References
Key articles
Prete A, Bancos I. Glucocorticoid induced adrenal insufficiency. BMJ. 2021 Jul 12;374:n1380.Full text Abstract
Broersen LH, Pereira AM, Jørgensen JO, et al. Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis. J Clin Endocrinol Metab. 2015 Jun;100(6):2171-80.Full text Abstract
Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013 Aug 15;9(1):30.Full text Abstract
Ahmet A, Kim H, Spier S. Adrenal suppression: a practical guide to the screening and management of this under-recognized complication of inhaled corticosteroid therapy. Allergy Asthma Clin Immunol. 2011 Aug 25;7(1):13.Full text Abstract
Arlt W, Society for Endocrinology Clinical Committee. Society for Endocrinology endocrine emergency guidance: emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. Endocr Connect. 2016 Sep;5(5):G1-3.Full text Abstract
Ahmet A, Kim H, Spier S. Adrenal suppression: a practical guide to the screening and management of this under-recognized complication of inhaled corticosteroid therapy. Allergy Asthma Clin Immunol. 2011 Aug 25;7(1):13Full text Abstract
Reference articles
1. Prete A, Bancos I. Glucocorticoid induced adrenal insufficiency. BMJ. 2021 Jul 12;374:n1380.Full text Abstract
2. Goldbloom EB, Mokashi A, Cummings EA, et al. Symptomatic adrenal suppression among children in Canada. Arch Dis Child. 2017 Apr;102(4):338-9. Abstract
3. Broersen LH, Pereira AM, Jørgensen JO, et al. Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis. J Clin Endocrinol Metab. 2015 Jun;100(6):2171-80.Full text Abstract
4. Rensen N, Gemke RJ, van Dalen EC, et al. Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia. Cochrane Database Syst Rev. 2017 Nov 6;(11):CD008727.Full text Abstract
5. Smith RW, Downey K, Gordon M, et al. Prevalence of hypothalamic-pituitary-adrenal axis suppression in children treated for asthma with inhaled corticosteroid. Paediatr Child Health. 2012 May;17(5):e34-9.Full text Abstract
6. Sidoroff M, Kolho KL. Screening for adrenal suppression in children with inflammatory bowel disease discontinuing glucocorticoid therapy. BMC Gastroenterol. 2014 Mar 24;14:51.Full text Abstract
7. Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013 Aug 15;9(1):30.Full text Abstract
8. Bowden SA, Connolly AM, Kinnett K, et al. Management of adrenal insufficiency risk after long-term systemic glucocorticoid therapy in duchenne muscular dystrophy: clinical practice recommendations. J Neuromuscul Dis. 2019;6(1):31-41.Full text Abstract
9. Johnston PC, Lansang MC, Chatterjee S, et al. Intra-articular glucocorticoid injections and their effect on hypothalamic-pituitary-adrenal (HPA)-axis function. Endocrine. 2015 Mar;48(2):410-6. Abstract
10. Iranmanesh A, Gullapalli D, Singh R, et al. Hypothalamo-pituitary-adrenal axis after a single epidural triamcinolone injection. Endocrine. 2017 Aug;57(2):308-13. Abstract
11. Ahmet A, Kim H, Spier S. Adrenal suppression: a practical guide to the screening and management of this under-recognized complication of inhaled corticosteroid therapy. Allergy Asthma Clin Immunol. 2011 Aug 25;7(1):13.Full text Abstract
12. Wlodarczyk JH, Gibson PG, Caeser M. Impact of inhaled corticosteroids on cortisol suppression in adults with asthma: a quantitative review. Ann Allergy Asthma Immunol. 2008 Jan;100(1):23-30. Abstract
13. Scutelnicu A, Panaitescu AM, Ciobanu AM, et al. Iatrogenic Cushing's syndrome as a consequence of nasal use of betamethasone spray during pregnancy. Acta Endocrinol (Buchar). 2020 Oct-Dec;16(4):511-7. Abstract
14. Güven A. Different potent glucocorticoids, different routes of exposure but the same result: iatrogenic Cushing’s syndrome and adrenal insufficiency. J Clin Res Pediatr Endocrinol. 2020 Nov 25;12(4):383-92.Full text Abstract
15. Nieman LK. Consequences of systemic absorption of topical glucocorticoids. J Am Acad Dermatol. 2011 Jul;65(1):250-2. Abstract
16. Delitala AP, Fanciulli G, Maioli M, et al. Primary symptomatic adrenal insufficiency induced by megestrol acetate. Neth J Med. 2013 Jan;71(1):17-21. Abstract
