Asthma in children

References

Key articles

Global Initiative for Asthma. 2024 Global strategy for asthma management and prevention. May 2024 [internet publication].Full text

British Thoracic Society. British guideline on the management of asthma. Jul 2019 [internet publication].Full text

National Institute for Health and Care Excellence. Asthma: diagnosis, monitoring and chronic asthma management. Mar 2021 [internet publication].Full text

National Heart, Lung, and Blood Institute; National Asthma Education and Prevention Program. Guidelines for the diagnosis and management of asthma. Aug 2007 [internet publication].Full text

Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC), Cloutier MM, Baptist AP, et al. 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec;146(6):1217-70.Full text  Abstract

Reference articles

1. Global Initiative for Asthma. 2024 Global strategy for asthma management and prevention. May 2024 [internet publication].Full text

2. Mohan A, Lugogo NL, Hanania NA, et al. Questions in mild asthma: an official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2023 Jun 1;207(11):e77-e96. Abstract

3. Yang CL, Hicks EA, Mitchell P, et al. 2021 Canadian Thoracic Society Guideline – a focused update on the management of very mild and mild asthma​. Can J Respir Crit Care Sleep Med. 2021;5(4):205-45.Full text

4. Asher MI, Rutter CE, Bissell K, et al. Worldwide trends in the burden of asthma symptoms in school-aged children: Global Asthma Network Phase I cross-sectional study. Lancet. 2021 Oct 30;398(10311):1569-80.Full text  Abstract

5. Song P, Adeloye D, Salim H, et al. Global, regional, and national prevalence of asthma in 2019: a systematic analysis and modelling study. J Glob Health. 2022 Jun 29;12:04052.Full text  Abstract

6. Centers for Disease Control and Prevention. Most recent national asthma data. [internet publication].​Full text

7. de Aguiar KB, Anzolin M, Zhang L. Global prevalence of exercise-induced bronchoconstriction in childhood: a meta-analysis. Pediatr Pulmonol. 2018 Apr;53(4):412-25.Full text  Abstract

8. British Thoracic Society. British guideline on the management of asthma. Jul 2019 [internet publication].Full text

9. Thacher JD, Gehring U, Gruzieva O, et al. Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis - a MeDALL project. Environ Health Perspect. 2018 Apr 12;126(4):047005.Full text  Abstract

10. Alcazar CG, Paes VM, Shao Y, et al. The association between early-life gut microbiota and childhood respiratory diseases: a systematic review. Lancet Microbe. 2022 Nov;3(11):e867-80. Abstract

11. Hehua Z, Qing C, Shanyan G, et al. The impact of prenatal exposure to air pollution on childhood wheezing and asthma: A systematic review. Environ Res. 2017 Nov;159:519-30. Abstract

12. McKenzie C, Tan J, Macia L, Mackay CR. The nutrition-gut microbiome-physiology axis and allergic diseases. Immunol Rev. 2017 Jul;278(1):277-95. Abstract

13. Sobczak M, Pawliczak R. Relationship between vitamin D and asthma from gestational to adulthood period: a meta-analysis of randomized clinical trials. BMC Pulm Med. 2023 Jun 17;23(1):212. Abstract

14. Wang L, Hu X, Xiang C. Does the timing of antibiotic exposure in pregnancy impact the risk of development of pediatric asthma? A systematic review and meta-analysis. J Asthma. 2023 May;60(5):856-67. Abstract

15. Brustad N, Chawes B. Vitamin D primary prevention of respiratory infections and asthma in early childhood: evidence and mechanisms. J Allergy Clin Immunol Pract. 2024 Feb 14;S2213-2198(24)00161-2. Abstract

16. Sun T, Yu HY, Yang M, et al. Risk of asthma in preterm infants with bronchopulmonary dysplasia: a systematic review and meta-analysis. World J Pediatr. 2023 Jun;19(6):549-56. Abstract

17. Been JV, Lugtenberg MJ, Smets E, et al. Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis. PLoS Med. 2014 Jan;11(1):e1001596. Abstract

18. Grandinetti R, Fainardi V, Caffarelli C, et al. Risk factors affecting development and persistence of preschool wheezing: consensus document of the Emilia-Romagna Asthma (ERA) Study Group. J Clin Med. 2022 Nov 4;11(21):6558. Abstract

19. Koppelman GH, Los H, Postma DS. Genetic and environment in asthma: the answer of twin studies. Eur Respir J. 1999 Jan;13(1):2-4.Full text  Abstract

20. Fan Z, Liu T, Na W. Association of nitric oxide synthase gene polymorphism with asthma: a systematic review and meta-analysis. Clin Respir J. 2023 Jun;17(6):516-26. Abstract

21. Aarafi H, Yadegari A, Dastgheib SA, et al. Association of +1923C > T, -1112C > T and +2044A > G Polymorphisms in IL-13 Gene with Susceptibility to Pediatric Asthma: A Systematic Review and Meta-Analysis. Fetal Pediatr Pathol. 2022 Apr;41(2):259-277.Full text  Abstract

22. Ruan Z, Shi Z, Zhang G, et al. Asthma susceptible genes in children: a meta-analysis. Medicine (Baltimore). 2020 Nov 6;99(45):e23051. Abstract

23. Chen X, Hu J, Li K, et al. Association of the IL-4R Q576R polymorphism with pediatric asthma: a meta-analysis. Afr Health Sci. 2022 Sep;22(3):307-16. Abstract

24. Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003 Oct 9;349(15):1414-22.Full text  Abstract

25. Lowe AJ, Carlin JB, Bennett CM, et al. Do boys do the atopic march while girls dawdle? J Allergy Clin Immunol. 2008 May;121(5):1190-5. Abstract

26. Li H, Dai T, Liu C, et al. Phenotypes of atopic dermatitis and the risk for subsequent asthma: a systematic review and meta-analysis. J Am Acad Dermatol. 2022 Feb;86(2):365-72. Abstract

27. Dharmage SC, Lowe AJ, Tang MLK. Revisiting the atopic march current evidence. Am J Respir Crit Care Med. 2022 Oct 15;206(8):925-6. Abstract

28. Meng Q, Nagarajan S, Son Y, et al. Asthma, oculonasal symptoms, and skin test sensitivity across National Health and Nutrition Examination Surveys. Ann Allergy Asthma Immunol. 2016 Feb;116(2):118-25.e5.Full text  Abstract

29. Wadhwa V, Lodge CJ, Dharmage SC, et al. The association of early life viral respiratory illness and atopy on asthma in children: systematic review and meta-analysis. J Allergy Clin Immunol Pract. 2020 Sep;8(8):2663-72.e7. Abstract

30. van Meel ER, Mensink-Bout SM, den Dekker HT, et al. Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children. Eur Respir J. 2022 Oct;60(4):2102395. Abstract

31. Makrinioti H, Hasegawa K, Lakoumentas J, et al. The role of respiratory syncytial virus- and rhinovirus-induced bronchiolitis in recurrent wheeze and asthma - a systematic review and meta-analysis. Pediatr Allergy Immunol. 2022 Mar;33(3):e13741. Abstract

32. Toelle BG, Xuan W, Peat JK, et al. Childhood factors that predict asthma in young adulthood. Eur Respir J. 2004 Jan;23(1):66-70.Full text  Abstract

33. Wang YT, Hu KR, Zhao J, et al. The association between exposure to second-hand smoke and disease in the Chinese population: a systematic review and meta-analysis. Biomed Environ Sci. 2023 Jan 20;36(1):24-37. Abstract

34. Wong M, Forno E, Celedón JC. Asthma interactions between obesity and other risk factors. Ann Allergy Asthma Immunol. 2022 Sep;129(3):301-6. Abstract

35. Di Cicco M, Sepich M, Beni A, et al. How E-cigarettes and vaping can affect asthma in children and adolescents. Curr Opin Allergy Clin Immunol. 2022 Apr 1;22(2):86-94. Abstract

36. Rose JJ, Krishnan-Sarin S, Exil VJ, et al. Cardiopulmonary impact of electronic cigarettes and vaping products: a scientific statement from the American Heart Association. Circulation. 2023 Aug 22;148(8):703-28. Abstract

37. Achakulwisut P, Brauer M, Hystad P, et al. Global, national, and urban burdens of paediatric asthma incidence attributable to ambient NO2 pollution: estimates from global datasets. Lancet Planet Health. 2019 Apr;3(4):e166-78.Full text  Abstract

