Preterm labor

References

Key articles

National Institute for Health and Care Excellence. Preterm labour and birth. Jun 2022 [internet publication].Full text

Shennan AH, Story L, Royal College of Obstetricians, Gynaecologists. Cervical cerclage: green-top guideline no. 75. BJOG. 2022 Jun;129(7):1178-210.Full text  Abstract

EPPPIC Group. Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials. Lancet. 2021 Mar 27;397(10280):1183-94.Full text  Abstract

Royal College of Obstetricians and Gynaecologists. Care of women presenting with suspected preterm prelabour rupture of membranes from 24+0 weeks of gestation. Green-top guideline no. 73. Jun 2019 [internet publication].Full text

American College of Obstetricians and Gynecologists' Committee on Committee Opinion-Obstetrics. ACOG committee opinion no. 713: antenatal corticosteroid therapy for fetal maturation. Obstet Gynecol. 2017 Aug;130(2):e102-9.Full text  Abstract

Reference articles

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25. Suff N, Xu VX, Glazewska-Hallin A, et al. Previous term emergency caesarean section is a risk factor for recurrent spontaneous preterm birth; a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2022 Apr;271:108-11.Full text  Abstract

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32. Health Services Safety Investigations Body. Management of preterm labour and birth of twins. Aug 2022 [internet publication].Full text

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35. Iams JD, Johnson FF, Sonek J, et al. Cervical competence as a continuum: a study of ultrasonographic cervical length and obstetric performance. Am J Obstet Gynecol. 1995;172:1097-1103. Abstract

36. Peaceman AM, Andrews WW, Thorp JM, et al. Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial. Am J Obstet Gynecol. 1997;177:13-18. Abstract

37. Gyetvai K, Hannah ME, Hodnett ED, et al. Tocolytics for preterm labor: a systematic review. Obstet Gynecol. 1999;94:869-877. Abstract

38. Dodd JM, Jones L, Flenady V, et al. Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth. Cochrane Database Syst Rev. 2013;(7):CD004947.Full text  Abstract

39. Kyrgiou M, Athanasiou A, Kalliala IEJ, et al. Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease. Cochrane Database Syst Rev. 2017 Nov 2;11(11):CD012847.Full text  Abstract

40. Ananth CV, Getahun D, Peltier MR, et al. Recurrence of spontaneous versus medically indicated preterm birth. Am J Obstet Gynecol. 2006 Sep;195(3):643-50. Abstract

41. Arbyn M, Kyrgiou M, Simoens C, et al. Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis. BMJ. 2008 Sep 18;337:a1284.Full text  Abstract

42. Castanon A, Brocklehurst P, Evans H, et al; PaCT Study Group. Risk of preterm birth after treatment for cervical intraepithelial neoplasia among women attending colposcopy in England: retrospective-prospective cohort study. BMJ. 2012 Aug 16;345:e5174.Full text  Abstract

43. Castanon A, Landy R, Brocklehurst P, et al. Risk of preterm delivery with increasing depth of excision for cervical intraepithelial neoplasia in England: nested case-control study. BMJ. 2014 Nov 5;349:g6223.Full text  Abstract

44. Morken NH, Gunnes N, Magnus P, et al. Risk of spontaneous preterm delivery in a low-risk population: the impact of maternal febrile episodes, urinary tract infection, pneumonia and ear-nose-throat infections. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):310-4. Abstract

45. Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020 Sep 1;370:m3320.Full text  Abstract

46. Simbar M, Nazarpour S, Sheidaei A. Evaluation of pregnancy outcomes in mothers with COVID-19 infection: a systematic review and meta-analysis. J Obstet Gynaecol. 2023 Dec;43(1):2162867.Full text  Abstract

47. Shennan A, Crawshaw S, Briley A, et al. A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study. BJOG. 2006 Jan;113(1):65-74.Full text  Abstract

48. Shennan A, Jones G, Hawken J, et al. Fetal fibronectin test predicts delivery before 30 weeks of gestation in high risk women, but increases anxiety. BJOG. 2005 Mar;112(3):293-8.Full text  Abstract

49. Ruma MS, Betts M, Dodman S, et al. Predictive value of quantitative fetal fibronectin for spontaneous preterm birth in asymptomatic pregnancies: a systematic literature review and meta-analysis. J Matern Fetal Neonatal Med. 2023 Dec;36(2):2279923.Full text  Abstract

