Pt 1):1257-62. Abstract

29. Ogilvy-Stuart AL, Clayton PE, Shalet SM. Cranial irradiation and early puberty. J Clin Endocrinol Metab. 1994 Jun;78(6):1282-6. Abstract

30. Latronico AC, Brito VN, Carel JC. Causes, diagnosis, and treatment of central precocious puberty. Lancet Diabetes Endocrinol. 2016 Mar;4(3):265-74. Abstract

31. Teles MG, Bianco SD, Brito VN, et al. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med. 2008 Feb 14;358(7):709-15.Full text  Abstract

32. Abreu AP, Dauber A, Macedo DB, et al. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27;368(26):2467-75.Full text  Abstract

33. Dauber A, Cunha-Silva M, Macedo DB, et al. Paternally inherited DLK1 deletion associated with familial central precocious puberty. J Clin Endocrinol Metab. 2017 May 1;102(5):1557-67.Full text  Abstract

34. Nanduri VR, Stanhope R. Why is the retention of gonadotropin secretion common in children with panhypopituitarism due to septo-optic dysplasia? Eur J Endocrinol. 1999 Jan;140(1):48-50. Abstract

35. Parent AS, Teilmann G, Juul A, et al. The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev. 2003 Oct;24(5):668-93.Full text  Abstract

36. Proos LA, Hofvander Y, Tuvemo T. Menarcheal age and growth pattern of Indian girls adopted in Sweden - I: menarcheal age. Acta Paediatr Scand. 1991 Aug-Sep;80(8-9):852-8. Abstract

37. Herman-Giddens ME, Sandler AD, Friedman NE. Sexual precocity in girls: an association with sexual abuse? Am J Dis Child. 1988 Apr;142(4):431-3. Abstract

38. Nogueira K, Liberman B, Pimentel-Filho FR, et al. hCG-secreting pineal teratoma causing precocious puberty: report of two patients and review of the literature. J Pediatr Endocrinol Metab. 2002 Sep-Oct;15(8):1195-201. Abstract

39. Ojeda SR, Lomniczi A, Mastronardi C, et al. Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach? Endocrinology. 2006 Mar;147(3):1166-74.Full text  Abstract

40. Howard SR. Interpretation of reproductive hormones before, during and after the pubertal transition-Identifying health and disordered puberty. Clin Endocrinol (Oxf). 2021 Nov;95(5):702-15.Full text  Abstract

41. Martha PM Jr, Rogol AD, Veldhuis JD, et al. Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. J Clin Endocrinol Metab. 1989 Sep;69(3):563-70. Abstract

42. Veldhuis JD, Metzger DL, Martha PM Jr, et al. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab. 1997 Oct;82(10):3414-20. Abstract

43. Ogilvy-Stuart AL, Clayton PE, Shalet SM. Cranial irradiation and early puberty. J Clin Endocrinol Metab. 1994 Jun;78(6):1282-6. Abstract

44. Latronico AC, Abell AN, Arnhold IJ, et al. A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty. J Clin Endocrinol Metab. 1998 Jul;83(7):2435-40. Abstract

45. Kremer H, Martens JW, van Reen M, et al. A limited repertoire of mutations of the luteinizing hormone (LH) receptor gene in familial and sporadic patients with male LH-independent precocious puberty. J Clin Endocrinol Metab. 1999 Mar;84(3):1136-40. Abstract

46. Hayes P. International adoption, "early" puberty, and underrecorded age. Pediatrics. 2013 Jun;131(6):1029-31. Abstract

47. Jung H, Parent AS, Ojeda SR. Hypothalamic hamartoma: a paradigm/model for studying the onset of puberty. Endocr Dev. 2005;8:81-93. Abstract

48. Zacharin M. The spectrum of McCune Albright syndrome. Pediatr Endocrinol Rev. 2007 Aug;4(suppl 4):412-8. Abstract

49. Volkl TM, Dorr HG. McCune-Albright syndrome: clinical picture and natural history in children and adolescents. J Pediatr Endocrinol Metab. 2006 May;19(suppl 2):551-9. Abstract

50. Mieszczak J, Eugster EA. Treatment of precocious puberty in McCune-Albright syndrome. Pediatr Endocrinol Rev. 2007 Aug;4(suppl 4):419-22. Abstract

51. Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952 Apr;40(4):423-41. Abstract

52. Pasternak Y, Friger M, Loewenthal N, et al. The utility of basal serum LH in prediction of central precocious puberty in girls. Eur J Endocrinol. 2012 Feb;166(2):295-9. Abstract

53. Howard SR, Ghauri R, El-Khairi R. GnRH analogue stimulation testing to Investigate precocious puberty. Jul 2021 [internet publication].Full text

54. Mahachoklertwattana P, Kaplan SL, Grumbach MM. The luteinizing hormone-releasing hormone-secreting hypothalamic hamartoma is a congenital malformation: natural history. J Clin Endocrinol Metab. 1993 Jul;77(1):118-24. Abstract

55. Kaplowitz PB. Do 6-8 year old girls with central precocious puberty need routine brain imaging? Int J Pediatr Endocrinol. 2016 May 4;2016:9.Full text  Abstract

56. Palmert MR, Dunkel L. Clinical practice. Delayed puberty. N Engl J Med. 2012 Feb 2;366(5):443-53. Abstract

57. Kaplowitz P, Bloch C; Section on Endocrinology, American Academy of Pediatrics. Evaluation and referral of children with signs of early puberty. Pediatrics. 2016 Jan;137(1).Full text  Abstract