38. Garcia E, Berhane KT, Islam T, et al. Association of changes in air quality with incident asthma in children in California, 1993-2014. JAMA. 2019 May 21;321(19):1906-15.Full text  Abstract

39. Reddy KRBK, Gupta N, Bhattacharya BG, et al. Impact of air pollution on allergic rhinitis and asthma: consensus statement by Indian Academy of Pediatrics.. Indian Pediatr. 2021 Aug 15;58(8):765-70. Abstract

40. Boogaard H, Patton AP, Atkinson RW, et al. Long-term exposure to traffic-related air pollution and selected health outcomes: a systematic review and meta-analysis. Environ Int. 2022 Jun;164:107262. Abstract

41. Song M, Hwang S, Son E, et al. Geographical differences of risk of asthma and allergic rhinitis according to urban/rural area: a systematic review and meta-analysis of cohort studies. J Urban Health. 2023 Jun;100(3):478-92. Abstract

42. Rodrigues MB, Carvalho DS, Chong-Silva DC, et al. Association between exposure to pesticides and allergic diseases in children and adolescents: a systematic review with meta-analysis. J Pediatr (Rio J). 2022 Nov-Dec;98(6):551-64. Abstract

43. Gilden RC, Harris RL, Friedmann EJ, et al. Systematic review: association of pesticide exposure and child wheeze and asthma. Curr Pediatr Rev. 2023;19(2):169-78. Abstract

44. Burbank AJ, Hernandez ML, Jefferson A, et al. Environmental justice and allergic disease: a work group report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee. J Allergy Clin Immunol. 2023 Mar;151(3):656-70.Full text  Abstract

45. Payne DN, Rogers AV, Adelroth E, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med. 2003 Jan 1;167(1):78-82.Full text  Abstract

46. Illi S, von Mutius E, Lau S, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006 Aug 26;368(9537):763-70. Abstract

47. Oswald H, Phelan PD, Lanigan A, et al. Childhood asthma and lung function in mid-adult life. Pediatr Pulmonol. 1997 Jan;23(1):14-20. Abstract

48. Peat JK, Tovey E, Gray EJ, et al. Asthma severity and morbidity in a population sample of Sydney schoolchildren: part II importance of house dust mite allergens. Aust N Z J Med. 1994 Jun;24(3):270-6. Abstract

49. Hahn DL. Chlamydia pneumoniae and chronic asthma: updated systematic review and meta-analysis of population attributable risk. PLoS One. 2021;16(4):e0250034. Abstract

50. Liu X, Wang Y, Chen C, et al. Mycoplasma pneumoniae infection and risk of childhood asthma: a systematic review and meta-analysis. Microb Pathog. 2021 Jun;155:104893. Abstract

51. Martinez FD, Wright AL, Taussig LM, et al; The Group Health Medical Associates. Asthma and wheezing in the first six years of life. N Engl J Med. 1995 Jan 19;332(3):133-8.Full text  Abstract

52. Benson VS, Hartl S, Barnes N, et al. Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis. Eur Respir J. 2022 Jan;59(1):2004590. Abstract

53. Denlinger LC, Phillips BR, Ramratnam S, et al. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-13. Abstract

54. Kang SW, Kim SK, Han YR, et al. Promoter polymorphism (-308G/A) of tumor necrosis factor-alpha (TNF-α) gene and asthma risk: an updated meta-analysis. Genet Test Mol Biomarkers. 2019 Jun;23(6):363-72. Abstract

55. Yu X, Wang LW, He Q, et al. Correlation study on β2-adrenergic receptor gene polymorphisms and asthma susceptibility: evidence based on 57 case-control studies. Eur Rev Med Pharmacol Sci. 2019 May;23(9):3908-25. Abstract

56. He L, Zhou X, Mo H, et al. The association between vitamin D receptor gene polymorphisms and asthma: a systematic review and meta-analysis. Ann Palliat Med. 2022 Feb;11(2):574-87. Abstract

57. Cardenas A, Fadadu RP, Koppelman GH. Epigenome-wide association studies of allergic disease and the environment. J Allergy Clin Immunol. 2023 Sep;152(3):582-90. Abstract

58. Holst GJ, Pedersen CB, Thygesen M, et al. Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study. BMJ. 2020 Aug 19;370:m2791. Abstract

59. Bettiol A, Gelain E, Milanesio E, et al. The first 1000 days of life: traffic-related air pollution and development of wheezing and asthma in childhood. A systematic review of birth cohort studies. Environ Health. 2021 Apr 17;20(1):46. Abstract

60. Maung TZ, Bishop JE, Holt E, et al. Indoor air pollution and the health of vulnerable groups: a systematic review focused on particulate matter (PM), volatile organic compounds (VOCs) and their effects on children and people with pre-existing lung disease. Int J Environ Res Public Health. 2022 Jul 19;19(14):8752. Abstract

61. Nassikas NJ, McCormack MC, Ewart G, et al. Indoor air sources of outdoor air pollution: health consequences, policy, and recommendations: an official American Thoracic Society workshop report. Ann Am Thorac Soc. 2024 Mar;21(3):365-76.Full text  Abstract

62. Centers for Disease Control and Prevention. Most recent national asthma data. May 2023 [internet publication].​Full text

63. Chowdhury NU, Guntur VP, Newcomb DC, et al. Sex and gender in asthma. Eur Respir Rev. 2021 Dec 31;30(162):210067.Full text  Abstract

64. Azizpour Y, Delpisheh A, Montazeri Z, et al. Effect of childhood BMI on asthma: a systematic review and meta-analysis of case-control studies. BMC Pediatr. 2018 Apr 26;18(1):143.Full text  Abstract

65. Reyes-Angel J, Kaviany P, Rastogi D, et al. Obesity-related asthma in children and adolescents. Lancet Child Adolesc Health. 2022 Oct;6(10):713-24. Abstract

66. Oosterholt S, Pavord ID, Brusselle G, et al. Modelling ASthma TrEatment Responses (MASTER): effect of individual patient characteristics on the risk of exacerbation in moderate or severe asthma: a time-to-event analysis of randomized clinical trials. Br J Clin Pharmacol. 2023 Nov;89(11):3273-90. Abstract

67. Deng X, Ma J, Yuan Y, et al. Association between overweight or obesity and the risk for childhood asthma and wheeze: an updated meta-analysis on 18 articles and 73 252 children. Pediatr Obes. 2019 Sep;14(9):e12532. Abstract

68. Mallah N, Turner JM, González-Barcala FJ, et al. Gastroesophageal reflux disease and asthma exacerbation: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2022 Jan;33(1):e13655. Abstract

69. Kopsaftis Z, Yap HS, Tin KS, et al. Pharmacological and surgical interventions for the treatment of gastro-oesophageal reflux in adults and children with asthma. Cochrane Database Syst Rev. 2021 May 17;(5):CD001496.Full text  Abstract

70. Wang R, Mihaicuta S, Tiotiu A, et al. Asthma and obstructive sleep apnoea in adults and children - an up-to-date review. Sleep Med Rev. 2022 Feb;61:101564. Abstract

71. Prasad B, Nyenhuis SM, Imayama I, et al. Asthma and obstructive sleep apnea overlap: what has the evidence taught us? Am J Respir Crit Care Med. 2020 Jun 1;201(11):1345-57.Full text  Abstract

72. Rogers L. Role of sleep apnea and gastroesophageal reflux in severe asthma. Immunol Allergy Clin North Am. 2016 Aug;36(3):461-71. Abstract

73. Wijs LA, Fusco MR, Doherty DA, et al. Asthma and allergies in offspring conceived by ART: a systematic review and meta-analysis. Hum Reprod Update. 2021 Dec 21;28(1):132-48. Abstract

74. Liang Y, Zhang J, Bai S, et al. Short-term and long-term effects of cesarean section on asthma and wheezing: a cohort study and meta-analysis. Respir Med. 2023 Aug-Sep;215:107300. Abstract

75. Słabuszewska-Jóźwiak A, Szymański JK, Ciebiera M, et al. Pediatrics consequences of caesarean section - a systematic review and meta-analysis. Int J Environ Res Public Health. 2020 Oct 31;17(21):8031. Abstract

76. Zimmermann P, Messina N, Mohn WW, et al. Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: a systematic review. J Allergy Clin Immunol. 2019 Feb;143(2):467-85. Abstract

