Summary
Definition
History and exam
Diagnostic investigations
1st investigations to order
- serum urea and creatinine
- FBC with WBC differential
- urinalysis
- trial of discontinuing offending medication
- anti-neutrophil cytoplasmic antibody (ANCA)
- anti-nuclear antibody (ANA)
- anti-double stranded DNA (anti-ds DNA)
- complement profile
Investigations to consider
- kidney ultrasound
- kidney biopsy
- kidney gallium scan
- urine cytokines
Treatment algorithm
Contributors
Authors
Professor of Medicine (Nephrology)
Section of Nephrology
Department of Internal Medicine
Yale School of Medicine
New Haven
CT
Disclosures
MAP declares that he has no competing interests.
Assistant Professor of Medicine (Nephrology)
Yale Program of Applied Translational Research
Department of Internal Medicine
Yale School of Medicine
New Haven
CT
Disclosures
DGM has received a grant from the National Institutes of Health (K23DK-117065), focusing on biomarkers of acute interstitial nephritis, and is supported by the Yale O'Brien Center, focusing on subclinical acute interstitial nephritis. He has a provisional patent application (co-inventor) for provisional patent number 62/716,465, "System and methods for diagnosing acute interstitial nephritis".
Prof. Mark A. Perazella and Dr Dennis G. Moledina would like to gratefully acknowledge Dr James Marsh, Dr Alice Appel, Dr Gerald Appel, and Dr Kate Shiell, previous contributors to this topic.
Disclosures
JM, AA, GA, and KS declare that they have no competing interests.
Peer reviewers
Assistant Professor
Chicago Medical School
Rosalind Franklin University
Lombard
IL
Disclosures
IM declares that he has no competing interests.
Associate Professor
Nephrologist
McMaster University
Hamilton
Ontario
Canada
Disclosures
CC declares that she has no competing interests.
Consultant Nephrologist/Lead Clinician
Renal Unit
Glasgow Royal Infirmary
NHS Greater Glasgow and Clyde
Glasgow
UK
Disclosures
RM declares that he has no competing interests.
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