Acute asthma exacerbation in children

References

Key articles

Global Initiative for Asthma. 2024 GINA report, global strategy for asthma management and prevention. May 2024 [Internet publication].Full text

British Thoracic Society/Scottish Intercollegiate Guidelines Network. SIGN 158: British guideline on the management of asthma. A national clinical guideline. Jul 2019 [internet publication].Full text

Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC), Cloutier MM, Baptist AP, et al. 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec;146(6):1217-70.Full text  Abstract

National Asthma Council. Australian asthma handbook. April 2022 [internet publication].Full text

Reference articles

1. Mallol J, Crane J, von Mutius E, et al; ISAAC Phase Three Study Group. The International Study of Asthma and Allergies in Childhood (ISAAC) phase three: a global synthesis. Allergol Immunopathol (Madr). 2013 Mar-Apr;41(2):73-85.Full text  Abstract

2. Serebrisky D, Wiznia A. Pediatric asthma: a global epidemic. Ann Glob Health. 2019 Jan 22;85(1):6.Full text  Abstract

3. Centers for Disease Control and Prevention. Most recent national asthma data. May 2023 [internet publication].Full text

4. American Lung Association. Asthma and children fact sheet. 2023 [internet publication].Full text

5. Becker CD, Scheidegger J, Marincek B. Hepatic vein occlusion: morphologic features on computed tomography and ultrasonography. Gastrointest Radiol. 1986;11(4):305-11. Abstract

6. Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995 May 13;310(6989):1225-9.Full text  Abstract

7. Global Initiative for Asthma. 2024 GINA report, global strategy for asthma management and prevention. May 2024 [Internet publication].Full text

8. Greenberg SB. Respiratory consequences of rhinovirus infection. Arch Intern Med. 2003 Feb 10;163(3):278-84.Full text  Abstract

9. Perez A, Lively JY, Curns A, et al. Respiratory virus surveillance among children with acute respiratory illnesses - new vaccine surveillance network, , United States, 2016-2021. MMWR Morb Mortal Wkly Rep. 2022 Oct 7;71(40):1253-9.Full text  Abstract

10. Pike KC, Akhbari M, Kneale D, et al. Interventions for autumn exacerbations of asthma in children. Cochrane Database Syst Rev. 2018 Mar 8;3(3):CD012393.Full text  Abstract

11. Singh AM, Busse WW. Asthma exacerbations. 2: Aetiology. Thorax. 2006 Sep;61(9):809-16.Full text  Abstract

12. Biscardi S, Lorrot M, Marc E, et al. Mycoplasma pneumoniae and asthma in children. Clin Infect Dis. 2004 May 15;38(10):1341-6. Abstract

13. Custovic A, de Moira AP, Murray CS, et al. Environmental influences on childhood asthma: allergens. Pediatr Allergy Immunol. 2023 Feb;34(2):e13915.Full text  Abstract

14. Agnihotri NT, Saltoun C. Acute severe asthma (status asthmaticus). Allergy Asthma Proc. 2019 Nov 1;40(6):406-9. Abstract

15. Torres I. When is TMJ surgery indicated? J Oral Maxillofac Surg. 1987 Feb;45(2):98. Abstract

16. Zheng XY, Ding H, Jiang LN, et al. Association between air pollutants and asthma emergency room visits and hospital admissions in time series studies: a systematic review and meta-analysis. PLoS One. 2015;10(9):e0138146.Full text  Abstract

17. Lim H, Kwon HJ, Lim JA, et al. Short-term effect of fine particulate matter on children's hospital admissions and emergency department visits for asthma: a systematic review and meta-analysi. J Prev Med Public Health. 2016 Jul;49(4):205-19.Full text  Abstract

18. Nassikas NJ, McCormack MC, Ewart G, et al. Indoor air sources of outdoor air pollution: health consequences, policy, and recommendations: an official American Thoracic Society workshop report. Ann Am Thorac Soc. 2024 Mar;21(3):365-76.Full text  Abstract

19. McArdle CE, Dowling TC, Carey K, et al. Asthma-associated emergency department visits during the Canadian Wildfire Smoke Episodes - United States, April-August 2023. MMWR Morb Mortal Wkly Rep. 2023 Aug 25;72(34):926-32.Full text  Abstract