77. Lai T, Wu M, Liu J, et al. Acid-suppressive drug use during pregnancy and the risk of childhood asthma: a meta-analysis. Pediatrics. 2018 Feb;141(2):e20170889.Full text  Abstract

78. Muhammad Danial Song HJJ, Min Lee CT, Ci Ng FY, et al. Childhood acid suppressants may increase allergy risk - a systematic review and meta-analysis. J Allergy Clin Immunol Pract. 2023 Jan;11(1):228-37.e8. Abstract

79. Zhang MZ, Chu SS, Xia YK, et al. Environmental exposure during pregnancy and the risk of childhood allergic diseases. World J Pediatr. 2021 Oct;17(5):467-75. Abstract

80. Singh M, Varukolu S, Chauhan A, et al. Paracetamol exposure and asthma: What does the evidence say? An overview of systematic reviews. Pediatr Pulmonol. 2021 Oct;56(10):3189-99. Abstract

81. Cait A, Wedel A, Arntz JL, et al. Prenatal antibiotic exposure, asthma, and the atopic march: a systematic review and meta-analysis. Allergy. 2022 Nov;77(11):3233-48. Abstract

82. Güngör D, Nadaud P, LaPergola CC, et al. Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review. Am J Clin Nutr. 2019 Mar 1;109(suppl_7):772S-99S. Abstract

83. Maas T, Kaper J, Sheikh A, et al. Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD006480.Full text  Abstract

84. D'Amato G, Ortega OPM, Annesi-Maesano I, et al. Prevention of allergic asthma with allergen avoidance measures and the role of exposome. Curr Allergy Asthma Rep. 2020 Feb 26;20(3):8. Abstract

85. Burns J, Boogaard H, Polus S, et al. Interventions to reduce ambient particulate matter air pollution and their effect on health. Cochrane Database Syst Rev. 2019 May 20;(5):CD010919.Full text  Abstract

86. Khreis H, Cirach M, Mueller N, et al. Outdoor air pollution and the burden of childhood asthma across Europe. Eur Respir J. 2019 Oct;54(4):1802194. Abstract

87. Jia Y, Huang Y, Wang H, et al. A dose-response meta-analysis of the association between the maternal omega-3 long-chain polyunsaturated fatty acids supplement and risk of asthma/wheeze in offspring. BMC Pediatr. 2022 Jul 16;22(1):422. Abstract

88. Malmir H, Larijani B, Esmaillzadeh A. Fish consumption during pregnancy and risk of allergic diseases in the offspring: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2022;62(27):7449-59. Abstract

89. Bisgaard H, Mikkelsen M, Rasmussen MA, et al. Atopic and non-atopic effects of fish oil supplementation during pregnancy. Thorax. 2023 Dec;78(12):1168-74. Abstract

90. Venter C, Agostoni C, Arshad SH, et al. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology. Pediatr Allergy Immunol. 2020 Nov;31(8):889-912.Full text  Abstract

91. Osborn DA, Sinn JK, Jones LJ. Infant formulas containing hydrolysed protein for prevention of allergic disease. Cochrane Database Syst Rev. 2018 Oct 19;(10):CD003664.Full text  Abstract

92. Schindler T, Sinn JK, Osborn DA. Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy. Cochrane Database Syst Rev. 2016 Oct 28;10:CD010112.Full text  Abstract

93. Meirlaen L, Levy EI, Vandenplas Y. Prevention and management with pro-, pre and synbiotics in children with asthma and allergic rhinitis: a narrative review. Nutrients. 2021 Mar 14;13(3):934. Abstract

94. Du X, Wang L, Wu S, et al. Efficacy of probiotic supplementary therapy for asthma, allergic rhinitis, and wheeze: a meta-analysis of randomized controlled trials. Allergy Asthma Proc. 2019 Jul 1;40(4):250-60. Abstract

95. Koumpagioti D, Boutopoulou B, Moriki D, et al. Does adherence to the mediterranean diet have a protective effect against asthma and allergies in children? A systematic review. Nutrients. 2022 Apr 13;14(8):1618. Abstract

96. Papamichael MM, Shrestha SK, Itsiopoulos C, et al. The role of fish intake on asthma in children: a meta-analysis of observational studies. Pediatr Allergy Immunol. 2018 Jun;29(4):350-60. Abstract

97. Rosas-Salazar C, Chirkova T, Gebretsadik T, et al. Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study. Lancet. 2023 May 20;401(10389):1669-80. Abstract

98. Moral L, Vizmanos G, Torres-Borrego J, et al. Asthma diagnosis in infants and preschool children: a systematic review of clinical guidelines. Allergol Immunopathol (Madr). 2019 Mar-Apr;47(2):107-21. Abstract

99. Gupta S, Thériault G. Do not diagnose or routinely treat asthma or chronic obstructive pulmonary disease without pulmonary function testing. BMJ. 2023 Mar 20;380:e072834. Abstract

100. National Institute for Health and Care Excellence. Asthma: diagnosis, monitoring and chronic asthma management. Mar 2021 [internet publication].Full text

101. Cane RS, Ranganathan SC, McKenzie SA. What do parents of wheezy children understand by "wheeze"? Arch Dis Child. 2000 Apr;82(4):327-32.Full text  Abstract

102. Lai K, Satia I, Song WJ, et al. Cough and cough hypersensitivity as treatable traits of asthma. Lancet Respir Med. 2023 Jul;11(7):650-62. Abstract

103. National Heart, Lung, and Blood Institute; National Asthma Education and Prevention Program. Guidelines for the diagnosis and management of asthma. Aug 2007 [internet publication].Full text

104. Chang TS, Lemanske RF Jr, Guilbert TW, et al. Evaluation of the modified asthma predictive index in high-risk preschool children. J Allergy Clin Immunol Pract. 2013 Mar;1(2):152-6.Full text  Abstract

105. Colicino S, Munblit D, Minelli C, et al. Validation of childhood asthma predictive tools: a systematic review. Clin Exp Allergy. 2019 Apr;49(4):410-18. Abstract

106. Kothalawala DM, Kadalayil L, Weiss VBN, et al. Prediction models for childhood asthma: a systematic review. Pediatr Allergy Immunol. 2020 Aug;31(6):616-27. Abstract

107. Daines L, McLean S, Buelo A, et al. Systematic review of clinical prediction models to support the diagnosis of asthma in primary care. NPJ Prim Care Respir Med. 2019 May 9;29(1):19. Abstract

108. Reyna ME, Dai R, Tran MM, et al. Development of a symptom-based tool for screening of children at high risk of preschool asthma. JAMA Netw Open. 2022 Oct 3;5(10):e2234714. Abstract

109. Morice AH, Millqvist E, Bieksiene K, et al. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J. 2020 Jan;55(1):1901136. Abstract

110. Chang AB, Oppenheimer JJ, Irwin RS, et al. Managing chronic cough as a symptom in children and management algorithms: CHEST guideline and expert panel report. Chest. 2020 Jul;158(1):303-29. Abstract

111. Gaillard EA, Kuehni CE, Turner S, et al. European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years. Eur Respir J. 2021 Oct;58(5):2004173.Full text  Abstract

112. Miller MR, Crapo R, Hankinson J, et al. General considerations for lung function testing. Eur Respir J. 2005 Jul;26(1):153-61. Abstract

113. Stanojevic S, Kaminsky DA, Miller MR, et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J. 2022 Jul;60(1):.Full text  Abstract

114. Iftikhar IH, Greer M, Jaiteh A. A meta-analysis of diagnostic test agreement between eucapnic voluntary hyperventilation and cardiopulmonary exercise tests for exercise-induced bronchoconstriction. Lung. 2019 Aug;197(4):483-92. Abstract

115. Hengeveld VS, van der Kamp MR, Thio BJ, et al. The need for testing-the exercise challenge test to disentangle causes of childhood exertional dyspnea. Front Pediatr. 2021;9:773794.Full text  Abstract

116. Kessler KR. Relationship between the use of asthma action plans and asthma exacerbations in children with asthma: a systematic review. J Asthma Allergy Educators. 2011 Dec 3;2(1):11-21.

