Neonatal jaundice

References

Key articles

Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999 Jan;103(1):6-14. Abstract

Maisels MJ, Bhutani VK, Bogen D, et al. Hyperbilirubinemia in the newborn infant ≥35 weeks' gestation: an update with clarifications. Pediatrics. 2009 Oct;124(4):1193-8. Abstract

Woodgate P, Jardine LA. Neonatal jaundice: phototherapy. BMJ Clin Evid. 2015 May 22;2015:. Abstract

Gu J, Zhu Y, Zhao J. The efficacy of intravenous fluid supplementation for neonatal hyperbilirubinemia: a meta-analysis of randomized controlled studies. J Matern Fetal Neonatal Med. 2019 Nov 17;1-6. Abstract

Mandour YM, El Sayed MA, El Sayed Morgan A, et al. Audiological assessment of neonatal hyperbilirubinemia. Int J Pediatr Otorhinolaryngol. 2020 Aug;135:110126. Abstract

Reference articles

1. Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999 Jan;103(1):6-14. Abstract

2. Kumar RK. Neonatal jaundice: an update for family physicians. Aust Fam Physician. 1999 Jul;28(7):679-82. Abstract

3. Manning D, Todd P, Maxwell M, et al. Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland. Arch Dis Child Fetal Neonatal Ed. 2007 Sep;92(5):F342-6.Full text  Abstract

4. Ebbesen F, Andersson C, Verder H, et al. Extreme hyperbilirubinaemia in term and near-term infants in Denmark. Acta Paediatr. 2005 Jan;94(1):59-64. Abstract

5. Smitherman H, Stark AR, Bhutani VK. Early recognition of neonatal hyperbilirubinemia and its emergent management. Semin Fetal Neonatal Med. 2006 Jun;11(3):214-24. Abstract

6. Greco C, Arnolda G, Boo NY, et al. Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat. Neonatology. 2016;110(3):172-80.Full text  Abstract

7. Setia S, Villaveces A, Dhillon P, et al. Neonatal jaundice in Asian, white, and mixed-race infants. Arch Pediatr Adolesc Med. 2002 Mar;156(3):276-9.Full text  Abstract

8. Maisels MJ, Kring E. Transcutaneous bilirubin levels in the first 96 hours in a normal newborn population of > or = 35 weeks' gestation. Pediatrics. 2006 Apr;117(4):1169-73. Abstract

9. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004 Jul;114(1):297-316.Full text  Abstract

10. Maisels MJ. What's in a name? Physiologic and pathologic jaundice: the conundrum of defining normal bilirubin levels in the newborn. Pediatrics. 2006 Aug;118(2):805-7. Abstract

11. Wang J, Yin J, Xue M, et al. Roles of UGT1A1 Gly71Arg and TATA promoter polymorphisms in neonatal hyperbilirubinemia: a meta-analysis. Gene. 2020 Apr 30;736:144409. Abstract

12. Klein CJ, Revenis M, Kusenda C, et al. Parenteral nutrition-associated conjugated hyperbilirubinemia in hospitalized infants. J Am Diet Assoc. 2010 Nov;110(11):1684-95. Abstract

13. Gottesman LE, Del Vecchio MT, Aronoff SC. Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects. BMC Pediatr. 2015 Nov 20;15:192.Full text  Abstract

14. Lain SJ, Roberts CL, Bowen JR, et al. Early discharge of infants and risk of readmission for jaundice. Pediatrics. 2015 Feb;135(2):314-21.Full text  Abstract

15. De Luca D, Jackson GL, Tridente A, et al. Transcutaneous bilirubin nomograms: a systematic review of population differences and analysis of bilirubin kinetics. Arch Pediatr Adolesc Med. 2009 Nov;163(11):1054-9.Full text  Abstract

16. Centers for Disease Control and Prevention. What are Jaundice and Kernicterus? Nov 2019 [internet publication].Full text

17. Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002 Feb 15;65(4):599-606.Full text  Abstract

