References
Key articles
Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. Abstract
Kusumoto FM, Schoenfeld MH, Barrett C, et al. 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019 Aug 20;74(7):e51-156.Full text Abstract
Panchal AR, Bartos JA, Cabañas JG, et al. Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2020 Oct 20;142(16_suppl_2):S366-S468.Full text Abstract
Reference articles
1. Spodick DH, Raju P, Bishop RL, et al. Operational definition of normal sinus heart rate. Am J Cardiol. 1992 May 1;69(14):1245-6. Abstract
2. Spodick DH. Normal sinus heart rate: sinus tachycardia and sinus bradycardia redefined. Am Heart J. 1992 Oct;124(4):1119-21. Abstract
3. Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. Abstract
4. Tresch DD, Fleg JL. Unexplained sinus bradycardia: clinical significance and long term prognosis in apparently healthy persons older than 40 years. Am J Cardiol. 1986 Nov 1;58(10):1009-13. Abstract
5. Hilgard J, Ezri MD, Denes P. Significance of ventricular pauses of three seconds or more detected on twenty-four hour Holter recordings. Am J Cardiol. 1985 Apr 1;55(8):1005-8. Abstract
6. Wu DL, Yeh SJ, Lin FC, et al. Sinus automaticity and sinoatrial conduction in severe symptomatic sick sinus syndrome. J Am Coll Cardiol. 1992 Feb;19(2):355-64. Abstract
7. Kaplan BM, Langendorf R, Lev M, et al. Tachycardia-bradycardia syndrome (so-called "sick sinus syndrome"). Pathology, mechanisms and treatment. Am J Cardiol. 1973 Apr;31(4):497-508. Abstract
8. Wiens R, Lafia P, Marder CM, et al. Chronotropic incompetence in clinical exercise testing. Am J Cardiol. 1984 Jul 1;54(1):74-8. Abstract
9. Brignole M. Sick sinus syndrome. Clin Geriatr Med. 2002 May;18(2):211-27. Abstract
10. Walsh-Irwin C, Hannibal GB. Sick sinus syndrome. AACN Adv Crit Care. 2015 Oct-Dec;26(4):376-80. Abstract
11. Kusumoto FM, Schoenfeld MH, Barrett C, et al. 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019 Aug 20;74(7):e51-156.Full text Abstract
12. Bernstein AD, Parsonnet V. Survey of cardiac pacing in the United States in 1989. Am J Cardiol. 1992 Feb 1;69(4):331-8. Abstract
13. Narula OS, Samet P. Significance of first degree A-V block. Circulation. 1971 May;43(5):772-4. Abstract
14. Narula OS, Runge M, Samet P. Second-degree Wenckebach type AV block due to block within the atrium. Br Heart J. 1972 Nov;34(11):1127-36.Full text Abstract
15. Goodfriend MA, Barold SS. Tachycardia-dependent and bradycardia-dependent Mobitz type II atrioventricular block within the bundle of His. Am J Cardiol. 1974 Jun;33(7):908-13. Abstract
16. Lev M. The pathology of complete atrioventricular block. Prog Cardiovasc Dis. 1964 Jan;6:317-26. Abstract
17. Narula OS, Narula JT. Junctional pacemakers in man: response to overdrive suppression with and without parasympathetic blockade. Circulation. 1978 May;57(5):880-9. Abstract
18. Siontis GCM, Praz F, Lanz J, et al. New-onset arrhythmias following transcatheter aortic valve implantation: a systematic review and meta-analysis. Heart. 2018 Jul;104(14):1208-1215.Full text Abstract
19. Mangoni ME, Nargeot JL. Genesis and regulation of the heart automaticity. Physiol Rev. 2008 Jul;88(3):919-82. Abstract
20. Tisdale JE, Chung MK, Campbell KB, et al. Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association. Circulation. 2020 Oct 13;142(15):e214-e233.Full text Abstract
21. Griffiths C, Ioannou A, Dickinson B, et al. Drug-related bradycardia precipitating hospital admission in older adults: an ongoing problem. Eur J Hosp Pharm. 2021 Feb 24. Abstract
22. Becker HF, Koehler U, Stammnitz A, et al. Heart block in patients with sleep apnoea. Thorax. 1998 Oct;53 Suppl 3:S29-32.Full text Abstract
23. Garrigue S, Bordier P, Jaïs P, et al. Benefit of atrial pacing in sleep apnea syndrome. N Engl J Med. 2002 Feb 7;346(6):404-12.Full text Abstract
24. Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2021 Jul 20;144(3):e56-e67.Full text Abstract
25. Mehra R, Chung MK, Olshansky B, et al. Sleep-disordered breathing and cardiac arrhythmias in adults: Mechanistic insights and clinical implications: a scientific statement from the American Heart Association. Circulation. 2022 Aug 30;146(9):e119-36.Full text Abstract
26. Carlson SK, Patel AR, Chang PM. Bradyarrhythmias in congenital heart disease. Card Electrophysiol Clin. 2017 Jun;9(2):177-87. Abstract
27. Ackerman MJ, Priori SG, Willems S, et al; Heart Rhythm Society (HRS), European Heart Rhythm Association (EHRA). HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Heart Rhythm. 2011 Aug;8(8):1308-39.Full text Abstract
28. Sanghavi M, Rutherford JD. Cardiovascular physiology of pregnancy. Circulation. 2014 Sep 16;130(12):1003-8.Full text Abstract
29. Adamson DL, Nelson-Piercy C. Managing palpitations and arrhythmias during pregnancy. Heart. 2007 Dec;93(12):1630-6.Full text Abstract
30. Monté CP, Monté CJ, Boon P, et al. Epileptic seizures associated with syncope: Ictal bradycardia and ictal asystole. Epilepsy Behav. 2019 Jan;90:168-171.Full text Abstract
31. Zeltser D, Justo D, Halkin A, et al. Drug-induced atrioventricular block: prognosis after discontinuation of the culprit drug. J Am Coll Cardiol. 2004 Jul 7;44(1):105-8. Abstract
32. Jones SA. Ageing to arrhythmias: conundrums of connections in the ageing heart. J Pharm Pharmacol. 2006 Dec;58(12):1571-6. Abstract
33. Kaszala K, Kalahasty G, Ellenbogen KA. Cardiac pacing in the elderly. Am J Geriatr Cardiol. 2006 Mar-Apr;15(2):77-81. Abstract
34. Jones SA, Boyett MR, Lancaster MK. Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node. Circulation. 2007 Mar 13;115(10):1183-90.Full text Abstract
35. Mullins CB, Atkins JM. Prognoses and management of ventricular conduction block in acute myocardial infarction. Mod Concepts Cardiovasc Dis. 1976 Oct;45(10):129-33. Abstract
36. Meine T, Al-Khatib S, Alexander J, et al. Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy. Am Heart J. 2005 Apr;149(4):670-4. Abstract
37. Aplin M, Engstrom T, Vejlstrup NG, et al. Prognostic importance of complete atrioventricular block complicating acute myocardial infarction. Am J Cardiol. 2003 Oct 1;92(7):853-6. Abstract
38. Erkapic D, De Rosa S, Kelava A, et al. Risk for permanent pacemaker after transcatheter aortic valve implantation: a comprehensive analysis of the literature. J Cardiovasc Electrophysiol. 2012 Apr;23(4):391-7. Abstract
39. Nazif TM, Dizon JM, Hahn RT, et al; PARTNER Publications Office. Predictors and clinical outcomes of permanent pacemaker implantation after transcatheter aortic valve replacement: the PARTNER (Placement of AoRtic TraNscathetER Valves) trial and registry. JACC Cardiovasc Interv. 2015 Jan;8(1 Part A):60-9.Full text Abstract
40. Nisbet AM, Burton FL, Walker NL, et al. Acidosis slows electrical conduction through the atrio-ventricular node. Front Physiol. 2014 Jun 25;5:233.Full text Abstract
41. Glikson M, Nielsen JC, Kronborg MB, et al. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. Eur Heart J. 2021 Sep 14;42(35):3427-3520.Full text Abstract
43. Tilkian AG, Guilleminault C, Schroeder JS, et al. Sleep-induced apnea syndrome: prevalence of cardiac arrhythmias and their reversal after tracheostomy. Am J Med. 1977 Sep;63(3):348-58. Abstract
44. Abbott JA, Hirschfeld DS, Kunkel FW, et al. Graded exercise testing in patients with sinus node dysfunction. Am J Med. 1977 Mar;62(3):330-8. Abstract
45. Benditt DG, Ermis C, Lu F. Head-up tilt table testing. In: Zipes DP, Jalife J, eds. Cardiac electrophysiology: from cell to bedside. 4th ed. Philadelphia, PA: Saunders; 2004:812-22.