117. British Thoracic Society and Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. July 2019 [internet publication].Full text

118. Zimmerman B, Silverman FS, Tarlo SM, et al. Induced sputum: comparison of postinfectious cough with allergic asthma in children. J Allergy Clin Immunol. 2000 Mar;105(3):495-9. Abstract

119. Lex C, Ferreira F, Zacharasiewicz A, et al. Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests. Am J Respir Crit Care Med. 2006 Dec 15;174(12):1286-91. Abstract

120. Khatri SB, Iaccarino JM, Barochia A, et al. Use of fractional exhaled nitric oxide to guide the treatment of asthma: an official ATS clinical practice guideline. Am J Respir Crit Care Med. 2021 Nov 15;204(10):e97-109.Full text  Abstract

121. Yang CL, Hicks EA, Mitchell P, et al. Canadian Thoracic Society 2021 guideline update: diagnosis and management of asthma in preschoolers, children and adults. Can J Respir Crit Care Sleep Med. 2021;5(6):348-61.Full text

122. Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC), Cloutier MM, Baptist AP, et al. 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec;146(6):1217-70.Full text  Abstract

123. Collaro AJ, Chang AB, Marchant JM, et al. Developing fractional exhaled nitric oxide predicted and upper limit of normal values for a disadvantaged population. Chest. 2023 Mar;163(3):624-33. Abstract

124. Adams NP, Bestall JC, Lasserson TJ, Fluticasone versus placebo for chronic asthma in adults and children. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD003135. Abstract

125. Ducharme FM, Dell SD, Radhakrishnan D, et al. Diagnosis and management of asthma in preschoolers: a Canadian Thoracic Society and Canadian Paediatric Society position paper. Can Respir J. 2015 May;22(3):135-43.Full text  Abstract

126. von Mutius E, Nicolai T. Familial aggregation of asthma in a South Bavarian population. Am J Respir Crit Care Med. 1996 Apr;153(4 Pt 1):1266-72. Abstract

127. Chang AB, Oppenheimer JJ, Weinberger MM, et al. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and expert panel report. Chest. 2017 Apr;151(4):884-90.Full text  Abstract

128. Chang AB, Oppenheimer JJ, Dunlap W, et al. Yardstick for managing cough, part 2: in children. Ann Allergy Asthma Immunol. 2023 May;130(5):681-9. Abstract

129. Fitzpatrick AM, Jackson DJ, Mauger DT, et al. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016 Dec;138(6):1608-1618.e12. Abstract

130. Mallah N, Rodriguez-Segade S, Gonzalez-Barcala FJ, et al. Blood eosinophil count as predictor of asthma exacerbation. A meta-analysis. Pediatr Allergy Immunol. 2021 Apr;32(3):465-78. Abstract

131. National Institute for Health and Care Excellence. Bronchiolitis in children: diagnosis and management. Aug 2021 [internet publication].Full text

132. Farrell PM, White TB, Ren CL, et al. Diagnosis of cystic fibrosis: consensus guidelines from the cystic fibrosis foundation. J Pediatr. 2017 Feb;181:S4-15.Full text  Abstract

133. Lucas JS, Barbato A, Collins SA, et al. European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia. Eur Respir J. 2017 Jan 4;49(1):1601090.Full text  Abstract

134. Shapiro AJ, Davis SD, Polineni D, et al. Diagnosis of primary ciliary dyskinesia. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2018 Jun 15;197(12):e24-39.Full text  Abstract

135. Kantar A, Chang AB, Shields MD, et al. ERS statement on protracted bacterial bronchitis in children. Eur Respir J. 2017 Aug 24;50(2):1602139.Full text  Abstract

136. Saito J, Harris WT, Gelfond J, et al. Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough. Pediatr Pulmonol. 2006 Aug;41(8):709-19. Abstract

137. Moral L,Monzó MA, Benito JCJ, et al. Pediatric asthma: the REGAP consensus​. Anales de Pediatría. 2021;95:125.e1-e11.Full text

138. National Asthma Council Australia. Australian asthma handbook. Apr 2022 [internet publication].Full text

139. de Nijs SB, Venekamp LN, Bel EH. Adult-onset asthma: is it really different? Eur Respir Rev. 2013 Mar 1;22(127):44-52.Full text  Abstract

140. McMahon AW, Levenson MS, McEvoy BW, et al. Age and risks of FDA-approved long-acting β₂-adrenergic receptor agonists. Pediatrics. 2011 Nov;128(5):e1147-54. Abstract

141. Koldeweij C, Appelbaum N, Rodriguez Gonzalvez C, et al. Mind the gap: mapping variation between national and local clinical practice guidelines for acute paediatric asthma from the United Kingdom and the Netherlands. PLoS One. 2022;17(5):e0267445. Abstract

142. Zeiger RS, Mauger D, Bacharier LB, et al; CARE Network of the National Heart, Lung, and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011 Nov 24;365(21):1990-2001.Full text  Abstract

143. Chauhan BF, Chartrand C, Ducharme FM. Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD009611.Full text  Abstract

144. Kaiser SV, Huynh T, Bacharier LB, et al. Preventing exacerbations in preschoolers with recurrent wheeze: a meta-analysis. Pediatrics. 2016 Jun;137(6):e20154496. Abstract

145. Edwards SJ, von Maltzahn R, Naya IP, et al. Budesonide/formoterol for maintenance and reliever therapy of asthma: A meta analysis of randomised controlled trials. Int J Clin Pract. 2010 Apr;64(5):619-27. Abstract

146. Chauhan BF, Chartrand C, Ni Chroinin M, et al. Addition of long-acting beta2-agonists to inhaled corticosteroids for chronic asthma in children. Cochrane Database Syst Rev. 2015 Nov 24;(11):CD007949.Full text  Abstract

147. Chauhan BF, Ducharme FM. Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma. Cochrane Database Syst Rev. 2014 Jan 24;(1):CD003137.Full text  Abstract

148. Global Initiative for Asthma. Diagnosis and management of difficult-to-treat and severe asthma. 2022 [internet publication].Full text

149. Parsons JP, Hallstrand TS, Mastronarde JG, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013 May 1;187(9):1016-27.Full text  Abstract

150. Klain A, Indolfi C, Dinardo G, et al. Exercise-induced bronchoconstriction in children. Front Med (Lausanne). 2021;8:814976. Abstract

151. Zhang C, Hicks M, Ospina MB, et al. The impact of identifying laryngeal obstruction syndromes on reducing treatment of pediatric asthma: a systematic review. Pediatr Pulmonol. 2022 Jun;57(6):1401-15. Abstract

152. Stelmach I, Grzelewski T, Majak P, et al. Effect of different antiasthmatic treatments on exercise-induced bronchoconstriction in children with asthma. J Allergy Clin Immunol. 2008 Feb;121(2):383-9. Abstract

153. Souza Silva BRV, da Silva GAS, de Albuquerque Rodrigues Filho E, et al. Can physical exercise assist in controlling and reducing the severity of exercise-induced bronchospasm in children and adolescents? A systematic review. Clin Respir J. 2023 Jan;17(1):3-12. Abstract

154. Leung JS, Johnson DW, Sperou AJ, et al. A systematic review of adverse drug events associated with administration of common asthma medications in children. PLoS One. 2017;12(8):e0182738. Abstract

155. Sriprasart T, Waterer G, Garcia G, et al. Safety of SABA monotherapy in asthma management: a systematic review and meta-analysis. Adv Ther. 2023 Jan;40(1):133-58. Abstract

156. Calpin C, Macarthur C, Stephens D, et al. Effectiveness of prophylactic inhaled steroids in childhood asthma: a systemic review of the literature. J Allergy Clin Immunol. 1997 Oct;100(4):452-7. Abstract

157. Zhang L, Lasmar LB, Castro-Rodriguez JA. The impact of asthma and its treatment on growth: an evidence-based review. J Pediatr (Rio J). 2019 Mar-Apr;95(suppl 1):10-22. Abstract

158. Adams NP, Bestall JC, Jones P, et al. Fluticasone at different doses for chronic asthma in adults and children. Cochrane Database Syst Rev. 2008 Oct 8;2008(4):CD003534.Full text  Abstract

159. Adams N, Bestall J, Jones P. Beclomethasone at different doses for long-term asthma. Cochrane Database Syst Rev. 1999 Oct;1999(4):CD002879.Full text  Abstract

160. Tan DJ, Bui DS, Dai X, et al. Does the use of inhaled corticosteroids in asthma benefit lung function in the long-term? A systematic review and meta-analysis. Eur Respir Rev. 2021 Mar 31;30(159):200185. Abstract

161. Jackson DJ, Bacharier LB. Inhaled corticosteroids for the prevention of asthma exacerbations. Ann Allergy Asthma Immunol. 2021 Nov;127(5):524-9. Abstract

