The precise prevalence and incidence of HHS is difficult to determine because of the lack of population-based studies and the multiple comorbidities often found in these patients. However, the overall prevalence is estimated at less than 1% of all diabetes-related hospital admissions. The incidence of HHS has been estimated at a rate of 17.5 per 100,000 patient years.
HHS is seen most commonly in older patients and those of African-American ethnicity with diabetes. Mortality rates in HHS have been reported to be 5% to 20%, a rate that is 10-fold higher than that reported for diabetic ketoacidosis. Mortality increases significantly when the patient is above the age of 70 years. A combined state of severe hyperglycemia, hyperosmolality, and metabolic acidosis is seen in approximately 25% of all hyperglycemic emergencies.
Use of this content is subject to our disclaimer