Should be considered in all migrants or residents from endemic areas regardless of time since immigration.
Clinical clues include wheezing, abdominal distress, and eosinophilia.
Stool ova and parasite tests are relatively insensitive for detection of strongyloides larvae but are currently the tests of choice.
Treatment with ivermectin is recommended, regardless of resource setting.
Rapid spread of infection can lead to hyperinfection syndrome and disseminated disease, both of which are associated with a high mortality rate in immunosuppressed patients.
Empirical treatment should be considered when initiating corticosteroids in any high-risk patient due to risk of life-threatening hyperinfection.
Strongyloidiasis is an infection caused by the intestinal nematode Strongyloides stercoralis . Transmission occurs widely in tropical and subtropical areas, but also in countries with temperate climates.  The primary mode of infection is through larvae penetrating the skin. Strongyloides larvae migrate from subcutaneous tissues into the venous circulation, then to the lungs. Larvae migrate up the airways, are swallowed, and establish chronic infection in the intestinal tract as adults. New larvae continue this cycle within the human host creating indefinite auto-infection; meaning that, without treatment, infection is lifelong.
Lois & Richard King Distinguished Associate Professor
Department of Medicine
University of Minnesota
DRB is an author of a number of references cited in this monograph.
Department of Pediatrics
Boston Medical Center
EB declares that she is on a speaker's bureau for Merck. She is an author of a reference cited in this monograph.
Professor of Pediatrics
West Virginia University School of Medicine
LN is an author of a reference cited in this topic.
Professor of International Medicine and Honorary Consultant Physician
Liverpool School of Tropical Medicine
GG declares that he has no competing interests.
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