Wilms tumor

References

Key articles

Spreafico F, Fernandez CV, Brok J, et al. Wilms tumour. Nat Rev Dis Primers. 2021 Oct 14;7(1):75.Full text  Abstract

Lopyan NM, Ehrlich PF. Surgical management of Wilms tumor (nephroblastoma) and renal cell carcinoma in children and young adults. Surg Oncol Clin N Am. 2021 Apr;30(2):305-23. Abstract

Vujanić GM, Parsons LN, D'Hooghe E, et al. Pathology of Wilms' tumour in International Society of Paediatric Oncology (SIOP) and Children's Oncology Group (COG) renal tumour studies: similarities and differences. Histopathology. 2022 Jun;80(7):1026-37. Abstract

van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, et al. Position paper: rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol. 2017 Dec;14(12):743-52.Full text  Abstract

Dome JS, Mullen EA, Dix DB, et al. Impact of the first generation of Children's Oncology Group clinical trials on clinical practice for Wilms tumor. J Natl Compr Canc Netw. 2021 Aug 1;19(8):978-85.Full text  Abstract

Reference articles

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25. Coorens THH, Treger TD, Al-Saadi R, et al. Embryonal precursors of Wilms tumor. Science. 2019 Dec 6;366(6470):1247-51.Full text  Abstract

26. Perotti D, Spreafico F, Torri F, et al. Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse. Genes Chromosomes Cancer. 2012 Jul;51(7):644-53. Abstract

27. Gratias EJ, Jennings LJ, Anderson JR, et al. Gain of 1q is associated with inferior event-free and overall survival in patients with favorable histology Wilms tumor: a report from the Children's Oncology Group. Cancer. 2013 Nov 1;119(21):3887-94. Abstract

28. Gadd S, Huff V, Skol AD, et al. Genetic changes associated with relapse in favorable histology Wilms tumor: a Children's Oncology Group AREN03B2 study. Cell Rep Med. 2022 Jun 21;3(6):100644.Full text  Abstract

29. Breslow NE, Beckwith JB. Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study. J Natl Cancer Inst. 1982 Mar;68(3):429-36. Abstract

30. Neville H, Ritchey ML, Shamberger RC, et al. The occurrence of Wilms tumor in horseshoe kidneys: a report from the National Wilms Tumor Study Group (NWTSG). J Pediatr Surg. 2002 Aug;37(8):1134-7. Abstract

31. Kalish JM, Doros L, Helman LJ, et al. Surveillance recommendations for children with overgrowth syndromes and predisposition to Wilms tumors and hepatoblastoma. Clin Cancer Res. 2017 Jul 1;23(13):e115-22.Full text  Abstract

32. Schienda J, Stopfer J. Cancer genetic counseling-current practice and future challenges. Cold Spring Harb Perspect Med. 2020 Jun 1;10(6):a036541.Full text  Abstract

33. Turner JT, Brzezinski J, Dome JS. Wilms tumor predisposition. 2003 Dec 19 (updated 2022 Mar 24). In: Adam MP, Mirzaa GM, Pagon RA, et al, eds. GeneReviews [internet]. Seattle, WA: University of Washington, Seattle; 1993-2023.Full text  Abstract

34. Gariépy-Assal L, Gilbert RD, Žiaugra A, et al. Management of Denys-Drash syndrome: a case series based on an international survey. Clin Nephrol Case Stud. 2018 Nov 12;6:36-44.Full text  Abstract

35. Green DM, Breslow NE, Beckwith JB, et al. Screening of children with hemihypertrophy, aniridia, and Beckwith-Wiedemann syndrome in patients with Wilms tumor: a report from the National Wilms Tumor Study. Med Pediatr Oncol. 1993;21(3):188-92. Abstract

36. Idowu BM, Tanimola AG. Wilm's tumor presenting with scrotal varicocele in an 11-month-old boy. Indian J Radiol Imaging. 2018 Apr-Jun;28(2):247-9.Full text  Abstract

37. Maas MH, Cransberg K, van Grotel M, et al. Renin-induced hypertension in Wilms tumor patients. Pediatr Blood Cancer. 2007 May;48(5):500-3. Abstract

