Esophageal cancer

References

Key articles

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: esophageal and esophagogastric junction cancers [internet publication].Full text

Obermannová R, Alsina M, Cervantes A, et al; ESMO Guidelines Committee. Oesophageal cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022 Oct;33(10):992-1004.Full text  Abstract

van Hagen P, Hulshof MC, van Lanschot JJ, et al; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012 May 31;366(22):2074-84.Full text  Abstract

Shapiro J, van Lanschot JJ, Hulshof MC, et al; CROSS study group. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol. 2015 Sep;16(9):1090-8. Abstract

Reference articles

1. Nagtegaal ID, Odze RD, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020 Jan;76(2):182-8.Full text  Abstract

2. Patel N, Benipal B. Incidence of esophageal cancer in the United States from 2001-2015: a United States Cancer Statistics analysis of 50 states. Cureus. 2018 Dec 10;10(12):e3709.Full text  Abstract

3. Thrumurthy SG, Chaudry MA, Thrumurthy SSD, et al. Oesophageal cancer: risks, prevention, and diagnosis. BMJ. 2019 Jul 9;366:l4373. Abstract

4. Rüdiger Siewert J, Feith M, Werner M, et al. Adenocarcinoma of the esophagogastric junction: results of surgical therapy based on anatomical/topographic classification in 1,002 consecutive patients. Ann Surg. 2000 Sep;232(3):353-61.Full text  Abstract

5. Curtis NJ, Noble F, Bailey IS, et al. The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction. J Surg Oncol. 2014 Mar;109(3):202-7.Full text  Abstract

6. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-63.Full text  Abstract

7. National Cancer Institute: Surveillance, Epidemiology, and End Results Program (SEER). Cancer stat facts: esophageal cancer. 2024 [internet publication].Full text

8. American Cancer Society. Cancer facts & figures 2024. 2024 [internet publication].Full text

9. Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49.Full text  Abstract

10. Uhlenhopp DJ, Then EO, Sunkara T, et al. Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin J Gastroenterol. 2020 Dec;13(6):1010-21. Abstract

11. Huang J, Koulaouzidis A, Marlicz W, et al. Global burden, risk factors, and trends of esophageal cancer: an analysis of cancer registries from 48 countries. Cancers (Basel). 2021 Jan 5;13(1):141.Full text  Abstract

12. Demeester SR. Epidemiology and biology of esophageal cancer. Gastrointest Cancer Res. 2009;3(2 suppl 1):S2-5.Full text  Abstract

13. Brown LM, Devesa SS, Chow WH. Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst. 2008 Aug 20;100(16):1184-7.Full text  Abstract

14. Torre LA, Siegel RL, Ward EM, et al. Global cancer incidence and mortality rates and trends - an update. Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):16-27.Full text  Abstract

15. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: esophageal and esophagogastric junction cancers [internet publication].Full text

16. Cummings LC, Cooper GS. Descriptive epidemiology of esophageal carcinoma in the Ohio Cancer Registry. Cancer Detect Prev. 2008;32(1):87-92. Abstract

17. Chen S, Zhou K, Yang L, et al. Racial differences in esophageal squamous cell carcinoma: incidence and molecular features. Biomed Res Int. 2017;2017:1204082.Full text  Abstract

18. Baquet CR, Commiskey P, Mack K, et al. Esophageal cancer epidemiology in blacks and whites: racial and gender disparities in incidence, mortality, survival rates and histology. J Natl Med Assoc. 2005 Nov;97(11):1471-8.Full text  Abstract

19. National Cancer Institute Surveillance, Epidemiology, and End Results Program. Esophagus: SEER incidence rates by age at diagnosis, 2015-2019. 2023 [internet publication].Full text

20. Xie SH, Lagergren J. The male predominance in esophageal adenocarcinoma. Clin Gastroenterol Hepatol. 2016 Mar;14(3):338-47.Full text  Abstract

21. He H, Chen N, Hou Y, et al. Trends in the incidence and survival of patients with esophageal cancer: a SEER database analysis. Thorac Cancer. 2020 May;11(5):1121-8.Full text  Abstract

22. Lagergren J. Etiology and risk factors for oesophageal adenocarcinoma: possibilities for chemoprophylaxis? Best Pract Res Clin Gastroenterol. 2006;20(5):803-12. Abstract

23. Tustumi F, Bernardo WM, da Rocha JRM, et al. Esophageal achalasia: a risk factor for carcinoma. A systematic review and meta-analysis. Dis Esophagus. 2017 Oct 1;30(10):1-8.Full text  Abstract

24. Nesteruk K, Spaander MCW, Leeuwenburgh I, et al. Achalasia and associated esophageal cancer risk: what lessons can we learn from the molecular analysis of Barrett's-associated adenocarcinoma? Biochim Biophys Acta Rev Cancer. 2019 Dec;1872(2):188291.Full text  Abstract

25. Kamangar F, Chow WH, Abnet CC, et al. Environmental causes of esophageal cancer. Gastroenterol Clin North Am. 2009 Mar;38(1):27-57, vii. Abstract

26. Freedman ND, Abnet CC, Leitzmann MF, et al. A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes. Am J Epidemiol. 2007 Jun 15;165(12):1424-33.Full text  Abstract

27. Cook MB, Kamangar F, Whiteman DC, et al. Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium. J Natl Cancer Inst. 2010 Sep 8;102(17):1344-53.Full text  Abstract

28. Gregson EM, Bornschein J, Fitzgerald RC. Genetic progression of Barrett's oesophagus to oesophageal adenocarcinoma. Br J Cancer. 2016 Aug 9;115(4):403-10.Full text  Abstract

29. Cossentino MJ, Wong RK. Barrett's esophagus and risk of esophageal adenocarcinoma. Semin Gastrointest Dis. 2003 Jul;14(3):128-35. Abstract

30. Kastelein F, van Olphen S, Steyerberg EW, et al. Surveillance in patients with long-segment Barrett's oesophagus: a cost-effectiveness analysis. Gut. 2015 Jun;64(6):864-71. Abstract

31. Verbeek RE, Spittuler LF, Peute A, et al. Familial clustering of Barrett's esophagus and esophageal adenocarcinoma in a European cohort. Clin Gastroenterol Hepatol. 2014 Oct;12(10):1656-63.e1.Full text  Abstract

32. Lagergren J, Bergström R, Lindgren A, et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999 Mar 18;340(11):825-31.Full text  Abstract

33. Alexandre L, Broughton T, Loke Y, et al. Meta-analysis: risk of esophageal adenocarcinoma with medications which relax the lower esophageal sphincter. Dis Esophagus. 2012 Aug;25(6):535-44.Full text  Abstract

34. Fang X, Wei J, He X, et al. Quantitative association between body mass index and the risk of cancer: a global meta-analysis of prospective cohort studies. Int J Cancer. 2018 Oct 1;143(7):1595-603.Full text  Abstract