162. Rodriguez-Martinez CE, Sossa-Briceño MP, Garcia-Marcos L. Use of inhaled corticosteroids on an intermittent or as-needed basis in pediatric asthma: a systematic review of the literature. J Asthma. 2022 Nov;59(11):2189-200. Abstract

163. Powell H, Gibson PG. High dose versus low dose inhaled corticosteroid as initial starting dose for asthma in adults and children. Cochrane Database Syst Rev. 2004 Apr;2004(2):CD004109.Full text  Abstract

164. Guilbert TW, Mauger DT, Allen DB, et al; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone. J Allergy Clin Immunol. 2011 Nov;128(5):956-63.e1-7.Full text  Abstract

165. Cazeiro C, Silva C, Mayer S, et al. Inhaled corticosteroids and respiratory infections in children with asthma: a meta-analysis. Pediatrics. 2017 Mar;139(3). Abstract

166. Sielinou Kamgang KH, Rhedin SA, Almqvist C, et al. Use of inhaled corticosteroids and the risk of hospitalisation for pneumonia in children with asthma: a nationwide cohort study. Thorax. 2024 Apr 15;79(5):395-402. Abstract

167. Raissy HH, Sternberg AL, Williams P, et al. Risk of cataracts in the Childhood Asthma Management Program Cohort. J Allergy Clin Immunol. 2010 Aug;126(2):389-92.Full text  Abstract

168. Kunøe A, Sevelsted A, Chawes BLK, et al. Height and bone mineral content after inhaled corticosteroid use in the first 6 years of life. Thorax. 2022 Aug;77(8):745-51. Abstract

169. Zhang L, Prietsch SO, Ducharme FM. Inhaled corticosteroids in children with persistent asthma: effects on growth. Cochrane Database Syst Rev. 2014 Jul 17;2014(7):CD009471. Abstract

170. Kwda A, Gldc P, Baui B, et al. Effect of long term inhaled corticosteroid therapy on adrenal suppression, growth and bone health in children with asthma. BMC Pediatr. 2019 Nov 5;19(1):411. Abstract

171. Lapi F, Kezouh A, Suissa S, et al. The use of inhaled corticosteroids and the risk of adrenal insufficiency. Eur Respir J. 2013 Jul;42(1):79-86. Abstract

172. Kramer S, Rottier BL, Scholten RJ, et al. Ciclesonide versus other inhaled corticosteroids for chronic asthma in children. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD010352.Full text  Abstract

173. Bleecker ER, Menzies-Gow AN, Price DB, et al. Systematic literature review of systemic corticosteroid use for asthma management. Am J Respir Crit Care Med. 2020 Feb 1;201(3):276-93. Abstract

174. Kelly HW, Van Natta ML, Covar RA, et al. CAMP Research Group. The effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) study. Pediatrics. 2008 Jul;122(1):e53-61.Full text  Abstract

175. Aljebab F, Choonara I, Conroy S. Systematic review of the toxicity of short-course oral corticosteroids in children. Arch Dis Child. 2016 Apr;101(4):365-70. Abstract

176. Aljebab F, Choonara I, Conroy S. Long-course oral corticosteroid toxicity in children. Arch Dis Child. 2016 Sep;101(9):e2. Abstract

177. Wechsler ME, Szefler SJ, Ortega VE, et al. Step-up therapy in black children and adults with poorly controlled asthma. N Engl J Med. 2019 Sep 26;381(13):1227-39.Full text  Abstract

178. Ducharme FM, Ni Chroinin M, Greenstone I, et al. Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. Cochrane Database Syst Rev. 2010 May 12;(5):CD005535.Full text  Abstract

179. Ni Chroinin M, Greenstone I, Lasserson TJ. Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD005307.Full text  Abstract

180. Cates CJ, Schmidt S, Ferrer M, et al. Inhaled steroids with and without regular salmeterol for asthma: serious adverse events. Cochrane Database Syst Rev. 2018 Dec 3;(12):CD006922.Full text  Abstract

181. Food and Drug Administration. FDA drug safety communication: FDA review finds no significant increase in risk of serious asthma outcomes with long-acting beta agonists (LABAs) used in combination with inhaled corticosteroids (ICS). Jan 2018 [internet publication].Full text

182. Lemanske RF Jr, Mauger DT, Sorkness CA, et al. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 2010 Mar 18;362(11):975-85.Full text  Abstract

183. Lasserson TJ, Ferrara G, Casali L. Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD004106.Full text  Abstract

184. Guan R, Liu Y, Ren D, et al. The efficacy and safety of fluticasone propionate/formoterol compared with fluticasone propionate/salmeterol in treating pediatric asthma: a systematic review and meta-analysis. J Int Med Res. 2020 Mar;48(3):300060519889442. Abstract

185. O'Shea O, Stovold E, Cates CJ. Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events. Cochrane Database Syst Rev. 2021 Apr 14;4(4):CD007694.Full text  Abstract

186. Mukhopadhyay A, Waked M, Gogtay J, et al. Comparing the efficacy and safety of formoterol/budesonide pMDI versus its mono-components and other LABA/ICS in patients with asthma. Respir Med. 2020 Aug-Sep;170:106055. Abstract

187. Reddel HK, Brusselle G, Lamarca R, et al. Safety and effectiveness of as-needed formoterol in asthma patients taking inhaled corticosteroid (ICS)-formoterol or ICS-salmeterol maintenance therapy. J Allergy Clin Immunol Pract. 2023 Jul;11(7):2104-14.e3.Full text  Abstract

188. Maspero JF, Duenas-Meza E, Volovitz B, et al. Oral montelukast versus inhaled beclomethasone in 6- to 11-year-old children with asthma: results of an open-label extension study evaluating long-term safety, satisfaction, and adherence with therapy. Curr Med Res Opin. 2001 Jan 1;17(2):96-104. Abstract

189. Miligkos M, Bannuru RR, Alkofide H, et al. Leukotriene-receptor antagonists versus placebo in the treatment of asthma in adults and adolescents: a systematic review and meta-analysis. Ann Intern Med. 2015 Nov 17;163(10):756-67.Full text  Abstract

190. Chauhan BF, Jeyaraman MM, Singh Mann A, et al. Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma. Cochrane Database Syst Rev. 2017 Mar 16;3:CD010347.Full text  Abstract

191. Castro-Rodriguez JA, Rodriguez-Martinez CE, Ducharme FM. Daily inhaled corticosteroids or montelukast for preschoolers with asthma or recurrent wheezing: a systematic review. Pediatr Pulmonol. 2018 Dec;53(12):1670-7. Abstract

192. Chauhan BF, Ducharme FM. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children. Cochrane Database Syst Rev. 2012 May 16;(5):CD002314.Full text  Abstract

193. Chauhan BF, Ben Salah R, Ducharme FM. Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma. Cochrane Database Syst Rev. 2013 Oct 2;(10):CD009585.Full text  Abstract

194. Zhou XJ, Qin Z, Lu J, et al. Efficacy and safety of salmeterol/fluticasone compared with montelukast alone (or add-on therapy to fluticasone) in the treatment of bronchial asthma in children and adolescents: a systematic review and meta-analysis. Chin Med J (Engl). 2021 Nov 15;134(24):2954-61. Abstract

195. Fogel RB, Rosario N, Aristizabal G, et al. Effect of montelukast or salmeterol added to inhaled fluticasone on exercise-induced bronchoconstriction in children. Ann Allergy Asthma Immunol. 2010 Jun;104(6):511-7. Abstract

196. Dixon EG, Rugg-Gunn CE, Sellick V, et al. Adverse drug reactions of leukotriene receptor antagonists in children with asthma: a systematic review. BMJ Paediatr Open. 2021;5(1):e001206. Abstract

197. Food and Drug Administration. FDA requires boxed warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis. Mar 2020 [internet publication].Full text

198. Ekhart C, van Hunsel F, Sellick V, et al. Neuropsychiatric reactions with the use of montelukast. BMJ. 2022 Mar 29;376:e067554. Abstract

199. Dixon EG, King C, Lilley A, et al. Deprescribing montelukast in children with asthma: a systematic review. BMJ Open. 2022 Jan 31;12(1):e053112. Abstract

200. Benard B, Bastien V, Vinet B, et al. Neuropsychiatric adverse drug reactions in children initiated on montelukast in real-life practice. Eur Respir J. 2017 Aug 17;50(2):1700148.Full text  Abstract