18. Abu-Heija AT, Al-Bash M, Mathew M. Gestational and Pregestational Diabetes Mellitus in Omani Women: Comparison of obstetric and perinatal outcomes. Sultan Qaboos Univ Med J. 2015 Nov;15(4):e496-500.Full text  Abstract

19. Ghosh S, Ghosh K. Maternal and neonatal outcomes in gestational diabetes mellitus. J Indian Med Assoc. 2013 May;111(5):330-1, 336. Abstract

20. Cosson E, Benchimol M, Carbillon L, et al. Universal rather than selective screening for gestational diabetes mellitus may improve fetal outcomes. Diabetes Metab. 2006 Apr;32(2):140-6.Full text  Abstract

21. Khatun N, Latif SA, Uddin MM. Infant outcomes of gestational diabetes mellitus. Mymensingh Med J. 2005 Jan;14(1):29-31. Abstract

22. Berk MA, Mimouni F, Miodovnik M, et al. Macrosomia in infants of insulin-dependent diabetic mothers. Pediatrics. 1989 Jun;83(6):1029-34. Abstract

23. Widness JA, Susa JB, Garcia JF, et al. Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesus fetuses. J Clin Invest. 1981 Mar;67(3):637-42.Full text  Abstract

24. Singla DA, Sharma S, Sharma M, et al. Evaluation of risk factors for exchange range hyperbilirubinemia and neurotoxicity in neonates from hilly terrain of India. Int J Appl Basic Med Res. 2017 Oct-Dec;7(4):228-32.Full text  Abstract

25. Gundur NM, Kumar P, Sundaram V, et al. Natural history and predictive risk factors of prolonged unconjugated jaundice in the newborn. Pediatr Int. 2010 Oct;52(5):769-72.Full text  Abstract

26. Oral E, Gezer A, Cagdas A, et al. Oxytocin infusion in labor: the effect different indications and the use of different diluents on neonatal bilirubin levels. Arch Gynecol Obstet. 2003 Jan;267(3):117-20.Full text  Abstract

27. Olusanya BO, Slusher TM. Infants at risk of significant hyperbilirubinemia in poorly-resourced countries: evidence from a scoping review. World J Pediatr. 2015 Nov;11(4):293-9. Abstract

28. Muchowski KE. Evaluation and treatment of neonatal hyperbilirubinemia. Am Fam Physician. 2014 Jun 1;89(11):873-8. Abstract

29. Kuzniewicz MW, Escobar GJ, Wi S, et al. Risk factors for severe hyperbilirubinemia among infants with borderline bilirubin levels: a nested case-control study. J Pediatr. 2008 Aug;153(2):234-40.Full text  Abstract

30. Fonseca MJ, Severo M, Barros H, et al. Determinants of weight changes during the first 96 hours of life in full-term newborns. Birth. 2014 Jun;41(2):160-8.Full text  Abstract

31. Yang WC, Zhao LL, Li YC, et al. Bodyweight loss in predicting neonatal hyperbilirubinemia 72 hours after birth in term newborn infants. BMC Pediatr. 2013 Sep 21;13:145.Full text  Abstract

32. McDonald SJ, Middleton P. Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst Rev. 2013 Jul 11;(7):CD004074.Full text  Abstract

33. Zhou J, Yang C, Zhu W, et al. Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study. Biomed Res Int. 2018;2018:7803175.Full text  Abstract

34. Queensland Clinical Guidelines. Maternity and neonatal clinical guideline: neonatal jaundice. Jun 2019 [internet publication].Full text

35. National Institute for Health and Care Excellence. Jaundice in newborn babies under 28 days. October 2016 [internet publication].Full text

36. National Association of Neonatal Nurses. Prevention of acute bilirubin encephalopathy and kernicterus in newborns. Position Statement #3049. NANN Board of Directors, March 2010. Adv Neonatal Care. 2010 Jun;10(3):112-8. Abstract