35. Petrick JL, Jensen BW, Sørensen TIA, et al. Overweight patterns between childhood and early adulthood and esophageal and gastric cardia adenocarcinoma risk. Obesity (Silver Spring). 2019 Sep;27(9):1520-6.Full text  Abstract

36. Samanic C, Chow WH, Gridley G, et al. Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control. 2006 Sep;17(7):901-9. Abstract

37. Chow WH, Blot WJ, Vaughan TL, et al. Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst. 1998 Jan 21;90(2):150-5.Full text  Abstract

38. Lagergren J, Bergström R, Nyrén O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann Intern Med. 1999 Jun 1;130(11):883-90. Abstract

39. Smith M, Zhou M, Whitlock G, et al. Esophageal cancer and body mass index: results from a prospective study of 220,000 men in China and a meta-analysis of published studies. Int J Cancer. 2008 Apr 1;122(7):1604-10.Full text  Abstract

40. Tian J, Zuo C, Liu G, et al. Cumulative evidence for the relationship between body mass index and the risk of esophageal cancer: an updated meta-analysis with evidence from 25 observational studies. J Gastroenterol Hepatol. 2020 May;35(5):730-43. Abstract

41. Jin Y, Yang T, Li D, et al. Effect of dietary cholesterol intake on the risk of esophageal cancer: a meta-analysis. J Int Med Res. 2019 Sep;47(9):4059-68.Full text  Abstract

42. O'Doherty MG, Cantwell MM, Murray LJ, et al. Dietary fat and meat intakes and risk of reflux esophagitis, Barrett's esophagus and esophageal adenocarcinoma. Int J Cancer. 2011 Sep 15;129(6):1493-502.Full text  Abstract

43. Bagnardi V, Rota M, Botteri E, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer. 2015 Feb 3;112(3):580-93.Full text  Abstract

44. Oze I, Charvat H, Matsuo K, et al. Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? Cancer Med. 2019 Oct;8(14):6414-25.Full text  Abstract

45. Salaspuro MP. Alcohol consumption and cancer of the gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2003 Aug;17(4):679-94. Abstract

46. Wang J, Zhao L, Yan H, et al. A meta-analysis and systematic review on the association between human papillomavirus (types 16 and 18) infection and esophageal cancer worldwide. PLoS One. 2016 Jul 13;11(7):e0159140.Full text  Abstract

47. Zhang SK, Guo LW, Chen Q, et al. The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis. BMC Cancer. 2015;15:1096.Full text  Abstract

48. Guo LW, Zhang SK, Liu SZ, et al. Human papillomavirus type-18 prevalence in oesophageal cancer in the Chinese population: a meta-analysis. Epidemiol Infect. 2016 Feb;144(3):469-77.Full text  Abstract

49. Liyanage SS, Rahman B, Ridda I, et al. The aetiological role of human papillomavirus in oesophageal squamous cell carcinoma: a meta-analysis. PLoS One. 2013 Jul 24;8(7):e69238.Full text  Abstract

50. Koshiol J, Kreimer AR. Lessons from Australia: human papillomavirus is not a major risk factor for esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):1889-92.Full text  Abstract

51. Lagergren J, Wang Z, Bergström R, et al. Human papillomavirus infection and esophageal cancer: a nationwide seroepidemiologic case-control study in Sweden. J Natl Cancer Inst. 1999 Jan 20;91(2):156-62.Full text  Abstract

52. Malekshah AF, Kimiagar M, Pourshams A, et al. Vitamin deficiency in Golestan Province, northern Iran: a high-risk area for esophageal cancer. Arch Iran Med. 2010 Sep;13(5):391-4. Abstract

53. Huang GL, Yang L, Su M, et al. Vitamin D3 and beta-carotene deficiency is associated with risk of esophageal squamous cell carcinoma - results of a case-control study in China. Asian Pac J Cancer Prev. 2014;15(2):819-23.Full text  Abstract

54. Chen T, Cheng H, Chen X, et al. Family history of esophageal cancer increases the risk of esophageal squamous cell carcinoma. Sci Rep. 2015 Nov 3;5:16038.Full text  Abstract

55. Gao Y, Hu N, Han X, et al. Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. BMC Cancer. 2009 Aug 5;9:269.Full text  Abstract

56. Andrici J, Eslick GD. Maté consumption and the risk of esophageal squamous cell carcinoma: a meta-analysis. Dis Esophagus. 2013 Nov-Dec;26(8):807-16.Full text  Abstract

57. Lubin JH, De Stefani E, Abnet CC, et al. Maté drinking and esophageal squamous cell carcinoma in South America: pooled results from two large multicenter case-control studies. Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):107-16.Full text  Abstract

58. Islami F, Boffetta P, Ren JS, et al. High-temperature beverages and foods and esophageal cancer risk - a systematic review. Int J Cancer. 2009 Aug 1;125(3):491-524.Full text  Abstract

59. Tai WP, Nie GJ, Chen MJ, et al. Hot food and beverage consumption and the risk of esophageal squamous cell carcinoma: a case-control study in a northwest area in China. Medicine (Baltimore). 2017 Dec;96(50):e9325.Full text  Abstract

60. Chen Y, Tong Y, Yang C, et al. Consumption of hot beverages and foods and the risk of esophageal cancer: a meta-analysis of observational studies. BMC Cancer. 2015 Jun 2;15:449.Full text  Abstract

61. Middleton DR, Menya D, Kigen N, et al. Hot beverages and oesophageal cancer risk in western Kenya: Findings from the ESCCAPE case-control study. Int J Cancer. 2019 Jun 1;144(11):2669-76.Full text  Abstract

62. Abnet CC, Kamangar F, Islami F, et al. Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3062-8.Full text  Abstract

63. Dar NA, Islami F, Bhat GA, et al. Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir. Br J Cancer. 2013 Sep 3;109(5):1367-72.Full text  Abstract

64. Menya D, Maina SK, Kibosia C, et al. Dental fluorosis and oral health in the African Esophageal Cancer Corridor: findings from the Kenya ESCCAPE case-control study and a pan-African perspective. Int J Cancer. 2019 Jul 1;145(1):99-109.Full text  Abstract

65. Arora H, Chacon AH, Choudhary S, et al. Bloom syndrome. Int J Dermatol. 2014 Jul;53(7):798-802. Abstract

66. Nalepa G, Clapp DW. Fanconi anaemia and cancer: an intricate relationship. Nat Rev Cancer. 2018 Mar;18(3):168-85. Abstract

67. Cameron AJ. Epidemiology of Barrett's esophagus and adenocarcinoma. Dis Esophagus. 2002;15(2):106-8.Full text  Abstract

68. Lagergren J, Bergström R, Adami HO, et al. Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma. Ann Intern Med. 2000 Aug 1;133(3):165-75. Abstract

69. Freedman ND, Murray LJ, Kamangar F, et al. Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium. Gut. 2011 Aug;60(8):1029-37.Full text  Abstract

70. Steevens J, Schouten LJ, Goldbohm RA, et al. Alcohol consumption, cigarette smoking and risk of subtypes of oesophageal and gastric cancer: a prospective cohort study. Gut. 2010 Jan;59(1):39-48. Abstract

