In the US, the prevalence of membranous nephropathy is close to 2000 patients per year. In contrast to other primary glomerular diseases, the incidence of MN has remained constant since the 1980s.[1]Haas M, Meehan SM, Karrison TG, et al. Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997. Am J Kidney Dis. 1997;30:621-631.
http://www.ncbi.nlm.nih.gov/pubmed/9370176?tool=bestpractice.com
It is one of the most common causes of nephrotic syndrome globally, just behind focal segmental glomerular sclerosis, which is the most common aetiology.[2]Swaminathan SL, Leung N, Lager DJ, et al. Changing incidence of glomerular disease in Olmsted County, Minnesota: a 30-year renal biopsy study. Clin J Am Soc Nephrol. 2006;1:483-487.
http://cjasn.asnjournals.org/content/1/3/483.full
[3]Chen A, Frank R, Vento S, et al. Idiopathic membranous nephropathy in pediatric patients: presentation, response to therapy, and long-term outcome. BMC Nephrol. 2007;8:11.
http://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-8-11
http://www.ncbi.nlm.nih.gov/pubmed/17683621?tool=bestpractice.com
This disease affects patients of all ages and races but is more common in men, and is most commonly diagnosed in middle age. Incidence peaks in the fourth to fifth decades of life.[4]Cattran DC. Idiopathic membranous glomerulonephritis. Kidney Int. 2001;59:1983-1994.
http://www.kidney-international.org/article/S0085-2538%2815%2947692-6/fulltext
MN is rare in the paediatric population but is serious when it occurs.[3]Chen A, Frank R, Vento S, et al. Idiopathic membranous nephropathy in pediatric patients: presentation, response to therapy, and long-term outcome. BMC Nephrol. 2007;8:11.
http://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-8-11
http://www.ncbi.nlm.nih.gov/pubmed/17683621?tool=bestpractice.com
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