Non-alcoholic fatty liver disease (NAFLD) is now considered the most common cause of chronic liver disease in the US. It is a clinico-histopathological diagnosis and is generally considered to be a diagnosis of exclusion. It consists of a spectrum of diseases ranging from bland (without inflammation) steatosis to end-stage liver disease. The two extremes of the disease can often be diagnosed with non-invasive means. Intermediate stages frequently will require histological analysis.
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