20. Meek HC, Aydin-Ghormoz H, Bush K, et al. Notes from the field: asthma-associated emergency department visits during a wildfire smoke event - New York, June 2023. MMWR Morb Mortal Wkly Rep. 2023 Aug 25;72(34):933-5.Full text  Abstract

21. McDonald VM, Archbold G, Beyene T, et al. Asthma and landscape fire smoke: a Thoracic Society of Australia and New Zealand position statement. Respirology. 2023 Nov;28(11):1023-35.Full text  Abstract

22. Anderson SD. How does exercise cause asthma attacks? Curr Opin Allergy Clin Immunol. 2006 Feb;6(1):37-42. Abstract

23. Johnston NW, Sears MR. Asthma exacerbations. 1: epidemiology. Thorax. 2006 Aug;61(8):722-8. Abstract

24. Rank MA, Hagan JB, Park MA, et al. The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 2013 Mar;131(3):724-9. Abstract

25. Reyes-Angel J, Kaviany P, Rastogi D, et al. Obesity-related asthma in children and adolescents. Lancet Child Adolesc Health. 2022 Oct;6(10):713-24. Abstract

26. Buelo A, McLean S, Julious S, et al. At-risk children with asthma (ARC): a systematic review. Thorax. 2018 Sep;73(9):813-24.Full text  Abstract

27. Denlinger LC, Phillips BR, Ramratnam S, et al. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-13.Full text  Abstract

28. Mallah N, Turner JM, González-Barcala FJ, et al. Gastroesophageal reflux disease and asthma exacerbation: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2022 Jan;33(1):e13655.Full text  Abstract

29. Rose JJ, Krishnan-Sarin S, Exil VJ, et al. Cardiopulmonary impact of electronic cigarettes and vaping products: a scientific statement from the American Heart Association. Circulation. 2023 Aug 22;148(8):703-28.Full text  Abstract

30. Sallard E, Schult F, Baehren C, et al. Viral infection and respiratory exacerbation in children: results from a local German pediatric exacerbation cohort. Viruses. 2022 Feb 27;14(3):491.Full text  Abstract

31. Haselkorn T, Fish JE, Zeiger RS, et al. Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol. 2009 Nov;124(5):895-902.e1-4.Full text  Abstract

32. Nwaru BI, Ekström M, Hasvold P, et al. Overuse of short-acting β(2)-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme. Eur Respir J. 2020 Apr;55(4):1901872.Full text  Abstract

33. Melani AS, Bonavia M, Cilenti V, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med. 2011 Jun;105(6):930-8.Full text  Abstract

34. Fuhlbrigge AL, Kitch BT, Paltiel AD, et al. FEV(1) is associated with risk of asthma attacks in a pediatric population. J Allergy Clin Immunol. 2001 Jan;107(1):61-7.Full text  Abstract

35. Kwon JW, Jung H, Kim SH, et al. High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function. Respir Med. 2019 Apr;150:38-44.Full text  Abstract

36. Pongracic JA, Krouse RZ, Babineau DC, et al. Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents. J Allergy Clin Immunol. 2016 Oct;138(4):1030-1041.Full text  Abstract

37. Hernandez-Ramirez G, Barber D, Tome-Amat J, et al. Alternaria as an inducer of allergic sensitization. J Fungi (Basel). 2021 Oct 7;7(10):838.Full text  Abstract

38. Engelkes M, Janssens HM, de Jongste JC, et al. Medication adherence and the risk of severe asthma exacerbations: a systematic review. Eur Respir J. 2015 Feb;45(2):396-407.Full text  Abstract

39. British Thoracic Society/Scottish Intercollegiate Guidelines Network. SIGN 158: British guideline on the management of asthma. A national clinical guideline. Jul 2019 [internet publication].Full text

40. Miller MK, Lee JH, Miller DP, et al. Recent asthma exacerbations: a key predictor of future exacerbations. Respir Med. 2007 Mar;101(3):481-9.Full text  Abstract