201. Sunther M, Marchon K, Gupta A. Tiotropium in the management of paediatric and adolescent asthma: systematic review. Paediatr Respir Rev. 2021 Jun;38:58-62. Abstract

202. Kaplan A, FitzGerald JM, Buhl R, et al. Comparing LAMA with LABA and LTRA as add-on therapies in primary care asthma management. NPJ Prim Care Respir Med. 2020 Nov 11;30(1):50. Abstract

203. Vrijlandt EJLE, El Azzi G, Vandewalker M, et al. Safety and efficacy of tiotropium in children aged 1-5 years with persistent asthmatic symptoms: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2018 Feb;6(2):127-37. Abstract

204. Kim LHY, Saleh C, Whalen-Browne A, et al. Triple vs dual inhaler therapy and asthma outcomes in moderate to severe asthma: a systematic review and meta-analysis. JAMA. 2021 Jun 22;325(24):2466-79. Abstract

205. Agache I, Beltran J, Akdis C, et al. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma. Allergy. 2020 May;75(5):1023-42. Abstract

206. Agache I, Rocha C, Beltran J, et al. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma. Allergy. 2020 May;75(5):1043-57. Abstract

207. Jackson DJ, Bacharier LB, Phipatanakul W, et al. Dupilumab pharmacokinetics and effect on type 2 biomarkers in children with moderate-to-severe asthma. Ann Allergy Asthma Immunol. 2023 Jul;131(1):44-51.e4. Abstract

208. Bacharier LB, Maspero JF, Katelaris CH, et al. Dupilumab in children with uncontrolled moderate-to-severe asthma. N Engl J Med. 2021 Dec 9;385(24):2230-40. Abstract

209. Agache I, Akdis CA, Akdis M, et al. EAACI biologicals guidelines - recommendations for severe asthma. Allergy. 2021 Jan;76(1):14-44. Abstract

210. Khaleva E, Rattu A, Brightling C, et al. Development of core outcome measures sets for paediatric and adult severe asthma (COMSA). Eur Respir J. 2023 Apr;61(4):2200606. Abstract

211. Gallagher A, Edwards M, Nair P, et al. Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma. Cochrane Database Syst Rev. 2021 Oct 19;10(10):CD012929. Abstract

212. Farne HA, Wilson A, Milan S, et al. Anti-IL5 therapies for asthma. Cochrane Database Syst Rev. 2022 Jul 12;7(7):CD010834.Full text  Abstract

213. Kulus M, Hébert J, Garcia E, et al. Omalizumab in children with inadequately controlled severe allergic (IgE-mediated) asthma. Curr Med Res Opin. 2010 Jun;26(6):1285-93. Abstract

214. Atkinson CE, Schworer SA, Matthews K, et al. Omalizumab is associated with improved asthma outcomes in children and adolescents with serum immunoglobulin E above dosing guidelines. J Allergy Clin Immunol Pract. 2022 Oct;10(10):2756-7.e1. Abstract

215. Cheng L, Yang T, Ma X, et al. Effectiveness and safety studies of omalizumab in children and adolescents with moderate-to-severe asthma. J Pharm Pract. 2023 Apr;36(2):370-82. Abstract

216. McClain V. Differing definitions. J Hum Lact. 1992 Mar;8(1):7. Abstract

217. Jackson DJ, Bacharier LB, Gergen PJ, et al. Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial. Lancet. 2022 Aug 13;400(10351):502-11. Abstract

218. Bacharier LB, Maspero JF, Katelaris CH, et al. Assessment of long-term safety and efficacy of dupilumab in children with asthma (LIBERTY ASTHMA EXCURSION): an open-label extension study. Lancet Respir Med. 2024 Jan;12(1):45-54. Abstract

219. Papi A, Nicolini G, Baraldi E, et al. Regular vs prn nebulized treatment in wheeze preschool children. Allergy. 2009 Oct;64(10):1463-71. Abstract

220. Eid NS, Noonan MJ, Chipps B, et al. Once- vs twice-daily budesonide/formoterol in 6- to 15-year-old patients with stable asthma. Pediatrics. 2010 Sep;126(3):e565-75. Abstract

221. Kapadia CR, Nebesio TD, Myers SE, et al. Endocrine effects of inhaled corticosteroids in children. JAMA Pediatr. 2016 Feb;170(2):163-70.Full text  Abstract

222. Martinez FD, Chinchilli VM, Morgan WJ, et al. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet. 2011 Feb 19;377(9766):650-7.Full text  Abstract

223. Sumino K, Bacharier LB, Taylor J, et al. A pragmatic trial of symptom-based inhaled corticosteroid use in African-American children with mild asthma. J Allergy Clin Immunol Pract. 2020 Jan;8(1):176-85.e2. Abstract

224. Rodrigo GJ, Neffen H. Efficacy and safety of tiotropium in school-age children with moderate-to-severe symptomatic asthma: a systematic review. Pediatr Allergy Immunol. 2017 Sep;28(6):573-8. Abstract

225. Holguin F, Cardet JC, Chung KF, et al. Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2020 Jan;55(1):1900588.Full text  Abstract

226. Ahmed H, Turner S. Severe asthma in children-a review of definitions, epidemiology, and treatment options in 2019. Pediatr Pulmonol. 2019 Jun;54(6):778-87. Abstract

227. Lei WT, Lin HH, Tsai MC, et al. The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials. Drug Des Devel Ther. 2018;12:3825-45.Full text  Abstract

228. Stokes JR, Bacharier LB. Prevention and treatment of recurrent viral-induced wheezing in the preschool child. Ann Allergy Asthma Immunol. 2020 Aug;125(2):156-62.Full text  Abstract

229. Brusselle GG, Vanderstichele C, Jordens P, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax. 2013 Apr;68(4):322-9.Full text  Abstract

230. Undela K, Goldsmith L, Kew KM, et al. Macrolides versus placebo for chronic asthma. Cochrane Database Syst Rev. 2021 Nov 22;11(11):CD002997.Full text  Abstract

231. de Boer GM, Żółkiewicz J, Strzelec KP, et al. Bacterial lysate therapy for the prevention of wheezing episodes and asthma exacerbations: a systematic review and meta-analysis. Eur Respir Rev. 2020 Dec 31;29(158):190175.Full text  Abstract

232. Yao S, Qin R, Song X, et al. Bacterial lysate add-on therapy in adult and childhood asthma: a systematic review and meta-analysis. J Thorac Dis. 2023 Jun 30;15(6):3143-57.Full text  Abstract

233. de Boer GM, Braunstahl GJ, van der Ploeg EK, et al. Bacterial lysate add-on therapy to reduce exacerbations in severe asthma: a double-blind placebo-controlled trial. Clin Exp Allergy. 2021 Sep;51(9):1172-84.Full text  Abstract

234. Wedner HJ, Fujisawa T, Guilbert TW, et al. Benralizumab in children with severe eosinophilic asthma: pharmacokinetics and long-term safety (TATE study). Pediatr Allergy Immunol. 2024 Mar;35(3):e14092.Full text  Abstract

235. Bleecker ER, FitzGerald JM, Chanez P, et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β(2)-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016 Oct 29;388(10056):2115-27. Abstract

236. FitzGerald JM, Bleecker ER, Nair P, et al. Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2016 Oct 29;388(10056):2128-41. Abstract

237. Nair P, Wenzel S, Rabe KF, et al. Oral glucocorticoid-sparing effect of benralizumab in severe asthma. N Engl J Med. 2017 Jun 22;376(25):2448-58.Full text  Abstract

238. Harrison TW, Chanez P, Menzella F, et al. Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial. Lancet Respir Med. 2021 Mar;9(3):260-74. Abstract

239. Menzies-Gow A, Gurnell M, Heaney LG, et al. Oral corticosteroid elimination via a personalised reduction algorithm in adults with severe, eosinophilic asthma treated with benralizumab (PONENTE): a multicentre, open-label, single-arm study. Lancet Respir Med. 2022 Jan;10(1):47-58. Abstract

240. Plaza Moral V, Alobid I, Álvarez Rodríguez C, et al. GEMA 5.3. Spanish guideline on the management of asthma. Open Respir Arch. 2023 Oct-Dec;5(4):100277.Full text  Abstract

241. McGeachie MJ, Yates KP, Zhou X, et al. Patterns of growth and decline in lung function in persistent childhood asthma. N Engl J Med. 2016 May 12;374(19):1842-52. Abstract