71. Bracesco N, Sanchez AG, Contreras V, et al. Recent advances on Ilex paraguariensis research: minireview. J Ethnopharmacol. 2011 Jul 14;136(3):378-84. Abstract

72. Sewram V, De Stefani E, Brennan P, et al. Maté consumption and the risk of squamous cell esophageal cancer in uruguay. Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):508-13. Abstract

73. Castellsagué X, Muñoz N, De Stefani E, et al. Influence of mate drinking, hot beverages and diet on esophageal cancer risk in South America. Int J Cancer. 2000 Nov 15;88(4):658-64.Full text  Abstract

74. Vingeliene S, Chan DSM, Vieira AR, et al. An update of the WCRF/AICR systematic literature review and meta-analysis on dietary and anthropometric factors and esophageal cancer risk. Ann Oncol. 2017 Oct 1;28(10):2409-19.Full text  Abstract

75. Liu J, Wang J, Leng Y, et al. Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: a meta-analysis of observational studies. Int J Cancer. 2013 Jul 15;133(2):473-85.Full text  Abstract

76. Castro C, Peleteiro B, Lunet N. Modifiable factors and esophageal cancer: a systematic review of published meta-analyses. J Gastroenterol. 2018 Jan;53(1):37-51. Abstract

77. Bjelakovic G, Nikolova D, Simonetti RG, et al. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev. 2008 Jul 16;(3):CD004183.Full text  Abstract

78. Kang JH, Luben R, Alexandre L, et al. Dietary antioxidant intake and the risk of developing Barrett's oesophagus and oesophageal adenocarcinoma. Br J Cancer. 2018 Jun;118(12):1658-61.Full text  Abstract

79. Myung SK, Yang HJ. Efficacy of vitamin and antioxidant supplements in prevention of esophageal cancer: meta-analysis of randomized controlled trials. J Cancer Prev. 2013 Jun;18(2):135-43.Full text  Abstract

80. National Cancer Institute. Esophageal cancer prevention (PDQ®) - health professional version. Sep 2022 [internet publication].Full text

81. Corley DA, Kerlikowske K, Verma R, et al. Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology. 2003 Jan;124(1):47-56.Full text  Abstract

82. Wang F, Lv ZS, Fu YK. Nonsteroidal anti-inflammatory drugs and esophageal inflammation - Barrett's esophagus - adenocarcinoma sequence: a meta-analysis. Dis Esophagus. 2011 Jul;24(5):318-24.Full text  Abstract

83. Snider EJ, Kaz AM, Inadomi JM, et al. Chemoprevention of esophageal adenocarcinoma. Gastroenterol Rep (Oxf). 2020 Aug;8(4):253-60.Full text  Abstract

84. Alexandre L, Clark AB, Cheong E, et al. Systematic review: potential preventive effects of statins against oesophageal adenocarcinoma. Aliment Pharmacol Ther. 2012 Aug;36(4):301-11.Full text  Abstract

85. Thomas T, Loke Y, Beales ILP. Systematic review and meta-analysis: use of statins is associated with a reduced incidence of oesophageal adenocarcinoma. J Gastrointest Cancer. 2018 Dec;49(4):442-54.Full text  Abstract

86. Arai J, Niikura R, Hayakawa Y, et al. Chemoprevention of oesophageal squamous-cell carcinoma and adenocarcinoma: a multicentre retrospective cohort study. Digestion. 2022;103(3):192-204.Full text  Abstract

87. Ebright M, Krasna M. Overview: esophageal and proximal stomach malignancy. In: Sugarbaker DJ, ed. Adult chest surgery: concepts and procedures. New York, NY: McGraw-Hill; 2009:chapter 10.

88. Obermannová R, Alsina M, Cervantes A, et al; ESMO Guidelines Committee. Oesophageal cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022 Oct;33(10):992-1004.Full text  Abstract

89. American College of Radiology. ACR appropriateness criteria: staging and follow-up of esophageal cancer. 2022 [internet publication].Full text

90. Picus D, Balfe DM, Koehler RE, et al. Computed tomography in the staging of esophageal carcinoma. Radiology. 1983 Feb;146(2):433-8. Abstract

91. Jayaprakasam VS, Yeh R, Ku GY, et al. Role of imaging in esophageal cancer management in 2020: update for radiologists. AJR Am J Roentgenol. 2020 Nov;215(5):1072-84.Full text  Abstract

92. Dave UR, Williams AD, Wilson JA, et al. Esophageal cancer staging with endoscopic MR imaging: pilot study. Radiology. 2004 Jan;230(1):281-6. Abstract

93. Wong R, Walker-Dilks C, Raifu A. Evidence-based guideline recommendations on the use of positron emission tomography imaging in oesophageal cancer. Clin Oncol (R Coll Radiol). 2012 Mar;24(2):86-104. Abstract

94. Kwee RM. Prediction of tumor response to neoadjuvant therapy in patients with esophageal cancer with use of 18F FDG PET: a systematic review. Radiology. 2010 Mar;254(3):707-17. Abstract

95. Rebollo Aguirre AC, Ramos-Font C, Villegas PR, et al. 18F-fluorodeoxiglucose positron emission tomography for the evaluation of neoadjuvant therapy response in esophageal cancer: systematic review of the literature. Ann Surg. 2009 Aug;250(2):247-54. Abstract

96. Javeri H, Xiao L, Rohren E, et al. The higher the decrease in the standardized uptake value of positron emission tomography after chemoradiation, the better the survival of patients with gastroesophageal adenocarcinoma. Cancer. 2009 Nov 15;115(22):5184-92.Full text  Abstract

97. Chen YM, Pan XF, Tong LJ, et al. Can 18F-fluorodeoxyglucose positron emission tomography predict responses to neoadjuvant therapy in oesophageal cancer patients? A meta-analysis. Nucl Med Commun. 2011 Nov;32(11):1005-10. Abstract

98. Zhu W, Xing L, Yue J, et al. Prognostic significance of SUV on PET/CT in patients with localised oesophagogastric junction cancer receiving neoadjuvant chemotherapy/chemoradiation: a systematic review and meta-analysis. Br J Radiol. 2012 Sep;85(1017):e694-701.Full text  Abstract

99. Flamen P, Lerut A, Van Cutsem E, et al. Utility of positron emission tomography for the staging of patients with potentially operable esophageal carcinoma. J Clin Oncol. 2000 Sep 15;18(18):3202-10. Abstract

100. Krill T, Baliss M, Roark R, et al. Accuracy of endoscopic ultrasound in esophageal cancer staging. J Thorac Dis. 2019 Aug;11(suppl 12):S1602-9.Full text  Abstract

101. Vazquez-Sequeiros E, Wiersema MJ, Clain JE, et al. Impact of lymph node staging on therapy of esophageal carcinoma. Gastroenterology. 2003 Dec;125(6):1626-35.Full text  Abstract