41. Altamimi S, Robertson G, Jastaniah W, et al. Single-dose oral dexamethasone in the emergency management of children with exacerbations of mild to moderate asthma. Pediatr Emerg Care. 2006 Dec;22(12):786-93. Abstract

42. Oosterholt S, Pavord ID, Brusselle G, et al. Modelling ASthma TrEatment Responses (MASTER): effect of individual patient characteristics on the risk of exacerbation in moderate or severe asthma: a time-to-event analysis of randomized clinical trials. Br J Clin Pharmacol. 2023 Nov;89(11):3273-90.Full text  Abstract

43. Noble M, Burden A, Stirling S, et al. Predicting asthma-related crisis events using routine electronic healthcare data: a quantitative database analysis study. Br J Gen Pract. 2021 Dec;71(713):e948-57.Full text  Abstract

44. McLeish AC, Zvolensky MJ. Asthma and cigarette smoking: a review of the empirical literature. J Asthma. 2010 May;47(4):345-61.Full text  Abstract

45. Thien F. Asthma: its phenotypes and the influences of analgesics. Aust J Pharmacy. 2007;88:76-80.

46. Centers for Disease Control and Prevention. Risk factors. 2016 [Internet publication].Full text

47. Bancroft GJ, Schreiber RD, Unanue ER. T cell-independent macrophage activation in scid mice. Curr Top Microbiol Immunol. 1989;152:235-42. Abstract

48. National Heart, Lung, and Blood Institute. Guidelines for the diagnosis and management of asthma. Aug 2007 [Internet publication].Full text

49. Harris K, Kneale D, Lasserson TJ, et al. School-based self-management interventions for asthma in children and adolescents: a mixed methods systematic review. Cochrane Database Syst Rev. 2019 Jan 28;1(1):CD011651.Full text  Abstract

50. Kew KM, Malik P, Aniruddhan K, et al. Shared decision-making for people with asthma. Cochrane Database Syst Rev. 2017 Oct 3;10(10):CD012330.Full text  Abstract

51. Normansell R, Kew KM, Stovold E. Interventions to improve adherence to inhaled steroids for asthma. Cochrane Database Syst Rev. 2017 Apr 18;4(4):CD012226.Full text  Abstract

52. Chan A, De Simoni A, Wileman V, et al. Digital interventions to improve adherence to maintenance medication in asthma. Cochrane Database Syst Rev. 2022 Jun 13;6(6):CD013030.Full text  Abstract

53. Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC), Cloutier MM, Baptist AP, et al. 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec;146(6):1217-70.Full text  Abstract

54. Chen KYH, Saxon L, Robertson C, et al. Reducing asthma hospitalisations in at-risk children: a systematic review. J Paediatr Child Health. 2021 Sep;57(9):1376-84.Full text  Abstract

55. Still L, Dolen WK. The perception of asthma severity in children. Curr Allergy Asthma Rep. 2016 Jul;16(7):50. Abstract

56. National Asthma Council. Australian asthma handbook. April 2022 [internet publication].Full text

57. Chavasse R, Seddon P, Bara A, et al. Short acting beta agonists for recurrent wheeze in children under 2 years of age. Cochrane Database Syst Rev. 2002;(3):CD002873.Full text  Abstract

58. Kelly AM, Kyle E, McAlpine R. Venous pCO(2) and pH can be used to screen for significant hypercarbia in emergency patients with acute respiratory disease. J Emerg Med. 2002 Jan;22(1):15-9. Abstract

59. National Institute for Health and Care Excellence. Asthma: diagnosis, monitoring and chronic asthma management​. Nov 2017 [Internet publication].Full text

60. Gorelick MH, Stevens MW, Schultz T, et al. Difficulty in obtaining peak expiratory flow measurements in children with acute asthma. Pediatr Emerg Care. 2004 Jan;20(1):22-6. Abstract

61. Turner S, Cotton S, Wood J, et al. Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial. Lancet Respir Med. 2022 Jun;10(6):584-92. Abstract

62. Centers for Disease Control and Prevention.​ Best practices for healthcare professionals on the use of polymerase chain reaction (PCR) for diagnosing pertussis. Aug 2022 [Internet publication].Full text

