Gestational diabetes mellitus

Gestational diabetes mellitus (GDM) develops during pregnancy and is usually diagnosed at 24 to 28 weeks of gestation on the basis of elevated plasma glucose levels on glucose tolerance testing.

Goal of therapy is to achieve maternal glucose levels that are as close to normal as possible in order to avoid fetal macrosomia and complications.

Initial therapy for gestational diabetes is usually dietary modification. Insulin is started when acceptable glucose levels cannot be maintained with diet alone.

Maternal postnatal testing for diabetes or impaired glucose tolerance is performed at 4 to 6 weeks following delivery.

The risk for recurrence of GDM in subsequent pregnancies or progression to type 2 diabetes is high.

Gestational diabetes mellitus (GDM) was previously defined as any degree of glucose intolerance with onset or first recognition during pregnancy. This definition included a population of women with pre-existing type 2 diabetes, so the definition has been modified to indicate that the diagnosis is after the first trimester of pregnancy.[1]American Diabetes Association. Standards of medical care in diabetes - 2021. Diabetes Care. 2021 Jan;44(suppl 1):S1-232. https://care.diabetesjournals.org/content/44/Supplement_1 It is usually recognised at 24 to 28 weeks of gestation on the basis of abnormal glucose tolerance testing.[1]American Diabetes Association. Standards of medical care in diabetes - 2021. Diabetes Care. 2021 Jan;44(suppl 1):S1-232. https://care.diabetesjournals.org/content/44/Supplement_1 The criteria for diagnosing GDM remain controversial.

BMJ talk medicine podcast: Gestational diabetes external link opens in a new window