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Toxic ingestions in children

Última revisão: 17 Jul 2025
Última atualização: 12 Aug 2025

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • medication error in infants
  • witnessed ingestion or child found with empty bottle or pill
  • history of deliberate ingestion
  • history of substance misuse
  • sympathomimetic toxidrome
  • antimuscarinic toxidrome
  • opioid toxidrome
  • sedative-hypnotic toxidrome
  • cholinergic toxidrome
Detalhes completos

Outros fatores diagnósticos

  • nausea, vomiting, or diarrhea
  • altered mental status
  • fever or hyperthermia
  • staining or burns of the mouth and oropharynx
  • hypertension or hypotension
  • hyperventilation or hypoventilation
  • seizures
  • blindness or reduced vision
  • reduced hearing or tinnitus
  • reddened skin coloration
  • symptoms and signs of hypoglycemia
  • jaundice
  • hyperreflexia and myoclonus
  • muscle rigidity
  • nystagmus
  • ataxia
  • stridor
Detalhes completos

Fatores de risco

  • presence of medications in the household
  • easy access to medications or household chemicals
  • young age
  • pica
  • emotional stress
  • history of depression or other mental illness
  • female sex
  • family history of alcohol use disorder
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • serum electrolytes
  • serum BUN
  • serum creatinine
  • fingerstick or serum glucose
  • capillary blood gas or ABG
  • anion gap
  • serum lactate
  • serum ketones or acetone
  • INR
  • LFTs
  • serum acetaminophen levels
  • serum salicylate levels
  • urine drug screen
  • urinalysis
  • ECG
  • pregnancy test
  • serum creatine kinase
  • abdominal x-ray
  • chest x-ray
Detalhes completos

Tests to avoid

  • hair or nail testing
Detalhes completos

Investigações a serem consideradas

  • ethanol level
  • serum methanol or ethylene glycol
  • serum digoxin level
  • serum anticonvulsant levels
  • serum iron levels
  • serum lithium, theophylline, or whole blood heavy metal levels
  • comprehensive urine drug screen
  • therapeutic trial of naloxone
  • therapeutic trial of sodium bicarbonate
  • therapeutic trial of atropine and pralidoxime
  • therapeutic trial of flumazenil
  • therapeutic trial of octreotide
  • therapeutic trial of physostigmine
Detalhes completos

Algoritmo de tratamento

AGUDA

asymptomatic

symptomatic and/or high-risk ingestion and/or elevated drug levels

Colaboradores

Autores

David L. Eldridge, MD

Associate Professor of Pediatrics

Senior Associate Dean of Academic Affairs

Brody School of Medicine at East Carolina University

Greenville

NC

Declarações

DLE has received research grants and been a site investigator for a closed clinical trial from GlaxoSmithKline and a closed clinical trial from Cempra Pharmaceuticals. DLE is an author of two of the references cited in this topic.

Matthew R. Ledoux, MD

Chair, Department of Pediatrics

Pediatrician in Chief Maynard Children's Hospital

Associate Professor of Pediatrics

Maynard Distinguished Scholar of Pediatrics

Brody School of Medicine at East Carolina University

ECU Health

Greenville

NC

Declarações

MRL declares that he has no competing interests.

Agradecimentos

Dr David Eldridge and Dr Matthew Ledoux would like to gratefully acknowledge Dr Cynthia K. Aaron and Dr Keenan M. Bora, previous contributors to this topic.

Declarações

CKA and KMB declare that they have no competing interests.

Revisores

Laurie Prescott, MD, FRCP

Emeritus Professor of Clinical Pharmacology

Faculty of Medicine

University of Edinburgh

Edinburgh

UK

Declarações

LP declares that he has no competing interests.

Mark Mannenbach, MD

Consultant in Pediatric Emergency Medicine

Assistant Professor of Pediatric and Adolescent Medicine

Mayo Clinic College of Medicine

Rochester

MN

Declarações

MM declares that he has no competing interests.

Colin A. Graham, MBChB, MPH, MD, FRCSEd, FRCSGlasg, FIMCRCSEd, FCCP, FCEM, FHKCEM, FHKAM

Editor

European Journal of Emergency Medicine

Professor of Emergency Medicine

Chinese University of Hong Kong

Hong Kong

People's Republic of China

Declarações

CAG is the editor of the European Journal of Emergency Medicine and receives an annual honorarium from Wolters Kluwer Health, the journal's publishers.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Hoffman RS, Burns MM, Gosselin S. Ingestion of caustic substances. N Engl J Med. 2020 Apr 30;382(18):1739-48.

McKay C. Can the laboratory help me? Toxicology laboratory testing in the possibly poisoned pediatric patient. Clin Pedi EM. 2005;6:116-22.

Dart RC, Goldfrank LR, Erstad BL, et al. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med. 2018 Mar;71(3):314-25.e1.Texto completo  Resumo

Royal College of Emergency Medicine. College of Emergency Medicine and National Poisons Information Service guideline on antidote availability for emergency departments, 2021 update. Dec 2021 [internet publication].Texto completo

American Academy of Clinical Toxicology, European Association of Poisons Centres and Clinical Toxicologists. Position paper: single-dose activated charcoal. Clin Toxicol (Phila). 2005;43(2):61-87.Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
  • Diagnósticos diferenciais

    • Nontoxic causes of wide complex tachycardia
    • Nontoxic causes of status epilepticus
    • Nontoxic causes of anion gap metabolic acidosis
    Mais Diagnósticos diferenciais
  • Diretrizes

    • Expert consensus for a national essential antidote list: e-Delphi method
    • Guideline on antidote availability for emergency departments
    Mais Diretrizes
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