102. Puli SR, Reddy JB, Bechtold ML, et al. Staging accuracy of esophageal cancer by endoscopic ultrasound: a meta-analysis and systematic review. World J Gastroenterol. 2008 Mar 14;14(10):1479-90.Full text  Abstract

103. van Rossum PSN, Goense L, Meziani J, et al. Endoscopic biopsy and EUS for the detection of pathologic complete response after neoadjuvant chemoradiotherapy in esophageal cancer: a systematic review and meta-analysis. Gastrointest Endosc. 2016 May;83(5):866-79. Abstract

104. de Gouw DJJM, Klarenbeek BR, Driessen M, et al. Detecting pathological complete response in esophageal cancer after neoadjuvant therapy based on imaging techniques: a diagnostic systematic review and meta-analysis. J Thorac Oncol. 2019 Jul;14(7):1156-71.Full text  Abstract

105. van der Bogt RD, van der Wilk BJ, Poley JW, et al. Endoscopic ultrasound and fine-needle aspiration for the detection of residual nodal disease after neoadjuvant chemoradiotherapy for esophageal cancer. Endoscopy. 2020 Mar;52(3):186-92. Abstract

106. Puli SR, Reddy JB, Bechtold ML, et al. Accuracy of endoscopic ultrasound in the diagnosis of distal and celiac axis lymph node metastasis in esophageal cancer: a meta-analysis and systematic review. Dig Dis Sci. 2008 Sep;53(9):2405-14. Abstract

107. Forbes N, Coelho-Prabhu N, Al-Haddad, et al; ASGE Standards of Practice Committee. Adverse events associated with EUS and EUS-guided procedures. Gastrointest Endosc. 2022 Jan;95(1):16-26. Abstract

108. de Graaf GW, Ayantunde AA, Parsons SL, et al. The role of staging laparoscopy in oesophagogastric cancers. Eur J Surg Oncol. 2007 Oct;33(8):988-92. Abstract

109. Mehta K, Bianco V, Awais O, et al. Minimally invasive staging of esophageal cancer. Ann Cardiothorac Surg. 2017 Mar;6(2):110-8.Full text  Abstract

110. Luketich JD, Friedman DM, Weigel TL, et al. Evaluation of distant metastases in esophageal cancer: 100 consecutive positron emission tomography scans. Ann Thorac Surg. 1999 Oct;68(4):1133-7.Full text  Abstract

111. College of American Pathologists. Template for reporting results of DNA mismatch repair testing. ​Jun 2021 [internet publication].Full text

112. Kulangara K, Zhang N, Corigliano E, et al. Clinical utility of the Combined Positive Score for programmed death ligand-1 expression and the approval of pembrolizumab for treatment of gastric cancer. Arch Pathol Lab Med. 2019 Mar;143(3):330-7.Full text  Abstract

113. Doki Y, Ajani JA, Kato K, et al; CheckMate 648 Trial Investigators. Nivolumab combination therapy in advanced esophageal squamous-cell carcinoma. N Engl J Med. 2022 Feb 3;386(5):449-62.Full text  Abstract

114. Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010 Aug 28;376(9742):687-97. Abstract

115. Cederholm T, Barazzoni R, Austin P, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017 Feb;36(1):49-64.Full text  Abstract

116. Dunbar KB, Okolo P 3rd, Montgomery E, et al. Confocal laser endomicroscopy in Barrett's esophagus and endoscopically inapparent Barrett's neoplasia: a prospective, randomized, double-blind, controlled, crossover trial. Gastrointest Endosc. 2009 Oct;70(4):645-54.Full text  Abstract

117. Curvers WL, Herrero LA, Wallace MB, et al. Endoscopic tri-modal imaging is more effective than standard endoscopy in identifying early-stage neoplasia in Barrett's esophagus. Gastroenterology. 2010 Oct;139(4):1106-14.Full text  Abstract

118. Leggett CL, Gorospe EC. Application of confocal laser endomicroscopy in the diagnosis and management of Barrett's esophagus. Ann Gastroenterol. 2014;27(3):193-9.Full text  Abstract

119. Amin MB, Edge S, Greene F, et al. (eds); American Joint Committee on Cancer. AJCC cancer staging manual. 8th ed. New York, NY: Springer; 2017.

120. Fotis D, Doukas M, Wijnhoven BP, et al. Submucosal invasion and risk of lymph node invasion in early Barrett's cancer: potential impact of different classification systems on patient management. United European Gastroenterol J. 2015 Dec;3(6):505-13.Full text  Abstract

121. Participants in the Paris Workshop. The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc. 2003 Dec;58(6 suppl):S3-43.Full text  Abstract

122. Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, et al. Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2015 Sep;47(9):829-54.Full text  Abstract

123. Gockel I, Sgourakis G, Lyros O, et al. Risk of lymph node metastasis in submucosal esophageal cancer: a review of surgically resected patients. Expert Rev Gastroenterol Hepatol. 2011 Jun;5(3):371-84. Abstract

124. Akutsu Y, Uesato M, Shuto K, et al. The overall prevalence of metastasis in T1 esophageal squamous cell carcinoma: a retrospective analysis of 295 patients. Ann Surg. 2013 Jun;257(6):1032-8. Abstract

125. Chen R, Ma S, Guan C, et al. The National Cohort of Esophageal Cancer - Prospective Cohort Study of Esophageal Cancer and Precancerous Lesions based on High-Risk Population in China (NCEC-HRP): study protocol. BMJ Open. 2019 Apr 3;9(4):e027360.Full text  Abstract

126. Qumseya B, Sultan S, Bain P, et al; ASGE Standards of Practice Committee. ASGE guideline on screening and surveillance of Barrett's esophagus. Gastrointest Endosc. 2019 Sep;90(3):335-59.e2.Full text  Abstract

127. Sharma P, Shaheen NJ, Katzka D, et al. AGA clinical practice update on endoscopic treatment of Barrett's esophagus with dysplasia and/or early cancer: expert review. Gastroenterology. 2020 Feb;158(3):760-9.Full text  Abstract

128. Fitzgerald RC, di Pietro M, Ragunath K, et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus. Gut. 2014 Jan;63(1):7-42.Full text  Abstract

129. Shaheen NJ, Falk GW, Iyer PG, et al. Diagnosis and management of Barrett's esophagus: an updated ACG guideline. Am J Gastroenterol. 2022 Apr 1;117(4):559-87.Full text  Abstract

130. Shaheen NJ, Sharma P, Overholt BF, et al. Radiofrequency ablation in Barrett's esophagus with dysplasia. N Engl J Med. 2009 May 28;360(22):2277-88.Full text  Abstract

131. Coelho-Prabhu N, Forbes N, Thosani NC, et al; ASGE Standards of Practice Committee. Adverse events associated with EGD and EGD-related techniques. Gastrointest Endosc. 2022 Sep;96(3):389-401.e1.Full text  Abstract

132. Storm AC, Fishman DS, Buxbaum JL, et al; ASGE Standards of Practice Committee. American Society for Gastrointestinal Endoscopy guideline on informed consent for GI endoscopic procedures. Gastrointest Endosc. 2022 Feb;95(2):207-15.e2.Full text  Abstract

