Chronic kidney disease (CKD) is a common condition that is often unrecognised until the most advanced stages. It is estimated that 9% to 13% of the adult population worldwide has CKD.[3]Webster AC, Nagler EV, Morton RL, et al. Chronic kidney disease. Lancet. 2017 Mar 25;389(10075):1238-52.
http://www.ncbi.nlm.nih.gov/pubmed/27887750?tool=bestpractice.com
[4]Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease - a systematic review and meta-analysis. PLoS One. 2016 Jul 6;11(7):e0158765.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158765
http://www.ncbi.nlm.nih.gov/pubmed/27383068?tool=bestpractice.com
[5]GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020 Feb 29;395(10225):709-33.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30045-3/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/32061315?tool=bestpractice.com
In 2017, the estimated worldwide prevalence of CKD stages 1 to 2 accounted for 5%, stage 3 for 3.9%, stage 4 for 0.16%, stage 5 for 0.07%, dialysis for 0.041%, and kidney transplantation for 0.011%.[5]GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020 Feb 29;395(10225):709-33.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30045-3/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/32061315?tool=bestpractice.com
The global prevalence of CKD is rising and is thought to be due to an ageing population; a higher incidence of diseases such as diabetes and hypertension, which are the most common causes in the adult population; and an increased incidence of glomerular disorders such as focal segmental glomerulosclerosis.[4]Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease - a systematic review and meta-analysis. PLoS One. 2016 Jul 6;11(7):e0158765.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158765
http://www.ncbi.nlm.nih.gov/pubmed/27383068?tool=bestpractice.com
[6]GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1789-858.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32279-7/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/30496104?tool=bestpractice.com
[7]Rosenberg AZ, Kopp JB. Focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2017 Mar 7;12(3):502-17. [Erratum in: Clin J Am Soc Nephrol. 2018 Dec 7;13(12):1889.]
https://cjasn.asnjournals.org/content/12/3/502
http://www.ncbi.nlm.nih.gov/pubmed/28242845?tool=bestpractice.com
Black people, Hispanic people, and those with a family member who has a diagnosis of kidney disease have a higher prevalence than the general population.[8]Kibria GMA, Crispen R. Prevalence and trends of chronic kidney disease and its risk factors among US adults: an analysis of NHANES 2003-18. Prev Med Rep. 2020 Sep 1;20:101193.
https://www.sciencedirect.com/science/article/pii/S2211335520301522
http://www.ncbi.nlm.nih.gov/pubmed/33101883?tool=bestpractice.com
[9]McClellan WM, Satko SG, Gladstone E, et al. Individuals with a family history of ESRD are a high-risk population for CKD: implications for targeted surveillance and intervention activities. Am J Kidney Dis. 2009 Mar;53(3 suppl 3):S100-6.
http://www.ncbi.nlm.nih.gov/pubmed/19231753?tool=bestpractice.com
Additionally, individuals with an episode of acute kidney injury are most likely to be at risk for chronic kidney injury and end-stage kidney disease in the future.[10]See EJ, Jayasinghe K, Glassford N, et al. Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure. Kidney Int. 2019 Jan;95(1):160-72.
http://www.ncbi.nlm.nih.gov/pubmed/30473140?tool=bestpractice.com
CKD is a condition associated with high racial and socioeconomic disparities. In 2016, the age-standardised incidence of end-stage renal disease was almost threefold higher among black people compared with white people in the US, whereas data from the ACCORD study revealed that race was not associated with accelerated development and progression of CKD in participants who received standardised medical care.[11]Gerber C, Cai X, Lee J, et al. Incidence and progression of chronic kidney disease in black and white individuals with type 2 diabetes. Clin J Am Soc Nephrol. 2018 Jun 7;13(6):884-92.
https://cjasn.asnjournals.org/content/13/6/884
http://www.ncbi.nlm.nih.gov/pubmed/29798889?tool=bestpractice.com
The results suggest that equitable health care delivery for patients with diabetes may reduce racial disparities in diabetes-associated CKD.