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53. Hincz P, Wilczynski J, Kozarzewski M, et al. Two-step test: the combined use of fetal fibronectin and sonographic examination of the uterine cervix for prediction of preterm delivery in symptomatic patients. Acta Obstet Gynecol Scand. 2002 Jan;81(1):58-63. Abstract

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58. American College of Obstetricians and Gynecologists Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin no. 171: management of preterm labor. Obstet Gynecol. 2016 Oct;128(4):e155-64.Full text  Abstract

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60. Heath VC, Southall TR, Souka AP, et al. Cervical length at 23 weeks of gestation: prediction of spontaneous preterm delivery. Ultrasound Obstet Gynecol. 1998 Nov;12(5):312-7. Abstract

61. Nygren P, Fu R, Freeman M, et al. Evidence on the benefits and harms of screening and treating pregnant women who are asymptomatic for bacterial vaginosis: an update review for the U.S. Preventive Services Task Force. Ann Intern Med. 2008 Feb 5;148(3):220-33.Full text  Abstract

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64. World Health Organization. WHO recommendation on tocolytic therapy for improving preterm birth outcomes. Sep 2022 [internet publication].Full text

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66. Althuisius SM, Dekker GA, Hummel P, et al. Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. Am J Obstet Gynecol. 2001 Nov;185(5):1106-12. Abstract

67. Alfirevic Z, Stampalija T, Medley N. Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev. 2017 Jun 6;6(6):CD008991.Full text  Abstract

68. Berghella V, Rafael TJ, Szychowski JM, et al. Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth: a meta-analysis. Obstet Gynecol. 2011 Mar;117(3):663-71. Abstract

69. To MS, Alfirevic Z, Heath VC, et al. Cervical cerclage for prevention of preterm delivery in women with short cervix: randomised controlled trial. Lancet. 2004 Jun 5;363(9424):1849-53. Abstract

70. Care A, Nevitt SJ, Medley N, et al. Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis. BMJ. 2022 Feb 15;376:e064547.Full text  Abstract

71. National Institute for Health and Care Excellence. Preterm labour and birth. Jun 2022 [internet publication].Full text

72. American College of Obstetricians and Gynecologists. ACOG practice advisory: updated clinical guidance for the use of progesterone supplementation for the prevention of recurrent preterm birth. Apr 2023 [internet publication].Full text

73. Shennan A, Suff N, Leigh Simpson J, et al. FIGO good practice recommendations on progestogens for prevention of preterm delivery. Int J Gynaecol Obstet. 2021 Oct;155(1):16-8.Full text  Abstract

74. Conde-Agudelo A, Romero R, Da Fonseca E, et al. Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis. Am J Obstet Gynecol. 2018 Jul;219(1):10-25.Full text  Abstract

75. Berghella V, Keeler SM, To MS, et al. Effectiveness of cerclage according to severity of cervical length shortening: a meta-analysis. Ultrasound Obstet Gynecol. 2010 Apr;35(4):468-73.Full text  Abstract

76. Blikman MJ, Le TM, Bruinse HW, et al. Ultrasound-predicated versus history-predicated cerclage in women at risk of cervical insufficiency: a systematic review. Obstet Gynecol Surv. 2008 Dec;63(12):803-12. Abstract

77. Simcox R, Seed PT, Bennett P, et al. A randomized controlled trial of cervical scanning vs history to determine cerclage in women at high risk of preterm birth (CIRCLE trial). Am J Obstet Gynecol. 2009 Jun;200(6):623.e1-6. Abstract

78. Burger NB, Brölmann HA, Einarsson JI, et al. Effectiveness of abdominal cerclage placed via laparotomy or laparoscopy: systematic review. J Minim Invasive Gynecol. 2011 Nov-Dec;18(6):696-704. Abstract

79. Shennan AH, Story L, Royal College of Obstetricians, Gynaecologists. Cervical cerclage: green-top guideline no. 75. BJOG. 2022 Jun;129(7):1178-210.Full text  Abstract

80. Shennan A, Chandiramani M, Bennett P, et al. MAVRIC: a multicenter randomized controlled trial of transabdominal vs transvaginal cervical cerclage. Am J Obstet Gynecol. 2020 Mar;222(3):261.e1-261.e9. Abstract

81. Ehsanipoor RM, Seligman NS, Saccone G, et al. Physical examination-indicated cerclage: a systematic review and meta-analysis. Obstet Gynecol. 2015 Jul;126(1):125-35. Abstract

82. Olatunbosun OA, al-Nuaim L, Turnell RW. Emergency cerclage compared with bed rest for advanced cervical dilatation in pregnancy. Int Surg. 1995 Apr-Jun;80(2):170-4. Abstract

