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Restless legs syndrome

Última revisão: 20 八月 2025
Última atualização: 10 九月 2025

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • presence of risk factors
  • urge to move the legs
  • dysaesthesias
  • evening or night symptoms
  • relieving factors (movement, stretching, massage)
  • location in lower extremities, less commonly upper extremities and torso
Detalhes completos

Outros fatores diagnósticos

  • alcohol use
  • caffeine use
Detalhes completos

Fatores de risco

  • conditions associated with iron deficiency
  • pregnancy
  • family history of RLS
  • use of certain drugs
  • female sex
  • increased age
  • obesity
  • diabetes mellitus
  • Parkinson's disease
  • multiple sclerosis
  • peripheral neuropathy
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • clinical diagnosis
  • iron studies
Detalhes completos

Algoritmo de tratamento

AGUDA

intermittent RLS: non-pregnant

intermittent RLS: pregnant

chronic persistent RLS: non-pregnant

chronic persistent RLS: pregnant

CONTÍNUA

refractory RLS: non-pregnant

refractory RLS: pregnant

Colaboradores

Autores

Nitun Verma, MD, MBA

Sleep Physician

AC Wellness

Cupertino

CA

Disclosures

NV declares that he has no competing interests.

Clete A. Kushida, MD, PhD, RPSGT

Acting Medical Director

Stanford Sleep Medicine Center

Director

Stanford Center for Human Sleep Research

Associate Professor

Stanford University Medical Center

Stanford Sleep Medicine Center

Redwood City

CA

Disclosures

CAK is an author of a number of references cited in this topic.

Peer reviewers

Magdolna Hornyak, MD

Associate Professor

Interdisciplinary Pain Center and Department for Psychiatry and Psychotherapy

University Medical Center Freiburg

Freiburg

Germany

Disclosures

MH declares that she has no competing interests.

K Ray Chaudhuri, MD, FRCP, DSc, FEAN

Professor of Movement Disorders and Neuroscience and Clinical Director

Parkinson Foundation International Centre of Excellence

King's College Hospital and King's College

Campus Research Director and Assistant Medical Director

King's College Hospital NHS Foundation Trust

London

UK

Disclosures

KRC declares that he has no competing interests.

Brian Koo, MD

Associate Professor of Neurology

Yale University

New Haven

CT

Declarações

BK declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Winkelman JW, Armstrong MJ, Allen RP, et al. Practice guideline summary: treatment of restless legs syndrome in adults - report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2016 Dec 13;87(24):2585-93.Texto completo  Resumo

American Academy of Sleep Medicine. The AASM international classification of sleep disorders - third edition, text revision (ICSD-3-TR). Jun 2023​ [internet publication].Texto completo

Silber MH, Buchfuhrer MJ, Earley CJ, et al. The management of restless legs syndrome: an updated algorithm. Mayo Clin Proc. 2021 Jul;96(7):1921-37.Texto completo  Resumo

Winkelman JW, Berkowski JA, DelRosso LM, et al. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2025 Jan 1;21(1):137-52.Texto completo  Resumo

Allen RP, Picchietti DL, Auerbach M, et al. Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Med. 2018 Jan;41:27-44.Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
  • Diagnósticos diferenciais

    • Periodic limb movement disorder (PLMD)
    • Akathisia
    • Peripheral neuropathy
    Mais Diagnósticos diferenciais
  • Diretrizes

    • Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline
    • International classification of sleep disorders, 3rd edition, text revision (ICSD-3-TR)
    Mais Diretrizes
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