242. Tai A, Tran H, Roberts M, et al. The association between childhood asthma and adult chronic obstructive pulmonary disease. Thorax. 2014 Sep;69(9):805-10. Abstract

243. Tagiyeva N, Devereux G, Fielding S, et al. Outcomes of childhood asthma and wheezy bronchitis. A 50-year cohort study. Am J Respir Crit Care Med. 2016 Jan 1;193(1):23-30.Full text  Abstract

244. Lommatzsch M, Buhl R, Canonica GW, et al. Pioneering a paradigm shift in asthma management: remission as a treatment goal. Lancet Respir Med. 2024 Feb;12(2):96-9. Abstract

245. Blaiss M, Oppenheimer J, Corbett M, et al. Consensus of an American College of Allergy, Asthma, and Immunology, American Academy of Allergy, Asthma, and Immunology, and American Thoracic Society workgroup on definition of clinical remission in asthma on treatment. Ann Allergy Asthma Immunol. 2023 Dec;131(6):782-5. Abstract

246. The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med. 2000 Oct 12;343:1054-63.Full text  Abstract

247. Sharek PJ, Bergman DA, Ducharme FM. Beclomethasone for asthma in children: effects on linear growth. Cochrane Database Syst Rev. 1999 Jul;1999(3):CD001282.Full text  Abstract

248. Castro-Rodriguez JA, Abarca K, Forno E. Asthma and the risk of invasive pneumococcal disease: a meta-analysis. Pediatrics. 2020 Jan;145(1):e20191200.Full text  Abstract

249. Saglani S, Malmstrom K, Pelkonen AS, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med. 2005 Apr 1;171(7):722-7.Full text  Abstract

250. Saglani S, Payne DN, Zhu J, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med. 2007 Nov 1;176(9):858-64.Full text  Abstract

251. Alavaikko S, Jaakkola MS, Tjaderhane L, et al. Asthma and caries: a systematic review and meta-analysis. Am J Epidemiol. 2011 Sep 15;174(6):631-41.Full text  Abstract

252. Wu AC, Tantisira K, Li L, et al; Childhood Asthma Management Program Research Group. Predictors of symptoms are different from predictors of severe exacerbations from asthma in children. Chest. 2011 Jul;140(1):100-7.Full text  Abstract

253. Horner CC, Mauger D, Strunk RC, et al; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity. J Allergy Clin Immunol. 2011 Nov;128(5):977-82.e1-2.Full text  Abstract

254. Gionfriddo MR, Hagan JB, Rank MA. Why and how to step down chronic asthma drugs. BMJ. 2017 Oct 16;359:j4438. Abstract

255. Nelsen LM, Kosinski M, Rizio AA, et al. A structured review evaluating content validity of the asthma control test, and its consistency with U.S. guidelines and patient expectations for asthma control. J Asthma. 2022 Mar;59(3):628-37.Full text  Abstract

256. Chu F, Kappel N, Akel M, et al. Validity of the childhood asthma control test in diverse populations: a systematic review. Pediatr Pulmonol. 2023 May;58(5):1322-36.Full text  Abstract

257. Fielding S, Pijnenburg M, de Jongste J, et al. What is a clinically meaningful change in exhaled nitric oxide for children with asthma? Pediatr Pulmonol. 2020 Mar;55(3):599-606. Abstract

258. Petsky HL, Cates CJ, Lasserson TJ, et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax. 2012 Mar;67(3):199-208. Abstract

259. Gomersal T, Harnan S, Essat M, et al. A systematic review of fractional exhaled nitric oxide in the routine management of childhood asthma. Pediatr Pulmonol. 2016 Mar;51(3):316-28. Abstract

260. Fielding S, Pijnenburg M, de Jongste JC, et al. Change in FEV1 and Feno measurements as predictors of future asthma outcomes in children. Chest. 2019 Feb;155(2):331-41.Full text  Abstract

261. Petsky HL, Kew KM, Chang AB. Exhaled nitric oxide levels to guide treatment for children with asthma. Cochrane Database Syst Rev. 2016 Nov 9;11:CD011439.Full text  Abstract

262. Liu WY, Jiesisibieke ZL, Tung TH. Effect of asthma education on health outcomes in children: a systematic review. Arch Dis Child. 2022 Dec;107(12):1100-5.Full text  Abstract

263. Pinnock H, Parke HL, Panagioti M, et al. Systematic meta-review of supported self-management for asthma: a healthcare perspective. BMC Med. 2017 Mar 17;15(1):64.Full text  Abstract

264. Cano-Garcinuno A, Diaz-Vazquez C, Carvajal-Uruena I, et al. Group education on asthma for children and caregivers: a randomized, controlled trial addressing effects on morbidity and quality of life. J Investig Allergol Clin Immunol. 2007;17(4):216-26. Abstract

265. Zemek RL, Bhogal SK, Ducharme FM. Systematic review of randomized controlled trials examining written action plans in children: what is the plan? Arch Pediatr Adolesc Med. 2008 Feb;162(2):157-63.Full text  Abstract

266. Wensley D, Silverman M. Peak flow monitoring for guided self-management in childhood asthma: a randomized controlled trial. Am J Respir Crit Care Med. 2004 Sep 15;170(6):606-12.Full text  Abstract

267. Hodkinson A, Bower P, Grigoroglou C, et al. Self-management interventions to reduce healthcare use and improve quality of life among patients with asthma: systematic review and network meta-analysis. BMJ. 2020 Aug 18;370:m2521.Full text  Abstract

268. Chan A, De Simoni A, Wileman V, et al. Digital interventions to improve adherence to maintenance medication in asthma. Cochrane Database Syst Rev. 2022 Jun 13;6(6):CD013030.Full text  Abstract

269. Smith JR, Noble MJ, Musgrave S, et al. The at-risk registers in severe asthma (ARRISA) study: a cluster-randomised controlled trial examining effectiveness and costs in primary care. Thorax. 2012 Dec;67(12):1052-60. Abstract

270. Campbell JD, Brooks M, Hosokawa P, et al. Community health worker home visits for Medicaid-enrolled children with asthma: effects on asthma outcomes and costs. Am J Public Health. 2015 Nov;105(11):2366-72. Abstract

271. Harris K, Kneale D, Lasserson TJ, et al. School-based self-management interventions for asthma in children and adolescents: a mixed methods systematic review. Cochrane Database Syst Rev. 2019 Jan 28;(1):CD011651.Full text  Abstract

272. Nanda A, Siles R, Park H, et al. Ensuring equitable access to guideline-based asthma care across the lifespan: tips and future directions to the successful implementation of the new NAEPP 2020 guidelines, a Work Group Report of the AAAAI Asthma, Cough, Diagnosis, and Treatment Committee. J Allergy Clin Immunol. 2023 Apr;151(4):869-80.Full text  Abstract

273. Ramdzan SN, Suhaimi J, Harris KM, et al. School-based self-management interventions for asthma among primary school children: a systematic review. NPJ Prim Care Respir Med. 2021 Apr 1;31(1):18.Full text  Abstract

274. Tyris J, Keller S, Parikh K. Social risk interventions and health care utilization for pediatric asthma: a systematic review and meta-analysis. JAMA Pediatr. 2022 Feb 1;176(2):e215103.Full text  Abstract

275. Gill I, Shah A, Lee EK, et al. Community interventions for childhood asthma ED visits and hospitalizations: a systematic review. 2022 Oct 1;150(4):e2021054825.Full text  Abstract

276. McCallum GB, Morris PS, Brown N, Chang AB. Culture-specific programs for children and adults from minority groups who have asthma. Cochrane Database Syst Rev. 2017 Aug 22;8:CD006580.Full text  Abstract

277. McGovern CM, Harrison R, Arcoleo K. Integrative review of programs to improve outcomes for children with comorbid asthma and anxiety/depressive symptoms. J Sch Nurs. 2023 Feb;39(1):37-50. Abstract

278. Thabrew H, Stasiak K, Hetrick SE, et al. Psychological therapies for anxiety and depression in children and adolescents with long-term physical conditions. Cochrane Database Syst Rev. 2018 Dec 22;(12):CD012488.Full text  Abstract

279. Law E, Fisher E, Eccleston C, et al. Psychological interventions for parents of children and adolescents with chronic illness. Cochrane Database Syst Rev. 2019 Mar 18;(3):CD009660.Full text  Abstract

280. Sharrad KJ, Sanwo O, Cuevas-Asturias S, et al. Psychological interventions for asthma in children and adolescents. Cochrane Database Syst Rev. 2024 Jan 11;1(1):CD013420.Full text  Abstract