17. Malik KJ, Wakelin K, Dean S, et al. Cushing's syndrome and hypothalamic-pituitary adrenal axis suppression induced by medroxyprogesterone acetate. Ann Clin Biochem. 1996 May;33 (Pt 3):187-9. Abstract
18. Chan CM, Mitchell AL, Shorr AF. Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis*. Crit Care Med. 2012 Nov;40(11):2945-53. Abstract
19. Bertagna C, Orth DN. Clinical and laboratory findings and results of therapy in 58 patients with adrenocortical tumors admitted to a single medical center (1951 to 1978). Am J Med. 1981 Nov;71(5):855-75. Abstract
20. Luton JP, Cerdas S, Billaud L, et al. Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. N Engl J Med. 1990 Apr 26;322(17):1195-201.Full text Abstract
21. Hawcutt DB, Francis B, Carr DF, et al. Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. Lancet Respir Med. 2018 Jun;6(6):442-50.Full text Abstract
22. Mebrahtu TF, Morgan AW, Keeley A, et al. Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England. J Clin Endocrinol Metab. 2019 Apr 22;104(9):3757-67.Full text Abstract
23. Schuetz P, Christ-Crain M, Schild U, et al. Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal axis in patients with acute exacerbation of chronic obstructive pulmonary disease. BMC Pulm Med. 2008 Jan 26;8:1.Full text Abstract
24. Streck WF, Lockwood DH. Pituitary adrenal recovery following short-term suppression with corticosteroids. Am J Med. 1979 Jun;66(6):910-4. Abstract
25. Villabona CV, Koh C, Panergo J, et al. Adrenocorticotropic hormone stimulation test during high-dose glucocorticoid therapy. Endocr Pract. 2009 Mar;15(2):122-7. Abstract
26. Duclos M, Guinot M, Colsy M, et al. High risk of adrenal insufficiency after a single articular steroid injection in athletes. Med Sci Sports Exerc. 2007 Jul;39(7):1036-43. Abstract
27. Mader R, Lavi I, Luboshitzky R. Evaluation of the pituitary-adrenal axis function following single intraarticular injection of methylprednisolone. Arthritis Rheum. 2005 Mar;52(3):924-8.Full text Abstract
28. Lansang MC, Farmer T, Kennedy L. Diagnosing the unrecognized systemic absorption of intra-articular and epidural steroid injections. Endocr Pract. 2009 Apr;15(3):225-8. Abstract
29. Ahmet A, Rowan-Legg A, Pancer L. Adrenal suppression from exogenous glucocorticoids: recognizing risk factors and preventing morbidity. [in fre]. Paediatr Child Health. 2021 Jul;26(4):242-54.Full text Abstract
30. Schurmeyer TH, Tsokos GC, Avgerinos PC, et al. Pituitary-adrenal responsiveness to corticotropin-releasing hormone in patients receiving chronic, alternate day glucocorticoid therapy. J Clin Endocrinol Metab. 1985 Jul;61(1):22-7. Abstract
31. Nakamura M, Abrouk M, Zhu H, et al. Update on the systemic risks of superpotent topical steroids. J Drugs Dermatol. 2017 Jul 1;16(7):643-8. Abstract
32. Arlt W, Society for Endocrinology Clinical Committee. Society for Endocrinology endocrine emergency guidance: emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. Endocr Connect. 2016 Sep;5(5):G1-3.Full text Abstract
33. Henzen C, Suter A, Lerch E, et al. Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment. Lancet. 2000 Feb 12;355(9203):542-5. Abstract
34. Nieman LK, Biller BM, Findling JW, et al. The diagnosis of Cushing's syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2008 May;93(5):1526-40.Full text Abstract
35. Erturk E, Jaffe CA, Barkan AL. Evaluation of the integrity of the hypothalamic-pituitary-adrenal axis by insulin hypoglycemia test. J Clin Endocrinol Metab. 1998 Jul;83(7):2350-4.Full text Abstract
36. Restituto P, Galofré JC, Gil MJ, et al. Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders. Clin Biochem. 2008 Jun;41(9):688-92. Abstract
37. Deutschbein T, Unger N, Mann K, et al. Diagnosis of secondary adrenal insufficiency: unstimulated early morning cortisol in saliva and serum in comparison with the insulin tolerance test. Horm Metab Res. 2009 Nov;41(11):834-9. Abstract
38. Thevenot T, Borot S, Remy-Martin A, et al. Assessment of adrenal function in cirrhotic patients using concentration of serum-free and salivary cortisol. Liver Int. 2011 Mar;31(3):425-33. Abstract