133. Alberta Health Services (Canada). Clinical practice guideline GI-009: esophageal cancer. Jun 2021 [internet publication].Full text

134. Groulx S, Limburg H, Doull M, et al; Canadian Task Force on Preventive Health Care. Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease. CMAJ. 2020 Jul 6;192(27):E768-77.Full text  Abstract

135. Shah MA, Kennedy EB, Catenacci DV, et al. Treatment of locally advanced esophageal carcinoma: ASCO guideline. J Clin Oncol. 2020 Aug 10;38(23):2677-94.Full text  Abstract

136. Pech O, Bollschweiler E, Manner H, et al. Comparison between endoscopic and surgical resection of mucosal esophageal adenocarcinoma in Barrett's esophagus at two high-volume centers. Ann Surg. 2011 Jul;254(1):67-72. Abstract

137. National Institute for Health and Care Excellence. Oesophago-gastric cancer: assessment and management in adults. Jul 2023 [internet publication].Full text

138. Ahmed O, Ajani JA, Lee JH. Endoscopic management of esophageal cancer. World J Gastrointest Oncol. 2019 Oct 15;11(10):830-41.Full text  Abstract

139. Ishihara R, Iishi H, Takeuchi Y, et al. Local recurrence of large squamous-cell carcinoma of the esophagus after endoscopic resection. Gastrointest Endosc. 2008 May;67(6):799-804. Abstract

140. Guo HM, Zhang XQ, Chen M, et al. Endoscopic submucosal dissection vs endoscopic mucosal resection for superficial esophageal cancer. World J Gastroenterol. 2014 May 14;20(18):5540-7.Full text  Abstract

141. Cao Y, Liao C, Tan A, et al. Meta-analysis of endoscopic submucosal dissection versus endoscopic mucosal resection for tumors of the gastrointestinal tract. Endoscopy. 2009 Sep;41(9):751-7. Abstract

142. ASGE standards of practice committee, Forbes N, Elhanafi SE, et al. American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations. Gastrointest Endosc. 2023 Sep;98(3):271-84.Full text  Abstract

143. di Pietro M, Canto MI, Fitzgerald RC. Endoscopic management of early adenocarcinoma and squamous cell carcinoma of the esophagus: screening, diagnosis, and therapy. Gastroenterology. 2018 Jan;154(2):421-36.Full text  Abstract

144. Jezerskyte E, Saadeh LM, Hagens ERC, et al. Long-term health-related quality of life after McKeown and Ivor Lewis esophagectomy for esophageal carcinoma. Dis Esophagus. 2020 Nov 18;33(11):doaa022.Full text  Abstract

145. Brusselaers N, Mattsson F, Lagergren J. Hospital and surgeon volume in relation to long-term survival after oesophagectomy: systematic review and meta-analysis. Gut. 2014 Sep;63(9):1393-400. Abstract

146. Derogar M, Sadr-Azodi O, Johar A, et al. Hospital and surgeon volume in relation to survival after esophageal cancer surgery in a population-based study. J Clin Oncol. 2013 Feb 10;31(5):551-7.Full text  Abstract

147. Butler N, Collins S, Memon B, et al. Minimally invasive oesophagectomy: current status and future direction. Surg Endosc. 2011 Jul;25(7):2071-83. Abstract

148. National Institute for Health and Care Excellence. Minimally invasive oesophagectomy. Sep 2011 [internet publication].Full text

149. Peng JS, Kukar M, Mann GN, et al. Minimally invasive esophageal cancer surgery. Surg Oncol Clin N Am. 2019 Apr;28(2):177-200. Abstract

150. Yibulayin W, Abulizi S, Lv H, et al. Minimally invasive oesophagectomy versus open esophagectomy for resectable esophageal cancer: a meta-analysis. World J Surg Oncol. 2016 Dec 8;14(1):304.Full text  Abstract

151. Worrell SG, Goodman KA, Altorki NK, et al. The Society of Thoracic Surgeons/American Society for Radiation Oncology updated clinical practice guidelines on multimodality therapy for locally advanced cancer of the esophagus or gastroesophageal junction. Ann Thorac Surg. 2024 Jan;117(1):15-32. Abstract

152. Biere SS, van Berge Henegouwen MI, Maas KW, et al. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet. 2012 May 19;379(9829):1887-92. Abstract

153. Mariette C, Markar SR, Dabakuyo-Yonli TS, et al. Hybrid minimally invasive esophagectomy for esophageal cancer. N Engl J Med. 2019 Jan 10;380(2):152-62.Full text  Abstract

154. van Hagen P, Hulshof MC, van Lanschot JJ, et al; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012 May 31;366(22):2074-84.Full text  Abstract

155. Kidane B, Coughlin S, Vogt K, et al. Preoperative chemotherapy for resectable thoracic esophageal cancer. Cochrane Database Syst Rev. 2015 May 19;(5):CD001556.Full text  Abstract

156. Conroy T, Galais MP, Raoul JL, et al; Fédération Francophone de Cancérologie Digestive and UNICANCER-GI Group. Definitive chemoradiotherapy with FOLFOX versus fluorouracil and cisplatin in patients with oesophageal cancer (PRODIGE5/ACCORD17): final results of a randomised, phase 2/3 trial. Lancet Oncol. 2014 Mar;15(3):305-14. Abstract

157. Li QQ, Liu MZ, Hu YH, et al. Definitive concomitant chemoradiotherapy with docetaxel and cisplatin in squamous esophageal carcinoma. Dis Esophagus. 2010 Apr;23(3):253-9.Full text  Abstract

158. Rivera F, Romero C, Jimenez-Fonseca P, et al. Phase II study to evaluate the efficacy of trastuzumab in combination with capecitabine and oxaliplatin in first-line treatment of HER2-positive advanced gastric cancer: HERXO trial. Cancer Chemother Pharmacol. 2019 Jun;83(6):1175-81.Full text  Abstract

159. Shah MA, Kennedy EB, Alarcon-Rozas AE, et al. Immunotherapy and targeted therapy for advanced gastroesophageal cancer: ASCO guideline. J Clin Oncol. 2023 Mar 1;41(7):1470-91.Full text  Abstract

160. Rha SY, Oh DY, Yañez P, et al. Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2023 Nov;24(11):1181-95. Abstract

161. National Institute for Health and Care Excellence. Nivolumab for previously treated unresectable advanced or recurrent oesophageal cancer. Jun 2021 [internet publication].​Full text

162. National Institute for Health and Care Excellence. Nivolumab with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinoma. Feb 2023 [internet publication].Full text

163. Andre T, Berton D, Curigliano G, et al. Safety and efficacy of anti-PD-1 antibody dostarlimab in patients (pts) with mismatch repair-deficient (dMMR) solid cancers: results from GARNET study.​ Paper presented at: American Society of Clinical Oncology 2021 gastrointestinal cancers symposium. Jan 15-17, 2021 (virtual). Colorectal cancer: abstract 9. J Clin Oncol. 2021 Jan 20;39(3_suppl):9.Full text

