Complement proteins play direct key roles in host microbial defense. They complement the actions of specific antibodies and aid the processing and removal of immune complexes.   The complement system is pro-inflammatory, and multiple complex control factors are necessary to ensure that potential tissue damage is limited or minimised. Disease states occur with deficiencies in complement proteins (which can cause increased risk of invasive bacterial infections, and may be associated with autoimmune disease), or defects of factors controlling, focussing, and limiting complement activation. Complement deficiencies can be inherited or acquired (secondary to a complement-consuming disease state).
DJU owns shares in pharmaceuticals Glaxo and Shire, and has had registration fees paid for CPD attendance at international conferences by ALK Alkabelo (2015 - EACCI - Allergy) and CSL - Bearing (2016 - ESID - Immunodeficiency).
Professor of Medicine
Adult Immunodeficiency Program
University of Colorado Denver
CK is an author of a reference cited in this monograph. CK has received speaker fees from Cention, Aventis Behring, and Bristol Myers Squibb. CK has received honorarium for speaking at the Aspen Allergy Conference, for the Colorado Allergy Society. CK ran the research program for a biotechnology company with an approximate budget of $3.5 million.
Consultant Clinical Immunologist
Department of Clinical Immunology
John Radcliffe Hospital
SM declares that he has no competing interests.
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