小结
定义
病史和体格检查
关键诊断因素
- presence of risk factors
- family history of vision loss
- past medical history of vitamin A (retinol) deficiency or malignancy
其他诊断因素
- decreased visual acuity in dim light
- variable pupillary responses (depending on underlying cause)
- retinal vascular attenuation
- visual field loss
- peripheral chorioretinal degeneration
- history of drugs that interfere with vitamin A (retinol) metabolism
危险因素
- retinitis pigmentosa
- congenital stationary night blindness
- vitamin A (retinol) deficiency
- cancer-associated retinopathy
- melanoma-associated retinopathy
- gyrate atrophy
- choroideraemia
诊断性检查
首要检查
- electroretinography (ERG)
- slit-biomicroscopy and indirect ophthalmoscopy
需考虑的检查
- serum vitamin A (retinol) level
- next-generation-sequencing
治疗流程
genetic night blindness
acquired night blindness
撰稿人
作者
Jonathan Smith, FRCOphth, MRCP
Consultant Ophthalmologist
Sunderland Eye Infirmary
Sunderland
UK
利益声明
JS has received sponsorship from Novartis, Bayer, and DORC for meeting travel and accommodation. JS was awarded a research grant in 2017 by the British Vitreoretinal Society.
Muhammad Raza Cheema, MRCGP, MRes, FRCOphth, FEBO
Specialist Registrar
Ophthalmology
Sunderland Eye Infirmary
Sunderland
UK
利益声明
MRC declares that he has no competing interests.
Wendy Adams, MRCP, FRCOphth
Consultant Ophthalmologist
Sunderland Eye Infirmary
Sunderland
UK
利益声明
WA declares that she has no competing interests.
鸣谢
Dr Jonathan Smith, Dr Wendy Adams, and Dr Muhammad Raza Cheema would like to gratefully acknowledge the assistance of Ms Karen Bradshaw. KB declares that she has no competing interests.
同行评议者
Makoto Nakamura, MD
Associate Professor
Department of Ophthalmology
Nagoya University Graduate School of Medicine
Nagoya
Japan
利益声明
MN declares that he has no competing interests.
Eric Amesbury, MD
Klara Spinks Fleming Fellow
Jules Stein Eye Institute
UCLA
Los Angeles
CA
利益声明
EA declares that he has no competing interests.
Creig S. Hoyt, MD
Emeritus Professor and Chairman
Department of Ophthalmology
University of California
San Francisco
CA
利益声明
CSH declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006 Nov 18;368(9549):1795-809. Abstract
Petzold A, Plant GT. Clinical disorders affecting mesopic vision. Ophthalmic Physiol Opt. 2006 May;26(3):326-41. Abstract
Goodwin P. Hereditary retinal disease. Curr Opin Ophthalmol. 2008 May;19(3):255-62. Abstract
Law WC, Rando RR. The molecular basis of retinoic acid induced night blindness. Biochem Biophys Res Commun. 1989 Jun 15;161(2):825-9. Abstract
Reference articles
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Differentials
- Myopia
- Glaucoma
- Optic neuropathy
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