Резюме
Aphasia is an acquired impairment of language that affects comprehension and production of words, sentences, and/or discourse. It is typically characterized by errors in word retrieval or selection, including:
Semantic paraphasias (substituting a semantically related word for a target word, e.g., calling a horse a cow)
Phonemic paraphasias (substituting one or more sounds in the word, e.g., calling a horse a force or using a non-word such as porse)
Neologisms (a series of sounds that do not comprise a word and are not similar to the target word)
Circumlocutions (e.g., calling a horse an animal that you ride with a saddle).
Typically, both oral and written language are affected, but occasionally only one modality of input or output is impaired.
Definitions: aphasia, dysarthria, and apraxia
It is important to distinguish aphasia from dysarthria or apraxia.
Aphasia is a selective impairment of language or the cognitive processes that underlie language. Individuals with dementia often have language problems, but they also have at least equally severe deficits in episodic memory, visuospatial skills, and/or executive functions (e.g., organization, planning, decision making).
Dysarthria is an acquired disorder of speech production due to weakness, slowness, reduced range of movement, or impaired timing and coordination of the muscles of the jaw, lips, tongue, palate, vocal folds, and/or respiratory muscles (the speech articulators).
Apraxia of speech is an impairment in the motor planning and programming of the speech articulators that cannot be attributed to dysarthria.
These 3 disorders can coexist, but often occur separately. They can be distinguished by evaluation of language (tests of word and sentence comprehension, naming, repetition, spontaneous speech, reading, and writing), as well as tests of articulation (tests assessing the strength, coordination, rate, and range of movement of the muscles of speech articulation) and motor speech programming.
Vascular classification of aphasias
The most common classification of aphasia divides the disorder into clinical syndromes of frequently co-occurring deficits that reflect the vascular territory affected in stroke.[1][2] For example, the Western aphasia battery and Boston diagnostic aphasia examination were designed to distinguish vascular syndromes.[3][4] The relationship between the symptoms and the vascular territory that is affected is not always consistent, but is more reliable acutely than chronically.[5]
Broca aphasia is characterized by nonfluent, poorly articulated, and agrammatic speech output (in both spontaneous speech and repetition) with relatively spared word comprehension. Individuals with Broca aphasia often have difficulty understanding syntactically complex or semantically reversible sentences (e.g., "touch your nose after you touch your foot") but have little trouble understanding simple, semantically nonreversible sentences. This collection of syndromes is usually associated with ischemia or other lesions in the left posterior inferior frontal cortex, in the distribution of the superior division of the left middle cerebral artery (MCA).
Wernicke aphasia is characterized by fluent but meaningless speech output and repetition, with poor word and sentence comprehension. It is typically due to ischemia in the posterior superior temporal cortex, in the distribution of the inferior division of the left MCA.
Conduction aphasia is characterized by disproportionately impaired repetition with otherwise fluent speech. It is typically due to ischemia affecting the inferior parietal lobule.
Transcortical aphasia is characterized by relatively spared repetition. Transcortical sensory aphasia usually results from ischemia involving the watershed area between the left MCA and left posterior cerebral artery (PCA) territory.
Transcortical motor aphasia usually results from ischemia involving the watershed area between the left MCA and left anterior cerebral artery (ACA) territory.
Mixed transcortical aphasia results from lesions in the left MCA and left PCA territory, in combination with the left MCA and left ACA territory. Repetition is the primary language ability.
Anomic aphasia is characterized by impaired naming and tissue damage in the angular gyrus or posterior middle/inferior temporal cortex.
Global aphasia denotes severe impairment in all aspects of language; the area of ischemia often involves both anterior and posterior language areas (Broca and Wernicke areas).[Figure caption and citation for the preceding image starts]: Broca’s area, Wernicke’s area and the angular gyrus.Created by the BMJ Knowledge Centre. [Citation ends].
[Figure caption and citation for the preceding image starts]: Watershed areas between the anterior, middle and posterior cerebral artery territories.Created by the BMJ Knowledge Centre. [Citation ends].
Fluency classification of aphasias
Fluency is a multidimensional term referring to the melody, prosody (pattern of stress and intonation), phrase length, rate of speech, grammaticality, effort, and articulatory precision of spontaneous speech. This is often tested by asking the patient to describe a complex picture depicting a number of activities.
Patients with fluent aphasia (melodious, effortless, well-articulated speech, which may have little content) tend to have posterior lesions in the left hemisphere, whereas patients with nonfluent aphasia (effortful, poorly-articulated speech, with more accurate content than speech sounds) tend to have anterior lesions in the brain. However, because fluency is a multidimensional term based on factors that can dissociate (grammatical accuracy, rate of speech, prosody, effort, articulatory precision, hesitations), it is often difficult to judge. A patient can be fluent on one dimension and nonfluent on another. Therefore, there is often disagreement between 2 people in judging fluency of an aphasic individual.
Fluent aphasias are typically due to lesions posterior to the central sulcus:
Wernicke aphasia with fluent, jargon speech and poor comprehension
Transcortical sensory aphasia, characterized by well-preserved repetition abilities in the context of poor comprehension and fluent but meaningless propositional speech
Conduction aphasia in which fluent spontaneous speech is preserved but repetition is impaired
Anomic aphasia with deficit of word finding and naming.
