The presentation varies from asymptomatic to having signs and symptoms at the involved site or organ. Dissemination of disease is more common with non-gastric MALT lymphomas (about 25% present with disseminated disease, including stage 4 disease). Diagnosis is based on history, physical examination, radiological imaging studies, histopathological and immunohistochemical assessment of the biopsy specimen, and special molecular laboratory techniques.
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