Evaluation of pancytopenia

References

Key articles

Young NS. Aplastic Anemia. N Engl J Med. 2018 Oct 25;379(17):1643-56.Full text  Abstract

Williams DA, Bennett C, Bertuch A, et al. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer. 2014 May;61(5):869-74.Full text  Abstract

Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016 May 19;127(20):2391-405.Full text  Abstract

Reference articles

1. Saha KC. Diagnosis of arsenicosis. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003 Jan;38(1):255-72. Abstract

2. Parker C, Omine M, Richards S, et al; International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005 Dec 1;106(12):3699-709.Full text  Abstract

3. Gregory JJ Jr, Wagner JE, Verlander PC, et al. Somatic mosaicism in Fanconi anemia: evidence of genotypic reversion in lymphohematopoietic stem cells. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2532-7. Abstract

4. Chessells JM. Pitfalls in the diagnosis of childhood leukaemia. Br J Haematol. 2001 Sep;114(3):506-11. Abstract

5. Faivre L, Guardiola P, Lewis C, et al. Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. Blood. 2000 Dec 15;96(13):4064-70. Abstract

6. Khincha PP, Savage SA. Neonatal manifestations of inherited bone marrow failure syndromes. Semin Fetal Neonatal Med. 2016 Feb;21(1):57-65.Full text  Abstract

7. Calado RT, Young NS. Telomere diseases. N Engl J Med. 2009 Dec 10;361(24):2353-65. Abstract

8. Mason PJ, Bessler M. The genetics of dyskeratosis congenita. Cancer Genet. 2011 Dec;204(12):635-45. Abstract

9. Keller RB, Gagne KE, Usmani GN, et al. Ctc1 mutations in a patient with dyskeratosis congenita. Pediatr Blood Cancer. 2012 Aug;59(2):311-4. Abstract

10. Perdigones N, Perin JC, Schiano I, et al. Clonal hematopoiesis in patients with dyskeratosis congenita. Am J Hematol. 2016 Dec;91(12):1227-33.Full text  Abstract

11. Kirwan M, Dokal I. Dyskeratosis congenita: a genetic disorder of many faces. Clin Genet. 2008 Feb;73(2):103-12. Abstract

12. Appelbaum FR, Barrall J, Storb R, et al. Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anemia. Exp Hematol. 1987 Dec;15(11):1134-9. Abstract

13. Vulliamy TJ, Marrone A, Knight SW, et al. Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation. Blood. 2006 Apr 1;107(7):2680-5. Abstract

14. Bluteau O, Sebert M, Leblanc T, et al. A landscape of germ line mutations in a cohort of inherited bone marrow failure patients. Blood. 2018 Feb 15;131(7):717-32.Full text  Abstract

15. Cines DB, Liebman H, Stasi R. Pathobiology of secondary immune thrombocytopenia. Semin Hematol. 2009 Jan;46(1 Suppl 2):S2-14.Full text  Abstract

16. Norton A, Roberts I. Management of Evans syndrome. Br J Haematol. 2006 Jan;132(2):125-37.Full text  Abstract

17. Camitta BM, Rappeport JM, Parkman R, et al. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood. 1975 Mar;45(3):355-63.Full text  Abstract

18. Bacigalupo A, Hows J, Gluckman E, et al. Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party. Br J Haematol. 1988 Oct;70(2):177-82. Abstract

19. Killick SB, Bown N, Cavenagh J, et al; British Society for Standards in Haematology. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016 Jan;172(2):187-207.Full text  Abstract

20. Young NS. Aplastic Anemia. N Engl J Med. 2018 Oct 25;379(17):1643-56.Full text  Abstract

21. Weinzierl EP, Arber DA. The differential diagnosis and bone marrow evaluation of new-onset pancytopenia. Am J Clin Pathol. 2013 Jan;139(1):9-29.Full text  Abstract

22. Williams DA, Bennett C, Bertuch A, et al. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer. 2014 May;61(5):869-74.Full text  Abstract

23. Desai AV, Perpich M, Godley LA. Clinical assessment and diagnosis of germline predisposition to hematopoietic malignancies: the University of Chicago experience. Front Pediatr. 2017 Dec 6;5:252.Full text  Abstract

24. Weinzierl EP, Arber DA. Bone marrow evaluation in new-onset pancytopenia. Hum Pathol. 2013 Jun;44(6):1154-64. Abstract

25. Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital. BMC Hematol. 2013 Nov 6;13(1):10. Abstract

26. Savage RA, Hoffman GC, Shaker K. Diagnostic problems involved in detection of metastatic neoplasms by bone marrow aspirate compared with needle biopsy. Am J. Clin Pathol. 1978 Oct;70(4):623-7. Abstract

27. Sanz MA, Martin G, Gonzalez M, et al. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group. Blood. 2004 Feb 15;103(4):1237-43. Abstract

28. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016 May 19;127(20):2391-405.Full text  Abstract

29. Janckila AJ, Wallace JH, Yam LT. Generalized monocyte deficiency in leukaemic reticuloendotheliosis. Scand J Haematol. 1982 Aug;29(2):153-60. Abstract

30. Bernasconi P, Boni M, Cavigliano PM, et al. Clinical relevance of cytogenetics in myelodysplastic syndromes. Ann N Y Acad Sci. 2006 Nov;1089:395-410. Abstract

31. Dezern AE, Borowitz MJ. ICCS/ESCCA consensus guidelines to detect GPI-deficient cells in paroxysmal nocturnal hemoglobinuria (PNH) and related disorders part 1 - clinical utility. Cytometry B Clin Cytom. 2018 Jan;94(1):16-22.Full text  Abstract

32. International Agranulocytosis and Aplastic Anemia Study Group. Incidence of aplastic anemia: the relevance of diagnostic criteria. Blood. 1987 Dec;70(6):1718-21. Abstract

33. Centers for Disease Control and Prevention. Brucellosis: areas at risk. November 2012 [internet publication].Full text

34. Pereira RM, Velloso ER, Menezes, et al. Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. Clin Rheum. 1998;17(3):219-22. Abstract

35. CE Allen, Yu X, Kozinetz CA, et al. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008 Jun;50(6):1227-35. Abstract

36. Sieni E, Cetica V, Hackmann Y, et al. Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning. Front Immunol. 2014 Apr 16;5:167.Full text  Abstract

37. Seif AE, Manno CS, Sheen C, et al. Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study. Blood. 2010 Mar 18;115(11):2142-5.Full text  Abstract

38. Oliveira JB, Bleesing JJ, Dianzani U, et al. Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop. Blood. 2010 Oct 7;116(14):e35-40.Full text  Abstract

39. Chalayer E, Costedoat-Chalumeau N, Beyne-Rauzy O, et al. Bone marrow involvement in systemic lupus erythematosus. QJM. 2017 Nov 1;110(11):701-11. Abstract

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