Assessment of neutropenia

References

Key articles

Boxer LA, Newberger PE. A molecular classification of congenital neutropenia syndromes. Pediatr Blood Cancer. 2007 Oct 15;49(5):609-14.Full text  Abstract

Cham B, Bonilla MA, Winkelstein J. Neutropenia associated with primary immunodeficiency syndromes. Semin Hematol. 2002 Apr;39(2):107-12. Abstract

Taplitz RA, Kennedy EB, Bow EJ, et al. Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America clinical practice guideline update. J Clin Oncol. 2018 May 10;36(14):1443-53.Full text  Abstract

Reference articles

1. Dale DC, Welte K. Neutrophenia and neutrophilia. In: Kaushansky K, Prchal JT, Burns LJ, et al, eds. Williams hematology. 10th ed. New York, NY: McGraw-Hill; 2021Full text

2. Lichtman MA. Classification and clinical manifestations of neutrophil disorders. In: Kaushansky K, Prchal JT, Burns LJ, et al, eds. Williams hematology. 10th ed. New York, NY: McGraw-Hill; 2021.Full text

3. Newburger PE, Dale DC. Evaluation and management of patients with isolated neutropenia. Semin Hematol. 2013 Jul;50(3):198-206.Full text  Abstract

4. Dallman PR. Reference ranges for leukocyte counts in children. In: Nathan DG, Orkin SH, eds. Nathan and Oski's hematology of infancy and childhood. 5th ed. Philadelphia, PA: WB Saunders; 1998.

5. Hsieh MM, Everhart JE, Byrd-Holt DD, et al. Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences. Ann Intern Med. 2007 Apr 3;146(7):486-92.Full text  Abstract

6. Orfanakis NG, Ostlund RE, Bishop CR, et al. Normal blood leukocyte concentration values. Am J Clin Pathol. 1970 May;53(5):647-51. Abstract

7. Reed WW, Diehl LF. Leukopenia, neutropenia, and reduced hemoglobin levels in healthy American blacks. Arch Intern Med. 1991 Mar;151(3):501-5. Abstract

8. Shoenfeld Y, Alkan ML, Asaly A, et al. Benign familial leukopenia and neutropenia in different ethnic groups. Eur J Haematol. 1988 Sep;41(3):273-7. Abstract

9. Andres E, Federici L, Weitten T, et al. Recognition and management of drug-induced blood cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. Expert Opin Drug Saf. 2008 Jul;7(4):481-9. Abstract

10. Berliner N, Horwitz M, Loughran TP Jr. Congenital and acquired neutropenia. Hematology Am Soc Hematol Educ Program. 2004:63-79.Full text  Abstract

11. Carmona-Bayonas A, Jimenez-Fonseca P, de Castro EM, et al. SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018). Clin Transl Oncol. 2019 Jan;21(1):75-86.Full text  Abstract

12. Wolach O, Bairey O, Lahav M, et al. Late-onset neutropenia after rituximab treatment: case series and comprehensive review of the literature. Medicine (Baltimore). 2010 Sep;89(5):308-18. Abstract

13. Andersohn F, Konzen C, Garbe E. Systematic review: Agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007 May 1;146(9):657-65. Abstract

14. Theophile H, Begaud B, Martin K., et al. Incidence of agranulocytosis in Southwest France. Eur J Epidemiol. 2004;19(6):563-5. Abstract

15. van der Klauw MM, Goudsmit R, Halie MR, et al. A population-based case-cohort study of drug-associated agranulocytosis. Arch Intern Med. 1999 Feb 22;159(4):369-74. Abstract

16. Andres E, Maloisel F, Kurtz JE, et al. Modern management of non-chemotherapy drug-induced agranulocytosis: a monocentric cohort study of 90 cases and review of the literature. Eur J Intern Med. 2002 Aug;13(5):324-8. Abstract

17. Salama A, Schutz B, Kiefel V, et al. Immune-mediated agranulocytosis related to drugs and their metabolites: mode of sensitization and heterogeneity of antibodies. Br J Haematol. 1989 Jun;72(2):127-32. Abstract

18. Murphy MF, Chapman JF, Metcalfe P, et al. Antibiotic-induced neutropenia. Lancet. 1985 Dec 7;2(8467):1306-7. Abstract

19. Bhatt V, Saleem A. Review: Drug-induced neutropenia - pathophysiology, clinical features, and management. Ann Clin Lab Sci. 2004 Spring;34(2):131-7. Abstract

20. Schwartzberg LS. Neutropenia: etiology and pathogenesis. Clin Cornerstone. 2006;8 (Suppl 5):S5-11. Abstract

21. Capsoni F, Sarzi-Puttini P, Zanella A. Primary and secondary autoimmune neutropenia. Arthritis Res Ther. 2005;7(5):208-14.Full text  Abstract

22. Klein C, Grudzien M, Appaswamy G, et al. HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet. 2007 Jan;39(1):86-92. Abstract

23. Bonilla MA, Dale D, Zeidler C, et al. Long-term safety of treatment with recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) in patients with severe congenital neutropenias. Br J Haematol. 1994 Dec;88(4):723-30. Abstract

24. Freedman MH. Safety of long-term administration of granulocyte colony-stimulating factor for severe chronic neutropenia. Curr Opin Hematol. 1997 May;4(3):217-24. Abstract

25. Welte K, Zeidler C, Dale DC. Severe congenital neutropenia. Semin Hematol. 2006 Jul;43(3):189-95. Abstract

26. Dror Y, Freedman MH. Shwachman-Diamond syndrome: An inherited preleukemic bone marrow failure disorder with aberrant hematopoietic progenitors and faulty marrow microenvironment. Blood. 1999 Nov 1;94(9):3048-54.Full text  Abstract

