The exact incidence of thrombophilia is unknown. However, the epidemiology of heritable thrombophilia is well documented. Inherited thrombophilia affects up to 10% of the population. Up to 50% of white people with venous thromboembolism (VTE) will have a heritable thrombophilia. Up to 6% of the white population are reported to be affected by factor V Leiden (genetic mutation in factor V) and 2% by prothrombin gene mutations. These mutations are rare in other ethnic groups. However, most carriers of these mutations remain asymptomatic. Antithrombin, protein C, and protein S deficiencies are less common and affect up to 0.02% (antithrombin), 0.4% (protein C), and 0.13% (protein S) of the population. These deficiencies are commonly found in Southeast Asians and are rare in black populations. An elevated coagulation factor VIII level is the most common cause of thrombophilia in black people (it is found in up to 35% of black people with VTE).
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