83. D'Antonio F, Eltaweel N, Prasad S, et al. Cervical cerclage for prevention of preterm birth and adverse perinatal outcome in twin pregnancies with short cervical length or cervical dilatation: a systematic review and meta-analysis. PLoS Med. 2023 Aug;20(8):e1004266.Full text  Abstract

84. EPPPIC Group. Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials. Lancet. 2021 Mar 27;397(10280):1183-94.Full text  Abstract

85. Sotiriadis A, Papatheodorou S, Makrydimas G. Perinatal outcome in women treated with progesterone for the prevention of preterm birth: a meta-analysis. Ultrasound Obstet Gynecol. 2012 Sep;40(3):257-66.Full text  Abstract

86. Dodd JM, Grivell RM, OBrien CM, et al. Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database Syst Rev. 2019 Nov 20;2019(11):CD012024.Full text  Abstract

87. Sanchez-Ramos L, Delke I, Zamora J, et al. Fetal fibronectin as a short-term predictor of preterm birth in symptomatic patients: a meta-analysis. Obstet Gynecol. 2009 Sep;114(3):631-40. Abstract

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89. Kuhrt K, Hezelgrave N, Foster C, et al. Development and validation of a tool incorporating quantitative fetal fibronectin to predict spontaneous preterm birth in symptomatic women. Ultrasound Obstet Gynecol. 2016 Feb;47(2):210-6. Abstract

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91. Boots AB, Sanchez-Ramos L, Bowers DM, et al. The short-term prediction of preterm birth: a systematic review and diagnostic metaanalysis. Am J Obstet Gynecol. 2014 Jan;210(1):54.e1-54.e10.Full text  Abstract

92. Berghella V, Saccone G. Cervical assessment by ultrasound for preventing preterm delivery. Cochrane Database Syst Rev. 2019 Sep 25;9(9):CD007235.Full text  Abstract

93. Honest H, Bachmann LM, Gupta JK, et al. Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review. BMJ. 2002 Aug 10;325(7359):301.Full text  Abstract

94. Williams MJ, Ramson JA, Brownfoot FC. Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth. Cochrane Database Syst Rev. 2022 Aug 9;8(8):CD006764.Full text  Abstract

95. Berghella V, Saccone G. Fetal fibronectin testing for reducing the risk of preterm birth. Cochrane Database Syst Rev. 2019 Jul 29;7(7):CD006843.Full text  Abstract

96. Bruijn MM, Kamphuis EI, Hoesli IM, et al. The predictive value of quantitative fibronectin testing in combination with cervical length measurement in symptomatic women. Am J Obstet Gynecol. 2016 Dec;215(6):793.e1-793.e8. Abstract

97. Bruijn M, Vis JY, Wilms FF, et al. Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women. BJOG. 2016 Nov;123(12):1965-71.Full text  Abstract

98. Watson HA, Carter J, Seed PT, et al. The QUiPP App: a safe alternative to a treat-all strategy for threatened preterm labor. Ultrasound Obstet Gynecol. 2017 Sep;50(3):342-6.Full text  Abstract

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100. Pirjani R, Moini A, Almasi-Hashiani A, et al. Placental alpha microglobulin-1 (PartoSure) test for the prediction of preterm birth: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2021 Oct;34(20):3445-57. Abstract

101. National Institute for Health and Care Excellence. Biomarker tests to help diagnose preterm labour in women with intact membranes. ​Jul 2018 [internet publication].Full text

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103. Odubamowo K, Garcia M, Muriithi F, et al. Self-collected versus health-care professional taken swab for identification of vaginal-rectal colonisation with group B streptococcus in late pregnancy: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2023 Jul;286:95-101.Full text  Abstract

104. Abbott DS, Radford SK, Seed PT, et al. Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women. Am J Obstet Gynecol. 2013 Feb;208(2):122.e1-6.Full text  Abstract

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106. Abbott DS, Hezelgrave NL, Seed PT, et al. Quantitative fetal fibronectin to predict preterm birth in asymptomatic women at high risk. Obstet Gynecol. 2015 May;125(5):1168-76. Abstract

107. Esplin MS, Elovitz MA, Iams JD, et al. Predictive accuracy of serial transvaginal cervical lengths and quantitative vaginal fetal fibronectin levels for spontaneous preterm birth among nulliparous women. JAMA. 2017 Mar 14;317(10):1047-1056. Abstract

108. American College of Obstetricians and Gynecologists. Prediction and prevention of spontaneous preterm birth: ACOG practice bulletin, number 234. Obstet Gynecol. 2021 Aug 1;138(2):e65-90. Abstract