38. van der Beek JN, Artunduaga M, Schenk JP, et al. Similarities and controversies in imaging of pediatric renal tumors: A SIOP-RTSG and COG collaboration. Pediatr Blood Cancer. 2022 Nov 9;e30080. Abstract

39. Provenzi M, Saettini F, Conter V, et al. Is there a role for FDG-PET for the assessment of treatment efficacy in Wilms' tumor? A case report and literature review. Pediatr Hematol Oncol. 2013 Oct;30(7):633-9. Abstract

40. Lopyan NM, Ehrlich PF. Surgical management of Wilms tumor (nephroblastoma) and renal cell carcinoma in children and young adults. Surg Oncol Clin N Am. 2021 Apr;30(2):305-23. Abstract

41. Vujanić GM, Gessler M, Ooms AHAG, et al. The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol. 2018 Nov;15(11):693-701.Full text  Abstract

42. van den Heuvel-Eibrink MM, van Tinteren H, Rehorst H, et al. Malignant rhabdoid tumours of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the SIOP renal tumour study group. Pediatr Blood Cancer. 2011 May;56(5):733-7. Abstract

43. Diller L, Ghahremani M, Morgan J, et al. Constitutional WT1 mutations in Wilms tumor patients. J Clin Oncol. 1998 Nov;16(11):3634-40. Abstract

44. Wittmann S, Zirn B, Alkassar M, et al. Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis. Genes Chromosomes Cancer. 2007 Feb;46(2):163-70. Abstract

45. Davidson A, Hartley PS, Shuttleworth MH. Erythrocytosis and iron deficiency anemia in Wilms tumor. J Pediatr Hematol Oncol. 2005 Sep;27(9):502. Abstract

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47. Breslow NE, Collins AJ, Ritchey ML, et al. End stage renal disease in patients with Wilms tumor: results from the National Wilms Tumor Study Group and the United States Renal Data System. J Urol. 2005 Nov;174(5):1972-5.Full text  Abstract

48. Czauderna P, Katski K, Kowalczyk J, et al. Venoocclusive liver disease (VOD) as a complication of Wilms' tumour management in the series of consecutive 206 patients. Eur J Pediatr Surg. 2000 Oct;10(5):300-3. Abstract

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50. Coppes MJ, Zandvoort SW, Sparling CR, et al. Acquired von Willebrand disease in Wilms' tumor patients. J Clin Oncol. 1992 Mar;10(3):422-7. Abstract

51. Amar AM, Tomlinson G, Green DM, et al. Clinical presentation of rhabdoid tumors of the kidney. J Pediatr Hematol Oncol. 2001 Feb;23(2):105-8. Abstract

52. Sandberg JK, Chi YY, Smith EA, et al. Imaging characteristics of nephrogenic rests versus small Wilms tumors: a report fom the Children's Oncology Group Study AREN03B2. AJR Am J Roentgenol. 2020 May;214(5):987-94.Full text  Abstract

53. van der Beek JN, Watson TA, Nievelstein RAJ, et al. MRI characteristics of pediatric renal tumors: a SIOP-RTSG Radiology Panel Delphi Study. J Magn Reson Imaging. 2022 Feb;55(2):543-52.Full text  Abstract

54. Brok JS, Shelmerdine S, Damsgaard F, et al. The clinical impact of observer variability in lung nodule classification in children with Wilms tumour. Pediatr Blood Cancer. 2022 Oct;69(10):e29759.Full text  Abstract

55. Vujanić GM, Parsons LN, D'Hooghe E, et al. Pathology of Wilms' tumour in International Society of Paediatric Oncology (SIOP) and Children's Oncology Group (COG) renal tumour studies: similarities and differences. Histopathology. 2022 Jun;80(7):1026-37. Abstract

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62. Ng A, Jenkinson H, Morland B, et al. Clear cell sarcoma: a dilemma on pathological staging and clinical management. Pediatr Hematol Oncol. 2005 Apr-May;22(3):257-61. Abstract