39. Galbois A, Rudler M, Massard J, et al. Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred. J Hepatol. 2010 Jun;52(6):839-45. Abstract
40. Raff H. Utility of salivary cortisol measurements in Cushing's syndrome andadrenal insufficiency. J Clin Endocrinol Metab. 2009 Oct;94(10):3647-55.Full text Abstract
41. Duplessis C, Rascona D, Cullum M, et al. Salivary and free serum cortisol evaluation. Mil Med. 2010 May;175(5):340-6. Abstract
42. Pastores SM, Annane D, Rochwerg B, et al. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Crit Care Med. 2018 Jan;46(1):146-8. Abstract
43. Marik PE, Pastores SM, Annane D, et al; American College of Critical Care Medicine. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med. 2008 Jun;36(6):1937-49. Abstract
44. Grinspoon SK, Biller BM. Clinical review 62: laboratory assessment of adrenal insufficiency. J Clin Endocrinol Metab. 1994 Oct;79(4):923-31. Abstract
45. Abdu TAM, Elhadd TA, Neary R, et al. Comparison of the low dose short Synacthen test (1 microg), the conventional dose short Synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease. J Clin Endocrinol Metab. 1999 Mar;84(3):838-43.Full text Abstract
46. Giordano R, Picu A, Bonelli L, et al. Hypothalamus-pituitary-adrenal axis evaluation in patients with hypothalamo-pituitary disorders: comparison of different provocative tests. Clin Endocrinol (Oxf). 2008 Jun;68(6):935-41. Abstract
47. Suliman AM, Smith TP, Labib M, et al. The low-dose ACTH test does not provide a useful assessment of the hypothalamic-pituitary-adrenal axis in secondary adrenal insufficiency. Clin Endocrinol (Oxf). 2002 Apr;56(4):533-9. Abstract
48. Gonzalez-Gonzalez JG, De la Garza-Hernandez NE, Mancillas-Adame LG, et al. A high-sensitivity test in the assessment of adrenocortical insufficiency: 10 microg vs 250 microg cosyntropin dose assessment of adrenocortical insufficiency. J Endocrinol. 1998 Nov;159(2):275-80.Full text Abstract
49. Kazlauskaite R, Evans AT, Villabona CV, et al; Consortium for Evaluation of Corticotropin Test in Hypothalamic-Pituitary Adrenal Insufficiency. Corticotropin tests for hypothalamic-pituitary-adrenal insufficiency: a metaanalysis. J Clin Endocrinol Metab. 2008 Nov;93(11):4245-53.Full text Abstract
50. Magnotti M, Shimshi M. Diagnosing adrenal insufficiency: which test is best - the 1-microg or the 250-microg cosyntropin stimulation test? Endocr Pract. 2008 Mar;14(2):233-8. Abstract
51. Ueland GÅ, Methlie P, Øksnes M, et al. The short cosyntropin test revisited: new normal reference range using LC-MS/MS. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1696-703.Full text Abstract
52. Ospina NS, Al Nofal A, Bancos I, et al. ACTH stimulation tests for the diagnosis of adrenal insufficiency: systematic review and meta-analysis. J Clin Endocrinol Metab. 2016 Feb;101(2):427-34.Full text Abstract
53. Ahmet A, Kim H, Spier S. Adrenal suppression: a practical guide to the screening and management of this under-recognized complication of inhaled corticosteroid therapy. Allergy Asthma Clin Immunol. 2011 Aug 25;7(1):13Full text Abstract
54. Liu MM, Reidy AB, Saatee S, et al. Perioperative steroid management: approaches based on current evidence. Anesthesiology. 2017 Jul;127(1):166-72.Full text Abstract
55. Yong SL, Coulthard P, Wrzosek A. Supplemental perioperative steroids for surgical patients with adrenal insufficiency. Cochrane Database Syst Rev. 2012 Dec 12;12:CD005367. Abstract
56. Arafah BM. Perioperative glucocorticoid therapy for patients with adrenal insufficiency: dosing based on pharmacokinetic data. J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgaa042. Abstract
57. Woodcock T, Barker P, Daniel S, et al. Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK. Anaesthesia. 2020 May;75(5):654-63.Full text Abstract
58. Hopkins RL, Leinung MC. Exogenous Cushing's syndrome and glucocorticoid withdrawal. Endocrinol Metab Clin North Am. 2005 Jun;34(2):371-84;ix. Abstract
59. Stewart PM. The adrenal cortex. In: Larsen PR, Kronenberg HM, Melmed S, et al., eds. Williams textbook of endocrinology. 10th ed. Philadelphia, PA: WB Saunders; 2003:491-551.
Use of this content is subject to our disclaimer