Criteria

Marsh criteria[39]

Histological changes on small intestinal biopsy

  • 0: normal villous architecture with no increase in intra-epithelial lymphocytes

  • I: normal villous architecture with increased intra-epithelial lymphocytes

  • II: increased intra-epithelial lymphocytes and crypt hyperplasia with normal villi

  • IIIa: increased intra-epithelial lymphocytes and crypt hyperplasia with partial villous atrophy

  • IIIb: increased intra-epithelial lymphocytes and crypt hyperplasia with subtotal villous atrophy

  • IIIc: increased intra-epithelial lymphocytes and crypt hyperplasia with total villous atrophy.

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