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Night blindness

Последний просмотренный: 20 Aug 2025
Last updated: 05 Sep 2023

Резюме

Определение

Анамнез и осмотр

Ключевые диагностические факторы

  • family history of vision loss
  • history of retinitis pigmentosa
  • congenital stationary night blindness
  • past medical history of vitamin A deficiency or malignancy
Полная информация

Другие диагностические факторы

  • decreased visual acuity in dim light
  • variable pupillary responses (depending on underlying cause)
  • retinal vascular attenuation
  • visual field loss
  • peripheral chorioretinal degeneration
  • history of drugs that interfere with vitamin A metabolism
Полная информация

Факторы риска

  • retinitis pigmentosa
  • congenital stationary night blindness
  • vitamin A deficiency
  • cancer-associated retinopathy
  • melanoma-associated retinopathy
  • gyrate atrophy
  • choroideremia
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • electroretinography (ERG)
  • slit-biomicroscopy and indirect ophthalmoscopy
Полная информация

Исследования, проведение которых нужно рассмотреть

  • serum vitamin A level
  • next-generation-sequencing
Полная информация

Алгоритм лечения

Острый

genetic night blindness

acquired night blindness

Составители

Авторы

Jonathan Smith, FRCOphth, MRCP

Consultant Ophthalmologist

Sunderland Eye Infirmary

Sunderland

UK

Раскрытие информации

JS has received sponsorship from Novartis, Bayer, and DORC for meeting travel and accommodation. JS was awarded a research grant in 2017 by the British Vitreoretinal Society.

Muhammad Raza Cheema, MRCGP, MRes, FRCOphth, FEBO

Specialist Registrar

Ophthalmology

Sunderland Eye Infirmary

Sunderland

UK

Раскрытие информации

MRC declares that he has no competing interests.

Wendy Adams, MRCP, FRCOphth

Consultant Ophthalmologist

Sunderland Eye Infirmary

Sunderland

UK

Раскрытие информации

WA declares that she has no competing interests.

Выражение благодарностей

Dr Jonathan Smith, Dr Wendy Adams, and Dr Muhammad Raza Cheema would like to gratefully acknowledge the assistance of Ms Karen Bradshaw. KB declares that she has no competing interests.

Рецензенты

Makoto Nakamura, MD

Associate Professor

Department of Ophthalmology

Nagoya University Graduate School of Medicine

Nagoya

Japan

Раскрытие информации

MN declares that he has no competing interests.

Eric Amesbury, MD

Klara Spinks Fleming Fellow

Jules Stein Eye Institute

UCLA

Los Angeles

CA

Declarações

EA declares that he has no competing interests.

Creig S. Hoyt, MD

Emeritus Professor and Chairman

Department of Ophthalmology

University of California

San Francisco

CA

Declarações

CSH declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006 Nov 18;368(9549):1795-809. Resumo

Petzold A, Plant GT. Clinical disorders affecting mesopic vision. Ophthalmic Physiol Opt. 2006 May;26(3):326-41. Resumo

Goodwin P. Hereditary retinal disease. Curr Opin Ophthalmol. 2008 May;19(3):255-62. Resumo

Law WC, Rando RR. The molecular basis of retinoic acid induced night blindness. Biochem Biophys Res Commun. 1989 Jun 15;161(2):825-9. Resumo

Artigos de referência

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