37. New South Wales Government. Neonatal - jaundice identification and management in neonates ≥32 weeks gestation. November 2016 [internet publication].Full text

38. Boo NY, Chang YF, Leong YX, et al. The point-of-care Bilistick method has very short turn-around-time and high accuracy at lower cutoff levels to predict laboratory-measured TSB. Pediatr Res. 2019 Aug;86(2):216-220.Full text  Abstract

39. Greco C, Iskander IF, Akmal DM, et al. Comparison between Bilistick System and transcutaneous bilirubin in assessing total bilirubin serum concentration in jaundiced newborns. J Perinatol. 2017 Sep;37(9):1028-1031.Full text  Abstract

40. Rohsiswatmo R, Oswari H, Amandito R, et al. Agreement test of transcutaneous bilirubin and bilistick with serum bilirubin in preterm infants receiving phototherapy. BMC Pediatr. 2018 Sep 29;18(1):315.Full text  Abstract

41. Kamineni B, Tanniru A, Vardhelli V, et al. Accuracy of Bilistick (a point-of-care device) to detect neonatal hyperbilirubinemia. J Trop Pediatr. 2020 Dec 1;66(6):630-636.Full text  Abstract

42. Benchimol EI, Walsh CM, Ling SC, et al. Early diagnosis of neonatal cholestatic jaundice: test at 2 weeks. Can Fam Physician. 2009 Dec;55(12):1184-92.Full text  Abstract

43. Fawaz R, Baumann U, Ekong U, et al. Guideline for the evaluation of cholestatic jaundice in infants: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):154-68.Full text  Abstract

44. Trikalinos TA, Chung M, Lau J, et al. Systematic review of screening for bilirubin encephalopathy in neonates. Pediatrics. 2009 Oct;124(4):1162-71. Abstract

45. Ip S, Chung M, Trikalinos T, et al. Screening for bilirubin encephalopathy. Agency for Healthcare Research and Quality. 2009;1.Full text  Abstract

46. Bhutani VK, Johnson LH, Keren R. Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week. Pediatr Clin North Am. 2004 Aug;51(4):843-61. Abstract

47. Maisels MJ, Bhutani VK, Bogen D, et al. Hyperbilirubinemia in the newborn infant ≥35 weeks' gestation: an update with clarifications. Pediatrics. 2009 Oct;124(4):1193-8. Abstract

48. Mishra S, Chawla D, Agarwal R, et al. Transcutaneous bilirubinometry reduces the need for blood sampling in neonates with visible jaundice. Acta Paediatr. 2009 Dec;98(12):1916-9. Abstract

49. De Luca D, Jackson GL, Tridente A, et al. Transcutaneous bilirubin nomograms: a systematic review of population differences and analysis of bilirubin kinetics. Arch Pediatr Adolesc Med. 2009 Nov;163(11):1054-9.Full text  Abstract

50. Dijk PH, Hulzebos CV. An evidence-based view on hyperbilirubinaemia. Acta Paediatr. 2012 Apr;101(464):3-10. Abstract

51. Maisels MJ. Neonatal jaundice. Pediatr Rev. 2006 Dec;27(12):443-54. Abstract

52. Bhutani VK; Committee on Fetus and Newborn; American Academy of Pediatrics. Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2011 Oct;128(4):e1046-52. Reaffirmed Jan 2022.Full text  Abstract

53. Donneborg ML, Vandborg PK, Hansen BM, et al. Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia. J Perinatol. 2018 Feb;38(2):154-8.Full text  Abstract

54. Nuntnarumit P, Naka C. Comparison of the effectiveness between the adapted-double phototherapy versus conventional-single phototherapy. J Med Assoc Thai. 2002 Nov;85 Suppl 4:S1159-66. Abstract

55. Sarici SU, Alpay F, Unay B, et al. Double versus single phototherapy in term newborns with significant hyperbilirubinemia. J Trop Pediatr. 2000 Feb;46(1):36-9.Full text  Abstract