Nonfluent aphasias encompass the regions anterior to the central sulcus:
Broca aphasia
Transcortical motor aphasia with difficulty in initiating and organizing responses, but relatively preserved repetition
Mixed transcortical aphasia in which echolalia (repetition) is the only preserved language skill
Global aphasia characterized by severe impairment in speech and comprehension, and stereotypical utterances.
Disorders that only affect reading are referred to as types of alexia. Those that only affect writing are types of agraphia.[6][7]
An important variable that complicates these deficit associations is the remarkable reorganization of structure-function relationships that often occurs after brain lesions, such that undamaged parts of the brain assume the functions of the damaged part over time, resulting in recovery from even the most severe aphasias (usually only after appropriate language therapy).
Ventral versus dorsal stream classification of aphasia
Ventral stream: a stream of processing that supports the interface between sensory-phonologic networks with semantic-conceptual network ("sound to meaning"), from Heschl gyrus bilaterally through the left temporal cortex, with widespread connections to semantic representations bilaterally. Lesions in the ventral stream disrupt word comprehension as well as sentence comprehension.[8][9]
Dorsal stream: a stream of processing that supports the interface between sensory-phonologic networks and motor-articulatory networks ("sound to speech"), from Heschl gyrus bilaterally through left supramarginal gyrus and inferior frontal gyrus. Lesions in dorsal stream disrupt word and sentence repetition, grammatical sentence production, and speech articulation.[8][9]
Follow-up treatment
After identifying and treating the underlying cause of aphasia, such as acute stroke or herpes encephalitis, patients may have a residual aphasia. Such aphasic individuals benefit from referral to a speech language pathologist specializing in aphasia therapy.
Treatment should be individualized to address the person's residual deficits, communicative needs and priorities, and available resources.[10] Therapy often addresses the impaired cognitive processes underlying the individual's altered performance of language tasks. It is sometimes argued that intensive therapy (e.g., 5 days per week) is often more effective than less intensive therapy, unless the person is able to practice emerging skills on their own, often with the aid of a computer.[11][12] However, the dose (number of sessions) may actually be more important than the intensity.[13] Speech and language therapy can significantly improve functional communication, comprehension, and production of speech.[12]
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Alternatively, caregivers can be trained by the speech language pathologist to provide effective practice.[14] Therapy might be augmented with medications, such as memantine or donepezil, or with transcranial direct current stimulation.[15][16][17] Larger randomized controlled trials are needed to determine whether these interventions have a significant benefit over speech and language therapy alone.
Differentials
Common
- Ischemic stroke
- Intracerebral hemorrhage
- Alzheimer disease
- Traumatic head injury
Uncommon
- Subdural hematoma
- Subarachnoid hemorrhage
- Migraine
- Herpes encephalitis
- West Nile encephalitis
- Bacterial infection/abscess
- Fungal abscess
- Prion disease
- Toxoplasmosis
- Lyme disease
- Nonfluent/agrammatic-variant primary progressive aphasia (PPA)
- Semantic-variant PPA
- Logopenic-variant PPA
- Aphasia dysarthria motor neuron disease (amyotrophic lateral sclerosis [ALS]-frontotemporal degeneration)
- Primary brain tumor
- Brain metastases
- Multiple sclerosis
- Sarcoidosis
- Acute disseminated encephalomyelitis
- Seizure
- Conversion disorder
- Wernicke encephalopathy (thiamine deficiency)
Contributors
Authors
Argye E. Hillis, MD, MA
Professor of Neurology
Johns Hopkins University School of Medicine
Baltimore
MD
Disclosures
AEH has received grants from the National Institutes of Health (NIH) and receives royalties from Taylor & Francis for a textbook on aphasia. AEH is also an author of a number of references cited in this topic.
Peer reviewers
Brad Dickerson, MD
Director of the Frontotemporal Disorders Unit
Massachusetts General Hospital
Professor of Neurology
Harvard Medical School
Massachusetts
MA
Divulgaciones
BD declares that he has no competing interests.
Rajesh R. Tampi, MD, MS
Associate Clinical Professor of Psychiatry
Yale University School of Medicine
New Haven
CT
Divulgaciones
RRT declares that he has no competing interests.
Cory Toth, BSc, MD, FRCP(C)
Assistant Professor of Neurosciences
Hotchkiss Brain Institute
University of Calgary
Alberta
Canada
Divulgaciones
CT declares that he has no competing interests.
Alexander Leff, MBBS, BSc, MRCP, PhD
Senior Clinical Lecturer and Honorary Consultant Neurologist
Institute of Neurology
National Hospital for Neurology and Neurosurgery
University College London
London
UK
Divulgaciones
AL declares that he has no competing interests.
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Referencias
Artículos principales
Brady MC, Kelly H, Godwin J, et al. Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev. 2016;(6):CD000425.Texto completo Resumen
Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019 Dec;50(12):e344-418.Texto completo Resumen
Royal College of Physicians, Royal College of Physicians of Ireland, Scottish Intercollegiate Guidelines Network. National clinical guideline for stroke for the United Kingdom and Ireland. 2023 [internet publication].Texto completo
Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2022 Jul;53(7):e282-361.Texto completo Resumen
Expert Panel on Neurological Imaging, Ledbetter LN, Burns J, et al. ACR appropriateness criteria® cerebrovascular diseases-aneurysm, vascular malformation, and subarachnoid hemorrhage. J Am Coll Radiol. 2021 Nov;18(11s):S283-304.Texto completo Resumen
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