63. Green DM, Grigoriev YA, Nan B, et al. Congestive heart failure after treatment for Wilms' tumor: a report from the National Wilms' Tumor Study group. J Clin Oncol. 2001 Apr 1;19(7):1926-34. Abstract

64. Zisman A, Pantuck AJ, Wieder J, et al. Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol. 2002 Dec 1;20(23):4559-66. Abstract

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66. Tomlinson GE, Breslow NE, Dome J, et al. Rhabdoid tumor of the kidney in the National Wilms Tumor Study: age at diagnosis as a prognostic factor. J Clin Oncol. 2005 Oct 20;23(30):7641-5. Abstract

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72. de Campos Vieira Abib S, Chui CH, Cox S, et al. International Society of Paediatric Surgical Oncology (IPSO) surgical practice guidelines. Ecancermedicalscience. 2022 Feb 17;16:1356.Full text  Abstract

73. Nelson MV, van den Heuvel-Eibrink MM, Graf N, et al. New approaches to risk stratification for Wilms tumor. Curr Opin Pediatr. 2021 Feb 1;33(1):40-8.Full text  Abstract

74. Dome JS, Fernandez CV, Mullen EA, et al. Children's Oncology Group's 2013 blueprint for research: renal tumors. Pediatr Blood Cancer. 2013 Jun;60(6):994-1000. Abstract

75. van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, et al. Position paper: rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol. 2017 Dec;14(12):743-52.Full text  Abstract

76. Hol JA, Jewell R, Chowdhury T, et al. Wilms tumour surveillance in at-risk children: literature review and recommendations from the SIOP-Europe Host Genome Working Group and SIOP Renal Tumour Study Group. Eur J Cancer. 2021 Aug;153:51-63.Full text  Abstract

77. Heppe RK, Koyle MA, Beckwith JB. Nephrogenic rests in Wilms tumor patients with the Drash syndrome. J Urol. 1991 Jun;145(6):1225-8. Abstract

78. Beckwith JB. Nephrogenic rests and the pathogenesis of Wilms tumor: developmental and clinical considerations. Am J Med Genet. 1998 Oct 2;79(4):268-73. Abstract

79. Beckwith JB. Management of incidentally encountered nephrogenic rests. J Pediatr Hematol Oncol. 2007 Jun;29(6):353-4. Abstract

80. Israels T, Moreira C, Scanlan T, et al. SIOP PODC: clinical guidelines for the management of children with Wilms tumour in a low income setting. Pediatr Blood Cancer. 2013 Jan;60(1):5-11.Full text  Abstract

81. Vanden Berg RN, Bierman EN, Noord MV, et al. Nephron-sparing surgery for Wilms tumor: a systematic review. Urol Oncol. 2016 Jan;34(1):24-32.Full text  Abstract

82. D'Angio GJ. The National Wilms Tumor Study: a 40 year perspective. Lifetime Data Anal. 2007 Dec;13(4):463-70. Abstract

83. Dix DB, Seibel NL, Chi YY, et al. Treatment of stage IV favorable histology Wilms tumor with lung metastases: a report from the Children's Oncology Group AREN0533 study. J Clin Oncol. 2018 Jun 1;36(16):1564-70.Full text  Abstract

84. Dome JS, Mullen EA, Dix DB, et al. Impact of the first generation of Children's Oncology Group clinical trials on clinical practice for Wilms tumor. J Natl Compr Canc Netw. 2021 Aug 1;19(8):978-85.Full text  Abstract

85. Fernandez CV, Perlman EJ, Mullen EA, et al. Clinical outcome and biological predictors of relapse after nephrectomy only for very low-risk Wilms tumor: a report from Children's Oncology Group AREN0532. Ann Surg. 2017 Apr;265(4):835-40.Full text  Abstract

86. Dix DB, Fernandez CV, Chi YY, et al. Augmentation of therapy for combined loss of heterozygosity 1p and 16q in favorable histology Wilms tumor: a Children's Oncology Group AREN0532 and AREN0533 study report. J Clin Oncol. 2019 Oct 20;37(30):2769-77.Full text  Abstract