63. Giddings EH, Carmean SL. Reduced brightness contrast as a reading aid. Percept Mot Skills. 1989 Oct;69(2):383-6. Abstract

64. Chang AB, Fortescue R, Grimwood K, et al. Task Force report: European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis. Eur Respir J. 2021 Feb 11;2002990. Abstract

65. Saito J, Harris WT, Gelfond J, et al. Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough. Pediatr Pulmonol. 2006 Aug;41(8):709-19. Abstract

66. Sunman B, Ademhan Tural D, Ozsezen B, et al. Current approach in the diagnosis and management of allergic bronchopulmonary aspergillosis in children with cystic fibrosis. Front Pediatr. 2020 Oct 20;8:582964.Full text  Abstract

67. Patterson TF, Thompson GR 3rd, Denning DW, et al. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Aug 15;63(4):e1-e60.Full text  Abstract

68. Normansell R, Sayer B, Waterson S, et al. Antibiotics for exacerbations of asthma. Cochrane Database Syst Rev. 2018 Jun 25;(6):CD002741.Full text  Abstract

69. Leatherman J. Mechanical ventilation for severe asthma. Chest. 2015 Jun;147(6):1671-80. Abstract

70. Schuh S, Sweeney J, Rumantir M, et al. Effect of nebulized magnesium vs placebo added to albuterol on hospitalization among children with refractory acute asthma treated in the emergency department: a randomized clinical trial. JAMA. 2020 Nov 24;324(20):2038-47. Abstract

71. Su Z, Li R, Gai Z. Intravenous and nebulized magnesium sulfate for treating acute asthma in children: a systematic review and meta-analysis. Pediatr Emerg Care. 2018 Jun;34(6):390-5. Abstract

72. Cheuk DK, Chau TC, Lee SL. A meta-analysis on intravenous magnesium sulphate for treating acute asthma. Arch Dis Child. 2005 Jan;90(1):74-7.Full text  Abstract

73. Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous magnesium sulfate treatment for acute asthma in the emergency department: a systematic review of the literature. Ann Emerg Med. 2000 Sep;36(3):181-90. Abstract

74. Powell C, Kolamunnage-Dona R, Lowe J, et al. Magnesium sulphate in acute severe asthma in children (MAGNETIC): a randomised, placebo-controlled trial. Lancet Respir Med. 2013 Jun;1(4):301-8. Abstract

75. Knightly R, Milan SJ, Hughes R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2017 Nov 28;11:CD003898.Full text  Abstract

76. Alansari K, Ahmed W, Davidson BL, et al. Nebulized magnesium for moderate and severe pediatric asthma: a randomized trial. Pediatr Pulmonol. 2015 Dec;50(12):1191-9.Full text  Abstract

77. Cates CJ, Welsh EJ, Rowe BH. Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev. 2013 Sep 13;(9):CD000052.Full text  Abstract

78. Rowe BH, Spooner C, Ducharme FM, et al. Early emergency department treatment of acute asthma with systemic corticosteroids. Cochrane Database Syst Rev. 2001 Jan 22;(1):CD002178.Full text  Abstract

79. Craig SS, Dalziel SR, Powell CV, et al. Interventions for escalation of therapy for acute exacerbations of asthma in children: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2020 Aug 5;(8):CD012977.Full text  Abstract

80. Griffiths B, Ducharme FM. Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children. Cochrane Database Syst Rev. 2013 Aug 21;(8):CD000060.Full text  Abstract

81. Sears MR. Inhaled beta agonists. Ann Allergy. 1992 May;68(5):446. Abstract

82. Everard ML, Bara A, Kurian M, et al. Anticholinergic drugs for wheeze in children under the age of two years. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001279.Full text  Abstract

83. Camargo CA Jr, Spooner CH, Rowe BH. Continuous versus intermittent beta-agonists for acute asthma. Cochrane Database Syst Rev. 2003 Oct 23;(4):CD001115.Full text  Abstract

84. Kulalert P, Phinyo P, Patumanond J, et al. Continuous versus intermittent short-acting β2-agonists nebulization as first-line therapy in hospitalized children with severe asthma exacerbation: a propensity score matching analysis. Asthma Res Pract. 2020 Jul 2;6:6.Full text  Abstract