58. Eugster EA. Treatment of central precocious puberty. J Endocr Soc. 2019 May 1;3(5):965-72.Full text  Abstract

59. Lewis KA, Goldyn AK, West KW, et al. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6.Full text  Abstract

60. Eugster EA, Clarke W, Kletter GB, et al. Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial. J Clin Endocrinol Metab. 2007 May;92(5):1697-704. Abstract

61. Hirsch HJ, Gillis D, Strich D, et al. The histrelin implant: a novel treatment for central precocious puberty. Pediatrics. 2005 Dec;116(6):e798-802. Abstract

62. Tuvemo T. Treatment of central precocious puberty. Expert Opin Investig Drugs. 2006 May;15(5):495-505. Abstract

63. Galluzzi F, Salti R, Bindi G, et al. Adult height comparison between boys and girls with precocious puberty after long-term gonadotrophin-releasing hormone analogue therapy. Acta Paediatr. 1998 May;87(5):521-7. Abstract

64. Paul D, Conte FA, Grumbach MM, et al. Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5 years. J Clin Endocrinol Metab. 1995 Feb;80(2):546-51. Abstract

65. Kletter GB, Kelch RP. Clinical review 60: effects of gonadotropin-releasing hormone analog therapy on adult stature in precocious puberty. J Clin Endocrinol Metab. 1994 Aug;79(2):331-4. Abstract

66. Bangalore Krishna K, Fuqua JS, Rogol AD, et al. Use of gonadotropin-releasing hormone analogs in children: update by an international consortium. Horm Res Paediatr. 2019;91(6):357-72.Full text  Abstract

67. Kaplowitz PB, Backeljauw PF, Allen DB. Toward more targeted and cost-effective gonadotropin-releasing hormone analog treatment in girls with central precocious puberty. Horm Res Paediatr. 2018;90(1):1-7.Full text  Abstract

68. Syed FA, Chalew SA. Ketoconazole treatment of gonadotropin independent precocious puberty in girls with McCune-Albright syndrome: a preliminary report. J Pediatr Endocrinol Metab. 1999 Jan-Feb;12(1):81-3. Abstract

69. Feuillan PP, Foster CM, Pescovitz OH, et al. Treatment of precocious puberty in the McCune-Albright syndrome with the aromatase inhibitor testolactone. N Engl J Med. 1986 Oct 30;315(18):1115-9. Abstract

70. Feuillan P, Calis K, Hill S, et al. Letrozole treatment of precocious puberty in girls with the McCune-Albright syndrome: a pilot study. J Clin Endocrinol Metab. 2007 Jun;92(6):2100-6. Abstract

71. Kreher NC, Pescovitz OH, Delameter P, et al. Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole. J Pediatr. 2006 Sep;149(3):416-20. Abstract

72. Feuillan P, Merke D, Leschek EW, et al. Use of aromatase inhibitors in precocious puberty. Endocr Relat Cancer. 1999 Jun;6(2):303-6.Full text  Abstract

73. Leschek EW, Jones J, Barnes KM, et al. Six-year results of spironolactone and testolactone treatment of familial male-limited precocious puberty with addition of deslorelin after central puberty onset. J Clin Endocrinol Metab. 1999 Jan;84(1):175-8. Abstract

74. Laue L, Kenigsberg D, Pescovitz OH, et al. Treatment of familial male precocious puberty with spironolactone and testolactone. N Engl J Med. 1989 Feb 23;320(8):496-502. Abstract

75. US Food and Drug Administration. FDA drug safety communication: FDA limits usage of Nizoral (ketoconazole) oral tablets due to potentially fatal liver injury and risk of drug interactions and adrenal gland problems. 19 May 2016 [internet publication].Full text

76. Lee PA. Medroxyprogesterone therapy for sexual precocity in girls. Am J Dis Child. 1981 May;135(5):443-5. Abstract

77. Eugster EA, Rubin SD, Reiter EO, et al. Tamoxifen treatment for precocious puberty in McCune-Albright syndrome: a multicenter trial. J Pediatr. 2003 Jul;143(1):60-6. Abstract

78. Carel JC, Lahlou N, Roger M, et al. Precocious puberty and statural growth. Hum Reprod Update. 2004 Mar-Apr;10(2):135-47.Full text  Abstract

79. Cook DM, Yuen KC, Biller BM, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone-deficient adults and transition patients - 2009 update. Endocr Pract. 2009 Sep-Oct;15(suppl 2):1-29. Abstract

80. GH Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab. 2000 Nov;85(11):3990-3.Full text  Abstract

81. Almeida MQ, Brito VN, Lins TS, et al. Long-term treatment of familial male-limited precocious puberty (testotoxicosis) with cyproterone acetate or ketoconazole. Clin Endocrinol (Oxf). 2008 Jul;69(1):93-8. Abstract

82. Paterson WF, McNeill E, Young D, et al. Auxological outcome and time to menarche following long-acting goserelin therapy in girls with central precocious or early puberty. Clin Endocrinol (Oxf). 2004 Nov;61(5):626-34. Abstract

83. Paterson WF, Hollman AS, Reid S, et al. Efficacy of Zoladex LA (goserelin) in the treatment of girls with central precocious or early puberty. Arch Dis Child. 1998 Oct;79(4):323-7.Full text  Abstract

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