87. Fernandez CV, Mullen EA, Chi YY, et al. Outcome and prognostic factors in stage III favorable-histology Wilms tumor: a report from the Children's Oncology Group study AREN0532. J Clin Oncol. 2018 Jan 20;36(3):254-61.Full text  Abstract

88. Ehrlich P, Chi YY, Chintagumpala MM, et al. Results of the first prospective multi-institutional treatment study in children with bilateral Wilms tumor (AREN0534): a report from the Children's Oncology Group. Ann Surg. 2017 Sep;266(3):470-8.Full text  Abstract

89. Ehrlich PF, Chi YY, Chintagumpala MM, et al. Results of treatment for patients with multicentric or bilaterally predisposed unilateral Wilms tumor (AREN0534): a report from the Children's Oncology Group. Cancer. 2020 Aug 1;126(15):3516-25.Full text  Abstract

90. Hamilton TE, Ritchey ML, Haase GM, et al. The management of synchronous bilateral Wilms tumor: a report from the National Wilms Tumor Study Group. Ann Surg. 2011 May;253(5):1004-10. Abstract

91. Kieran K, Davidoff AM. Nephron-sparing surgery for bilateral Wilms tumor. Pediatr Surg Int. 2015 Mar;31(3):229-36. Abstract

92. Kieran K, Williams MA, McGregor LM, et al. Repeat nephron-sparing surgery for children with bilateral Wilms tumor. J Pediatr Surg. 2014 Jan;49(1):149-53.Full text  Abstract

93. Aronson DC, Slaar A, Heinen RC, et al. Long-term outcome of bilateral Wilms tumors (BWT). Pediatr Blood Cancer. 2011 Jul 1;56(7):1110-3. Abstract

94. Daw NC, Chi YY, Kim Y, et al. Treatment of stage I anaplastic Wilms' tumour: a report from the Children's Oncology Group AREN0321 study. Eur J Cancer. 2019 Sep;118:58-66.Full text  Abstract

95. Dome JS, Cotton CA, Perlman EJ, et al. Treatment of anaplastic histology Wilms' tumor: results from the fifth National Wilms' Tumor Study. J Clin Oncol. 2006 May 20;24(15):2352-8. Abstract

96. Daw NC, Chi YY, Kalapurakal JA, et al. Activity of vincristine and irinotecan in diffuse anaplastic Wilms tumor and therapy outcomes of stage II to IV disease: results of the Children's Oncology Group AREN0321 study. J Clin Oncol. 2020 May 10;38(14):1558-68.Full text  Abstract

97. Speafico F, Pritchard Jones K, Malogolowkin MH, et al. Treatment of relapsed Wilms tumors: lessons learned. Expert Rev Anticancer Ther. 2009 Dec;9(12):1807-15. Abstract

98. Oostveen RM, Pritchard-Jones K. Pharmacotherapeutic management of Wilms tumor: an update. Paediatr Drugs. 2019 Feb;21(1):1-13. Abstract

99. Dome JS, Graf N, Geller JI, et al. Advances in Wilms tumor treatment and biology: progress through international collaboration. J Clin Oncol. 2015 Sep 20;33(27):2999-3007.Full text  Abstract

100. Malogolowkin MH, Hemmer MT, Le-Rademacher J, et al. Outcomes following autologous hematopoietic stem cell transplant for patients with relapsed Wilms' tumor: a CIBMTR retrospective analysis. Bone Marrow Transplant. 2017 Nov;52(11):1549-55.Full text  Abstract

101. Brok J, Mavinkurve-Groothuis AMC, Drost J, et al. Unmet needs for relapsed or refractory Wilms tumour: mapping the molecular features, exploring organoids and designing early phase trials - a collaborative SIOP-RTSG, COG and ITCC session at the first SIOPE meeting. Eur J Cancer. 2021 Feb;144:113-22. Abstract

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104. Green DM. The treatment of stages I-IV favorable histology Wilms' tumor. J Clin Oncol. 2004 Apr 15;22(8):1366-72. Abstract

105. Breslow NE, Beckwith JB, Haase GM, et al. Radiation therapy for favorable histology Wilms tumor: prevention of flank recurrence did not improve survival on National Wilms Tumor Studies 3 and 4. Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):203-9.Full text  Abstract

