The diagnosis of osteosarcoma should be considered in any patient that presents with bone pain, particularly if the patient is in the first or second decade of life. Rarely, patients older than this can be affected, although these cases tend to be secondary osteosarcomas related to previous radiotherapy or a history of Paget's disease. Referral to an oncology consultant is indicated in all cases of osteosarcoma, even if initial radiographs are inconclusive.

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