56. Gutta S, Shenoy J, Kamath SP, et al. Light emitting diode (LED) phototherapy versus conventional phototherapy in neonatal hyperbilirubinemia: a single blinded randomized control trial from coastal India. Biomed Res Int. 2019;2019:6274719.Full text  Abstract

57. Mills JF, Tudehope D. Fibreoptic phototherapy for neonatal jaundice. Cochrane Database Syst Rev. 2001;(1):CD002060.Full text  Abstract

58. Kumar P, Murki S, Malik GK, et al. Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi center randomized controlled trial. Indian Pediatr. 2010 Feb;47(2):131-7.Full text  Abstract

59. Woodgate P, Jardine LA. Neonatal jaundice: phototherapy. BMJ Clin Evid. 2015 May 22;2015:. Abstract

60. Kumar P, Chawla D, Deorari A. Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD007969.Full text  Abstract

61. Tayman C, Tatli MM, Aydemir S, et al. Overhead is superior to underneath light-emitting diode phototherapy in the treatment of neonatal jaundice: a comparative study. J Paediatr Child Health. 2010 May;46(5):234-7. Abstract

62. Tridente A, De Luca D. Efficacy of light-emitting diode versus other light sources for treatment of neonatal hyperbilirubinemia: a systematic review and meta-analysis. Acta Paediatr. 2012 May;101(5):458-65. Abstract

63. Sarin M, Dutta S, Narang A. Randomized controlled trial of compact fluorescent lamp versus standard phototherapy for the treatment of neonatal hyperbilirubinemia. Indian Pediatr. 2006 Jul;43(7):583-90. Abstract

64. Maimburg RD, Olsen J, Sun Y. Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. Epilepsy Res. 2016 Aug;124:67-72. Abstract

65. Newman TB, Wu YW, Kuzniewicz MW, et al. Childhood seizures after phototherapy. Pediatrics. 2018 Oct;142(4):e20180648. Abstract

66. Morris BH, Oh W, Tyson JE, et al; NICHD Neonatal Research Network. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008 Oct 30;359(18):1885-96.Full text  Abstract

67. Okwundu CI, Okoromah CA, Shah PS. Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants. Cochrane Database Syst Rev. 2012 Jan 18;(1):CD007966.Full text  Abstract

68. Van Rostenberghe H, Ho JJ, Lim CH, et al. Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia. Cochrane Database Syst Rev. 2020 Jul 1;7:CD012011.Full text  Abstract

69. Goyal P, Mehta A, Kaur J, et al. Fluid supplementation in management of neonatal hyperbilirubinemia: a randomized controlled trial. J Matern Fetal Neonatal Med. 2018 Oct;31(20):2678-84.Full text  Abstract

70. Gu J, Zhu Y, Zhao J. The efficacy of intravenous fluid supplementation for neonatal hyperbilirubinemia: a meta-analysis of randomized controlled studies. J Matern Fetal Neonatal Med. 2019 Nov 17;1-6. Abstract

71. Mitra S, Samanta M, Sarkar M, et al. Pre-exchange 5% albumin infusion in low birth weight neonates with intensive phototherapy failure: a randomized controlled trial. J Trop Pediatr. 2011 Jun;57(3):217-21. Abstract

72. Lai NM, Ahmad Kamar A, Choo YM, et al. Fluid supplementation for neonatal unconjugated hyperbilirubinaemia. Cochrane Database Syst Rev. 2017 Aug 1;(8):CD011891.Full text  Abstract

73. Dash N, Kumar P, Sundaram V, et al. Pre-exchange albumin administration in neonates with hyperbilirubinemia: a randomized controlled trial. Indian Pediatr. 2015 Sep;52(9):763-7. Abstract

74. Huizing K, Røislien J, Hansen T. Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and AB0 incompatibility. Acta Paediatr. 2008 Oct;97(10):1362-5. Abstract