164. Barr H, Dix AJ, Kendall C, et al. Review article: the potential role for photodynamic therapy in the management of upper gastrointestinal disease. Aliment Pharmacol Ther. 2001 Mar;15(3):311-21.Full text  Abstract

165. Weigel TL, Frumiento C, Gaumintz E. Endoluminal palliation for dysphagia secondary to esophageal carcinoma. Surg Clin North Am. 2002 Aug;82(4):747-61. Abstract

166. Chen M, Pennathur A, Luketich JD. Role of photodynamic therapy in unresectable esophageal and lung cancer. Lasers Surg Med. 2006 Jun;38(5):396-402. Abstract

167. Petersen BT, Chuttani R, Croffie J, et al. Photodynamic therapy for gastrointestinal disease. Gastrointest Endosc. 2006 Jun;63(7):927-32. Abstract

168. Greenwald BD, Dumot JA, Horwhat JD, et al. Safety, tolerability, and efficacy of endoscopic low-pressure liquid nitrogen spray cryotherapy in the esophagus. Dis Esophagus. 2010 Jan;23(1):13-9.Full text  Abstract

169. National Institute for Health and Care Excellence. Balloon cryoablation for squamous dysplasia of the oesophagus. Oct 2020 [internet publication].Full text

170. Dai Y, Li C, Xie Y, et al. Interventions for dysphagia in oesophageal cancer. Cochrane Database Syst Rev. 2014 Oct 30;(10):CD005048.Full text  Abstract

171. Merkow RP, Bilimoria KY, Keswani RN, et al. Treatment trends, risk of lymph node metastasis, and outcomes for localized esophageal cancer. J Natl Cancer Inst. 2014 Jul;106(7):dju133.Full text  Abstract

172. Berry MF, Zeyer-Brunner J, Castleberry AW, et al. Treatment modalities for T1N0 esophageal cancers: a comparative analysis of local therapy versus surgical resection. J Thorac Oncol. 2013 Jun;8(6):796-802.Full text  Abstract

173. Nentwich MF, von Loga K, Reeh M, et al. Depth of submucosal tumor infiltration and its relevance in lymphatic metastasis formation for T1b squamous cell and adenocarcinomas of the esophagus. J Gastrointest Surg. 2014 Feb;18(2):242-9. Abstract

174. Cen P, Hofstetter WL, Correa AM, et al. Lymphovascular invasion as a tool to further subclassify T1b esophageal adenocarcinoma. Cancer. 2008 Mar 1;112(5):1020-7.Full text  Abstract

175. Minsky BD, Pajak TF, Ginsberg RJ, et al. INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol. 2002 Mar 1;20(5):1167-74. Abstract

176. Khushalani NI, Leichman CG, Proulx G, et al. Oxaliplatin in combination with protracted-infusion fluorouracil and radiation: report of a clinical trial for patients with esophageal cancer. J Clin Oncol. 2002 Jun 15;20(12):2844-50. Abstract

177. Herskovic A, Martz K, al-Sarraf M, et al. Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med. 1992 Jun 11;326(24):1593-8.Full text  Abstract

178. Cooper JS, Guo MD, Herskovic A, et al; Radiation Therapy Oncology Group. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). JAMA. 1999 May 5;281(17):1623-7.Full text  Abstract

179. Oppedijk V, van der Gaast A, van Lanschot JJ, et al. Patterns of recurrence after surgery alone versus preoperative chemoradiotherapy and surgery in the CROSS trials. J Clin Oncol. 2014 Feb 10;32(5):385-91.Full text  Abstract

180. Hirst NG, Gordon LG, Whiteman DC, et al. Is endoscopic surveillance for non-dysplastic Barrett's esophagus cost-effective? Review of economic evaluations. J Gastroenterol Hepatol. 2011 Feb;26(2):247-54. Abstract

181. Mariette C, Dahan L, Mornex F, et al. Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901. J Clin Oncol. 2014 Aug 10;32(23):2416-22.Full text  Abstract

182. Kranzfelder M, Schuster T, Geinitz H, et al. Meta-analysis of neoadjuvant treatment modalities and definitive non-surgical therapy for oesophageal squamous cell cancer. Br J Surg. 2011 Jun;98(6):768-83.Full text  Abstract

183. Sjoquist KM, Burmeister BH, Smithers BM, et al. Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncol. 2011 Jul;12(7):681-92. Abstract

184. Shapiro J, van Lanschot JJ, Hulshof MC, et al; CROSS study group. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol. 2015 Sep;16(9):1090-8. Abstract

185. Eyck BM, van Lanschot JJB, Hulshof MCCM, et al; CROSS Study Group. Ten-year outcome of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer: the randomized controlled CROSS trial. J Clin Oncol. 2021 Jun 20;39(18):1995-2004.Full text  Abstract

186. Ychou M, Boige V, Pignon JP, et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol. 2011 May 1;29(13):1715-21.Full text  Abstract

187. Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019 May 11;393(10184):1948-57. Abstract

188. Cunningham D, Allum WH, Stenning SP, et al; MAGIC Trial Participants. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355:11-20.Full text  Abstract

189. Reynolds JV, Preston SR, O'Neill B, et al. Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial. Lancet Gastroenterol Hepatol. 2023 Nov;8(11):1015-27.Full text  Abstract

190. ClinicalTrials.gov. Perioperative chemotherapy compared to neoadjuvant chemoradiation in patients with adenocarcinoma of the esophagus (ESOPEC). ClinicalTrials.gov Identifier: NCT02509286. May 2024 [internet publication].Full text

191. Hoeppner J, Lordick F, Brunner T, et al. ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286). BMC Cancer. 2016 Jul 19;16:503.Full text  Abstract

192. Stahl M, Stuschke M, Lehmann N, et al. Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol. 2005 Apr 1;23(10):2310-7.Full text  Abstract

193. Bedenne L, Michel P, Bouché O, et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol. 2007 Apr 1;25(10):1160-8.Full text  Abstract

194. Vellayappan BA, Soon YY, Ku GY, et al. Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer. Cochrane Database Syst Rev. 2017 Aug 22;(8):CD010511.Full text  Abstract

195. Vincent J, Mariette C, Pezet D, et al; Fédération Francophone de Cancérologie Digestive (FFCD). Early surgery for failure after chemoradiation in operable thoracic oesophageal cancer. Analysis of the non-randomised patients in FFCD 9102 phase III trial: chemoradiation followed by surgery versus chemoradiation alone. Eur J Cancer. 2015 Sep;51(13):1683-93. Abstract

196. Markar S, Gronnier C, Duhamel A, et al. Salvage surgery after chemoradiotherapy in the management of esophageal cancer: is it a viable therapeutic option? J Clin Oncol. 2015 Nov 20;33(33):3866-73.Full text  Abstract

