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Achlorhydria

Última revisão: 30 Sep 2024
Última atualização: 29 Dec 2022

Resumo

Definição

História e exame físico

Outros fatores diagnósticos

  • age >60 years
  • female sex
  • autoimmune disorders
  • weakness
  • lethargy
  • decreased exercise tolerance
  • skin and conjunctival pallor
  • paresthesias and difficulty ambulating
  • nutritional deficiency (cobalamin, iron, calcium, vitamin D)
  • enteric infection
  • memory loss, irritability, depression, and dementia
  • ataxia, shuffling gait, decreased position sense, decreased vibration sense
  • pale, smooth, and glossy tongue
  • koilonychia
Detalhes completos

Fatores de risco

  • autoimmune disorders
  • age >60 years
  • Helicobacter pylori infection
  • prior gastric surgery
  • hypergastrinemia
  • gastric carcinoid
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • hemoglobin
  • biopsy of corpus and/or fundus of stomach
  • intragastric pH
Detalhes completos

Investigações a serem consideradas

  • serum gastrin
  • gastric acid secretory test (gastric analysis)
  • parietal cell antibodies
  • intrinsic factor antibodies
  • diagnostic tests for Helicobacter pylori infection
Detalhes completos

Novos exames

  • serum pepsinogen I and II (PGI and PGII)

Algoritmo de tratamento

Aguda

all patients

Colaboradores

Autores

Mitchell L. Schubert, MD
Mitchell L. Schubert

Professor of Medicine and Physiology

Virginia Commonwealth University Health System

Chief of Gastroenterology

McGuire VAMC

Richmond

VA

Declarações

MLS is an author of several studies referenced in this topic.

Joseph Spataro, MD
Joseph Spataro

Academic Fellow

Division of Gastroenterology, Hepatology, and Nutrition

Virginia Commonwealth University Health System

Richmond

VA

Declarações

JS declares that he has no competing interests.

Hamzeh Saraireh, MD
Hamzeh Saraireh

Academic Fellow

Division of Gastroenterology, Hepatology, and Nutrition

Virginia Commonwealth University Health System

Richmond

VA

Declarações

HS declares that he is the author of one study referenced in this topic.

Agradecimentos

Dr Mitchell L. Schubert, Dr Joseph Spataro, and Dr Hamzeh Saraireh would like to gratefully acknowledge Dr Juan Diego Baltodano, a previous contributor to this topic.

Declarações

JDB declares that he has no competing interests.

Revisores

Joseph Pisegna, MD

Professor of Medicine

David Geffen School of Medicine at UCLA

Los Angeles

CA

Declarações

JP declares that he has no competing interests.

Heinz F. Hammer, MD

Associate Professor of Gastroenterology and Internal Medicine

Medical University of Graz

Attending Gastroenterologist

University Hospitals Graz

Austria

Declarações

HFH has been reimbursed by AstraZeneca, Nycomed, and Janssen, the manufacturers of proton-pump inhibitors, for attending several conferences and speaking, and has been paid by AstraZeneca for running educational programs.

  • Diagnósticos diferenciais

    • Antisecretory drug-induced hypochlorhydria and hypergastrinemia
    Mais Diagnósticos diferenciais
  • Diretrizes

    • Adverse events associated with EGD and EGD-related techniques
    • American Society for Gastrointestinal Endoscopy guideline on informed consent for GI endoscopic procedures
    Mais Diretrizes
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