46. Morillo CA, Camacho ME, Wood MA, et al. Diagnostic utility of mechanical, pharmacological and orthostatic stimulation of the carotid sinus in patients with unexplained syncope. J Am Coll Cardiol. 1999 Nov 1;34(5):1587-94. Abstract
47. Brignole M, Sutton R, Menozzi C, et al. Early application of an implantable loop recorder allows effective specific therapy in patients with recurrent suspected neurally mediated syncope. Eur Heart J. 2006 May;27(9):1085-92.Full text Abstract
48. Krahn AD, Klein GJ, Yee R, et al. The high cost of syncope: cost implications of a new insertable loop recorder in the investigation of recurrent syncope. Am Heart J. 1999 May;137(5):870-7. Abstract
49. Englund A, Bergfeldt L, Rosenqvist M. Pharmacological stress testing of the His-Purkinje system in patients with bifascicular block. Pacing Clin Electrophysiol. 1998 Oct;21(10):1979-87. Abstract
50. Scheinman MM, Peters RW, Suavé MJ, et al. Value of the H-Q interval in patients with bundle branch block and the role of prophylactic permanent pacing. Am J Cardiol. 1982 Dec;50(6):1316-22. Abstract
51. Menozzi C, Brignole M, Garcia-Civera R, et al; International Study on Syncope of Uncertain Etiology (ISSUE) Investigators. Mechanism of syncope in patients with heart disease and negative electrophysiologic test. Circulation. 2002 Jun 11;105(23):2741-5.Full text Abstract
52. Brignole M, Menozzi C, Moya A, et al; International Study on Syncope of Uncertain Etiology (ISSUE) Investigators. Mechanism of syncope in patients with bundle branch block and negative electrophysiological test. Circulation. 2001 Oct 23;104(17):2045-50.Full text Abstract
53. Stegman SS, Burroughs JM, Henthorn RW. Asymptomatic bradyarrhythmias as a marker for sleep apnea: appropriate recognition and treatment may reduce the need for pacemaker therapy. Pacing Clin Electrophysiol. 1996 Jun;19(6):899-904. Abstract
54. Kaushik V, Leon AR, Forrester JS Jr, et al. Bradyarrhythmias, temporary and permanent pacing. Crit Care Med. 2000 Oct;28(suppl 10):N121-8. Abstract
56. Benditt DG, Benson DW Jr, Kreitt J, et al. Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. Am J Cardiol. 1983 Dec 1;52(10):1223-9. Abstract
57. Sra JS, Jazayeri MR, Avitall B, et al. Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole. N Engl J Med. 1993 Apr 15;328(15):1085-90.Full text Abstract
58. Sweeney MO, Hellkamp AS, Ellenbogen KA, et al. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2003 Jun 17;107(23):2932-7.Full text Abstract
59. Gillis AM, Russo AM, Ellenbogen KA, et al. HRS/ACCF expert consensus statement on pacemaker device and mode selection. J Am Coll Cardiol. 2012 Aug 14;60(7):682-703.Full text Abstract
60. Edwards SJ, Karner C, Trevor N, et al. Dual-chamber pacemakers for treating symptomatic bradycardia due to sick sinus syndrome without atrioventricular block: a systematic review and economic evaluation. Health Technol Assess. 2015 Aug;19(65):1-210. Abstract
61. Wilkoff BL, Cook JR, Epstein AE, et al; DAVID Trial Investigators. Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA. 2002 Dec 25;288(24):3115-23.Full text Abstract
62. Sweeney MO, Bank AJ, Nsah E, et al. Minimizing ventricular pacing to reduce atrial fibrillation in sinus-node disease. N Engl J Med. 2007 Sep 6;357(10):1000-8.Full text Abstract
63. Curtis AB, Worley SJ, Adamson PB, et al. Biventricular pacing for atrioventricular block and systolic dysfunction. N Engl J Med. 2013 Apr 25;368(17):1585-93.Full text Abstract
64. Grubb BP. Neurocardiogenic syncope and related disorders of orthostatic intolerance. Circulation. 2005 Jun 7;111(22):2997-3006.Full text Abstract
65. Grubb BP. Clinical practice: neurocardiogenic syncope. N Engl J Med. 2005 Mar 10;352(10):1004-10. Abstract
66. Theodorakis GN, Leftheriotis D, Livanis EG, et al. Fluoxetine vs. propranolol in the treatment of vasovagal syncope: a prospective, randomized, placebo-controlled study. Europace. 2006 Mar;8(3):193-8.Full text Abstract
67. Brignole M, Moya A, de Lange FJ, et al. 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018 Jun 1;39(21):1883-948.Full text Abstract
68. Brignole M, Menozzi C, Moya A, et al; International Study on Syncope of Uncertain Etiology 3 (ISSUE-3) Investigators. Pacemaker therapy in patients with neurally mediated syncope and documented asystole. Third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial. Circulation. 2012 May 29;125(21):2566-71.Full text Abstract
69. Gopinathannair R, Salgado BC, Olshansky B. Pacing for vasovagal syncope. Arrhythm Electrophysiol Rev. 2018 Jun;7(2):95-102.Full text Abstract
70. Savelieva I, Fumagalli S, Kenny RA, et al. EHRA expert consensus document on the management of arrhythmias in frailty syndrome, endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA). Europace. 2023 Apr 15;25(4):1249-76.Full text Abstract
71. Burri H, Jastrzebski M, Cano Ó, et al. EHRA clinical consensus statement on conduction system pacing implantation: executive summary. Endorsed by the Asia-Pacific Heart Rhythm Society (APHRS), Canadian Heart Rhythm Society (CHRS) and Latin-American Heart Rhythm Society (LAHRS). Europace. 2023 Apr 15;25(4):1237-48.Full text Abstract
72. Su L, Wang S, Wu S, et al. Long-term safety and feasibility of left bundle branch pacing in a large single-center study. Circ Arrhythm Electrophysiol. 2021 Feb;14(2):e009261.Full text Abstract
73. Panchal AR, Bartos JA, Cabañas JG, et al. Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2020 Oct 20;142(16_suppl_2):S366-S468.Full text Abstract
74. Shen WK, Sheldon RS, Benditt DG, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2017 Aug 1;70(5):e39-110.Full text Abstract
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