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Night blindness

Last reviewed: 25 Jul 2025
Last updated: 05 Sep 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • family history of vision loss
  • past medical history of vitamin A (retinol) deficiency or malignancy
Full details

Other diagnostic factors

  • decreased visual acuity in dim light
  • variable pupillary responses (depending on underlying cause)
  • retinal vascular attenuation
  • visual field loss
  • peripheral chorioretinal degeneration
  • history of drugs that interfere with vitamin A (retinol) metabolism
Full details

Risk factors

  • retinitis pigmentosa
  • congenital stationary night blindness
  • vitamin A (retinol) deficiency
  • cancer-associated retinopathy
  • melanoma-associated retinopathy
  • gyrate atrophy
  • choroideraemia
Full details

Diagnostic investigations

1st investigations to order

  • electroretinography (ERG)
  • slit-biomicroscopy and indirect ophthalmoscopy
Full details

Investigations to consider

  • serum vitamin A (retinol) level
  • next-generation-sequencing
Full details

Treatment algorithm

ACUTE

genetic night blindness

acquired night blindness

Contributors

Authors

Jonathan Smith, FRCOphth, MRCP

Consultant Ophthalmologist

Sunderland Eye Infirmary

Sunderland

UK

Disclosures

JS has received sponsorship from Novartis, Bayer, and DORC for meeting travel and accommodation. JS was awarded a research grant in 2017 by the British Vitreoretinal Society.

Muhammad Raza Cheema, MRCGP, MRes, FRCOphth, FEBO

​Specialist Registrar

Ophthalmology

Sunderland Eye Infirmary

Sunderland

UK

Declarações

MRC declares that he has no competing interests.

Wendy Adams, MRCP, FRCOphth

Consultant Ophthalmologist

Sunderland Eye Infirmary

Sunderland

UK

Declarações

WA declares that she has no competing interests.

Agradecimentos

Dr Jonathan Smith, Dr Wendy Adams, and Dr Muhammad Raza Cheema would like to gratefully acknowledge the assistance of Ms Karen Bradshaw. KB declares that she has no competing interests.

Revisores

Makoto Nakamura, MD

Associate Professor

Department of Ophthalmology

Nagoya University Graduate School of Medicine

Nagoya

Japan

Declarações

MN declares that he has no competing interests.

Eric Amesbury, MD

Klara Spinks Fleming Fellow

Jules Stein Eye Institute

UCLA

Los Angeles

CA

Declarações

EA declares that he has no competing interests.

Creig S. Hoyt, MD

Emeritus Professor and Chairman

Department of Ophthalmology

University of California

San Francisco

CA

Declarações

CSH declares that he has no competing interests.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006 Nov 18;368(9549):1795-809. Resumo

Petzold A, Plant GT. Clinical disorders affecting mesopic vision. Ophthalmic Physiol Opt. 2006 May;26(3):326-41. Resumo

Goodwin P. Hereditary retinal disease. Curr Opin Ophthalmol. 2008 May;19(3):255-62. Resumo

Law WC, Rando RR. The molecular basis of retinoic acid induced night blindness. Biochem Biophys Res Commun. 1989 Jun 15;161(2):825-9. Resumo

Artigos de referência

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