75. Beken S, Hirfanoglu I, Turkyilmaz C, et al. Intravenous immunoglobulin G treatment in ABO hemolytic disease of the newborn, is it myth or real? Indian J Hematol Blood Transfus. 2014 Mar;30(1):12-5.Full text  Abstract

76. Zwiers C, Scheffer-Rath ME, Lopriore E, et al. Immunoglobulin for alloimmune hemolytic disease in neonates. Cochrane Database Syst Rev. 2018 Mar 18;(3):CD003313.Full text  Abstract

77. Flaherman VJ, Maisels MJ, Academy of Breastfeeding Medicine. ABM Clinical Protocol #22: Guidelines for management of jaundice in the breastfeeding infant 35 weeks or more of gestation-revised 2017. Breastfeed Med. 2017 Jun;12(5):250-7.Full text  Abstract

78. Thayyil S, Milligan DW. Single versus double volume exchange transfusion in jaundiced newborn infants. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004592.Full text  Abstract

79. Reddy P, Najundaswamy S, Mehta R, et al. Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant. J Perinatol. 2003 Sep;23(6):507-8. Abstract

80. Drummond GS, Kappas A. Chemoprevention of severe neonatal hyperbilirubinemia. Semin Perinatol. 2004 Oct;28(5):365-8. Abstract

81. Bhutani VK, Poland R, Meloy LD, et al. Clinical trial of tin mesoporphyrin to prevent neonatal hyperbilirubinemia. J Perinatol. 2016 Jul;36(7):533-9.Full text  Abstract

82. Slusher TM, Olusanya BO, Vreman HJ, et al. A randomized trial of phototherapy with filtered sunlight in African neonates. N Engl J Med. 2015 Sep 17;373(12):1115-24.Full text  Abstract

83. Gholitabar M, McGuire H, Rennie J, et al. Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia. Cochrane Database Syst Rev. 2012 Dec 12;(12):CD009017.Full text  Abstract

84. Xiong T, Chen D, Duan Z, et al. Clofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review. Indian Pediatr. 2012 Jan;49(1):35-41.Full text  Abstract

85. Kumar P, Adhisivam B, Vishnu Bhat B. Clofibrate as an adjunct to phototherapy for unconjugated hyperbilirubinemia in term neonates. Indian J Pediatr. 2017 Oct;84(10):763-7.Full text  Abstract

86. Dey SK, Islam S, Jahan I, et al. Association of hyperbilirubinemia requiring phototherapy or exchange transfusion with hearing impairment among admitted term and late preterm newborn in a NICU. Mymensingh Med J. 2020 Apr;29(2):405-413. Abstract

87. Bhandari V, Narang A, Mann SB, et al. Brain stem electric response audiometry in neonates with hyperbilirubinemia. Indian J Pediatr. 1993 May-Jun;60(3):409-13. Abstract

88. Funato M, Teraoka S, Tamai H, et al. Follow-up study of auditory brainstem responses in hyperbilirubinemic newborns treated with exchange transfusion. Acta Paediatr Jpn. 1996 Feb;38(1):17-21.Full text  Abstract

89. Mandour YM, El Sayed MA, El Sayed Morgan A, et al. Audiological assessment of neonatal hyperbilirubinemia. Int J Pediatr Otorhinolaryngol. 2020 Aug;135:110126. Abstract

90. Karimzadeh P, Fallahi M, Kazemian M, et al. Bilirubin induced encephalopathy. Iran J Child Neurol. 2020 Winter;14(1):7-19.Full text  Abstract

91. Blumovich A, Mangel L, Yochpaz S, et al. Risk factors for readmission for phototherapy due to jaundice in healthy newborns: a retrospective, observational study. BMC Pediatr. 2020 May 26;20(1):248.Full text  Abstract

92. Khadem Al-Hosseini M, Rahideh ST, Saadati A, et al. The effect of vitamin C supplementation in the last month of pregnancy on neonatal bilirubin levels; A double-blind randomized clinical trial. Complement Ther Med. 2020 May;50:102359. Abstract

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