106. Termuhlen AM, Tersak JM, Liu Q, et al. Twenty-five year follow-up of childhood Wilms tumor: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer. 2011 Dec 15;57(7):1210-6. Abstract

107. Osterheld MC, Caron L, Meagher-Villemure K. Role of DNA content analysis and immunohistochemistry in the evaluation of the risk of unfavourable outcome in Wilms' tumours. Anticancer Res. 2008 Apr;28(2A):751-6. Abstract

108. Malogolowkin M, Cotton CA, Green DM, et al. Treatment of Wilms tumor relapsing after initial treatment with vincristine, actinomycin D, and doxorubicin. A report from the National Wilms Tumor Study Group. Pediatr Blood Cancer. 2008 Feb;50(2):236-41. Abstract

109. Grundy PE, Breslow NE, Li S, et al. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005 Oct 10;23(29):7312-21. Abstract

110. Nakadate H, Yokomori K, Watanabe N, et al. Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan. Int J Cancer. 2001 Nov 1;94(3):396-400.Full text  Abstract

111. Messahel B, Williams R, Ridolfi A, et al. Allele loss at 16q defines poorer prognosis Wilms tumour irrespective of treatment approach in the UKW1-3 clinical trials: a Children's Cancer and Leukaemia Group (CCLG) study. Eur J Cancer. 2009 Mar;45(5):819-26. Abstract

112. Ehrlich PF, Anderson JR, Ritchey ML, et al. Clinicopathologic findings predictive of relapse in children with stage III favorable-histology Wilms tumor. J Clin Oncol. 2013 Mar 20;31(9):1196-201. Abstract

113. Reinhard H, Semler O, Burger D, et al. Results of the SIOP 93-01/GPOH trial and study for the treatment of patients with unilateral nonmetastatic Wilms Tumor. Klin Padiatr. 2004 May-Jun;216(3):132-40. Abstract

114. Berger M, Fernandez-Pineda I, Cabello R, et al. The relationship between the site of metastases and outcome in children with stage IV Wilms tumor: data from 3 European pediatric cancer institutions. J Pediatr Hematol Oncol. 2013 Oct;35(7):518-24. Abstract

115. Pasqualini C, Furtwängler R, van Tinteren H, et al. Outcome of patients with stage IV high-risk Wilms tumour treated according to the SIOP2001 protocol: a report of the SIOP Renal Tumour Study Group. Eur J Cancer. 2020 Mar;128:38-46. Abstract

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117. Breslow NE, Takashima JR, Ritchey ML, et al. Renal failure in the Denys-Drash and Wilms tumor-aniridia syndromes. Cancer Res. 2000 Aug 1;60(15):4030-2.Full text  Abstract

118. Kist-van Holthe JE, Ho PL, Stablein D, et al. Outcome of renal transplantation for Wilms' tumor and Denys-Drash syndrome: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Transplant. 2005 Jun;9(3):305-10. Abstract

119. Amirian ES. The role of Hispanic ethnicity in pediatric Wilms' tumor survival. Pediatr Hematol Oncol. 2013 May;30(4):317-27. Abstract

120. Wright KD, Green DM, Daw NC. Late effects of treatment for Wilms tumor. Pediatr Hematol Oncol. 2009 Sep;26(6):407-13. Abstract

121. Greenberg M, Burnweit C, Filler R, et al. Preoperative chemotherapy for children with Wilms' tumor. J Pediatr Surg. 1991 Aug;26(8):949-53. Abstract

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123. Kalapurakal JA, Nan B, Norkool P, et al. Treatment outcomes in adults with favorable histologic type Wilms tumor-an update from the National Wilms Tumor Study Group. Int J Radiat Oncol Biol Phys. 2004 Dec 1;60(5):1379-84. Abstract

124. Pein F, Tournade MF, Zucker JM, et al. Etoposide and carboplatin: a highly effective combination in relapsed or refractory Wilms tumor: a phase II study by the French Society of Pediatric Oncology. J Clin Oncol. 1994 May;12(5):931-6. Abstract

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