85. Jackson DJ, Bacharier LB, Mauger DT, et al. Quintupling inhaled glucocorticoids to prevent childhood asthma exacerbations. N Engl J Med. 2018 Mar 8;378(10):891-901.Full text  Abstract

86. Hendeles L, Sherman J. Are inhaled corticosteroids effective for acute exacerbations of asthma in children? J Pediatr. 2003 Feb;142(2 Suppl):S26-32. Abstract

87. Kew KM, Flemyng E, Quon BS, et al. Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children. Cochrane Database Syst Rev. 2022 Sep 26;9(9):CD007524.Full text  Abstract

88. Garrett J, Williams S, Wong C, et al. Treatment of acute asthmatic exacerbations with an increased dose of inhaled steroid. Arch Dis Child. 1998 Jul;79(1):12-7.Full text  Abstract

89. Hasegawa K, Craig SS, Teach SJ, et al. Management of asthma exacerbations in the emergency department. J Allergy Clin Immunol Pract. 2020 Dec 31 [Epub ahead of print]. Abstract

90. Edmonds ML, Milan SJ, Camargo-Jr CA, et al. Early use of inhaled corticosteroids in the emergency department treatment of acute asthma. Cochrane Database Syst Rev. 2012 Dec 12;(12):CD002308.Full text  Abstract

91. Kearns N, Maijers I, Harper J, et al. Inhaled corticosteroids in acute asthma: a systemic review and meta-analysis. J Allergy Clin Immunol Pract. 2020 Feb;8(2):605-17.e6. Abstract

92. Dahan E, El Ghazal N, Nakanishi H, et al. Dexamethasone versus prednisone/prednisolone in the management of pediatric patients with acute asthmatic exacerbations: a systematic review and meta-analysis. J Asthma. 2023 Aug;60(8):1481-92. Abstract

93. Kirkland SW, Cross E, Campbell S, et al. Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for acute asthma. Cochrane Database Syst Rev. 2018 Jun 2;6(6):CD012629.Full text  Abstract

94. Langton Hewer S, Hobbs J, Reid F, et al. Prednisolone in acute childhood asthma: clinical responses to three dosages. Respir Med. 1998 Mar;92(3):541-6. Abstract

95. Buddala PK, Chandrasekaran V, Harichandrakumar KT. A 3-day course of 1 mg/kg versus 2 mg/kg bodyweight prednisolone for 1- to 5-year-old children with acute moderate exacerbation of asthma: a randomized double-blind noninferiority trial. Paediatr Child Health. 2021 Jul;26(4):e189-93.Full text  Abstract

96. Normansell R, Kew KM, Mansour G. Different oral corticosteroid regimens for acute asthma. Cochrane Database Syst Rev. 2016 May 13;(5):CD011801.Full text  Abstract

97. Yao TC, Wang JY, Chang SM, et al. Association of oral corticosteroid bursts with severe adverse events in children. JAMA Pediatr. 2021 Jul 1;175(7):723-9.Full text  Abstract

98. Hendeles L. Selecting a systemic corticosteroid for acute asthma in young children. J Pediatr. 2003 Feb;142(2 Suppl):S40-4. Abstract

99. Price D, Castro M, Bourdin A, et al. Short-course systemic corticosteroids in asthma: striking the balance between efficacy and safety. Eur Respir Rev. 2020 Apr 3;29(155):190151.Full text  Abstract

100. Bleecker ER, Al-Ahmad M, Bjermer L, et al. Systemic corticosteroids in asthma: a call to action from World Allergy Organization and Respiratory Effectiveness Group. World Allergy Organ J. 2022 Dec;15(12):100726.Full text  Abstract

101. Chang AB, Clark R, Sloots TP, et al. A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial. Med J Aust. 2008 Sep 15;189(6):306-10. Abstract

102. Storr J, Barrell E, Barry W, et al. Effect of a single oral dose of prednisolone in acute childhood asthma. Lancet. 1987 Apr 18;1(8538):879-82. Abstract

