The best estimates of the frequency of FTD derive from studies in the UK, the Netherlands, and Canada. In Cambridge, UK, data derived from the records of speciality clinics and hospitals in several communities showed a prevalence of 15 cases per 100,000 in adults aged 45 to 64 years. In the Zuid-Holland province of the Netherlands, data derived from annual surveys of all neurologists and physicians practising showed a lower prevalence, 6.7 cases per 100,000 in the 45 to 64 age group. Age-specific prevalence rates were also calculated: 1.2 per 100,000 in the 40 to 49 age group; 3.6 per 100,000 in the 50 to 59 age group; 9.4 per 100,000 in the 60 to 69 age group; and 3.8 in the 70 to 79 age group. While the Cambridge study observed a 4.7-fold higher prevalence among men, the Zuid-Holland study reported a 1:1 gender distribution of cases. These two studies showed mean age at onset to be 53 and 58 years, respectively. Another study in Canada, which also ascertained clinic-based cases, reported a prevalence of 12% in adults <70 years of age.
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