Epidemiology

The true incidence of NMS is not known because the available evidence is inconclusive.[14] Estimates range from 0.02% to 3%.[15] An important limitation when considering published estimates is that they are almost exclusively incidence proportions (number of new cases over a period of time divided by number of persons at risk at the beginning of the time period) rather than true incidence rates (number of new cases over a period of time divided by the person-time at risk).[14] Reported incidence has declined over the last 20 years, which may reflect greater awareness with heightened vigilance and more prompt clinical intervention. Other possible factors may include systematic reporting bias,[14] an evolving practice trend toward the use of second-generation antipsychotic medications (SGAs), and caution in using high initial doses of antipsychotics.

BMJ Best Practice is an evidence-based point of care tool for healthcare practitioners.

To continue reading and access all of BMJ Best Practice's pages you'll need to log in or start a free trial.

You can access through your institution if your hospital, university, trust or other institution provides access to BMJ Best Practice through either OpenAthens or Shibboleth.

Use of this content is subject to our disclaimer