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111. Abenhaim HA, Morin L, Benjamin A. Does availability of fetal fibronectin testing in the management of threatened preterm labor affect the utilization of hospital resources? J Obstet Gynaecol Can. 2005 Jul;27(7):689-94. Abstract

112. Watts DH, Krohn MA, Hillier SL, et al. Characteristics of women in preterm labor associated with elevated C-reactive protein levels. Obstet Gynecol. 1993 Oct;82(4 Pt 1):509-14. Abstract

113. Lewis DF, Adair CD, Weeks JW, et al. A randomized clinical trial of daily nonstress testing versus biophysical profile in the management of preterm premature rupture of membranes. Am J Obstet Gynecol. 1999 Dec;181(6):1495-9. Abstract

114. Royal College of Obstetricians and Gynaecologists. Care of women presenting with suspected preterm prelabour rupture of membranes from 24+0 weeks of gestation. Green-top guideline no. 73. Jun 2019 [internet publication].Full text

115. Royal College of Obstetricians and Gynaecologists. Group B streptococcal disease, early-onset. Green-top guideline no. 36. Sep 2017 [internet publication].Full text

116. American College of Obstetricians and Gynecologists. ACOG committee opinion no. 797: prevention of group B streptococcal early-onset disease in newborns. Obstet Gynecol. 2020 Feb;135(2):e51-72.Full text  Abstract

117. Kenyon S, Boulvain M, Neilson JP. Antibiotics for preterm rupture of membranes. Cochrane Database Syst Rev. 2013 Dec 2;(12):CD001058.Full text  Abstract

118. World Health Organization. WHO recommendations on antenatal corticosteroids for improving preterm birth outcomes. Sep 2022 [internet publication].Full text

119. American College of Obstetricians and Gynecologists' Committee on Practice Bulletins - Obstetrics. ACOG practice bulletin no. 217: prelabor rupture of membranes. Obstet Gynecol. 2020 Mar;135(3):e80-97.Full text  Abstract

120. Combs CA, McCune M, Clark R, et al. Aggressive tocolysis does not prolong pregnancy or reduce neonatal morbidity after preterm premature rupture of the membranes. Am J Obstet Gynecol. 2004 Jun;190(6):1723-8; discussion 1728-31. Abstract

121. Morris JM, Roberts CL, Bowen JR, et al. Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial. Lancet. 2016 Jan 30;387(10017):444-52. Abstract

122. Bond DM, Middleton P, Levett KM, et al. Planned early birth versus expectant management for women with preterm prelabour rupture of membranes prior to 37 weeks' gestation for improving pregnancy outcome. Cochrane Database Syst Rev. 2017 Mar 3;3(3):CD004735.Full text  Abstract

123. Valencia CM, Mol BW, Jacobsson B, et al. FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth. Int J Gynaecol Obstet. 2021 Oct;155(1):8-12.Full text  Abstract

124. National Institute for Health and Care Excellence. Inducing labour. Nov 2021 [internet publication].Full text

125. American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 765: Avoidance of nonmedically indicated early-term deliveries and associated neonatal morbidities. Obstet Gynecol. 2019 Feb;133(2):e156-63.Full text  Abstract

126. McGoldrick E, Stewart F, Parker R, et al. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2020 Dec 25;12(12):CD004454.Full text  Abstract

127. American College of Obstetricians and Gynecologists' Committee on Committee Opinion-Obstetrics. ACOG committee opinion no. 713: antenatal corticosteroid therapy for fetal maturation. Obstet Gynecol. 2017 Aug;130(2):e102-9.Full text  Abstract

128. Stock SJ, Thomson AJ, Papworth S, et al. Antenatal corticosteroids to reduce neonatal morbidity and mortality: green-top guideline no. 74. BJOG. 2022 Jul;129(8):e35-60.Full text  Abstract

129. Elimian A, Garry D, Figueroa R, et al. Antenatal betamethasone compared with dexamethasone (betacode trial): a randomized controlled trial. Obstet Gynecol. 2007 Jul;110(1):26-30. Abstract

130. American College of Obstetricians and Gynecologists. ACOG practice advisory:​ use of antenatal corticosteroids at 22 weeks of gestation. Sep 2021 [internet publication].Full text

131. Gyamfi-Bannerman C, Thom EA, Blackwell SC, et al. Antenatal betamethasone for women at risk for late preterm delivery. N Engl J Med. 2016 Apr 7;374(14):1311-20. Abstract

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