103. Ho L, Landau LI, Le Souef PN. Lack of efficacy of single-dose prednisolone in moderately severe asthma. Med J Aust. 1994 Jun 6;160(11):701-4. Abstract

104. Griffiths B, Kew KM. Intravenous magnesium sulfate for treating children with acute asthma in the emergency department. Cochrane Database Syst Rev. 2016 Apr 29;4(4):CD011050.Full text  Abstract

105. Pruikkonen H, Tapiainen T, Kallio M, et al. Intravenous magnesium sulfate for acute wheezing in young children: a randomised double-blind trial. Eur Respir J. 2018 Feb 7;51(2):1701579.Full text  Abstract

106. Roberts G, Newsom D, Gomez K, et al. Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised controlled trial. Thorax. 2003 Apr;58(4):306-10.Full text  Abstract

107. Kirby C. Comparison of intravenous and inhaled salbutamol in severe acute asthma. Pediatr Rev Commun. 1988;3:67-77.

108. Browne GJ, Penna AS, Phung X, et al. Randomised trial of intravenous salbutamol in early management of acute severe asthma in children. Lancet. 1997 Feb 1;349(9048):301-5. Abstract

109. Browne GJ, Lam LT. Single-dose intravenous salbutamol bolus for managing children with acute severe asthma in the emergency department: reanalysis of data. Pediatr Crit Care Med. 2002 Apr;3(2):117-23. Abstract

110. Travers A, Jones AP, Kelly K, et al. Intravenous beta2-agonists for acute asthma in the emergency department. Cochrane Database Syst Rev. 2001 Jan 22:(1):CD002988.Full text  Abstract

111. Nair P, Milan SJ, Rowe BH. Addition of intravenous aminophylline to inhaled beta(2)-agonists in adults with acute asthma. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD002742.Full text  Abstract

112. Travers AH, Jones AP, Camargo CA Jr, et al. Intravenous beta(2)-agonists versus intravenous aminophylline for acute asthma. Cochrane Database Syst Rev. 2012 Dec 12;(12):CD010256.Full text  Abstract

113. Baggott C, Hardy JK, Sparks J, et al. Epinephrine (adrenaline) compared to selective beta-2-agonist in adults or children with acute asthma: a systematic review and meta-analysis. Thorax. 2022 Jun;77(6):563-72. Abstract

114. Schramm CM, Carroll CL. Advances in treating acute asthma exacerbations in children. Curr Opin Pediatr. 2009 Jun;21(3):326-32. Abstract

115. Baudin F, Buisson A, Vanel B, et al. Nasal high flow in management of children with status asthmaticus: a retrospective observational study. Ann Intensive Care. 2017 Dec;7(1):55.Full text  Abstract

116. Russi BW, Lew A, McKinley SD, et al. High-flow nasal cannula and bilevel positive airway pressure for pediatric status asthmaticus: a single center, retrospective descriptive and comparative cohort study. J Asthma. 2022 Apr;59(4):757-64. Abstract

117. Gates RM, Haynes KE, Rehder KJ, et al. High-flow nasal cannula in pediatric critical asthma. Respir Care. 2021 Aug;66(8):1240-6.Full text  Abstract

118. Korang SK, Feinberg J, Wetterslev J, et al. Non-invasive positive pressure ventilation for acute asthma in children. Cochrane Database Syst Rev. 2016 Sep 30;(9):CD012067.Full text  Abstract

119. Rodrigo G, Pollack C, Rodrigo C, et al. Heliox for nonintubated acute asthma patients. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD002884.Full text  Abstract

120. Kim IK, Phrampus E, Venkataraman S, et al. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics. 2005 Nov;116(5):1127-33. Abstract

121. Camargo CA Jr, Smithline HA, Malice MP, et al. A randomized controlled trial of intravenous montelukast in acute asthma. Am J Respir Crit Care Med. 2003 Feb 15;167(4):528-33.Full text  Abstract

122. Watts K, Chavasse RJ. Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst Rev. 2012 May 16;(5):CD006100.Full text  Abstract

123. Adachi M, Taniguchi H, Tohda Y, et al. The efficacy and tolerability of intravenous montelukast in acute asthma exacerbations in Japanese patients. J Asthma. 2012 Aug;49(6):649-56. Abstract