197. Mitchell KG, Nelson DB, Corsini EM, et al. Morbidity following salvage esophagectomy for squamous cell carcinoma: the MD Anderson experience. Dis Esophagus. 2020 Mar 16;33(3):doz067.Full text  Abstract

198. Cancer Research UK. Oesophageal cancer treatment statistics. 2021 [internet publication].Full text

199. Urschel JD, Vasan H. A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer. Am J Surg. 2003 Jun;185(6):538-43. Abstract

200. Fiorica F, Di Bona D, Schepis F, et al. Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis. Gut. 2004 Jul;53(7):925-30.Full text  Abstract

201. Brücher BL, Becker K, Lordick F, et al. The clinical impact of histopathologic response assessment by residual tumor cell quantification in esophageal squamous cell carcinomas. Cancer. 2006 May 15;106(10):2119-27.Full text  Abstract

202. Kelly RJ, Ajani JA, Kuzdzal J, et al; CheckMate 577 Investigators. Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med. 2021 Apr 1;384(13):1191-203.Full text  Abstract

203. National Institute for Health and Care Excellence. Nivolumab for adjuvant treatment of resected oesophageal or gastro-oesophageal junction cancer. Nov 2021 [internet publication].Full text

204. Ferrell BR, Temel JS, Temin S, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2017 Jan;35(1):96-112.Full text  Abstract

205. Janmaat VT, Steyerberg EW, van der Gaast A, et al. Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer. Cochrane Database Syst Rev. 2017 Nov 28;(11):CD004063.Full text  Abstract

206. Wagner AD, Syn NL, Moehler M, et al. Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev. 2017 Aug 29;(8):CD004064.Full text  Abstract

207. Montagnani F, Turrisi G, Marinozzi C, et al. Effectiveness and safety of oxaliplatin compared to cisplatin for advanced, unresectable gastric cancer: a systematic review and meta-analysis. Gastric Cancer. 2011 Mar;14(1):50-5.Full text  Abstract

208. Cunningham D, Starling N, Rao S, et al; Upper Gastrointestinal Clinical Studies Group of the National Cancer Research Institute of the United Kingdom. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 2008 Jan 3;358(1):36-46.Full text  Abstract

209. Van Cutsem E, Moiseyenko VM, Tjulandin S, et al; V325 Study Group. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol. 2006 Nov 1;24(31):4991-7.Full text  Abstract

210. Findlay M, Cunningham D, Norman A, et al. A phase II study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF). Ann Oncol. 1994 Sep;5(7):609-16.Full text  Abstract

211. Webb A, Cunningham D, Scarffe JH, et al. Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer. J Clin Oncol. 1997 Jan;15(1):261-7. Abstract

212. Ross P, Nicolson M, Cunningham D, et al. Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol. 2002 Apr 15;20(8):1996-2004. Abstract

213. Elimova E, Janjigian YY, Mulcahy M, et al. It is time to stop using epirubicin to treat any patient with gastroesophageal adenocarcinoma. J Clin Oncol. 2017 Feb;35(4):475-7.Full text  Abstract

214. Al-Batran SE, Hartmann JT, Probst S, et al. Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. J Clin Oncol. 2008 Mar 20;26(9):1435-42.Full text  Abstract

215. Dank M, Zaluski J, Barone C, et al. Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction. Ann Oncol. 2008 Aug;19(8):1450-7.Full text  Abstract

216. Guimbaud R, Louvet C, Ries P, et al. Prospective, randomized, multicenter, phase III study of fluorouracil, leucovorin, and irinotecan versus epirubicin, cisplatin, and capecitabine in advanced gastric adenocarcinoma: a French intergroup (Fédération Francophone de Cancérologie Digestive, Fédération Nationale des Centres de Lutte Contre le Cancer, and Groupe Coopérateur Multidisciplinaire en Oncologie) study. J Clin Oncol. 2014 Nov 1;32(31):3520-6.Full text  Abstract

217. Shen L, Kato K, Kim SB, et al. Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): a randomized phase III study. J Clin Oncol. 2022 Sep 10;40(26):3065-76.Full text  Abstract

218. ClinicalTrials.gov. A study of tislelizumab (BGB-A317) versus chemotherapy as second line treatment in participants with advanced esophageal squamous cell carcinoma.​ NCT03430843. Dec 2023 [internet publication].​Full text

219. Xu J, Kato K, Raymond E, et al. Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma (RATIONALE-306): a global, randomised, placebo-controlled, phase 3 study. Lancet Oncol. 2023 May;24(5):483-95. Abstract

220. ClinicalTrials.gov. A study of tislelizumab (BGB-A317) in combination with chemotherapy as first line treatment in participants with advanced esophageal squamous cell carcinoma.​ NCT03783442. Nov 2023 [internet publication].​Full text

221. Wainberg ZA, Enzinger PC, Kang YK, et al. Randomized double-blind placebo-controlled phase 2 study of bemarituzumab combined with modified FOLFOX6 (mFOLFOX6) in first-line (1L) treatment of advanced gastric/gastroesophageal junction adenocarcinoma (FIGHT). Paper presented at: American Society of Clinical Oncology 2021 gastrointestinal cancers symposium. Esophageal and gastric cancer: abstract 160. J Clin Oncol. 2021 Jan 20;39(3_suppl):160.Full text

222. Catenacci DV, Tesfaye A, Tejani M, et al. Bemarituzumab with modified FOLFOX6 for advanced FGFR2-positive gastroesophageal cancer: FIGHT Phase III study design. Future Oncol. 2019 Jun;15(18):2073-82.Full text  Abstract

223. Wang ZX, Cui C, Yao J, et al. Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): a multi-center phase 3 trial. Cancer Cell. 2022 Mar 14;40(3):277-88. Abstract

224. Luo H, Lu J, Bai Y, et al. Effect of camrelizumab vs placebo added to chemotherapy on survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma: the ESCORT-1st randomized clinical trial. JAMA. 2021 Sep 14;326(10):916-25.Full text  Abstract

225. Zhang X, Liang H, Li Z, et al. Perioperative or postoperative adjuvant oxaliplatin with S-1 versus adjuvant oxaliplatin with capecitabine in patients with locally advanced gastric or gastro-oesophageal junction adenocarcinoma undergoing D2 gastrectomy (RESOLVE): an open-label, superiority and non-inferiority, phase 3 randomised controlled trial. Lancet Oncol. 2021 Aug;22(8):1081-92. Abstract

226. Ji Y, Du X, Zhu W, et al. Efficacy of concurrent chemoradiotherapy with S-1 vs radiotherapy alone for older patients with esophageal cancer: a multicenter randomized phase 3 clinical trial. JAMA Oncol. 2021 Oct 1;7(10):1459-66.Full text  Abstract

227. van der Sluis PC, van der Horst S, May AM, et al. Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer: a randomized controlled trial. Ann Surg. 2019 Apr;269(4):621-30. Abstract

228. de Groot EM, van der Horst S, Kingma BF, et al. Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open esophagectomy: long-term follow-up of a randomized clinical trial. Dis Esophagus. 2020 Nov 26;33(supplement_2):doaa079.Full text  Abstract