281. Kew KM, Carr R, Donovan T, Gordon M. Asthma education for school staff. Cochrane Database Syst Rev. 2017 Apr 12;4:CD012255.Full text  Abstract

282. Ten Have P, van Hal P, Wichers I, et al. Turning green: the impact of changing to more eco-friendly respiratory healthcare - a carbon and cost analysis of Dutch prescription data. BMJ Open. 2022 Jun 14;12(6):e055546.Full text  Abstract

283. Adabla S, Nabors LA, Sanyaolu O, et al. Scoping review: multiple stakeholders and child asthma management interventions. J Asthma. 2023 Aug;60(8):1503-12.Full text  Abstract

284. Bickel S, Cohen RT, Needleman JP, et al. Appropriate inhaler use in children with asthma: barriers and opportunities through the lens of the socio-ecological model. J Asthma. 2023 Jul;60(7):1269-79.Full text  Abstract

285. Roberts G, Vazquez-Ortiz M, Knibb R, et al. EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma. Allergy. 2020 Nov;75(11):2734-52.Full text  Abstract

286. McTague K, Prizeman G, Shelly S, et al. Youths with asthma and their experiences of self-management education: a systematic review of qualitative evidence. J Adv Nurs. 2022 Dec;78(12):3987-4002.Full text  Abstract

287. Safety update on home use of nebulisers for acute asthma treatment in children. Drug Ther Bull. 2022 Dec;60(12):180.Full text  Abstract

288. Chen KYH, Saxon L, Robertson C, et al. Reducing asthma hospitalisations in at-risk children: a systematic review. J Paediatr Child Health. 2021 Sep;57(9):1376-84.Full text  Abstract

289. Gøtzsche PC, Johansen HK. House dust mite control measures for asthma. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD001187.Full text  Abstract

290. Blackhall K, Appleton S, Cates CJ. Ionisers for chronic asthma. Cochrane Database Syst Rev. 2012 Sep 12;2012(9):CD002986.Full text  Abstract

291. Kilburn S, Lasserson TJ, McKean M. Pet allergen control measures for allergic asthma in children and adults. Cochrane Database Syst Rev. 2001 Jan 22;(1):CD002989.Full text  Abstract

292. Campbell F, Jones K. Feather vs. non-feather bedding for asthma. Cochrane Database Syst Rev. 2000 Oct 23;(4):CD002154.Full text  Abstract

293. Beamon S, Falkenbach A, Fainburg G, et al. Speleotherapy for asthma. Cochrane Database Syst Rev. 2001 Apr 23;(2):CD001741.Full text  Abstract

294. Singh M, Jaiswal N. Dehumidifiers for chronic asthma. Cochrane Database Syst Rev. 2013 Jun 13;(6):CD003563.Full text  Abstract

295. Agache I, Lau S, Akdis CA, et al. EAACI Guidelines on Allergen Immunotherapy: House dust mite-driven allergic asthma. Allergy. 2019 May;74(5):855-873.Full text  Abstract

296. Fortescue R, Kew KM, Leung MST. Sublingual immunotherapy for asthma. Cochrane Database Syst Rev. 2020 Sep 14;9(9):CD011293.Full text  Abstract

297. Kappen J, Diamant Z, Agache I, et al. Standardization of clinical outcomes used in allergen immunotherapy in allergic asthma: An EAACI position paper. Allergy. 2023 Nov;78(11):2835-50.Full text  Abstract

298. To T, Fong I, Zhu J, et al. Effect of smoke-free legislation on respiratory health services use in children with asthma: a population-based open cohort study in Ontario, Canada. BMJ Open. 2021 Aug 5;11(8):e048137.Full text  Abstract

299. Radó MK, Mölenberg FJM, Westenberg LEH, et al. Effect of smoke-free policies in outdoor areas and private places on children's tobacco smoke exposure and respiratory health: a systematic review and meta-analysis. Lancet Public Health. 2021 Aug;6(8):e566-78.Full text  Abstract

300. Schuers M, Chapron A, Guihard H, et al. Impact of non-drug therapies on asthma control: a systematic review of the literature. Eur J Gen Pract. 2019 Apr;25(2):65-76.Full text  Abstract

301. Shah S, Kim E, Kim KN, et al. Can individual protective measures safeguard cardiopulmonary health from air pollution? A systematic review and meta-analysis. Environ Res. 2023 Jul 15;229:115708.Full text  Abstract

302. Khalaf Z, Bush A, Saglani S, et al. Influence of age on clinical characteristics, pharmacological management and exacerbations in children with asthma. Thorax. 2024 Jan 18;79(2):112-9. Abstract

303. Okoniewski W, Lu KD, Forno E. Weight loss for children and adults with obesity and asthma. A systematic review of randomized controlled trials. Ann Am Thorac Soc. 2019 May;16(5):613-25.Full text  Abstract

304. Brożek JL, Bousquet J, Agache I, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017 Oct;140(4):950-958.Full text  Abstract

305. Razi C, Bakirtas A, Harmanci K, et al. Effect of montelukast on symptoms and exhaled nitric oxide levels in 7- to 14-year-old children with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2006 Dec;97(6):767-74. Abstract

306. Chen ST, Lu KH, Sun HL, et al. Randomized placebo-controlled trial comparing montelukast and cetirizine for treating perennial allergic rhinitis in children aged 2-6 yr. Pediatr Allergy Immunol. 2006 Feb;17(1):49-54. Abstract

307. Nayak A, Langdon RB. Montelukast in the treatment of allergic rhinitis: an evidence-based review. Drugs. 2007;67(6):887-901. Abstract

308. Taramarcaz P, Gibson PG. Intranasal corticosteroids for asthma control in people with coexisting asthma and rhinitis. Cochrane Database Syst Rev. 2003 Jul 21;(3):CD003570.Full text  Abstract

309. Carson KV, Chandratilleke MG, Picot J, et al. Physical training for asthma. Cochrane Database Syst Rev. 2013 Sep 30;(9):CD001116.Full text  Abstract

310. Nyenhuis SM, Kahwash B, Cooke A, et al. Recommendations for physical activity in asthma: a work group report of the AAAAI Sports, Exercise, and Fitness Committee. J Allergy Clin Immunol Pract. 2022 Feb;10(2):433-43. Abstract

311. Kahwash BM, Gregory KL, Sharp LK, et al. Results from a national survey of asthma provider beliefs and practices regarding exercise and asthma: a work group report of the AAAAI Committee on Sports, Exercise, and Fitness. J Allergy Clin Immunol Pract. 2022 Jul;10(7):1778-83.Full text  Abstract

312. Crosbie A. The effect of physical training in children with asthma on pulmonary function, aerobic capacity and health-related quality of life: a systematic review of randomized control trials. Pediatr Exerc Sci. 2012 Aug;24(3):472-89. Abstract

313. Beggs S, Foong YC, Le HC, et al. Swimming training for asthma in children and adolescents aged 18 years and under. Cochrane Database Syst Rev. 2013;(4):CD009607.Full text  Abstract

314. Soucek M, Vock P, Daepp M, et al. [Spiral-CT: a new technique for volumetric scans. II. Potential clinical applications]. [in ger]. Rontgenpraxis. 1990 Oct;43(10):365-75. Abstract

315. Francisco CO, Bhatawadekar SA, Babineau J, et al. Effects of physical exercise training on nocturnal symptoms in asthma: Systematic review. PLoS One. 2018;13(10):e0204953.Full text  Abstract

316. Cates CJ, Rowe BH. Vaccines for preventing influenza in people with asthma. Cochrane Database Syst Rev. 2013 Feb 28;2013(2):CD000364.Full text  Abstract

317. Schwarze J, Openshaw P, Jha A, et al. Influenza burden, prevention, and treatment in asthma - a scoping review by the EAACI Influenza in asthma task force. Allergy. 2018 Jun;73(6):1151-81.Full text  Abstract

318. Bandell A, Ambrose CS, Maniaci J, et al. Safety of live attenuated influenza vaccine (LAIV) in children and adults with asthma: a systematic literature review and narrative synthesis. Expert Rev Vaccines. 2021 Jun;20(6):717-28.Full text  Abstract

319. Yepes-Nuñez JJ, Fiocchi A, Pawankar R, et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin D. World Allergy Organ J. 2016 May 17;9:17.Full text  Abstract

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