Incidence of TLS is unknown, as it has not been accurately assessed or documented in the majority of tumour types. It is more prevalent in haematological malignancies with high proliferating rates, tumour burden, and chemosensitivity (e.g., acute lymphocytic leukaemia and Burkitt's lymphoma). Males and females of any age or ethnicity can be affected. Advanced age may increase the risk of developing TLS due to reduced glomerular filtration rate and the presence of comorbid conditions.
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