Last reviewed: 28 Oct 2020
Last updated: 24 Sep 2020

Summary

Definition

History and exam

Key diagnostic factors

  • facial or generalised oedema
  • age >1 year but <8 years

Other diagnostic factors

  • normal BP
  • absence of haematuria
  • history of recent viral illness
  • dyspnoea
  • history of lymphoma or leukemia

Risk factors

  • age >1 year but <8 years
  • Hodgkin's lymphoma
  • leukemia
  • recent viral illness
  • hepatitis B or C infection
  • low birth weight (LBW)

Diagnostic investigations

1st investigations to order

  • urinalysis
  • 24-hour urine protein
  • urine protein/creatinine ratio
  • serum albumin level
  • serum lipid profile
  • serum complement levels
  • serum electrolyte panel
  • full blood count (FBC)
  • glomerular filtration rate (GFR)
  • serum LFTs
  • renal ultrasound
More 1st investigations to order

Treatment algorithm

Contributors

Mehul P. Dixit

Professor and Chief Medical Director

Pediatric Dialysis & Renal Transplantation

Pediatric Nephrology

Department of Pediatrics

Blair E. Batson Hospital for Children

University of Mississippi Medical Center

Jackson

MS

Disclosures

MPD has acted as a consultant for Retrophin Pharmaceuticals.

Dr Mehul P. Dixit would like to gratefully acknowledge Dr Robert Mathias, a previous contributor to this topic. RM declares that he has no competing interests.

Peer reviewersVIEW ALL

Associate Professor of Paediatrics and Paediatric Nephrologist

Department of Maternal and Child Health

Nelson R. Mandela School of Medicine

University of KwaZulu-Natal

Durban

South Africa

Disclosures

RB is an author of a reference cited in the monograph.

Professor of Pediatrics

Vice Chairman for Affiliate & Network Affairs

Chief, Section on Nephrology

Division of Pediatric Nephrology

Children's Hospital at Montefiore of Albert Einstein College of Medicine

New York

NY

Disclosures

FJK declares that he has no competing interests.

Use of this content is subject to our disclaimer