124. Morris CR, Becker AB, Piñieiro A, et al. A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma. Ann Allergy Asthma Immunol. 2010 Feb;104(2):161-71. Abstract

125. Food and Drug Administration. FDA requires boxed warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis. Mar 2020 [internet publication].Full text

126. Rodrigo GJ, Neffen H, Colodenco FD, et al. Formoterol for acute asthma in the emergency department: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2010 Mar;104(3):247-52. Abstract

127. Bussamra MH, Stelmach R, Rodrigues JC, et al. A randomized, comparative study of formoterol and terbutaline dry powder inhalers in the treatment of mild to moderate asthma exacerbations in the pediatric acute care setting. Ann Allergy Asthma Immunol. 2009 Sep;103(3):248-53. Abstract

128. Arun JJ, Lodha R, Kabra SK. Bronchodilatory effect of inhaled budesonide/formoterol and budesonide/salbutamol in acute asthma: a double-blind, randomized controlled trial. BMC Pediatr. 2012 Mar 7;12:21.Full text  Abstract

129. Stefanidis C, Martineau AR, Nwokoro C, et al. Vitamin D for secondary prevention of acute wheeze attacks in preschool and school-age children. Thorax. 2019 Oct;74(10):977-85. Abstract

130. Williamson A, Martineau AR, Sheikh A, et al. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2023 Feb 6;2(2):CD011511.Full text  Abstract

131. Centers for Disease Control and Prevention. Most recent asthma data. Dec 2022 [internet publication].Full text

132. Mukherjee M, Cunningham S, Bhuia MR, et al. Asthma in paediatric intensive care in England residents: observational study. Sci Rep. 2022 Jan 25;12(1):1315.Full text  Abstract

133. Bergstrom SE, Boman G, Eriksson L, et al. Asthma mortality among Swedish children and young adults, a 10-year study. Respir Med. 2008 Sep;102(9):1335-41. Abstract

134. Roberts G, Patel N, Levi-Schaffer F, et al. Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. J Allergy Clin Immunol. 2003 Jul;112(1):168-74. Abstract

135. O'Byrne PM, Pedersen S, Lamm CJ, et al. START Investigators Group. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med. 2009 Jan 1;179(1):19-24. Abstract

136. Stack AM, Caputo GL. Pneumomediastinum in childhood asthma. Pediatr Emerg Care. 1996 Apr;12(2):98-101. Abstract

137. Kravis LP. An analysis of fifteen childhood asthma fatalities. J Allergy Clin Immunol. 1987 Sep;80(3 Pt 2):467-72. Abstract

138. Meduri GU, Cook TR, Turner RE, et al. Noninvasive positive pressure ventilation in status asthmaticus. Chest. 1996 Sep;110(3):767-74. Abstract

139. Edmonds ML, Milan SJ, Brenner BE, et al. Inhaled steroids for acute asthma following emergency department discharge. Cochrane Database Syst Rev. 2012 Dec 12;(12):CD002316.Full text  Abstract

140. Hall KK, Petsky HL, Chang AB, et al. Caseworker-assigned discharge plans to prevent hospital readmission for acute exacerbations in children with chronic respiratory illness. Cochrane Database Syst Rev. 2018 Nov 2;(11):CD012315.Full text  Abstract

141. Chan M, Gray M, Burns C, et al. Assessment of variation in care following hospital discharge for children with acute asthma. J Asthma Allergy. 2021;14:797-808.Full text  Abstract

142. Benavides S, Rodriguez JC, Maniscalco-Feichtl M. Pharmacist involvement in improving asthma outcomes in various healthcare settings: 1997 to present. Ann Pharmacother. 2009 Jan;43(1):85-97. Abstract

143. McCallum GB, Morris PS, Brown N, et al. Culture-specific programs for children and adults from minority groups who have asthma. Cochrane Database Syst Rev. 2017 Aug 22;(8):CD006580.Full text  Abstract

144. Wolf FM, Guevara JP, Grum CM, et al. Educational interventions for asthma in children. Cochrane Database Syst Rev. 2002 Oct 21;(4):CD000326.Full text  Abstract