27. Pearson HA, Lobel JS, Kocoshis SA, et al. A new syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction. J Pediatr. 1979 Dec;95(6):976-84. Abstract

28. Boxer LA, Newberger PE. A molecular classification of congenital neutropenia syndromes. Pediatr Blood Cancer. 2007 Oct 15;49(5):609-14.Full text  Abstract

29. van Raam BJ, Kuijpers TW. Mitochondrial defects lie at the basis of neutropenia in Barth syndrome. Curr Opin Hematol. 2009 Jan;16(1):14-9. Abstract

30. Ancliff PJ. Congenital neutropenia. Blood Rev. 2003 Dec;17(4):209-16. Abstract

31. Aprikyan AA, Liles WC, Park JR, et al. Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression of bcl-x in neutrophil precursors. Blood. 2000 Jan 1;95(1):320-7.Full text  Abstract

32. Kivitie-Kallio S, Norio R. Cohen syndrome: essential features, natural history, and heterogeneity. Am J Med Genet. 2001 Aug 1;102(2):125-35. Abstract

33. Taban M, Memoracion-Peralta DS, Wang H, et al. Cohen syndrome: report of nine cases and review of the literature, with emphasis on ophthalmic features. J AAPOS. 2007 Oct;11(5):431-7. Abstract

34. Cham B, Bonilla MA, Winkelstein J. Neutropenia associated with primary immunodeficiency syndromes. Semin Hematol. 2002 Apr;39(2):107-12. Abstract

35. Gorlin RJ, Gelb B, Diaz GA, et al. WHIM syndrome, an autosomal dominant disorder: clinical, hematological, and molecular studies. Am J Med Genet. 2000 Apr 24;91(5):368-76. Abstract

36. Heinz WJ, Buchheidt D, Christopeit M, et al. Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol. 2017 Nov;96(11):1775-92.Full text  Abstract

37. Paul M, Yahav D, Bivas A, et al. Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams. Cochrane Database Syst Rev. 2010 Nov 10;(11):CD005197.Full text  Abstract

38. James RM, Kinsey SE. The investigation and management of chronic neutropenia in children. Arch Dis Child. 2006 Oct;91(10):852-8.Full text  Abstract

39. Newburger PE. Disorders of neutrophil number and function. Hematology Am Soc Hematol Educ Program. 2006:104-10. Abstract

40. Zeidler C, Welte K. Kostmann syndrome and severe congenital neutropenia. Semin Hematol. 2002 Apr;39(2):82-8. Abstract

41. Andres E, Maloisel F. Idiosyncratic drug-induced agranulocytosis or acute neutropenia. Curr Opin Hematol. 2008 Jan;15(1):15-21. Abstract

42. Taplitz RA, Kennedy EB, Bow EJ, et al. Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America clinical practice guideline update. J Clin Oncol. 2018 May 10;36(14):1443-53.Full text  Abstract

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45. Royal College of Physicians. National Early Warning Score (NEWS) 2. Dec 2017 [internet publication].Full text

46. American College of Emergency Physicians (ACEP) Expert Panel on Sepsis. DART: an evidence-driven tool to guide the early recognition and treatment of sepsis and septic shock. [internet publication].Full text

47. Academy of Medical Royal Colleges. Statement on the initial antimicrobial treatment of sepsis. May 2022 [internet publication].Full text

48. Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-143.Full text  Abstract

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50. Link DC, Wun T. Myeloid disorders. In: Kahn MJ, Gregory SA, eds. American Society of Hematology Self-Assessment Program. 3rd ed. Washington, DC: American Society of Hematology; 2007.

51. Rogers CL, Bain BJ, Garg M, et al. British Society for Haematology guidelines for the laboratory diagnosis of malaria. Br J Haematol. 2022 May;197(3):271-82.Full text  Abstract

52. World Health Organization. WHO Guidelines for malaria. Jun 2022 [internet publication].Full text

53. Phillips RS, Wade R, Lehrnbecher T, et al. Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer. BMC Med. 2012 Jan 18;10:6.Full text  Abstract

54. Haeusler GM, Thursky KA, Slavin MA, et al. Risk stratification in children with cancer and febrile neutropenia: A national, prospective, multicentre validation of nine clinical decision rules. EClinicalMedicine. 2020 Jan;18:100220.Full text  Abstract

55. American College of Medical Genetics. Newborn screening ACT sheets and algorithms. August 2014 [internet publication].Full text

56. Pattanasin S, Proux S, Chompasuk D, et al. Evaluation of a new plasmodium lactate dehydrogenase assay (OptiMAL-IT) for the detection of malaria. Trans R Soc Trop Med Hyg. 2003 Nov-Dec;97(6):672-4.Full text  Abstract

57. Ashley EA, Touabi M, Ahrer M, et al. Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria. Malar J. 2009 Oct 27;8:241.Full text  Abstract

58. Yerlikaya S, Campillo A, Gonzalez IJ. A systematic review: performance of rapid diagnostic tests for the detection of plasmodium knowlesi, plasmodium malariae, and plasmodium ovale monoinfections in human blood. J Infect Dis. 2018 Jun 20;218(2):265-76.Full text  Abstract

59. Stauffer WM, Cartwright CP, Olson DA, et al. Diagnostic performance of rapid diagnostic tests versus blood smears for malaria in US clinical practice. Clin Infect Dis. 2009 Sep 15;49(6):908-13.Full text  Abstract

60. Nicastri E, Bevilacqua N, Sañé Schepisi M, et al. Accuracy of malaria diagnosis by microscopy, rapid diagnostic test, and PCR methods and evidence of antimalarial overprescription in non-severe febrile patients in two Tanzanian hospitals. Am J Trop Med Hyg. 2009 May;80(5):712-7. Abstract

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