229. Mai Q, Mo Z, He J, et al. Feasibility and clinical value of computed tomography-guided 125I brachytherapy for pain palliation in patients with retroperitoneal lymph node metastases. J Cancer Res Ther. 2020;16(2):372-8.Full text  Abstract

230. Zhang Y, Liu Z, Liang Y, et al. The effectiveness and prognostic factors of radioactive iodine-125 seed implantation for the treatment of cervical lymph node recurrence of esophageal squamous cell carcinoma after external beam radiation therapy. J Contemp Brachytherapy. 2020 Dec;12(6):579-85.Full text  Abstract

231. Fu WH, Wang LH, Zhou ZM, et al. Comparison of conformal and intensity-modulated techniques for simultaneous integrated boost radiotherapy of upper esophageal carcinoma. World J Gastroenterol. 2004 Apr 15;10(8):1098-102.Full text  Abstract

232. Chandra A, Guerrero TM, Liu HH, et al. Feasibility of using intensity-modulated radiotherapy to improve lung sparing in treatment planning for distal esophageal cancer. Radiother Oncol. 2005 Dec;77(3):247-53. Abstract

233. Tao H, Zhou Y, Yao C, et al. Phase II trial of intensity-modulated radiotherapy concurrent with chemotherapy for postoperative node-positive esophageal squamous cell carcinoma. Oncol Res. 2017 Sep 21;25(8):1357-62.Full text  Abstract

234. Hulshof MCCM, Geijsen ED, Rozema T, et al. Randomized study on dose escalation in definitive chemoradiation for patients with locally advanced esophageal cancer (ARTDECO Study). J Clin Oncol. 2021 Sep 1;39(25):2816-24.Full text  Abstract

235. Crehange G, M'vondo C, Bertaut A, et al. Exclusive chemoradiotherapy with or without radiation dose escalation in esophageal cancer: multicenter phase 2/3 randomized trial CONCORDE (PRODIGE-26)​. CENTRAL (Cochrane Central Register of Controlled Trials). 2021 Oct 30;(10):CN-02321697.Full text

236. Chuong MD, Hallemeier CL, Jabbour SK, et al. Improving outcomes for esophageal cancer using proton beam therapy. Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):488-97. Abstract

237. Wang J, Wei C, Tucker SL, et al. Predictors of postoperative complications after trimodality therapy for esophageal cancer. Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):885-91.Full text  Abstract

238. Lin SH, Hobbs BP, Verma V, et al. Randomized phase IIB trial of proton beam therapy versus intensity-modulated radiation therapy for locally advanced esophageal cancer. J Clin Oncol. 2020 May 10;38(14):1569-79.Full text  Abstract

239. ClinicalTrials.gov. Comparing proton therapy to photon radiation therapy for esophageal cancer.​ NCT03801876. Mar 2023 [internet publication].Full text

240. Yu J, Zhang X, Liao L, et al. Motion-robust intensity-modulated proton therapy for distal esophageal cancer. Med Phys. 2016 Mar;43(3):1111-8. Abstract

241. National Comprehensive Cancer Network. Clinical practice guidelines in oncology: management of immunotherapy-related toxicities [internet publication].Full text

242. Cancer Care Ontario. Preoperative or postoperative therapy for resectable esophageal cancer. Jun 2016 [internet publication].Full text

243. Little AG, Lerut AE, Harpole DH, et al. The Society of Thoracic Surgeons practice guidelines on the role of multimodality treatment for cancer of the esophagus and gastroesophageal junction. Ann Thorac Surg. 2014 Nov;98(5):1880-5.Full text  Abstract

244. Spaander MCW, van der Bogt RD, Baron TH, et al. Esophageal stenting for benign and malignant disease: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - update 2021. Endoscopy. 2021 Jul;53(7):751-62.Full text  Abstract

245. Robb WB, Messager M, Dahan L, et al; Fédération Francophone de Cancérologie Digestive; Société Française de Radiothérapie Oncologique; Union des Centres de Lutte Contre le Cancer; Groupe Coopérateur Multidisciplinaire en Oncologie; French EsoGAstric Tumour working group - Fédération de Recherche En Chirurgie. Patterns of recurrence in early-stage oesophageal cancer after chemoradiotherapy and surgery compared with surgery alone. Br J Surg. 2016 Jan;103(1):117-25.Full text  Abstract

246. National Cancer Institute: Surveillance, Epidemiology, and End Results (SEER) Program. Esophagus: SEER 5-year relative survival rates, 2012-2018. 2021 [internet publication].Full text

247. Athauda A, Nankivell M, Langley RE, et al. Impact of sex and age on chemotherapy efficacy, toxicity and survival in localised oesophagogastric cancer: a pooled analysis of 3265 individual patient data from four large randomised trials (OE02, OE05, MAGIC and ST03). Eur J Cancer. 2020 Sep;137:45-56.Full text  Abstract

248. Gottlieb-Vedi E, Kauppila JH, Malietzis G, et al. Long-term survival in esophageal cancer after minimally invasive compared to open esophagectomy: a systematic review and meta-analysis. Ann Surg. 2019 Dec;270(6):1005-17. Abstract

249. Society for Surgery of the Alimentary Tract. SSAT patient care guidelines: surgical treatment of esophageal cancer. J Gastrointest Surg. 2007 Sep;11(9):1216-8. Abstract

250. van Kooten RT, Voeten DM, Steyerberg EW, et al. Patient-related prognostic factors for anastomotic leakage, major complications, and short-term mortality following esophagectomy for cancer: a systematic review and meta-analyses. Ann Surg Oncol. 2022 Feb;29(2):1358-73.Full text  Abstract

251. Yasunaga H, Matsuyama Y, Ohe K, et al. Effects of hospital and surgeon case-volumes on postoperative complications and length of stay after esophagectomy in Japan. Surg Today. 2009;39(7):566-71. Abstract

252. Cooke DT, Lin GC, Lau CL, et al. Analysis of cervical esophagogastric anastomotic leaks after transhiatal esophagectomy: risk factors, presentation, and detection. Ann Thorac Surg. 2009 Jul;88(1):177-85.Full text  Abstract

253. Zhou X, Yao Z, Bai H, et al. Treatment-related adverse events of PD-1 and PD-L1 inhibitor-based combination therapies in clinical trials: a systematic review and meta-analysis. Lancet Oncol. 2021 Sep;22(9):1265-74. Abstract

254. Powell N, Ibraheim H, Raine T, et al. British Society of Gastroenterology endorsed guidance for the management of immune checkpoint inhibitor-induced enterocolitis. Lancet Gastroenterol Hepatol. 2020 Jul;5(7):679-97. Abstract

255. D'Journo XB, Martin J, Ferraro P, et al. The esophageal remnant after gastric interposition. Dis Esophagus. 2008;21(5):377-88.Full text  Abstract

256. American Cancer Society. Living as an esophagus cancer survivor. Jun 2020 [internet publication].Full text

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