145. Ducharme FM, Zemek RL, Chalut D, et al. Written action plan in pediatric emergency room improves asthma prescribing, adherence, and control. Am J Respir Crit Care Med. 2011 Jan 15;183(2):195-203.Full text  Abstract

146. Cano-Garcinuno A, Diaz-Vazquez C, Carvajal-Uruena I, et al. Group education on asthma for children and caregivers: a randomized, controlled trial addressing effects on morbidity and quality of life. J Investig Allergol Clin Immunol. 2007;17(4):216-26. Abstract

147. Zemek RL, Bhogal SK, Ducharme FM. Systematic review of randomized controlled trials examining written action plans in children: what is the plan? Arch Pediatr Adolesc Med. 2008 Feb;162(2):157-63.Full text  Abstract

148. Chang AB, Taylor B, Masters IB, et al. Indigenous healthcare worker involvement for indigenous adults and children with asthma. Cochrane Database Syst Rev. 2010 May 12;(5):CD006344.Full text  Abstract

149. Flores G, Bridon C, Torres S, et al. Improving asthma outcomes in minority children: a randomized, controlled trial of parent mentors. Pediatrics. 2009 Dec;124(6):1522-32. Abstract

150. Vuillermin P, South M, Robertson C. Parent-initiated oral corticosteroid therapy for intermittent wheezing illnesses in children. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD005311.Full text  Abstract

151. Ganaie MB, Munavvar M, Gordon M, et al. Patient- and parent-initiated oral steroids for asthma exacerbations. Cochrane Database Syst Rev. 2016 Dec 12;12(12):CD012195.Full text  Abstract

152. Boyd M, Lasserson TJ, McKean MC, et al. Interventions for educating children who are at risk of asthma-related emergency department attendance. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD001290.Full text  Abstract

153. Bravata DM, Gienger AL, Holty JE, et al. Quality improvement strategies for children with asthma: a systematic review. Arch Pediatr Adolesc Med. 2009 Jun;163(6):572-81.Full text  Abstract

154. Coffman JM, Cabana MD, Halpin HA, et al. Effects of asthma education on children's use of acute care services: a meta-analysis. Pediatrics. 2008 Mar;121(3):575-86. Abstract

155. Lavorini F, Magnan A, Dubus JC, et al. Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med. 2008 Apr;102(4):593-604. Abstract

156. Safety update on home use of nebulisers for acute asthma treatment in children. Drug Ther Bull. 2022 Dec;60(12):180. Abstract

157. Cates CJ, Rowe BH. Vaccines for preventing influenza in people with asthma. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD000364.Full text  Abstract

158. Pedroza A, Huerta JG, Garcia Mde L, et al. The safety and immunogenicity of influenza vaccine in children with asthma in Mexico. Int J Infect Dis. 2009 Jul;13(4):469-75. Abstract

159. Sheikh A, Alves B, Dhami S. Pneumococcal vaccine for asthma. Cochrane Database Syst Rev. 2002 Jan 21;(1):CD002165.Full text  Abstract

160. Brożek JL, Bousquet J, Agache I, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017 Oct;140(4):950-8.Full text  Abstract

161. Teoh L, Mackay IM, Van Asperen PP, et al. Presence of atopy increases the risk of asthma relapse. Arch Dis Child. 2018 Apr;103(4):346-51. Abstract

162. Wilson SR, Farber HJ, Knowles SB, et al. A randomized trial of parental behavioral counseling and cotinine feedback for lowering environmental tobacco smoke exposure in children with asthma: results of the LET'S Manage Asthma trial. Chest. 2011 Mar;139(3):581-90. Abstract

163. Mackay DF, Turner SW, Semple SE, et al. Associations between smoke-free vehicle legislation and childhood admissions to hospital for asthma in Scotland: an interrupted time-series analysis of whole-population data. Lancet Public Health. 2021 Aug;6(8):e579-86.Full text  Abstract

164. Rowe BH, Spooner CH, Ducharme FM, et al. Corticosteroids for preventing relapse following acute exacerbations of asthma. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000195.Full text  Abstract

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